EKS-EQC-00092

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-EQC-00092

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
Atypical/PIKK	408.4	2.6E-122	3728	4077	350

Status

Unreviewed

Ensembl Protein

ENSECAP00000018867

UniProt Accession

F6RGR8;

Protein Name

Protein Synonyms/Alias

Gene Name

DNAPK

Gene Synonyms/Alias

DNAPK;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSECAG00000020168	ENSECAP00000018961	ENSECAT00000022915
ENSECAG00000020168	ENSECAP00000018881	ENSECAT00000022823
ENSECAG00000020168	ENSECAP00000018867	ENSECAT00000022809
ENSECAG00000020168	ENSECAP00000018902	ENSECAT00000022846

Organism

Equus caballus

Functional Description

Protein Length

4137

Protein Sequence
(FASTA)

MAHSGSGLQS FLMQLQESLS AADRCSAAMA GYHLIRGLGQ ECMLSTGPAV LALQTSLVFS 60

KDFGLLVFVR KSLSIDEFRD CREEILKFLY IFLEKIGQKI TPYSLDIKNT CTSVYTKDKA 120

AKCKIPALDL LIKLLQTLRS SRLMDEFRVG ELFTKFYGEL ALKTKIPDTV LEKIYELLGV 180

LGEVHPSEMI SNSEQLFRAF LGELKSQMTS TVREPKLPVL AGCLKGLSSL MCNFTKSMEE 240

DPQTSREIFD FALKAIRPQI DLKRYAVPLA GLCLFTLHAS QFSTCLLENY VSLFEVLSKW 300

CGHTNIELKK AAHSALESFL KQVSFMVAKD AERHKNKLQY FMEQFYGIIR NMDSNSKDLS 360

IAIRGYGLFA GPCKVINAKD VDFMYVELIQ RCKQLFLTQT DTVDDHIYQM PSFLQSIASV 420

LLYLDTIPEV YTPVLEHLMV VQIDSFPQYS PKMQPVCCRA IVKVFLALAE KGPVLWNCIS 480

TVVHQGLIRI CSKPVVFQKG AGSESEDYHT SEEARTGKWK MPTYKDYLDL FRYLLSCDQM 540

MDSLLADEAF LFVNSSLHSL NRLLYDEFVK SVLKIVEKLD LTLEKQNVGE QEDETEATGV 600

WVIPTSDPAA NLHPAKPKDF SAFINLVEFC REILPEKHVE FFEPWVYSFA YELILQSTRL 660

PLISGFYKLL SVAVRNAKKM KYFEGVGPKS QKQSPEDLEK YSCFALFAKF SKEVSIKMKQ 720

YKDELLASCL TFILSLPHDI IELDVRAYVP ALQMAFKLGL SYTPLAEVGL NALEEWSGYI 780

CKHVIQPYYK DILPSLDGYL KTSVLSDETK NSWQVSALSR AAQKGFNKVV LKHLTKTKSI 840

SSNEALSLEE VRIRVVRILG SLGGQINKNL VTAASSDEMM KKCVAWDREK RLRFAVPFME 900

MKPVIYLDLF LPRVTELALS ASDRQTKVAA CEFLHSMVMF MLGKATQMPE DGQGSPPMYQ 960

LYKRTFPVLL RLACDVDQVT RQLYEPLVMQ LIHWFTNNKK FESQDTVALL ETILDGIVDP 1020

VDSTLRDFCG QCIQEFLKWS IKQTTPQQQE KSPVNTKSLF KRLYSFALHP NAFKRLGASL 1080

AFNNIYREFR EEESLVEQFV FEALVTYMES LALAHTDEKS LGTIQQCCDA IDHLSLIIEK 1140

KHVSLNKAKK RRLPRGFPPA TSLCLLDVVQ WLLANCGRPQ TECRHKSIEL FYKFVTLLPG 1200

NKSPFLWLKD IIKKEDISFL INTFEGGGRG CDRPSGILAQ PTLFHLQGPF SLRAALQWMD 1260

MLLAALECYN TFIEEKTLEA PKVLGTETQS SLWKAVAFFL ESIAMHDIMA AEKYFGTGAT 1320

GNRPSPQEGE RYNYSKCTIV VRIMEFTTTL LSTSPEGWKL LEKDVCNTNL MKLLVKTLCE 1380

PSSIGFNIGD VAVMNYLPSV CTNLMKALKK SPYKDILEMH LKEKITAQSI EELCAVDLYC 1440

PDACVDRARL ASVVSACKQL HRAGFLCVII PSQSADQHHS IGTKLLSLVY KSIAPGDEQQ 1500

CLPSLDPNCK RLASGLLELA FAFGGLCEHL VSLLLDTTVL SMPSRGGSQK NIVSFSHGEY 1560

FYSLFSETIN TELLKNLDLA VLELMKSSVD NPKMVSNVLN GMLDQSFRDR TSEKHQGLKL 1620

ATIILQNWKK CDSWWAKDSA PESKMAVLTL LAKILQIDSS VCFNTNHCMF PEVFTTYVSL 1680

LADSKLDLHL KATGQAIILL PFFTSLTGGS LEDLKVVLEN LIVSNFPMKS EEFPPGTLQY 1740

SNYVDCMKKF LDALELSESP MLLQLMTEIL CREQQHVMEE LFQSTFKKIA RKSSCITQLG 1800

