EKS-EQC-00415

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-EQC-00415

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
AGC/SGK	539.3	1.9E-162	193	450	258

Status

Unreviewed

Ensembl Protein

ENSECAP00000017911

UniProt Accession

F7BY67;

Protein Name

Protein Synonyms/Alias

Gene Name

SGK1

Gene Synonyms/Alias

SGK1;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSECAG00000020431	ENSECAP00000017911	ENSECAT00000021724

Organism

Equus caballus

Functional Description

Protein Length

526

Protein Sequence
(FASTA)

MVNKDMNGFP VKKCSAFQFF KKRVRRWIKN PMVSVDKHQS PSLKYTGPSV VHMPPGESDF 60

EPSLCQTCLG DHAFPRGGLP QEKESCSWET QSGCEVKEPC NPANILTTPD PRTFWTNDDS 120

AFMKQRRMGL NDFIQKIANN SYACKHPEVQ SILKISQPQE PELMNANPSP PPSPSQQINL 180

GPSSNPHAKP SDFHFLKVIG KGSFGKVLLA RHKAEEAFYA VKVLQKKAIL KKKEEKHIMS 240

ERNVLLKNVK HPFLVGLHFS FQTADKLYFV LDYINGGELF YHLQRERCFL EPRARFYAAE 300

IASALGYLHS LNIVYRDLKP ENILLDSQGH IVLTDFGLCK ENIEPNGTTS TFCGTPEYLA 360

PEVLHKQPYD RTVDWWCLGA VLYEMLYGLP PFYSRNTAEM YDNILNKPLQ LKPNITNSAR 420

HLLEGLLQKD RTKRLGAKDD FMEIKSHVFF SLINWDDLIN KKITPPFNPN VSGPSDLRHF 480

DPEFTEEPVP NSIGRSPDSI LLTASVKEAA EAFLGFSYAP PMDSFL 526

Nucleotide Sequence
(FASTA)

