EKS-EQC-00040

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-EQC-00040

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CK1/VRK	365.7	1.4E-109	145	411	267

Status

Unreviewed

Ensembl Protein

ENSECAP00000018114

UniProt Accession

F6UVY9;

Protein Name

Protein Synonyms/Alias

Gene Name

VRK3

Gene Synonyms/Alias

VRK3;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSECAG00000020568	ENSECAP00000018114	ENSECAT00000021945

Organism

Equus caballus

Functional Description

Protein Length

453

Protein Sequence
(FASTA)

MISFCPDCGK SIEAAFKFCP YCGKPLPTEQ HEAPQTFVRP LVSSFRGSRR ERNPSSETSP 60

KKVKWSGCVT SPTSSLFSDG DSSGSEDTLS PCERPKGSRS KPPTPKSSPQ TTKRSPQTLK 120

RSRVTISLEA LPTGTVLTDK NGRHWKLGSL QTRNDQGILY EAEPVSTFAR ESSSQKQRFS 180

LKLDAKDGRL FNEQNFFQRA AKPLQVNKWK KLYSAPLLAV PTCVGFGVHQ DKYRFLVLPS 240

LGRSLQSALD DNPKHVMSVR SVFQMACRLL DALEFLHENE YVHGNVTAEN IFVNPEDRSQ 300

VTLAGYGFAF RYSPGGKHVA YVEGSRSPHE GDLEFISMDL HKGCGPSRRS DLQTLGYCLL 360

KWLYGTLPWT NCLPNAEDIM KLKQKFLDNP EALVGQCSRW ISPSETLQEY LKVVMALQYD 420

EKPPYMLLRN NLEAMLQDLR VSAYDPLDLR MVP 453

Nucleotide Sequence
(FASTA)

