EKS-EQC-00163
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-EQC-00163
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
CAMK/RSKb440.12.7E-132411668258
StatusUnreviewed
Ensembl ProteinENSECAP00000019030
UniProt AccessionF6XIN7;
Protein NameRibosomal protein S6 kinase
Protein Synonyms/Alias
Gene NameRPS6KA2
Gene Synonyms/Alias RPS6KA2;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSECAG00000020508ENSECAP00000019030ENSECAT00000022999
OrganismEquus caballus
Functional Description
Protein Length729
Protein Sequence
(FASTA)
MKKFTVRRFF SVYLRKKSRS KSSSLSRLEE EGIVKEIDIS HHVKEGFEKA DPSQFELLKV 60
LGQGSYGKVF LVRKVKGSDA GQLYAMKVLK KATLKVRDRV RSKMERDILA EVNHPFIVKL 120
HYAFQTEGKL YLILDFLRGG DLFTRLSKEV MFTEEDVKFY LAELALALDH LHGLGIIYRD 180
LKPENILLDE EGHIKITDFG LSKEAIDHDK RAYSFCGTIE YMAPEVVNRR GHTQSADWWS 240
FGVLMFEMLT GSLPFQGKDR KETMALILKA KLGMPQFLSL EAQSLLRALF KRNPCNRLGA 300
GIDGVEEIKR HPFFVTIDWN KLYRKEVKPP FKPAVGRPED TFHFDPEFTA RTPTDSPGVP 360
PSANAHHLFR GFSFVASSLV QEPSQQDQHK TMVPPIVQQL HGNNIHFTDG YEIKEDIGVG 420
SYSVCKRCVH KATDAEYAVK VRPSARKNPG IQVWVLLRRG LHALPFSTSQ VYDDGKFVYL 480
VMELMRGGEL LDRILRQRYF SEREASDVLC TITKTMDYLH SQGVVHRDLK PSNILYMDES 540
GNPESIRICD FGFAKQLRAE NGLLMTPCYT ANFVAPEVLK RQGYDAACDI WSLGILLYTM 600
LAGFTPFANG PDDTPEEILA RIGSGKYALS GGNWDSISDA AKDVVSKMLH VDPQQRLTAV 660
QVLKHPWIVN REYLSQNQLS RQDVHLVKGA MAATYFALNR TPQAPRLEPV LSSSLAQRRG 720
MKRLTSTRL 729
Nucleotide Sequence
(FASTA)
ATGAAGAAGT TCACCGTGCG GAGGTTCTTC TCGGTGTACC TGCGCAAGAA GTCGCGCTCC 60
AAGAGCTCCA GTCTGAGTCG GCTCGAGGAG GAAGGCATTG TGAAGGAAAT TGACATCAGC 120
CATCATGTGA AAGAAGGATT TGAAAAGGCC GACCCTTCCC AGTTTGAACT GTTGAAAGTT 180
TTAGGACAAG GATCCTATGG AAAGGTGTTC CTGGTGAGGA AGGTAAAGGG ATCCGACGCT 240
GGACAGCTCT ATGCAATGAA GGTTCTTAAG AAAGCGACCT TAAAAGTTCG GGACCGAGTG 300
AGATCAAAGA TGGAGAGAGA CATTTTGGCA GAAGTGAATC ACCCTTTCAT TGTCAAGCTT 360
CATTATGCCT TTCAGACGGA AGGAAAGCTC TACCTGATTC TGGACTTCCT GCGGGGTGGG 420
GACCTCTTCA CCAGGCTCTC CAAAGAGGTC ATGTTTACTG AGGAGGATGT CAAGTTCTAC 480
TTGGCTGAGC TGGCCTTAGC TTTAGATCAC CTCCACGGGC TGGGCATCAT CTACAGAGAC 540
CTGAAACCTG AGAACATCCT CCTGGATGAA GAGGGACATA TTAAGATCAC AGACTTCGGG 600
CTGAGTAAGG AGGCCATCGA CCACGACAAG AGAGCCTATT CATTCTGTGG GACGATAGAA 660
TACATGGCTC CCGAGGTGGT GAACCGGCGA GGACACACGC AGAGCGCAGA CTGGTGGTCC 720
TTCGGTGTGC TGATGTTTGA GATGCTCACG GGGTCTCTGC CGTTCCAGGG GAAGGACAGG 780
AAGGAGACCA TGGCCCTCAT CCTCAAAGCC AAGCTGGGCA TGCCACAGTT CCTCAGCCTG 840
GAGGCCCAGA GTTTGCTCAG AGCCCTCTTC AAACGGAACC CGTGCAACCG ACTGGGTGCT 900