ATGGTAAACA AAGACATGAA TGGATTCCCG GTCAAGAAAT GCTCAGCCTT CCAATTTTTT 60

AAGAAGCGGG TACGAAGATG GATCAAGAAC CCGATGGTCA GTGTGGACAA GCATCAGAGT 120

CCCAGTCTGA AGTACACGGG CCCCTCGGTG GTACACATGC CACCAGGGGA GTCAGACTTC 180

GAGCCTTCCT TGTGTCAGAC GTGCCTGGGA GACCACGCTT TCCCGAGAGG GGGCCTCCCT 240

CAGGAGAAGG AGTCCTGCTC CTGGGAAACT CAATCTGGGT GTGAAGTGAA AGAGCCATGT 300

AATCCTGCCA ACATCTTAAC CACGCCTGAT CCGAGAACCT TCTGGACTAA CGATGATTCA 360

GCTTTCATGA AACAGAGGAG GATGGGCCTG AACGACTTTA TTCAGAAGAT TGCCAATAAC 420

TCCTATGCGT GCAAACACCC TGAAGTTCAG TCCATTTTGA AAATCTCCCA ACCTCAGGAG 480

CCTGAGCTTA TGAATGCCAA CCCTTCTCCT CCACCAAGTC CTTCTCAGCA AATCAACCTT 540

GGCCCATCAT CCAATCCTCA TGCTAAGCCA TCTGACTTTC ACTTCCTGAA AGTGATTGGG 600

AAGGGCAGTT TTGGAAAGGT TCTTCTCGCC AGACACAAAG CAGAAGAAGC ATTCTACGCA 660

GTCAAAGTTT TACAGAAGAA AGCGATCCTG AAAAAGAAGG AGGAAAAGCA TATCATGTCG 720

GAGCGGAATG TTCTCCTGAA GAATGTGAAA CACCCCTTCC TGGTGGGCCT TCACTTCTCT 780

TTCCAGACTG CTGACAAGCT GTACTTTGTC CTGGACTACA TCAACGGGGG AGAGCTGTTC 840

TACCATCTCC AGAGGGAGCG TTGCTTCCTG GAACCGCGGG CTCGTTTCTA TGCTGCTGAA 900

ATAGCCAGTG CCTTGGGTTA CCTGCACTCC CTGAACATCG TTTATAGAGA CTTAAAACCA 960

GAGAATATTT TGCTAGATTC ACAGGGACAC ATTGTCCTTA CTGACTTTGG GCTCTGCAAG 1020

GAGAACATTG AACCCAACGG CACGACATCC ACCTTCTGTG GCACGCCCGA GTATCTCGCA 1080

CCTGAGGTGC TTCATAAGCA GCCTTATGAC AGGACGGTGG ACTGGTGGTG CCTGGGCGCT 1140

GTCTTGTACG AGATGCTGTA CGGCCTGCCT CCTTTTTACA GCCGAAACAC CGCAGAGATG 1200

TACGACAACA TTCTGAACAA GCCCCTCCAG TTGAAGCCAA ATATTACAAA TTCTGCAAGA 1260

CACCTCCTGG AGGGCCTCCT GCAGAAGGAC AGGACAAAGA GGCTGGGTGC CAAGGATGAC 1320

TTCATGGAGA TTAAGAGCCA TGTCTTCTTC TCCCTCATTA ACTGGGATGA TCTCATTAAT 1380

AAGAAGATTA CTCCCCCTTT TAACCCAAAT GTGAGCGGCC CCAGCGACCT GCGGCACTTC 1440

GATCCCGAAT TTACCGAAGA GCCAGTCCCC AACTCCATCG GCAGGTCCCC GGACAGCATC 1500

CTCCTCACGG CCAGTGTCAA GGAAGCCGCC GAGGCCTTCC TCGGCTTCTC CTATGCCCCT 1560

CCCATGGACT CTTTCCTCTG A 1581

Domain Profile

S: 1     fdflkvigkgsfgkvllakrkadekfyavkvlqkkailkkkeekhimaernvllknvkhp  60

         f+flkvigkgsfgkvlla++ka+e+fyavkvlqkkailkkkeekhim+ernvllknvkhp

Q: 193   FHFLKVIGKGSFGKVLLARHKAEEAFYAVKVLQKKAILKKKEEKHIMSERNVLLKNVKHP  252

         9***********************************************************

S: 61    flvglhysfqtaeklyfvldyvnggelffhlqrersfleprarfyaaeiasalgylhsln  120

         flvglh+sfqta+klyfvldy+nggelf+hlqrer+fleprarfyaaeiasalgylhsln

Q: 253   FLVGLHFSFQTADKLYFVLDYINGGELFYHLQRERCFLEPRARFYAAEIASALGYLHSLN  312

         ************************************************************

S: 121   ivyrdlkpenilldskghvvltdfglckeeieaedttstfcgtpeylapevlrkkpydrt  180

         ivyrdlkpenillds+gh+vltdfglcke+ie + ttstfcgtpeylapevl+k+pydrt

Q: 313   IVYRDLKPENILLDSQGHIVLTDFGLCKENIEPNGTTSTFCGTPEYLAPEVLHKQPYDRT  372

         ************************************************************

S: 181   vdwwclgavlyemlyglppfysrdvaemydnilnkplqlkpgisvaalelleellekdrk  240

         vdwwclgavlyemlyglppfysr++aemydnilnkplqlkp+i+++a++lle+ll+kdr+

Q: 373   VDWWCLGAVLYEMLYGLPPFYSRNTAEMYDNILNKPLQLKPNITNSARHLLEGLLQKDRT  432

         ************************************************************

S: 241   krlgakedfleiknhvff  258

         krlgak+df+eik+hvff

Q: 433   KRLGAKDDFMEIKSHVFF  450

         *****************9

Domain Sequence
(FASTA)

FHFLKVIGKG SFGKVLLARH KAEEAFYAVK VLQKKAILKK KEEKHIMSER NVLLKNVKHP 60

FLVGLHFSFQ TADKLYFVLD YINGGELFYH LQRERCFLEP RARFYAAEIA SALGYLHSLN 120

IVYRDLKPEN ILLDSQGHIV LTDFGLCKEN IEPNGTTSTF CGTPEYLAPE VLHKQPYDRT 180

VDWWCLGAVL YEMLYGLPPF YSRNTAEMYD NILNKPLQLK PNITNSARHL LEGLLQKDRT 240

KRLGAKDDFM EIKSHVFF 258

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Echinops telfairi"; ?>Erinaceus europaeus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0035091	; F:phosphatidylinositol binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0007154	; P:cell communication
GO:0006974	; P:response to DNA damage stimulus

KEGG

ecb:100073151

;

InterPros

IPR000961	; AGC-kinase_C.
IPR011009	; Kinase-like_dom.
IPR001683	; Phox.
IPR017892	; Pkinase_C.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069	; Pkinase; 1.
PF00433	; Pkinase_C; 1.

SMARTs

SM00133	; S_TK_X; 1.
SM00220	; S_TKc; 1.

Prosites

PS51285	; AGC_KINASE_CTER; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013