ATGATCAGCT TCTGTCCAGA CTGTGGCAAA AGCATTGAAG CGGCATTCAA ATTCTGCCCC 60

TACTGTGGAA AACCTTTGCC CACAGAGCAG CATGAGGCGC CCCAGACCTT TGTCAGACCT 120

CTTGTTTCAT CCTTCCGAGG CTCAAGGAGA GAGAGGAACC CCAGTTCGGA AACCTCCCCC 180

AAGAAAGTAA AGTGGTCCGG CTGTGTCACC TCTCCCACGT CATCCCTCTT CTCAGATGGT 240

GACAGCTCTG GGTCTGAAGA TACCCTGAGT CCCTGTGAGA GACCCAAAGG GTCCCGGAGC 300

AAACCCCCAA CCCCCAAAAG CAGCCCGCAG ACAACCAAGC GAAGCCCTCA GACACTGAAG 360

CGGAGCCGAG TGACCATCTC GCTTGAGGCC CTGCCCACGG GGACGGTGCT GACGGACAAG 420

AATGGGCGGC ACTGGAAGCT GGGATCCCTG CAAACCAGGA ATGACCAGGG CATCCTCTAT 480

GAAGCGGAGC CCGTCTCCAC CTTCGCCCGC GAGTCAAGTT CCCAGAAGCA AAGGTTCTCC 540

CTTAAACTGG ATGCCAAGGA CGGGCGCTTG TTCAATGAGC AGAACTTCTT CCAGCGGGCC 600

GCCAAGCCTT TGCAAGTGAA CAAGTGGAAG AAGCTGTACT CGGCGCCCCT GCTGGCCGTC 660

CCCACCTGTG TCGGGTTTGG CGTGCACCAG GACAAATACA GGTTCCTGGT GCTCCCCAGC 720

CTGGGGAGGA GCCTTCAGTC GGCCCTGGAT GACAACCCAA AGCACGTGAT GTCGGTGAGG 780

TCTGTGTTCC AGATGGCCTG CCGGCTGCTG GATGCCCTGG AGTTCCTCCA TGAGAATGAG 840

TACGTTCATG GAAATGTGAC AGCTGAGAAT ATCTTTGTAA ATCCAGAGGA CCGGAGCCAG 900

GTGACCCTCG CAGGCTACGG CTTCGCCTTC CGCTATTCCC CAGGCGGCAA ACACGTGGCC 960

TACGTCGAAG GCAGCAGGAG CCCACACGAG GGGGACCTCG AGTTCATTAG CATGGACCTG 1020

CACAAGGGAT GCGGGCCCTC CCGCCGCAGC GACCTGCAGA CCCTGGGCTA CTGTTTGCTG 1080

AAGTGGCTCT ATGGGACCCT GCCCTGGACA AATTGCCTTC CCAACGCTGA GGATATCATG 1140

AAGCTAAAAC AGAAGTTTCT TGACAACCCG GAGGCCCTCG TGGGACAGTG CAGTCGCTGG 1200

ATCAGTCCCT CAGAGACGCT GCAGGAGTAC CTGAAGGTGG TGATGGCGCT CCAGTACGAC 1260

GAGAAGCCGC CCTACATGCT GCTGAGGAAC AATCTGGAGG CCATGTTGCA GGACCTGCGG 1320

GTGTCGGCCT ACGACCCCCT GGACCTCCGG ATGGTGCCCT AG 1362

Domain Profile

S: 1     wklgkkigkggfGeiyla.....ltckkeekdaklvvkvepkenGpLfvelkfyqraakk  55

         wklg+ ++++++G++y+a     ++ +++++++++++k+++k+ G+Lf+e++f+qraak+

Q: 145   WKLGSLQTRNDQGILYEAepvstFARESSSQKQRFSLKLDAKD-GRLFNEQNFFQRAAKP  203

         9*****************999877788999************9.****************

S: 56    eqikkwkkkkklkllgiPtliasGlhefegekyRflvlprlgrdLqklleqngkr.lsek  114

          q++kwkk ++ +ll++Pt++++G+h+   +kyRflvlp+lgr+Lq++l++n+k+ +s +

Q: 204   LQVNKWKKLYSAPLLAVPTCVGFGVHQ---DKYRFLVLPSLGRSLQSALDDNPKHvMSVR  260

         ***************************...*************************8999*

S: 115   tvlqlavrlldvleylHeneYvHgdikAanllleeeeasqvyLvdyGlayrycpegkhke  174

         +v+q+a+rlld+le+lHeneYvHg+++A+n+++++e+ sqv+L++yG+a+ry p+gkh++

Q: 261   SVFQMACRLLDALEFLHENEYVHGNVTAENIFVNPEDRSQVTLAGYGFAFRYSPGGKHVA  320

         ************************************************************

S: 175   ykedkrraHdGtleftslDaHkGvapsrRsDleiLgYcllkWltgkLPWeallkdpekvq  234

         y+e++r++H+G+lef+s+D+HkG++psrRsDl++LgYcllkWl+g+LPW+++l++ e+++

Q: 321   YVEGSRSPHEGDLEFISMDLHKGCGPSRRSDLQTLGYCLLKWLYGTLPWTNCLPNAEDIM  380

         ************************************************************

S: 235   kakekfldelpellkkllkkkssseelakyl  265

         k k+kfld++++l+ ++ ++ s+se+l++yl

Q: 381   KLKQKFLDNPEALVGQCSRWISPSETLQEYL  411

         ******************************8

Domain Sequence
(FASTA)

WKLGSLQTRN DQGILYEAEP VSTFARESSS QKQRFSLKLD AKDGRLFNEQ NFFQRAAKPL 60

QVNKWKKLYS APLLAVPTCV GFGVHQDKYR FLVLPSLGRS LQSALDDNPK HVMSVRSVFQ 120

MACRLLDALE FLHENEYVHG NVTAENIFVN PEDRSQVTLA GYGFAFRYSP GGKHVAYVEG 180

SRSPHEGDLE FISMDLHKGC GPSRRSDLQT LGYCLLKWLY GTLPWTNCLP NAEDIMKLKQ 240

KFLDNPEALV GQCSRWISPS ETLQEYL 267

Keyword

Complete proteome; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005634	; C:nucleus
GO:0005524	; F:ATP binding
GO:0004672	; F:protein kinase activity
GO:0070373	; P:negative regulation of ERK1 and ERK2 cascade
GO:0032516	; P:positive regulation of phosphoprotein phosphatase activity

KEGG

ecb:100052342

;

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.

Pfam

PF00069

; Pkinase; 1.

SMARTs

Prosites

PS50011

; PROTEIN_KINASE_DOM; 1.

Prints

Created Date

20-Feb-2013