LLESVYRMFR RDDLLSNITR QAFVDRSLLT LLWHCSLNAL REFFSKIVVE AINVLKSRFI 1860

KLNESAFDTQ ITKKMGYYKM LDVMYSRLPK DDVHSKESKI NQVFHGSCIT EGSELTKTLI 1920

KLCYDAFTEN MAGENQLLER RRLYHCAAYN CAISVVCCVF NELKFYQGFL FTEKPEKNLL 1980

IFENLIDLKR CYTFPIEVEV PMERKKKYLE IRKEAREAAS GDSDGPRYIS SLSYLADSSL 2040

SEEMSQFDFS TGVQSYSYSS QDPKSTTAHF RRQKHKESMI QDDILELEMD ELNQHECMAT 2100

MTALIKHMQR NQILPKEEEG SVPRNLPPWM KFLHDKLGNP SISLNIRLFL AKLVINTEEV 2160

FRPYARYWLS PLLQLVVSGN NGGEGIHYMV VEIVVIILSW TGLATPIGVP KDEVLANRLL 2220

HFLMKHVFHQ KRAVFRHNLE IIKTLVECWK DCLSIPYRLI FEKFSSTDPN SKDNSVGIQL 2280

LGIVMANNLP PYDPKCGIES IKYFQALVNN MSFVKYREVY AAAAEVLGLV LRYITERENI 2340

LEESVCELVI KQLKQHQNTM EDKFIVCLNK AVKNFPPLAD RFMNTVFFLL PKFHGVMKTL 2400

CLEVVLCRAE EITDLYLQLK SKDFIQVMRH RDDERQKVCL DIIYKMMAKL KPVELRELLN 2460

PVVEFISHPS PVCREQMYNI LMWIHDNYRD PESQADDDSQ EIFKLAKDVL IQGLIDENPG 2520

LQLIIRNFWS HETRLPSNTL DRLLALNSLY SPKIEAHFLS LATDFLLEMT SVSPDYSNPM 2580

FEHPLSECKF QEYTIDSDWR FRSTVLTPMF IETQASQSAL QTRTQEGSLS ARGVMTGQIR 2640

ATQQQYDFTP TQNTDGRSSF NWLTGNSIDP LVDFTVSSSS DSLSSSLLFA HKRSEKSQRV 2700

PLKSVGPDFG KKRLGLPGDE VDNKAKGGED NRAEILRLRR RFLKDREKLS LIYARKGVAE 2760

QKREKEIKSE LKMKHDAQVI LYRSYRQGDL PDIQIKYSSL ITPLQAVAQR DPIIAKQLFG 2820

SLFSGIIKEM DKYKTMSEKN NITQKLLQDF NNFLNTTVSF FPPFISCIQE ISCQHADLLS 2880

LNPASVSASC LASLQQPVGV RLLEEALLHL LPEEPPAKRV RGRPCLYPDF VRWMELAKLY 2940

RSIGEYDILR GIFNSEIGTK QVTQNALLAE ARNDYSEAVK QYNEALNKQE WVDGEPMEAE 3000

KDFWELASLD CYNQLAEWKS LAYCSTVSVD SANPPDLNKM WNEPFYQETY LPYMIRSKLK 3060

LLLQGEGDQS LLTFIDEAVS KELQKVLVEL HYSQELSLLY ILQDDVDRAK YYIENCIRIF 3120

MQSYSSIDVL LERSRLTKLQ SLQTLIEIQE FISFISKQGN LSSQIPLKRL LKTWTNRYPD 3180

AKMDPMNIWD DIITNRCFFL SKIEEKLTLP PDDHSMNTDG DEDSSDRMKV QEQEEDIYSL 3240

IKSCKFSMKM KMIESARKQK NFSLAMKLLK ELHKESKTRD DWLVKWVQSY CRLSHSRSQT 3300

QNRPEQILTV LKTVSLLDEN TSSYLSKNIP VSRDHNILLG TTYRIIANAL SSDPTCLAEI 3360

GESKARRILE LSGSSLENAE EVIAGLYQRV LHHLSEAVRI AEEEAQPFTR GQEPAVGVID 3420

AYMTLVDFCD QQLRKEEESS SVTESVQLQM YPALVVDKML KALRLHSNEA RLKFPRLLQI 3480

IEQYPEETLS LMTKEISSIP CWQFIGWISH MVALLDKEEA VAVHRTVEEI ADNYPQAMVY 3540

PFIISSESYS FKDTSTGYKN KEFVERIKIK LDQGGVIQDF INALEQLSHP EMLFKDWTDD 3600

IKVELEKNPV NRKNIEKMYE KMYATLGDPQ APGLGAFRRR FIQAFGKEFD KHFGRGGSKL 3660

PGMKPREFSD ITNSLFSKMC EVSKPPGNLK ECSPWMSDFK VEFLRSELEI PGQYDGKGKP 3720

VPEYHARIAG FDERIKVMAS MRKPKRIIIR GHDEREYPFL VKGGEDLRQD QRIEQLFEVM 3780

NVILSQDATC SQRSMQLKTY QVIPMTSRLG LIEWIENTFT LKELLLSNMS QEEKAACTSD 3840

PKAPPFEYRD WLTKMSGKCD VGAYMLMYKG ASRTETVTSF RKRESKVPAD LLKRAFVKMS 3900

TSPEAFLTLR SHFARSHALI CISHWILGIG DRHLNNFLVS METGGVIGID FGHAFGSATQ 3960

FLPVPELMPF RLTRQFINLM LPMKETGVMY SIMVHALRAF RSQSNLLANT MDVFVKEPSF 4020

DWKNFEQKML KKGGSWIQEI NVTEKNWYPR QKIHYAKRKL AGANPAVITC DELLLGHEKV 4080

AAFGDYVAVA RGSEDHNIRA QELESDLSEE AQVKCLIDQA TDPNILGRTW IGWEPWM 4137

Nucleotide Sequence
(FASTA)

