EKS-EQC-00290
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-EQC-00290
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/EGFR496.02.4E-149723980258
StatusUnreviewed
Ensembl ProteinENSECAP00000018571
UniProt AccessionF6VNY4;
Protein Name
Protein Synonyms/Alias
Gene NameERBB2
Gene Synonyms/Alias ERBB2;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSECAG00000020409ENSECAP00000018571ENSECAT00000022466
OrganismEquus caballus
Functional Description
Protein Length1258
Protein Sequence
(FASTA)
VSTMELAAWC RWGLLLALLP PGAAGTQVCT GTDMKLRLPA SPETHLDMLR HLYQGCQVVQ 60
GNLELTYLPA SASLSFLQDI QEVQGYVLIA HNQVRQVPLQ RLRIVRGTQL FEDNYALAVL 120
DNGDLLDNAT SATGAVPGGL RELQLRSLTE ILKGGVLIQR NPQLCHQDTI LWEDIFHKNN 180
QLTLTLIDTN RSRACQPCSP ACRPSHCWGE SSEDCQNLTR TVCAGGCARC KGPRPTDCCH 240
EQCAAGCTGP KHSDCLACLH FNHSGICELH CPSLVIYNTD TFESMPNPEG RYTFGASCVT 300
ACPYNYLSTD VGSCTLVCPL NNQEVTAEDG TQRCEKCSKP CARVCYGLGM EHLREVRAVT 360
SANIQDFAGC KKIFGSLAFL PESFEGDPAS NTAPLQPEQL RVFETLEEIT GYLYISAWPD 420
SLPDLSVFQN LRVIRGRVLH DGAYSLTLQG LGISWLGLRS LQELGSGLAL VHHNARLCFV 480
HTVPWAQLFR NPHQALLHSA NRPEDECVGE GLACYPLCAH GHCWGPGPTQ CVNCSQFLRG 540
QECVEECRVL QGLPREYVKD RYCLPCHPEC QPQNGSVTCF GSEADQCVAC THYKDPPFCV 600
ARCPSGVKPD LSFMPIWKFP DEEGTCQPCP INCTHSCLDL DDRGCPAEQR ASPVTSIIAA 660
VVGILLVVVI GLVLGILIKR RRQKIRKYTM RRLLQETELV EPLTPSGAMP NQAQMRILKE 720
TELRKVKVLG SGAFGTVYKG IWIPDGENVK IPVAIKVLRE NTSPKANKEI LDEAYVMAGV 780
GSPYVSRLLG ICLTSTVQLV TQLMPYGCLL DHVREHRGRL GSQDLLNWCV QIAKGMSYLE 840
DVRLVHRDLA ARNVLVKSPN HVKITDFGLA RLLDIDETEY HADGGKVPIK WMALESILRR 900
RFTHQSDVWS YGVTVWELMT FGAKPYDGIP AREIPDLLEK GERLPQPPIC TIDVYMIMVK 960
CWMIDSECRP RFRELVAEFS RMARDPQRFV VIQNEDLGPA SPLDSTFYRS LLEDDDMGDL 1020
VDAEEYLVPQ QGFFCPDPAP GAGGTAHRRH RSSSSRSGGG ELTLGLEPSE EEPPKSPLAP 1080
SEGAGSDVFD GDLGMGAAKG LQSLPQHDPS PLQRYSEDPT VPLPPETDGY VAPLSCSPQP 1140
EYVNQPEVRP QPPSPLEGPL SPCRPDGATL ERPKTLSPGK NGVVKDVFAF GGAVENPEYL 1200
APRSRAAPQP HPPPAFSPAF DNLYYWDQDP SERGSPPSTF EGTPTAENPE YLGLDVPV 1258
Nucleotide Sequence
(FASTA)
GTGAGCACCA TGGAGCTGGC GGCCTGGTGC CGCTGGGGGC TCCTCCTCGC CCTCCTGCCC 60
CCCGGAGCCG CGGGCACCCA AGTGTGCACC GGCACAGACA TGAAGCTGCG GCTGCCAGCC 120
AGTCCTGAGA CCCACCTGGA CATGCTCCGC CACCTCTACC AGGGCTGCCA GGTGGTGCAG 180
GGTAACCTGG AGCTCACCTA CCTGCCAGCC AGCGCCAGCC TCTCCTTCCT GCAGGATATC 240
CAGGAGGTGC AAGGCTATGT GCTCATCGCT CACAACCAAG TGAGACAGGT CCCACTGCAG 300
AGGCTGCGAA TCGTGCGAGG CACCCAGCTC TTTGAGGACA ACTACGCCCT GGCTGTGCTG 360
GACAATGGAG ACCTGCTGGA CAATGCCACC TCTGCTACAG GGGCTGTCCC AGGAGGGCTG 420
CGGGAGCTAC AGCTTCGAAG CCTCACAGAG ATCTTGAAGG GAGGGGTCTT GATCCAGCGG 480
AACCCCCAGC TCTGCCACCA GGACACGATT TTGTGGGAGG ACATCTTCCA CAAGAACAAC 540
