EKS-EQC-00272

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-EQC-00272

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TKL/STKR	447.4	2.3E-134	234	521	288

Status

Unreviewed

Ensembl Protein

ENSECAP00000018155

UniProt Accession

F6UG39;

Protein Name

Protein Synonyms/Alias

Gene Name

BMPR1A

Gene Synonyms/Alias

BMPR1A;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSECAG00000020461	ENSECAP00000018155	ENSECAT00000021993

Organism

Equus caballus

Functional Description

Protein Length

532

Protein Sequence
(FASTA)

MTQLSIYIRL LGAYLFIISH VQGQNLDSML HGTGVKSDPE QKKSENGATV APEDTLPFLK 60

CYCSGHCPDD AINNTCITNG HCFAIIEEDD QGETTLASGC MKYEGSDFQC KDSPKAQLRR 120

TIECCRTNLC NQYLQPTLPP VVIGPFFDGS IRWLVVLISM AVCIIAMIIF SSCFCYKHYC 180

KSISSRRRYN RDLEQDEAFI PVGESLKDLI DQSQSSGSGS GLPLLVQRTI AKQIQMVRQV 240

GKGRYGEVWM GKWRGEKVAV KVFFTTEEAS WFRETEIYQT VLMRHENILG FIAADIKGTG 300

SWTQLYLITD YHENGSLYDF LKCATLDTRA LLKLAYSAAC GLCHLHTEIY GTQGKPAIAH 360

RDLKSKNILI KKNGSCCIAD LGLAVKFNSD TNEVDVPLNT RVGTKRYMAP EVLDESLNKN 420

HFQPYIMADI YSFGLIIWEM ARRCVTGGIV EEYQLPYYNM VPNDPSYEDM REVVCVKRLR 480

PLVSNRWNSD ECLRAVLKLM SECWAHNPAS RLTALRIKKT LAKMVESQDV KI 532

Nucleotide Sequence
(FASTA)