ATGGCGCACT CCGGCTCTGG CCTACAGAGC TTTTTGATGC AGCTGCAGGA GTCCTTGTCC 60

GCCGCGGACC GCTGCAGCGC CGCGATGGCC GGTTACCATC TGATCCGGGG CCTGGGGCAG 120

GAGTGCATGC TGAGCACCGG CCCCGCTGTG CTGGCGTTAC AGACTTCCTT GGTTTTTTCC 180

AAAGATTTTG GTTTACTTGT ATTTGTTCGG AAATCACTTA GTATTGATGA ATTTCGTGAT 240

TGTAGAGAAG AAATCCTAAA ATTTTTATAT ATTTTCTTAG AAAAAATTGG CCAGAAGATC 300

ACACCTTATT CTCTTGATAT TAAGAATACT TGTACCAGTG TTTACACAAA AGATAAAGCT 360

GCCAAATGTA AAATTCCGGC CCTAGATCTT CTTATTAAGT TACTTCAGAC TTTGAGAAGT 420

TCTAGACTCA TGGATGAATT TAGAGTTGGA GAATTATTTA CCAAATTCTA TGGAGAACTT 480

GCCTTGAAAA CAAAAATACC AGATACAGTT TTAGAAAAAA TATATGAGCT CCTAGGAGTA 540

TTAGGTGAAG TTCATCCTAG TGAGATGATA AGTAATTCAG AACAACTGTT CCGGGCTTTT 600

CTGGGTGAAC TTAAGTCCCA GATGACATCA ACAGTAAGAG AGCCCAAACT ACCTGTTCTG 660

GCAGGGTGTC TGAAGGGATT GTCATCACTT ATGTGTAACT TCACTAAGTC CATGGAAGAA 720

GATCCCCAGA CTTCAAGGGA GATTTTTGAT TTTGCGTTAA AGGCAATTCG TCCTCAGATT 780

GATCTGAAGA GATATGCAGT GCCCTTAGCT GGTTTATGCT TATTTACCCT GCATGCATCT 840

CAATTTAGCA CCTGCCTTTT GGAGAACTAC GTTTCTTTGT TTGAAGTGCT GTCAAAATGG 900

TGTGGCCATA CAAACATAGA ATTGAAAAAA GCCGCACATT CAGCTCTGGA GTCTTTTCTG 960

AAACAGGTTT CTTTTATGGT GGCAAAAGAT GCAGAAAGGC ATAAGAATAA GCTGCAGTAC 1020

TTTATGGAGC AATTCTATGG AATCATCAGG AACATGGATT CAAATAGCAA GGATTTATCA 1080

ATTGCAATTC GTGGATATGG ACTTTTTGCA GGCCCTTGCA AGGTTATAAA TGCAAAAGAT 1140

GTTGACTTCA TGTACGTAGA GCTCATTCAG CGCTGCAAGC AGCTGTTCCT CACCCAGACA 1200

GATACTGTTG ATGACCATAT TTACCAGATG CCCAGTTTCC TCCAATCTAT TGCAAGTGTC 1260

TTGCTTTACC TTGATACAAT TCCTGAGGTG TATACTCCGG TTCTGGAACA TCTCATGGTG 1320

GTACAGATAG ACAGCTTCCC ACAGTATAGT CCAAAAATGC AGCCGGTGTG TTGTAGAGCC 1380

ATAGTGAAAG TTTTCCTAGC CTTAGCAGAA AAGGGACCAG TTCTCTGGAA TTGCATTAGT 1440

ACTGTGGTGC ATCAAGGTTT AATTAGAATA TGTTCTAAAC CAGTCGTCTT TCAAAAGGGT 1500

GCTGGGTCTG AATCCGAAGA CTATCATACA TCAGAGGAAG CTAGAACTGG CAAATGGAAA 1560

ATGCCCACAT ACAAAGACTA TTTGGATCTT TTTAGATATC TCCTGAGCTG TGACCAGATG 1620

ATGGATTCTC TTTTAGCAGA TGAAGCATTT CTCTTTGTGA ATTCCTCCCT TCATAGTCTG 1680

AATCGTTTGC TGTATGATGA ATTTGTAAAA TCAGTTTTGA AGATTGTTGA GAAATTGGAT 1740

CTTACACTAG AAAAACAGAA TGTTGGGGAG CAAGAGGATG AAACTGAAGC TACTGGTGTT 1800

TGGGTGATCC CGACTTCAGA TCCAGCGGCT AACTTGCACC CTGCTAAACC TAAAGATTTT 1860

TCAGCTTTCA TTAACCTGGT GGAATTTTGC AGAGAGATTC TTCCTGAGAA ACATGTAGAA 1920

TTTTTTGAGC CATGGGTTTA CTCATTTGCG TATGAATTAA TTTTGCAGTC TACACGGTTA 1980

CCACTCATCA GTGGTTTTTA CAAATTGCTT TCTGTTGCTG TGAGAAATGC CAAGAAAATG 2040

AAGTATTTTG AAGGAGTTGG TCCAAAGAGT CAGAAACAGT CTCCTGAGGA CCTAGAAAAG 2100

TATTCTTGCT TTGCTTTGTT TGCAAAATTT AGTAAAGAGG TATCAATTAA AATGAAGCAA 2160

TACAAAGATG AACTTTTGGC CTCCTGTTTG ACCTTTATTC TGTCCCTGCC ACATGACATC 2220

ATTGAACTTG ATGTTAGAGC CTACGTTCCT GCATTGCAGA TGGCTTTTAA ACTGGGCCTG 2280

AGCTATACTC CATTGGCGGA AGTAGGCCTG AATGCTCTAG AAGAATGGTC AGGTTACATC 2340

TGCAAACATG TAATTCAGCC CTATTATAAG GACATTCTAC CCAGCCTTGA TGGATATCTG 2400

AAAACTTCAG TCTTATCAGA TGAGACCAAG AATAGCTGGC AAGTGTCAGC ACTTTCTCGG 2460

GCTGCCCAGA AAGGATTTAA TAAAGTTGTG CTAAAACATC TGACAAAGAC AAAGAGCATT 2520

TCATCAAATG AAGCACTGTC CTTAGAAGAA GTGAGGATTA GAGTAGTACG GATACTTGGC 2580

TCTCTAGGAG GACAAATAAA CAAGAATCTC GTAACAGCTG CATCATCAGA TGAAATGATG 2640