CAGCTGACCC TCACGCTGAT AGACACCAAC CGCTCACGGG CCTGCCAACC CTGTTCTCCA 600
GCTTGTAGAC CCTCCCACTG CTGGGGAGAA AGTTCCGAGG ACTGTCAGAA CTTGACGAGA 660
ACTGTCTGTG CCGGTGGCTG TGCCCGCTGC AAGGGCCCGC GGCCCACCGA CTGCTGCCAT 720
GAGCAGTGTG CTGCCGGCTG CACAGGCCCC AAGCACTCCG ACTGCCTGGC CTGCCTCCAC 780
TTCAACCACA GCGGCATCTG TGAGCTGCAC TGCCCATCCC TGGTCATCTA CAACACGGAC 840
ACCTTCGAGT CCATGCCCAA CCCTGAGGGC CGGTATACCT TCGGCGCCAG CTGTGTGACC 900
GCCTGTCCTT ACAACTACCT GTCTACGGAC GTGGGATCCT GCACCCTGGT CTGTCCCCTG 960
AACAACCAAG AGGTGACAGC TGAGGACGGA ACACAGCGGT GTGAGAAATG CAGCAAGCCC 1020
TGTGCCCGAG TGTGCTATGG CCTGGGCATG GAACACCTGC GGGAGGTGAG GGCGGTCACC 1080
AGTGCCAACA TCCAGGACTT TGCTGGCTGC AAGAAGATCT TTGGGAGCCT GGCATTTCTG 1140
CCGGAGAGCT TTGAGGGGGA CCCAGCCTCC AACACGGCCC CCCTACAGCC TGAGCAGCTC 1200
AGAGTGTTTG AGACCCTGGA GGAGATCACA GGTTACCTGT ACATCTCAGC GTGGCCAGAC 1260
AGCCTGCCTG ACCTCAGTGT CTTCCAGAAC CTGCGAGTAA TCCGGGGCCG AGTTCTGCAT 1320
GATGGTGCCT ACTCGCTGAC CCTGCAAGGG CTGGGCATCA GCTGGTTGGG GCTGCGCTCG 1380
CTGCAGGAAC TGGGCAGCGG GCTGGCCCTT GTCCACCACA ATGCCCGCCT CTGCTTCGTC 1440
CACACGGTGC CCTGGGCCCA GCTCTTCCGG AACCCCCACC AGGCCCTGCT TCACAGTGCC 1500
AACCGCCCAG AGGACGAGTG TGTGGGCGAG GGCCTGGCCT GCTACCCGCT GTGCGCCCAC 1560
GGGCACTGCT GGGGTCCGGG CCCCACCCAG TGTGTCAACT GCAGCCAGTT CCTTCGGGGC 1620
CAGGAATGCG TGGAGGAATG CCGAGTACTG CAGGGGCTCC CCCGGGAATA TGTGAAGGAC 1680
AGGTACTGTC TGCCGTGCCA CCCCGAATGT CAGCCCCAGA ATGGCTCAGT GACTTGCTTT 1740
GGATCGGAGG CTGACCAGTG TGTGGCCTGC ACGCACTACA AGGACCCGCC CTTCTGCGTG 1800
GCTCGCTGCC CCAGCGGTGT GAAACCTGAC CTCTCCTTCA TGCCCATCTG GAAGTTCCCA 1860
GATGAGGAGG GCACGTGCCA GCCGTGCCCC ATCAACTGCA CCCACTCCTG TTTGGACCTG 1920
GATGACAGGG GCTGTCCCGC CGAACAGAGA GCCAGCCCTG TGACATCCAT CATTGCTGCT 1980
GTGGTGGGCA TTTTGCTGGT GGTGGTCATT GGTCTGGTCC TCGGCATCCT AATCAAGCGA 2040
AGGCGGCAGA AGATCCGGAA ATACACGATG CGGAGGCTGC TGCAGGAAAC GGAGCTGGTG 2100
GAGCCGCTGA CACCTAGCGG AGCGATGCCC AACCAGGCTC AGATGCGAAT CCTGAAAGAG 2160
ACAGAGCTGA GGAAGGTGAA GGTGCTTGGA TCCGGAGCTT TTGGCACAGT CTACAAGGGC 2220
ATCTGGATCC CTGATGGAGA AAATGTGAAA ATCCCAGTGG CCATCAAAGT GTTGAGGGAA 2280
AACACATCCC CCAAAGCCAA CAAAGAAATC TTGGACGAAG CATATGTGAT GGCTGGTGTG 2340
GGCTCTCCAT ATGTGTCCCG CCTCTTGGGC ATCTGCCTGA CATCCACAGT GCAGCTGGTG 2400
ACACAGCTTA TGCCCTATGG CTGCCTCCTA GACCACGTCC GAGAACACCG CGGCCGCCTG 2460
GGCTCCCAGG ACCTGCTGAA CTGGTGTGTG CAGATTGCTA AGGGGATGAG CTACTTGGAG 2520
GATGTGCGGC TTGTGCACAG GGACCTGGCT GCCCGGAATG TGCTGGTCAA GAGTCCCAAC 2580
CATGTCAAGA TTACAGACTT CGGGCTGGCT CGGCTGCTGG ACATTGACGA GACAGAGTAC 2640
CATGCGGATG GGGGCAAGGT GCCCATCAAG TGGATGGCGT TGGAGTCCAT TCTCCGCCGG 2700
CGGTTCACCC ACCAGAGTGA TGTGTGGAGC TATGGTGTGA CTGTGTGGGA GCTGATGACT 2760
TTTGGGGCCA AACCTTACGA TGGGATCCCA GCTCGGGAGA TCCCTGACCT GCTGGAGAAG 2820