GGCATCGATG GAGTGGAGGA GATCAAGCGC CATCCTTTCT TTGTTACCAT AGACTGGAAT 960
AAGCTGTACC GGAAGGAGGT CAAGCCACCC TTCAAACCTG CAGTGGGCCG GCCCGAGGAC 1020
ACCTTCCACT TTGACCCTGA GTTCACCGCA CGGACGCCCA CAGACTCACC TGGCGTCCCC 1080
CCCAGTGCCA ACGCTCATCA TCTGTTTAGA GGATTCAGTT TCGTGGCCTC AAGCCTGGTC 1140
CAGGAGCCTT CGCAGCAAGA TCAGCACAAA ACCATGGTTC CCCCCATCGT GCAGCAGTTA 1200
CACGGGAACA ACATCCACTT CACCGATGGC TATGAGATCA AGGAGGACAT CGGGGTGGGC 1260
TCCTACTCCG TGTGCAAGCG GTGTGTGCAT AAAGCTACTG ATGCAGAGTA TGCCGTGAAG 1320
GTAAGGCCGA GCGCACGGAA GAACCCGGGA ATCCAAGTGT GGGTCCTTCT GAGAAGGGGT 1380
CTGCATGCCC TTCCTTTCTC GACCTCCCAG GTCTACGACG ACGGGAAGTT CGTGTACCTC 1440
GTGATGGAGC TGATGCGCGG TGGGGAGCTC CTGGATCGCA TCCTCCGGCA GAGGTACTTC 1500
TCAGAGCGGG AGGCCAGTGA TGTCCTGTGC ACCATCACCA AGACCATGGA CTACCTCCAC 1560
TCCCAGGGGG TCGTGCATCG AGACCTGAAG CCGAGTAACA TACTGTACAT GGATGAGTCT 1620
GGAAACCCTG AATCCATCCG AATCTGTGAC TTTGGGTTTG CCAAGCAGCT GCGAGCCGAG 1680
AATGGGCTGC TGATGACACC CTGCTACACG GCAAACTTCG TTGCCCCAGA GGTCCTGAAG 1740
CGACAAGGCT ATGATGCGGC GTGTGACATC TGGAGTTTGG GGATCCTGTT ATACACCATG 1800
CTGGCGGGAT TTACCCCTTT TGCAAACGGA CCAGATGATA CCCCAGAGGA GATTTTGGCG 1860
AGGATTGGCA GTGGGAAATA TGCACTTTCT GGGGGAAATT GGGATTCCAT ATCTGATGCA 1920
GCCAAGGACG TTGTATCCAA GATGCTCCAC GTGGATCCTC AGCAGCGCCT GACGGCAGTG 1980
CAAGTCCTGA AACACCCGTG GATTGTGAAC AGGGAGTACC TATCCCAAAA CCAGCTCAGC 2040
AGACAAGACG TCCACCTGGT TAAGGGCGCG ATGGCCGCCA CATACTTTGC TCTCAACAGA 2100
ACCCCTCAGG CCCCACGGCT GGAGCCGGTG TTGTCGTCCA GCCTGGCTCA ACGCAGGGGC 2160
ATGAAGAGAC TCACATCCAC GAGGTTATAG 2190
Domain Profile
S: 1     yevkedlGvGsysvckrcvhkatnqefavkiidkskrdtseeieillryeqhpnivtlkd  60
         ye+ked+GvGsysvckrcvhkat+ e+avk+    ++++  ++ +llr + h    +  +
Q: 411   YEIKEDIGVGSYSVCKRCVHKATDAEYAVKVRPSARKNPGIQVWVLLRRGLHALPFSTSQ  470
         789*********************************************************
S: 61    vyddgkyvylvlellkGGelldrikkkkffsereasailrtlvkaveylheqGvvhrdlk  120
         vyddgk+vylv+el++GGelldri+++++fsereas++l+t++k+++ylh+qGvvhrdlk
Q: 471   VYDDGKFVYLVMELMRGGELLDRILRQRYFSEREASDVLCTITKTMDYLHSQGVVHRDLK  530
         ************************************************************
S: 121   penilyvdesdnaesikiidfGfaklkraengllktpcytlnfvapevlkrqGydeacdl  180
         p+nily+des+n+esi+i+dfGfak++raengll+tpcyt+nfvapevlkrqGyd+acd+
Q: 531   PSNILYMDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDI  590
         ************************************************************
S: 181   wslGvllytmlaGyvpfangpedtaeeilakikeGkfslsGeawdsvseeakdlvskllt  240