AAGAAGTGTG TGGCATGGGA CAGAGAAAAA AGACTCCGTT TTGCAGTACC ATTTATGGAG 2700

ATGAAGCCTG TCATTTATCT GGATCTATTC CTGCCTCGGG TCACCGAGTT AGCTCTTTCA 2760

GCTAGTGACA GGCAGACTAA AGTTGCAGCT TGTGAATTTT TACATAGCAT GGTTATGTTT 2820

ATGTTGGGAA AAGCCACTCA GATGCCTGAA GATGGTCAGG GTTCCCCACC CATGTACCAG 2880

CTCTATAAGC GAACTTTTCC TGTTTTACTT CGACTTGCAT GTGATGTAGA TCAGGTGACA 2940

AGGCAACTGT ATGAGCCACT AGTTATGCAA CTGATTCACT GGTTCACTAA CAACAAGAAA 3000

TTTGAAAGTC AGGACACTGT CGCCTTACTA GAAACGATAT TGGATGGAAT TGTGGACCCT 3060

GTTGACAGTA CTTTGAGAGA TTTTTGTGGT CAGTGTATTC AAGAATTCCT TAAATGGTCC 3120

ATTAAGCAGA CGACACCACA GCAGCAGGAA AAAAGTCCAG TAAATACCAA ATCGCTTTTC 3180

AAGCGACTGT ATAGCTTTGC ACTTCATCCG AATGCCTTCA AGAGGCTGGG AGCATCACTT 3240

GCTTTTAATA ATATCTACAG GGAATTCAGG GAAGAAGAGT CTCTGGTAGA ACAGTTTGTG 3300

TTTGAAGCCT TGGTAACGTA TATGGAAAGT CTGGCCTTAG CACATACAGA TGAGAAATCC 3360

TTAGGTACAA TTCAACAATG TTGTGATGCC ATTGATCATC TCAGTCTTAT CATTGAGAAG 3420

AAGCATGTTT CTTTAAACAA AGCAAAAAAA CGACGTTTGC CACGAGGCTT TCCACCTGCG 3480

ACATCACTGT GTTTATTGGA TGTGGTCCAG TGGCTTTTAG CCAATTGTGG GAGACCCCAG 3540

ACAGAATGTC GACACAAATC CATAGAACTC TTTTATAAAT TTGTTACTTT ATTGCCAGGC 3600

AACAAATCCC CTTTTTTATG GCTGAAAGAT ATTATCAAGA AAGAAGATAT TTCCTTTCTC 3660

ATAAACACAT TTGAGGGCGG GGGAAGAGGT TGTGATCGGC CGTCAGGCAT CCTTGCTCAG 3720

CCAACCCTCT TCCATTTGCA AGGGCCGTTC AGTCTCAGAG CTGCCCTGCA GTGGATGGAC 3780

ATGCTTCTGG CAGCACTGGA GTGCTACAAC ACATTCATTG AAGAGAAAAC CCTGGAAGCA 3840

CCCAAGGTCC TAGGTACTGA AACACAGTCT TCACTTTGGA AAGCGGTGGC TTTCTTTTTA 3900

GAAAGCATTG CTATGCATGA TATTATGGCA GCAGAAAAGT ACTTTGGCAC TGGGGCAACA 3960

GGTAACAGAC CCAGCCCACA AGAAGGAGAA AGATATAATT ATAGCAAATG TACAATTGTG 4020

GTCCGCATTA TGGAATTTAC CACAACGCTC CTCAGCACCT CCCCAGAAGG CTGGAAGCTG 4080

CTTGAGAAGG ATGTGTGTAA CACAAACCTT ATGAAACTCT TAGTGAAAAC CCTGTGTGAG 4140

CCCTCAAGCA TAGGTTTCAA CATCGGTGAT GTCGCAGTTA TGAACTATCT TCCCAGTGTT 4200

TGTACCAACC TGATGAAAGC ACTGAAGAAG TCCCCATACA AAGACATCCT GGAGATGCAC 4260

CTCAAGGAAA AGATAACAGC ACAGAGCATT GAAGAGCTCT GTGCAGTTGA CTTGTATTGC 4320

CCTGATGCTT GCGTGGACAG GGCCAGGCTG GCTTCTGTCG TGTCAGCTTG TAAACAACTT 4380

CATAGAGCGG GGTTTTTGTG TGTTATAATA CCATCTCAGT CTGCAGATCA GCATCATTCT 4440

ATTGGCACAA AACTTCTTTC CTTGGTTTAT AAAAGCATTG CACCTGGAGA TGAACAACAG 4500

TGCCTTCCTT CACTAGATCC CAATTGTAAG CGATTGGCCA GTGGACTTCT GGAGTTGGCC 4560

TTTGCTTTTG GAGGACTGTG TGAGCACCTT GTGAGTCTTC TCCTGGACAC GACAGTGTTG 4620

TCTATGCCAT CCAGAGGAGG GTCCCAGAAA AACATCGTCA GCTTCTCTCA TGGAGAGTAT 4680

TTTTATAGCT TGTTCTCAGA AACGATCAAC ACTGAATTGT TGAAAAATCT AGATCTTGCT 4740

GTATTGGAGC TCATGAAATC ATCTGTGGAT AATCCCAAAA TGGTGAGCAA TGTTTTGAAT 4800

GGTATGTTAG ATCAGAGCTT CAGGGATCGA ACCAGTGAGA AACACCAAGG ACTGAAACTT 4860

GCAACTATAA TTCTGCAAAA CTGGAAGAAG TGTGATTCAT GGTGGGCCAA AGATTCTGCT 4920

CCTGAAAGTA AAATGGCAGT GCTTACCTTG TTGGCAAAAA TTTTGCAGAT TGATTCATCT 4980

GTTTGTTTTA ATACAAATCA CTGCATGTTC CCTGAAGTCT TTACAACATA TGTTAGTCTA 5040

CTTGCTGATT CAAAGTTGGA TCTGCATTTA AAGGCAACAG GCCAAGCTAT AATTCTTCTT 5100

CCATTCTTCA CCAGTCTTAC TGGAGGCAGC CTTGAGGACC TTAAGGTTGT TCTTGAAAAC 5160

CTCATCGTTT CTAATTTTCC TATGAAATCT GAAGAATTTC CCCCAGGAAC TCTGCAGTAC 5220

