EKS-EQC-00244

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-EQC-00244

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CAMK/CAMKL	316.6	1.2E-94	12	264	253

Status

Unreviewed

Ensembl Protein

ENSECAP00000018665

UniProt Accession

F6UB22;

Protein Name

Protein Synonyms/Alias

Gene Name

MELK

Gene Synonyms/Alias

MELK;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSECAG00000020698	ENSECAP00000018677	ENSECAT00000022592
ENSECAG00000020698	ENSECAP00000018665	ENSECAT00000022580
ENSECAG00000020698	ENSECAP00000018744	ENSECAT00000022667

Organism

Equus caballus

Functional Description

Protein Length

655

Protein Sequence
(FASTA)

TMKDYDELLK YYELYETIGT GGFAKVKLAC HILTGEMVAI KIMDKNALGS DLPRIKTEID 60

ALKNLRHQHI CQLYHVLETA NKIFMVLEYC PGGELFDYII SQDRLSEEET RVIFRQIVAA 120

VAYVHSQGYA HRDLKPENLL FDEYHKLKLI DFGLCAKPKD NKDYHLQTCC GSLAYAAPEL 180

IQGKSYLGSE ADVWSMGILL YVLMCGFLPF DDDNVMALYK KIMRGKYEVP KWLSPSSILL 240

LQQMLQVDPK KRISVKNLLS HPWIMQDYNC AVEWQSKTPF IHLDDDCVTE LSVHHGNNRQ 300

TMEDLISLWQ YDHLTATYLL LQAKKTRGKP VRLRLPSFSC RQVSAIPFTN SKVNVRTFFH 360

LPNNLIIWVM GTMDFEDYEW CEDNSSTGVA TPQTPQFAKH WTESNGLESK SLTPVLCRAS 420

ANKLKNKENV YTPKSAVKNE ECFVFPEPKT PVNKNQHKRE ILTTPNRYTT PSKARNQCLK 480

ETPIKMPANS VGTEISMTGV ISPERRCRSV ELDLNQAHVE ETPKRKGTKV FGSLERGLDK 540

VITVLTRSKR RGSAKDGPRR LKLHYNVTTT RLVNPDQLLN EIMSVLRKQH VDFVQKGYTL 600

KCQTQSDFGK VTMQFELEVC QLQKPDVVGI RRQRLKGDAW VYKRLVEDIL SSCKV 655

Nucleotide Sequence
(FASTA)