GGGGAGCGGC TGCCCCAGCC CCCCATCTGC ACCATTGATG TCTACATGAT TATGGTCAAA 2880
TGTTGGATGA TTGACTCTGA ATGTCGGCCG AGGTTCCGGG AGTTGGTGGC CGAATTCTCC 2940
CGCATGGCCA GGGACCCCCA GCGCTTTGTG GTCATCCAGA ATGAGGACTT GGGCCCTGCC 3000
AGCCCCTTGG ACAGCACTTT CTACCGCTCG CTGCTGGAGG ATGATGACAT GGGGGACCTG 3060
GTAGATGCTG AGGAGTACCT GGTACCCCAG CAGGGCTTCT TCTGCCCGGA CCCTGCTCCT 3120
GGTGCTGGGG GCACAGCCCA CCGCAGGCAC CGCAGCTCAT CCTCCAGGAG TGGCGGTGGT 3180
GAGCTGACGC TGGGGCTGGA GCCCTCGGAG GAGGAGCCCC CCAAGTCTCC ACTGGCACCT 3240
TCAGAAGGGG CTGGCTCTGA TGTGTTTGAT GGTGACTTGG GAATGGGGGC AGCCAAGGGG 3300
CTGCAGAGCC TCCCACAACA TGACCCCAGC CCTCTACAGA GGTACAGCGA GGACCCCACA 3360
GTACCCCTGC CCCCGGAGAC TGACGGCTAT GTTGCCCCCC TGTCCTGCAG CCCCCAGCCT 3420
GAATACGTGA ACCAGCCAGA GGTTCGGCCG CAGCCCCCCT CGCCCCTAGA GGGCCCTCTG 3480
TCTCCTTGTC GACCTGATGG TGCCACTTTG GAAAGGCCCA AGACTCTCTC CCCCGGGAAG 3540
AATGGGGTTG TCAAAGACGT TTTTGCCTTT GGGGGTGCCG TGGAGAACCC TGAGTACTTG 3600
GCACCCCGGA GCAGAGCTGC CCCTCAGCCC CACCCTCCTC CTGCCTTCAG CCCAGCCTTT 3660
GACAACCTCT ATTACTGGGA CCAGGACCCA TCAGAGCGGG GCTCTCCACC CAGCACCTTT 3720
GAAGGGACCC CTACAGCAGA GAACCCGGAA TACCTGGGCC TGGACGTGCC AGTGTGA 3777
Domain Profile
S: 1     lkklkvlGsGafGtvykGiwipegenvkipvaikvleektgkkankelldealvlasldh  60
         l+k+kvlGsGafGtvykGiwip+genvkipvaikvl+e+t++kanke+ldea+v+a + +
Q: 723   LRKVKVLGSGAFGTVYKGIWIPDGENVKIPVAIKVLRENTSPKANKEILDEAYVMAGVGS  782
         69**********************************************************
S: 61    anlvrllglclsstlqlvtqllplGclldyvrehkdklGsqellnwcvqiakGmsyleek  120
         ++++rllg+cl+st+qlvtql+p+Gclld+vreh+++lGsq+llnwcvqiakGmsyle+ 
Q: 783   PYVSRLLGICLTSTVQLVTQLMPYGCLLDHVREHRGRLGSQDLLNWCVQIAKGMSYLEDV  842
         ************************************************************
S: 121   rlvhrdlaarnvlvkspnhvkitdfGlaklleadekelkaeggkvpikwlalesilkrky  180
         rlvhrdlaarnvlvkspnhvkitdfGla+ll+ de+e++a+ggkvpikw+alesil+r++
Q: 843   RLVHRDLAARNVLVKSPNHVKITDFGLARLLDIDETEYHADGGKVPIKWMALESILRRRF  902
         ************************************************************
S: 181   thqsdvwsyGvtvwelltfGakpydgipakeipdllekGerlaqppictidvymvlvkcw  240
         thqsdvwsyGvtvwel+tfGakpydgipa+eipdllekGerl+qppictidvym++vkcw
Q: 903   THQSDVWSYGVTVWELMTFGAKPYDGIPAREIPDLLEKGERLPQPPICTIDVYMIMVKCW  962
         ************************************************************
S: 241   midaesrpkfkelaeefs  258
         mid+e+rp+f+el++efs
Q: 963   MIDSECRPRFRELVAEFS  980
         ****************96
Domain Sequence
(FASTA)
LRKVKVLGSG AFGTVYKGIW IPDGENVKIP VAIKVLRENT SPKANKEILD EAYVMAGVGS 60
PYVSRLLGIC LTSTVQLVTQ LMPYGCLLDH VREHRGRLGS QDLLNWCVQI AKGMSYLEDV 120
RLVHRDLAAR NVLVKSPNHV KITDFGLARL LDIDETEYHA DGGKVPIKWM ALESILRRRF 180