AGTAATTATG TGGACTGCAT GAAGAAGTTT CTAGATGCAT TGGAATTATC TGAAAGCCCT 5280

ATGTTGTTGC AGTTGATGAC AGAAATTCTT TGTCGTGAAC AGCAACATGT TATGGAAGAA 5340

TTATTTCAGT CTACTTTCAA AAAGATTGCC AGAAAGAGTT CATGTATCAC ACAATTAGGC 5400

CTTCTGGAAA GTGTATATAG AATGTTCAGG AGGGATGACC TGCTTTCAAA TATCACTCGC 5460

CAAGCATTTG TAGACCGTTC TCTGCTCACT CTGTTGTGGC ACTGTAGCTT GAATGCTTTG 5520

AGGGAATTTT TTAGCAAAAT TGTGGTGGAA GCCATTAATG TGTTGAAGTC CAGATTTATA 5580

AAGCTGAATG AATCTGCCTT TGATACTCAA ATCACCAAGA AGATGGGCTA CTATAAGATG 5640

TTAGATGTGA TGTATTCTCG TCTTCCAAAA GATGATGTTC ACTCTAAGGA ATCTAAAATT 5700

AATCAAGTTT TCCATGGCTC ATGTATTACA GAAGGAAGTG AACTTACAAA GACACTTATT 5760

AAATTGTGCT ATGATGCCTT TACAGAGAAC ATGGCAGGTG AGAATCAGTT GCTGGAGAGG 5820

AGAAGACTTT ACCATTGTGC TGCATACAAC TGTGCCATTT CTGTTGTCTG CTGTGTCTTC 5880

AATGAATTAA AATTTTACCA AGGTTTTCTG TTTACTGAAA AACCAGAAAA GAACTTGCTT 5940

ATTTTTGAAA ATCTGATAGA CTTGAAGCGC TGCTACACGT TTCCTATAGA AGTTGAGGTT 6000

CCTATGGAGA GAAAGAAAAA GTACCTTGAA ATTAGAAAAG AAGCCAGGGA AGCAGCAAGT 6060

GGGGATTCAG ATGGTCCTCG TTATATATCT TCCTTGTCAT ATTTGGCAGA CAGTAGCCTG 6120

AGTGAGGAAA TGAGTCAATT TGATTTCTCG ACTGGAGTGC AGAGCTATTC ATATAGTTCC 6180

CAAGACCCTA AATCTACCAC TGCTCATTTT CGGAGACAGA AACATAAAGA GTCCATGATC 6240

CAAGATGATA TCCTGGAGTT AGAGATGGAT GAACTCAATC AACACGAATG TATGGCAACT 6300

ATGACTGCTC TGATTAAGCA CATGCAGAGA AATCAGATCC TCCCTAAGGA AGAAGAGGGT 6360

TCAGTGCCAA GAAATCTTCC TCCTTGGATG AAATTTCTTC ATGACAAACT AGGAAATCCA 6420

TCAATATCAT TAAATATCCG TCTCTTCTTA GCCAAGCTTG TTATTAATAC AGAAGAAGTC 6480

TTTCGTCCTT ACGCGAGATA CTGGCTCAGC CCCTTGCTGC AGCTGGTTGT TTCTGGAAAC 6540

AACGGAGGAG AAGGAATTCA CTATATGGTG GTTGAGATAG TGGTTATTAT TCTTTCATGG 6600

ACAGGATTAG CTACTCCTAT AGGTGTCCCT AAAGATGAAG TGTTAGCAAA TCGATTGCTT 6660

CATTTCCTAA TGAAACATGT TTTTCATCAA AAAAGAGCTG TATTTAGACA CAACCTCGAA 6720

ATTATAAAAA CCCTTGTTGA ATGCTGGAAG GATTGTTTAT CCATCCCTTA CAGGTTAATA 6780

TTTGAAAAGT TTTCCAGTAC AGATCCTAAT TCTAAAGACA ATTCAGTAGG AATTCAATTA 6840

CTAGGCATTG TAATGGCCAA TAACTTGCCT CCTTATGACC CAAAATGTGG CATAGAGAGC 6900

ATAAAATACT TTCAAGCTTT GGTCAATAAT ATGTCCTTTG TAAAATATAG AGAGGTATAT 6960

GCAGCAGCGG CAGAAGTTCT AGGACTTGTT CTTCGATATA TTACTGAGAG AGAAAATATA 7020

CTGGAGGAGT CTGTGTGTGA ACTGGTCATA AAACAGTTGA AGCAACATCA GAATACGATG 7080

GAGGACAAAT TTATTGTGTG CTTGAACAAA GCTGTGAAGA ACTTCCCTCC TCTTGCTGAT 7140

AGGTTTATGA ACACCGTGTT CTTCCTGCTG CCAAAATTTC ATGGCGTGAT GAAGACTCTC 7200

TGTCTGGAGG TGGTGCTGTG TCGTGCAGAG GAAATAACAG ATCTATACTT ACAGTTAAAG 7260

AGCAAGGATT TCATTCAAGT CATGAGACAT AGAGATGATG AAAGACAAAA AGTGTGTTTG 7320

GACATAATTT ATAAGATGAT GGCAAAATTG AAACCAGTAG AACTTCGAGA ACTTCTGAAT 7380

CCTGTTGTAG AATTCATTTC TCATCCTTCT CCAGTGTGTA GGGAACAAAT GTATAACATT 7440

CTCATGTGGA TTCATGACAA TTATCGAGAT CCAGAAAGTC AAGCAGATGA CGACTCCCAG 7500

GAAATATTTA AGTTGGCAAA AGATGTGTTG ATTCAAGGAT TGATCGATGA GAACCCTGGG 7560

CTTCAATTAA TTATTCGAAA TTTCTGGAGT CATGAAACTA GGTTACCTTC AAATACCTTG 7620

GATCGATTGT TGGCACTAAA TTCCCTATAT TCTCCTAAGA TAGAAGCACA CTTTTTAAGT 7680

TTAGCAACAG ATTTTCTGCT TGAAATGACC AGCGTGAGCC CAGATTATTC AAACCCTATG 7740

TTTGAGCATC CTCTGTCAGA ATGCAAATTT CAGGAATATA CTATTGATTC TGACTGGCGT 7800

TTCCGAAGTA CTGTTCTCAC TCCAATGTTT ATTGAGACTC AGGCCTCCCA AAGTGCTCTG 7860