ATGACTCAGC TATCTATTTA CATCAGATTA TTGGGAGCCT ATCTGTTCAT CATTTCTCAT 60

GTTCAAGGGC AGAATCTAGA CAGTATGCTC CATGGTACTG GGGTGAAGTC AGACCCCGAG 120

CAGAAGAAGT CAGAAAATGG AGCGACTGTG GCCCCGGAGG ACACCTTGCC TTTCTTAAAG 180

TGCTATTGCT CAGGACACTG CCCAGATGAT GCTATTAATA ACACGTGCAT AACTAATGGG 240

CATTGCTTTG CTATCATAGA AGAAGATGAC CAGGGAGAAA CCACATTAGC TTCGGGGTGT 300

ATGAAATATG AAGGGTCTGA TTTTCAGTGC AAGGATTCAC CAAAAGCCCA GCTACGCCGG 360

ACAATAGAAT GTTGTCGGAC CAATCTGTGT AACCAGTATT TGCAGCCTAC ACTGCCCCCT 420

GTCGTCATAG GCCCATTTTT CGACGGCAGC ATTCGATGGC TGGTCGTGCT CATCTCTATG 480

GCTGTCTGCA TAATCGCTAT GATCATCTTC TCCAGCTGCT TTTGTTACAA ACATTATTGC 540

AAGAGCATCT CAAGCAGACG TCGTTACAAT CGTGATTTGG AACAGGACGA AGCATTTATT 600

CCAGTCGGAG AATCATTAAA AGACCTTATT GACCAGTCGC AAAGTTCTGG GAGTGGGTCT 660

GGACTGCCTT TACTGGTGCA GCGAACTATT GCCAAACAGA TTCAGATGGT TCGGCAAGTT 720

GGTAAAGGCC GATATGGAGA AGTGTGGATG GGCAAATGGC GTGGTGAAAA AGTAGCAGTC 780

AAAGTGTTTT TTACCACTGA AGAAGCCAGC TGGTTTCGAG AAACAGAAAT CTATCAAACC 840

GTGCTAATGC GCCATGAAAA TATACTTGGT TTTATAGCAG CAGACATTAA AGGCACAGGT 900

TCCTGGACTC AGCTGTATTT GATTACTGAC TACCATGAAA ATGGATCTCT CTATGATTTC 960

CTGAAATGTG CTACACTAGA CACCAGAGCC CTACTCAAGC TGGCTTACTC AGCTGCCTGT 1020

GGGCTGTGCC ATCTCCACAC AGAAATTTAT GGCACCCAAG GAAAGCCTGC AATTGCTCAT 1080

CGAGACCTAA AGAGCAAAAA CATCCTCATC AAAAAAAATG GAAGTTGCTG TATTGCTGAC 1140

CTGGGCCTTG CTGTTAAATT CAACAGTGAT ACGAATGAAG TTGATGTACC CTTGAATACC 1200

AGGGTAGGTA CCAAACGCTA CATGGCTCCA GAAGTGCTCG ATGAGAGCCT GAATAAAAAC 1260

CATTTCCAGC CCTACATAAT GGCGGACATC TATAGCTTTG GTCTCATCAT TTGGGAGATG 1320

GCTCGTCGTT GTGTCACAGG AGGGATAGTG GAAGAGTACC AGTTGCCATA TTACAACATG 1380

GTACCCAATG ATCCATCCTA TGAAGATATG CGCGAGGTTG TGTGTGTCAA ACGTTTGCGG 1440

CCGCTTGTTT CTAATCGATG GAACAGTGAT GAATGTCTAC GAGCAGTTTT GAAGCTAATG 1500

TCAGAATGCT GGGCCCACAA TCCAGCCTCC AGACTGACAG CTCTGAGAAT CAAGAAGACA 1560

CTTGCCAAGA TGGTTGAATC CCAAGATGTA AAGATTTGA 1599

Domain Profile

S: 1     lklleligkGrygeVwkaklrgeevAvKifstedeaswkrEkeiyqtvllrhenilqfia  60

         +++++++gkGrygeVw++k+rge+vAvK+f+t++easw+rE+eiyqtvl+rhenil+fia

Q: 234   IQMVRQVGKGRYGEVWMGKWRGEKVAVKVFFTTEEASWFRETEIYQTVLMRHENILGFIA  293

         799*********************************************************

S: 61    adkkeedsltelllvteyhekgsLsdyLkretldveellrlalslasGlahLHeeivgtk  120

         ad+k ++s+t+l+l+t+yhe+gsL+d+Lk  tld++ ll+la+s+a+Gl+hLH+ei gt+

Q: 294   ADIKGTGSWTQLYLITDYHENGSLYDFLKCATLDTRALLKLAYSAACGLCHLHTEIYGTQ  353

         ************************************************************

S: 121   gkkKpaiaHRDlkskNilvkkdltcciaDlGLalkleeekeeldlaansqvGtkRYmaPE  180

         g  KpaiaHRDlkskNil+kk+++cciaDlGLa+k++++++e+d+  n++vGtkRYmaPE

Q: 354   G--KPAIAHRDLKSKNILIKKNGSCCIADLGLAVKFNSDTNEVDVPLNTRVGTKRYMAPE  411

         *..*********************************************************

S: 181   vleealnlkdfeafkraDvYslgLvlWEvasRceevdeeveeyklpfeevvgsdPsleem  240

         vl+e+ln ++f+ + +aD+Ys+gL++WE+a+Rc + +++veey+lp++++v++dPs+e+m

Q: 412   VLDESLNKNHFQPYIMADIYSFGLIIWEMARRCVT-GGIVEEYQLPYYNMVPNDPSYEDM  470

         ***********************************.************************

S: 241   kevvvekklrPkipeawkkkealkelsklleecWdadpeaRltalrvkkrl  291

         +evv++k+lrP ++++w+++e+l+++ kl++ecW+++p++Rltalr+kk+l

Q: 471   REVVCVKRLRPLVSNRWNSDECLRAVLKLMSECWAHNPASRLTALRIKKTL  521

         *************************************************97

Domain Sequence
(FASTA)

IQMVRQVGKG RYGEVWMGKW RGEKVAVKVF FTTEEASWFR ETEIYQTVLM RHENILGFIA 60

ADIKGTGSWT QLYLITDYHE NGSLYDFLKC ATLDTRALLK LAYSAACGLC HLHTEIYGTQ 120

GKPAIAHRDL KSKNILIKKN GSCCIADLGL AVKFNSDTNE VDVPLNTRVG TKRYMAPEVL 180

DESLNKNHFQ PYIMADIYSF GLIIWEMARR CVTGGIVEEY QLPYYNMVPN DPSYEDMREV 240

VCVKRLRPLV SNRWNSDECL RAVLKLMSEC WAHNPASRLT ALRIKKTL 288

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>

Gene Ontology

GO:0005901	; C:caveola
GO:0005524	; F:ATP binding
GO:0000981	; F:sequence-specific DNA binding RNA polymerase II transcription factor activity
GO:0005024	; F:transforming growth factor beta-activated receptor activity
GO:0030509	; P:BMP signaling pathway
GO:0051216	; P:cartilage development
GO:0048589	; P:developmental growth
GO:0009950	; P:dorsal/ventral axis specification
GO:0007398	; P:ectoderm development
GO:0042733	; P:embryonic digit morphogenesis
GO:0048568	; P:embryonic organ development
GO:0003272	; P:endocardial cushion formation
GO:0060914	; P:heart formation
GO:0035137	; P:hindlimb morphogenesis
GO:0006955	; P:immune response
GO:0001701	; P:in utero embryonic development
GO:0048368	; P:lateral mesoderm development
GO:0030324	; P:lung development
GO:0048382	; P:mesendoderm development
GO:0001707	; P:mesoderm formation
GO:0001880	; P:Mullerian duct regression
GO:0050768	; P:negative regulation of neurogenesis
GO:0014032	; P:neural crest cell development
GO:0021998	; P:neural plate mediolateral regionalization
GO:0042475	; P:odontogenesis of dentin-containing tooth
GO:0060021	; P:palate development
GO:0048352	; P:paraxial mesoderm structural organization
GO:0021983	; P:pituitary gland development
GO:0030501	; P:positive regulation of bone mineralization
GO:0050679	; P:positive regulation of epithelial cell proliferation
GO:0002053	; P:positive regulation of mesenchymal cell proliferation
GO:0045669	; P:positive regulation of osteoblast differentiation
GO:0010862	; P:positive regulation of pathway-restricted SMAD protein phosphorylation
GO:0060391	; P:positive regulation of SMAD protein import into nucleus
GO:0045893	; P:positive regulation of transcription, DNA-dependent
GO:0048378	; P:regulation of lateral mesodermal cell fate specification
GO:0001756	; P:somitogenesis
GO:0019827	; P:stem cell maintenance

KEGG

ecb:100064367

;

InterPros

IPR000472	; Activin_rcpt.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR008271	; Ser/Thr_kinase_AS.
IPR003605	; TGF_beta_rcpt_GS.

Pfam

PF01064	; Activin_recp; 1.
PF00069	; Pkinase; 1.
PF08515	; TGF_beta_GS; 1.

SMARTs

SM00467

; GS; 1.

Prosites

PS51256	; GS; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013