ACTATGAAAG ATTATGATGA ACTTCTCAAA TACTATGAAT TATATGAAAC TATTGGGACA 60

GGTGGCTTTG CAAAGGTCAA ACTTGCCTGC CATATCCTCA CTGGAGAAAT GGTTGCTATA 120

AAAATCATGG ATAAGAATGC ACTAGGGAGC GATTTGCCCC GGATCAAAAC AGAGATCGAT 180

GCCCTGAAGA ACCTGAGACA TCAGCATATA TGTCAACTCT ACCATGTGCT AGAGACAGCG 240

AACAAAATAT TCATGGTTCT TGAGTACTGC CCTGGAGGAG AGCTGTTTGA CTACATCATC 300

TCCCAGGATC GCCTGTCAGA GGAGGAGACG CGCGTCATCT TCCGGCAGAT AGTAGCTGCA 360

GTTGCTTACG TGCACAGCCA GGGCTATGCT CACAGGGACC TCAAACCAGA AAATTTGTTG 420

TTTGATGAAT ATCATAAATT AAAGCTGATT GACTTTGGTC TCTGTGCAAA ACCCAAGGAT 480

AACAAGGATT ACCACCTACA GACATGCTGT GGGAGTCTTG CTTATGCAGC ACCTGAATTA 540

ATACAAGGCA AATCATATCT GGGCTCAGAG GCAGATGTTT GGAGCATGGG CATACTCTTA 600

TATGTACTTA TGTGTGGCTT TCTACCATTT GATGACGATA ATGTCATGGC CTTGTACAAG 660

AAGATTATGA GAGGGAAATA TGAGGTTCCT AAGTGGCTCT CTCCCAGTAG CATTCTGCTT 720

CTTCAACAAA TGCTACAGGT GGACCCAAAG AAACGGATTT CTGTGAAAAA TCTATTGAGC 780

CATCCCTGGA TCATGCAAGA TTACAACTGT GCTGTTGAGT GGCAAAGCAA GACTCCTTTT 840

ATTCACCTTG ATGACGACTG TGTGACAGAA CTTTCTGTAC ATCACGGAAA CAATAGGCAA 900

ACAATGGAGG ATTTGATTTC GTTGTGGCAA TATGATCACC TCACAGCTAC CTATCTTCTG 960

CTTCAAGCCA AGAAGACTCG AGGGAAACCT GTTCGTTTAA GGCTTCCTTC TTTTTCCTGT 1020

AGACAAGTCA GTGCTATCCC CTTCACAAAC AGCAAGGTAA ATGTTAGAAC CTTCTTTCAT 1080

TTACCTAATA ATTTAATTAT TTGGGTGATG GGAACCATGG ATTTTGAAGA CTATGAATGG 1140

TGTGAAGACA ATTCATCGAC AGGTGTGGCT ACTCCCCAAA CACCACAGTT TGCCAAGCAT 1200

TGGACAGAAT CAAATGGTCT GGAATCTAAA TCATTAACTC CAGTATTATG CAGAGCATCT 1260

GCCAATAAAT TAAAGAACAA AGAGAATGTA TATACTCCTA AGTCTGCTGT TAAGAATGAA 1320

GAGTGCTTTG TATTTCCTGA ACCAAAGACT CCAGTTAATA AGAACCAGCA TAAAAGAGAA 1380

ATACTCACTA CACCAAATCG TTACACTACA CCCTCAAAAG CTAGAAACCA GTGCCTGAAG 1440

GAAACTCCAA TTAAAATGCC AGCAAATTCA GTGGGAACAG AAATATCAAT GACAGGCGTC 1500

ATTAGCCCTG AGAGGCGGTG TCGCTCAGTG GAACTGGATC TCAACCAAGC ACATGTAGAG 1560

GAAACTCCCA AAAGAAAAGG AACCAAAGTG TTTGGGAGCC TTGAGAGGGG TTTGGATAAG 1620

GTTATTACTG TGCTCACCAG GAGCAAAAGG AGGGGCTCTG CCAAAGATGG GCCGAGAAGA 1680

CTGAAGCTGC ACTATAATGT GACTACAACC AGATTAGTGA ATCCAGATCA ACTCTTGAAT 1740

GAAATAATGT CTGTTCTTCG AAAGCAGCAC GTTGACTTTG TACAGAAGGG CTACACACTG 1800

AAGTGTCAAA CACAGTCAGA TTTTGGCAAA GTGACAATGC AGTTTGAACT AGAAGTGTGC 1860

CAACTTCAAA AACCTGATGT GGTGGGTATC AGGAGGCAGC GGCTTAAGGG TGATGCCTGG 1920

GTTTACAAGA GACTAGTGGA AGACATCTTA TCTAGCTGCA AAGTATGA 1968

Domain Profile

S: 1     ykllktlGegsfgkVklakhketkekvavKiikkkklseeslekikrEieilkklkhpni  60

         y+l +t+G+g f+kVkla+h +t+e+va+Ki++k++l +  l +ik+Ei++lk+l+h++i

Q: 12    YELYETIGTGGFAKVKLACHILTGEMVAIKIMDKNALGS-DLPRIKTEIDALKNLRHQHI  70

         999*******************************88875.589*****************

S: 61    ikllevietkkklylvleyasggeLfdyieekgrlkekearklfkqlvsavkYlhskgiv  120

         ++l++v+et +k+++vley+ ggeLfdyi ++ rl+e+e+r +f+q+v+av Y+hs+g +

Q: 71    CQLYHVLETANKIFMVLEYCPGGELFDYIISQDRLSEEETRVIFRQIVAAVAYVHSQGYA  130

         ************************************************************

S: 121   HrDlKpeNllldkkenikiaDFGlanlfkeg..klletfcGsppYaaPellkgkkYegpk  178

         HrDlKpeNll+d+ +++k++DFGl+++ k++   +l+t+cGs++YaaPel++gk+Y g++

Q: 131   HRDLKPENLLFDEYHKLKLIDFGLCAKPKDNkdYHLQTCCGSLAYAAPELIQGKSYLGSE  190

         **************************877764589*************************

S: 179   vDvWslGvvLyalvtgklPfdeenlkellekilkgkleipkklskelesLlrklLvvdpe  238

         +DvWs+G++Ly+l++g lPfd++n+ +l++ki++gk+e+pk+ls++ + Ll+++L+vdp+

Q: 191   ADVWSMGILLYVLMCGFLPFDDDNVMALYKKIMRGKYEVPKWLSPSSILLLQQMLQVDPK  250

         ************************************************************

S: 239   kRatieeilkhewl  252

         kR++++++l+h+w+

Q: 251   KRISVKNLLSHPWI  264

         *************7

Domain Sequence
(FASTA)

YELYETIGTG GFAKVKLACH ILTGEMVAIK IMDKNALGSD LPRIKTEIDA LKNLRHQHIC 60

QLYHVLETAN KIFMVLEYCP GGELFDYIIS QDRLSEEETR VIFRQIVAAV AYVHSQGYAH 120

RDLKPENLLF DEYHKLKLID FGLCAKPKDN KDYHLQTCCG SLAYAAPELI QGKSYLGSEA 180

DVWSMGILLY VLMCGFLPFD DDNVMALYKK IMRGKYEVPK WLSPSSILLL QQMLQVDPKK 240

RISVKNLLSH PWI 253

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005938	; C:cell cortex
GO:0005886	; C:plasma membrane
GO:0005524	; F:ATP binding
GO:0005509	; F:calcium ion binding
GO:0004715	; F:non-membrane spanning protein tyrosine kinase activity
GO:0004674	; F:protein serine/threonine kinase activity
GO:0006915	; P:apoptotic process
GO:0061351	; P:neural precursor cell proliferation
GO:0043065	; P:positive regulation of apoptotic process
GO:0046777	; P:protein autophosphorylation

KEGG

InterPros

IPR001772	; Kinase-assoc_KA1.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF02149	; KA1; 1.
PF00069	; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS50032	; KA1; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013