CAGACCCGGA CCCAGGAAGG ATCCCTCTCA GCTCGAGGGG TAATGACTGG GCAGATACGG 7920

GCCACACAAC AGCAGTATGA TTTCACACCT ACGCAAAATA CAGATGGAAG AAGCTCTTTC 7980

AATTGGCTGA CTGGGAACAG CATTGACCCA CTGGTGGATT TTACGGTCTC CTCCTCATCT 8040

GATTCTTTGT CTTCCTCCTT GCTGTTTGCT CACAAGAGGA GTGAAAAATC ACAGAGAGTA 8100

CCCTTGAAGT CAGTAGGACC TGATTTTGGG AAAAAAAGGC TGGGCCTTCC AGGGGATGAG 8160

GTGGATAACA AAGCAAAAGG AGGTGAAGAC AATCGGGCAG AAATATTAAG ATTACGGAGA 8220

CGATTTTTAA AGGACCGAGA AAAGCTCAGT TTGATTTATG CCAGAAAAGG TGTTGCTGAA 8280

CAAAAACGAG AGAAGGAGAT CAAGAGTGAG TTAAAAATGA AGCACGATGC CCAAGTCATT 8340

TTGTACAGAA GTTACCGTCA AGGAGACCTT CCTGACATTC AGATTAAATA CAGCAGCCTG 8400

ATCACTCCCT TGCAAGCTGT GGCCCAGAGA GACCCAATAA TTGCAAAGCA GCTCTTTGGC 8460

AGCTTGTTTT CTGGAATTAT AAAAGAGATG GATAAATATA AGACCATGTC TGAAAAAAAC 8520

AACATTACTC AGAAGTTGCT CCAGGACTTC AATAATTTTC TTAACACCAC TGTCTCTTTC 8580

TTTCCACCTT TCATCTCCTG TATCCAGGAA ATTAGTTGCC AACACGCAGA CTTGCTGAGC 8640

CTCAACCCAG CTTCTGTCAG TGCCAGCTGC CTGGCCAGTC TGCAGCAGCC TGTAGGCGTC 8700

CGCCTTCTGG AGGAGGCCTT GCTCCACCTG CTGCCTGAAG AGCCACCTGC CAAGCGAGTT 8760

CGAGGGAGAC CCTGTCTCTA CCCTGATTTT GTCAGATGGA TGGAACTTGC TAAACTGTAT 8820

AGATCAATTG GAGAATATGA CATCCTCCGT GGGATTTTTA ATAGTGAGAT AGGAACAAAG 8880

CAAGTCACTC AGAATGCATT ATTAGCAGAA GCAAGAAATG ATTATTCTGA AGCCGTTAAG 8940

CAGTATAATG AGGCTCTCAA TAAACAAGAG TGGGTAGATG GTGAGCCTAT GGAAGCTGAG 9000

AAGGATTTTT GGGAACTTGC ATCCCTTGAC TGTTATAACC AACTTGCTGA GTGGAAATCA 9060

CTGGCATACT GTTCTACAGT CAGTGTTGAC AGTGCGAACC CTCCAGATTT AAATAAAATG 9120

TGGAATGAAC CATTTTATCA GGAGACCTAT CTACCTTACA TGATCCGCAG CAAGCTGAAG 9180

CTACTTCTGC AAGGTGAGGG AGACCAGTCC CTGCTGACAT TTATTGATGA AGCTGTGAGC 9240

AAGGAGCTCC AGAAGGTCCT TGTAGAGCTT CATTACAGTC AGGAATTGAG TCTCCTTTAT 9300

ATCCTACAAG ATGATGTCGA CAGAGCCAAA TATTATATTG AAAATTGCAT TCGGATTTTC 9360

ATGCAGAGCT ATTCTAGTAT TGATGTCCTT TTAGAGAGAA GTAGACTCAC CAAATTGCAA 9420

TCTCTACAAA CTTTAATAGA AATTCAGGAG TTCATCAGCT TTATAAGCAA ACAAGGTAAT 9480

TTATCATCTC AAATTCCCCT TAAGAGACTT CTAAAAACCT GGACAAACAG ATATCCGGAT 9540

GCTAAAATGG ACCCAATGAA CATCTGGGAT GACATCATCA CAAATCGATG TTTCTTTCTC 9600

AGCAAAATAG AAGAAAAACT GACTCTTCCT CCAGATGATC ATAGTATGAA CACAGATGGA 9660

GATGAAGATT CCAGTGACAG AATGAAAGTG CAGGAGCAGG AGGAAGATAT TTATTCTCTG 9720

ATTAAGAGCT GTAAGTTTTC CATGAAAATG AAGATGATAG AAAGTGCAAG GAAACAGAAA 9780

AATTTCTCAC TAGCCATGAA ACTATTAAAG GAGCTTCATA AAGAGTCAAA AACAAGAGAT 9840

GACTGGCTGG TGAAATGGGT GCAGAGCTAC TGTCGACTCA GTCACAGCCG GAGCCAGACC 9900

CAGAATCGTC CTGAGCAGAT CCTTACTGTG TTGAAAACAG TCTCTTTGTT GGATGAGAAC 9960

ACATCAAGCT ACTTAAGCAA AAATATTCCA GTTTCCCGTG ACCACAACAT TCTCTTGGGT 10020

ACAACTTACA GGATCATAGC TAATGCTCTC AGCAGTGATC CAACTTGCCT TGCTGAAATC 10080

GGGGAAAGCA AGGCTAGAAG AATCTTGGAG CTGTCTGGAT CCAGTTTAGA GAATGCAGAA 10140

GAGGTGATCG CAGGTCTATA CCAGAGAGTG TTGCATCACC TTTCTGAGGC CGTGCGGATT 10200

GCAGAGGAGG AGGCCCAGCC TTTCACTAGA GGCCAGGAAC CTGCAGTTGG GGTGATAGAT 10260

GCTTACATGA CACTGGTGGA TTTCTGTGAC CAGCAGCTCC GCAAGGAGGA AGAGAGTTCA 10320

TCAGTTACTG AGTCTGTACA ACTGCAGATG TATCCAGCCC TTGTGGTGGA CAAAATGTTA 10380

AAAGCTTTAA GACTGCATTC CAATGAAGCC AGGCTGAAGT TTCCCAGACT ACTGCAGATT 10440