THQSDVWSYG VTVWELMTFG AKPYDGIPAR EIPDLLEKGE RLPQPPICTI DVYMIMVKCW 240
MIDSECRPRF RELVAEFS 258
KeywordATP-binding; Complete proteome; Kinase; Nucleotide-binding; Phosphoprotein; Reference proteome; Transferase; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Felis catus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00280
EKS-ANC-00289
EKS-BOT-00298
EKS-CAJ-00305
EKS-CAF-00305
EKS-CAP-00334
EKS-DAR-00646
EKS-FEC-00284
EKS-GAA-00370
EKS-GOG-00296
EKS-HOS-00305
EKS-ICT-00281
EKS-LAC-00310
EKS-LOA-00309
EKS-MAM-00302
EKS-MOD-00293
EKS-MUM-00330
EKS-MUP-00296
EKS-MYL-00300
EKS-NOL-00275
EKS-ORN-00389
EKS-ORC-00281
EKS-ORL-00360
EKS-OTG-00303
EKS-RAN-00315
EKS-SAH-00280
EKS-SUS-00262
EKS-TAR-00391
EKS-TEN-00386
EKS-XET-00372
EKS-XIM-00379
Gene Ontology
GO:0016324; C:apical plasma membrane
GO:0016323; C:basolateral plasma membrane
GO:0010008; C:endosome membrane
GO:0016021; C:integral to membrane
GO:0043235; C:receptor complex
GO:0005524; F:ATP binding
GO:0004716; F:receptor signaling protein tyrosine kinase activity
GO:0004714; F:transmembrane receptor protein tyrosine kinase activity
GO:0007507; P:heart development
GO:0008045; P:motor neuron axon guidance
GO:0042552; P:myelination
GO:0033088; P:negative regulation of immature T cell proliferation in thymus
GO:0007528; P:neuromuscular junction development
GO:0007422; P:peripheral nervous system development
GO:0014065; P:phosphatidylinositol 3-kinase cascade
GO:0045785; P:positive regulation of cell adhesion
GO:0030307; P:positive regulation of cell growth
GO:0050679; P:positive regulation of epithelial cell proliferation
GO:0043406; P:positive regulation of MAP kinase activity
GO:0032321; P:positive regulation of Rho GTPase activity
GO:0045943; P:positive regulation of transcription from RNA polymerase I promoter
GO:0045945; P:positive regulation of transcription from RNA polymerase III promoter
GO:0045727; P:positive regulation of translation
GO:0070372; P:regulation of ERK1 and ERK2 cascade
GO:0032886; P:regulation of microtubule-based process
GO:0023014; P:signal transduction by phosphorylation
GO:0007169; P:transmembrane receptor protein tyrosine kinase signaling pathway
GO:0042060; P:wound healing
KEGG
InterPros
IPR021157; Cyt_c1_TM_anchor_C.
IPR000494; EGF_rcpt_L.
IPR006211; Furin-like_Cys-rich_dom.
IPR006212; Furin_repeat.
IPR009030; Growth_fac_rcpt.
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
IPR016245; Tyr_kinase_EGF/ERB/XmrK_rcpt.
Pfam
PF00757; Furin-like; 1.
PF07714; Pkinase_Tyr; 1.
PF01030; Recep_L_domain; 2.
SMARTs
SM00261; FU; 3.
SM00219; TyrKc; 1.
Prosites
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
Prints
PR00109; TYRKINASE.
Created Date20-Feb-2013