         wslG+llytmlaG++pfangp+dt+eeila+i++Gk++lsG++wds+s++akd+vsk+l+
Q: 591   WSLGILLYTMLAGFTPFANGPDDTPEEILARIGSGKYALSGGNWDSISDAAKDVVSKMLH  650
         ************************************************************
S: 241   vdpakrlkleqllkhswl  258
         vdp++rl++ q+lkh+w+
Q: 651   VDPQQRLTAVQVLKHPWI  668
         *****************8
Domain Sequence
(FASTA)
YEIKEDIGVG SYSVCKRCVH KATDAEYAVK VRPSARKNPG IQVWVLLRRG LHALPFSTSQ 60
VYDDGKFVYL VMELMRGGEL LDRILRQRYF SEREASDVLC TITKTMDYLH SQGVVHRDLK 120
PSNILYMDES GNPESIRICD FGFAKQLRAE NGLLMTPCYT ANFVAPEVLK RQGYDAACDI 180
WSLGILLYTM LAGFTPFANG PDDTPEEILA RIGSGKYALS GGNWDSISDA AKDVVSKMLH 240
VDPQQRLTAV QVLKHPWI 258
KeywordATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Xenopus tropicalis"; ?>
EKS-AIM-00154
EKS-ANC-00156
EKS-BOT-00161
EKS-CAJ-00165
EKS-CAF-00168
EKS-CAP-00161
EKS-DAR-00449
EKS-GAG-00139
EKS-GAA-00193
EKS-GOG-00162
EKS-HOS-00167
EKS-ICT-00156
EKS-LAC-00170
EKS-LOA-00159
EKS-MAM-00161
EKS-MEG-00128
EKS-MOD-00158
EKS-MUM-00167
EKS-MUP-00165
EKS-ORC-00150
EKS-OTG-00167
EKS-PES-00142
EKS-POA-00158
EKS-RAN-00159
EKS-SAH-00153
EKS-SUS-00139
EKS-XET-00150
Gene Ontology
GO:0005737; C:cytoplasm
GO:0005634; C:nucleus
GO:0005819; C:spindle
GO:0005524; F:ATP binding
GO:0000287; F:magnesium ion binding
GO:0004711; F:ribosomal protein S6 kinase activity
GO:0002035; P:brain renin-angiotensin system
GO:0010659; P:cardiac muscle cell apoptotic process
GO:0071322; P:cellular response to carbohydrate stimulus
GO:0060047; P:heart contraction
GO:0007507; P:heart development
GO:0007243; P:intracellular protein kinase cascade
GO:0000089; P:mitotic metaphase
GO:0045786; P:negative regulation of cell cycle
GO:0008285; P:negative regulation of cell proliferation
GO:0001556; P:oocyte maturation
GO:0018105; P:peptidyl-serine phosphorylation
GO:0043065; P:positive regulation of apoptotic process
GO:0010628; P:positive regulation of gene expression
GO:0070613; P:regulation of protein processing
KEGG
InterPros
IPR000961; AGC-kinase_C.
IPR011009; Kinase-like_dom.
IPR017892; Pkinase_C.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR016239; Ribosomal_S6_kinase_II.
IPR002290; Ser/Thr_dual-sp_kinase_dom.
IPR008271; Ser/Thr_kinase_AS.
Pfam
PF00069; Pkinase; 2.
PF00433; Pkinase_C; 1.
SMARTs
SM00133; S_TK_X; 1.
SM00220; S_TKc; 2.
Prosites
PS51285; AGC_KINASE_CTER; 1.
PS00107; PROTEIN_KINASE_ATP; 2.
PS50011; PROTEIN_KINASE_DOM; 2.
PS00108; PROTEIN_KINASE_ST; 2.
Prints
Created Date20-Feb-2013