ATAGAACAGT ATCCAGAGGA GACCCTGAGC CTAATGACCA AAGAGATTTC TTCCATTCCT 10500

TGCTGGCAGT TCATTGGCTG GATCAGCCAC ATGGTGGCCT TACTGGACAA AGAGGAAGCT 10560

GTCGCTGTCC ATCGCACAGT GGAAGAGATT GCTGATAACT ATCCACAGGC GATGGTCTAC 10620

CCATTTATAA TAAGCAGTGA AAGCTATTCC TTCAAAGATA CTTCTACTGG TTATAAGAAT 10680

AAGGAGTTTG TGGAAAGGAT TAAAATTAAG TTGGATCAAG GAGGAGTGAT TCAAGATTTT 10740

ATTAATGCCC TAGAACAGCT CTCTCATCCT GAAATGCTCT TTAAGGACTG GACTGATGAT 10800

ATCAAAGTTG AACTTGAAAA AAACCCTGTA AATAGAAAAA ACATTGAAAA GATGTATGAA 10860

AAAATGTATG CAACCTTGGG AGACCCACAG GCTCCAGGTC TTGGGGCTTT TCGAAGAAGG 10920

TTTATTCAGG CTTTTGGAAA AGAATTTGAT AAACACTTTG GGAGAGGAGG TTCTAAGCTA 10980

CCTGGAATGA AGCCCCGTGA ATTCAGTGAT ATTACCAACT CACTATTTTC AAAAATGTGC 11040

GAAGTCTCAA AGCCACCTGG GAATCTGAAA GAATGCTCGC CCTGGATGAG TGACTTCAAA 11100

GTAGAATTTT TGAGAAGTGA ACTGGAGATT CCTGGTCAGT ATGATGGCAA GGGAAAACCA 11160

GTGCCAGAAT ACCATGCACG AATTGCTGGG TTTGATGAGC GGATAAAAGT AATGGCTTCT 11220

ATGAGAAAAC CAAAGCGTAT CATCATCCGA GGCCATGATG AGAGAGAGTA CCCTTTCCTT 11280

GTGAAGGGAG GTGAAGATCT GAGGCAGGAC CAACGCATCG AGCAGCTCTT CGAGGTCATG 11340

AATGTCATCC TTTCCCAAGA TGCTACCTGT AGTCAGAGAA GCATGCAGCT AAAGACATAC 11400

CAGGTCATAC CCATGACCTC CAGATTAGGA CTAATTGAAT GGATTGAAAA TACTTTTACC 11460

TTGAAGGAAC TTCTTTTGAG TAACATGTCA CAAGAGGAGA AAGCAGCTTG TACAAGCGAT 11520

CCCAAAGCAC CACCATTTGA ATATAGAGAC TGGCTGACAA AGATGTCTGG GAAATGTGAT 11580

GTTGGTGCTT ACATGCTAAT GTATAAGGGA GCTAGTCGTA CTGAAACAGT CACATCTTTT 11640

AGAAAAAGAG AAAGTAAGGT GCCAGCCGAT CTCTTAAAGC GGGCCTTTGT GAAGATGAGT 11700

ACCAGCCCTG AGGCCTTCCT GACACTCCGC TCACACTTTG CCCGCTCTCA CGCTTTGATA 11760

TGCATTAGTC ACTGGATTCT GGGCATTGGA GATAGACATC TGAACAATTT CCTGGTAAGC 11820

ATGGAGACAG GTGGAGTGAT TGGAATCGAC TTTGGACATG CATTTGGATC AGCTACTCAG 11880

TTTCTGCCGG TCCCTGAGTT GATGCCTTTT CGTCTAACTC GCCAATTTAT CAATCTGATG 11940

TTACCAATGA AAGAAACAGG TGTTATGTAC AGTATCATGG TGCATGCACT GAGAGCCTTC 12000

CGCTCACAGT CCAACCTGCT TGCTAACACC ATGGACGTGT TTGTAAAGGA GCCTTCCTTC 12060

GACTGGAAAA ATTTTGAACA GAAAATGCTA AAAAAAGGAG GATCATGGAT TCAAGAAATA 12120

AATGTAACTG AAAAAAATTG GTATCCCCGG CAGAAAATAC ATTATGCTAA GAGAAAGTTA 12180

GCTGGTGCCA ATCCAGCAGT TATTACTTGT GATGAGTTAC TTCTGGGCCA TGAGAAGGTA 12240

GCTGCATTTG GAGATTATGT GGCTGTAGCA CGAGGAAGTG AAGATCACAA TATCCGTGCC 12300

CAAGAACTGG AGAGTGACCT TTCAGAAGAA GCTCAGGTGA AGTGCTTGAT TGACCAGGCA 12360

ACAGACCCCA ACATCCTTGG CAGAACTTGG ATAGGATGGG AGCCCTGGAT GTGA 12414

Domain Profile

S: 1     iagfderveilaskqkpkklllrGsdgkeypyLvkgkeDlrqdervlqlfslvNtlLakd  60

         iagfder++++as +kpk++++rG+d++eyp+Lvkg eDlrqd+r++qlf+++N +L +d

Q: 3728  IAGFDERIKVMASMRKPKRIIIRGHDEREYPFLVKGGEDLRQDQRIEQLFEVMNVILSQD  3787

         89**********************************************************

S: 61    ketsrrkLkirtykVvplstrsgliewventvsLkellkkl..vekkavlldqpi..syr  116

         +++s+r ++++ty+V+p+++r+gliew+ent +Lkell     +e+ka+  ++p+  + +

Q: 3788  ATCSQRSMQLKTYQVIPMTSRLGLIEWIENTFTLKELLLSNmsQEEKAACTSDPKapPFE  3847

         ************************************9987667899999999999999**

S: 117   ykdlstvqarkpklkhlkls.........levfkevlenlvpkdllkklllekfpspeew  167

         y d+ t+++ k ++ +++l+         +++f++++++ vp+dllk++++++++spe++

Q: 3848  YRDWLTKMSGKCDVGAYMLMykgasrtetVTSFRKRESK-VPADLLKRAFVKMSTSPEAF  3906

         ***************************************.********************

S: 168   felrkaytrslAvislvgyiLgLgdrhlenllidqetgevvhidfgvafekaktqlkvpe  227

         ++lr++++rs+A+i+++++iLg+gdrhl+n+l+ +etg v+ idfg+af++a+++l+vpe

Q: 3907  LTLRSHFARSHALICISHWILGIGDRHLNNFLVSMETGGVIGIDFGHAFGSATQFLPVPE  3966

         ************************************************************

S: 228   kvPFRLTrnivnalgvtgveGvfrasceavlrvlreskeklltiLevflydplvdwkk..  285

          +PFRLTr+++n++ +++++Gv++++++++lr++r++ + l ++++vf+++p++dwk+

Q: 3967  LMPFRLTRQFINLMLPMKETGVMYSIMVHALRAFRSQSNLLANTMDVFVKEPSFDWKNfe  4026

         ************************************************************

S: 286   ....kkktsketeeelaekakaealkikkllskvekaenavatrdllllee  332

             kk++s+++e++++ek++++++ki+++++k+++a++av+t+d+lll++

Q: 4027  qkmlKKGGSWIQEINVTEKNWYPRQKIHYAKRKLAGANPAVITCDELLLGH  4077

         **9999****************************************99987

Domain Sequence
(FASTA)

IAGFDERIKV MASMRKPKRI IIRGHDEREY PFLVKGGEDL RQDQRIEQLF EVMNVILSQD 60

ATCSQRSMQL KTYQVIPMTS RLGLIEWIEN TFTLKELLLS NMSQEEKAAC TSDPKAPPFE 120

YRDWLTKMSG KCDVGAYMLM YKGASRTETV TSFRKRESKV PADLLKRAFV KMSTSPEAFL 180

TLRSHFARSH ALICISHWIL GIGDRHLNNF LVSMETGGVI GIDFGHAFGS ATQFLPVPEL 240

MPFRLTRQFI NLMLPMKETG VMYSIMVHAL RAFRSQSNLL ANTMDVFVKE PSFDWKNFEQ 300

KMLKKGGSWI QEINVTEKNW YPRQKIHYAK RKLAGANPAV ITCDELLLGH 350

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005958	; C:DNA-dependent protein kinase-DNA ligase 4 complex
GO:0005667	; C:transcription factor complex
GO:0005524	; F:ATP binding
GO:0003677	; F:DNA binding
GO:0004677	; F:DNA-dependent protein kinase activity
GO:0006915	; P:apoptotic process
GO:0002326	; P:B cell lineage commitment
GO:0007420	; P:brain development
GO:0032869	; P:cellular response to insulin stimulus
GO:0006303	; P:double-strand break repair via nonhomologous end joining
GO:0035234	; P:germ cell programmed cell death
GO:0007507	; P:heart development
GO:0033152	; P:immunoglobulin V(D)J recombination
GO:0018105	; P:peptidyl-serine phosphorylation
GO:0043065	; P:positive regulation of apoptotic process
GO:0045944	; P:positive regulation of transcription from RNA polymerase II promoter
GO:0002328	; P:pro-B cell differentiation
GO:0031648	; P:protein destabilization
GO:0010332	; P:response to gamma radiation
GO:0001756	; P:somitogenesis
GO:0033077	; P:T cell differentiation in thymus
GO:0002360	; P:T cell lineage commitment
GO:0033153	; P:T cell receptor V(D)J recombination
GO:0000723	; P:telomere maintenance

KEGG

InterPros

IPR016024	; ARM-type_fold.
IPR003152	; FATC.
IPR011009	; Kinase-like_dom.
IPR012582	; NUC194.
IPR000403	; PI3/4_kinase_cat_dom.
IPR018936	; PI3/4_kinase_CS.
IPR003151	; PIK-rel_kinase_FAT.
IPR014009	; PIK_FAT.

Pfam

PF02259	; FAT; 1.
PF02260	; FATC; 1.
PF08163	; NUC194; 1.
PF00454	; PI3_PI4_kinase; 1.

SMARTs

SM00146

; PI3Kc; 1.

Prosites

PS51189	; FAT; 1.
PS51190	; FATC; 1.
PS00915	; PI3_4_KINASE_1; 1.
PS00916	; PI3_4_KINASE_2; 1.
PS50290	; PI3_4_KINASE_3; 1.

Prints

Created Date

20-Feb-2013