EKS-EQC-00285

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-EQC-00285

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
Other/IKK	441.1	1.9E-132	9	293	285

Status

Unreviewed

Ensembl Protein

ENSECAP00000018587

UniProt Accession

F6VNA3;

Protein Name

Protein Synonyms/Alias

Gene Name

TBK1

Gene Synonyms/Alias

TBK1;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSECAG00000020820	ENSECAP00000018587	ENSECAT00000022485

Organism

Equus caballus

Functional Description

Protein Length

729

Protein Sequence
(FASTA)

MQSTSNHLWL LSDILGQGAT ANVFRGRHKK TGDLFAIKVF NNISFLRPVD VQMREFEVLK 60

KLNHKNIVKL FAIEEETTTR HKVLVMEFCP CGSLYTVLEE PSNAYGLPES EFLIVLRDVV 120

GGMNHLRENG IVHRDIKPGN IMRVIGEDGQ SVYKLTDFGA ARELEDDEQF VSLYGTEEYL 180

HPDMYERAVL RKDHQKKYGA TVDLWSIGVT FYHAATGSLP FRPFEGPRRN KEVMYKILTG 240

KPSGAISGVQ KAENGPIDWS GDMPVSCSLS RGLQVLLTPV LANILEADQE KCWGFDQFFA 300

ETSDILHRMI IHVFSLQQMT AHKIYIHSYN TAAVFHELVY KQTKIISSNQ ELIYEGRRLV 360

LEPGRLAQHL PKTTEDNPIF VVSQEPLSAV GLIYEKISLP KVHPRYDLDG DASMAKAITG 420

VVCYACRVTS TLLLYQELMR KGIRWLIELV KDDYNETVHK KTEVVITLDF CIRNIEKTMK 480

VYEKLIEINL EAAELGEISD IHTKLLRLSS SQGTIETSLQ DIESKLSPSG LLTDAWAHQE 540

GTHPKDRHVE KLQVLLSCIT EIYYQFKKDK AERRLAYNEE QIHKFDKQKL YYHATKAMTH 600

FTDECVKKYE VFLDKSEEWM RKMLHLRKQL LALTNQCFDI EEEVSKYQDY TSELQETLPQ 660

KMFAASSGMK HAMTPVYPCS NTLVEMTLGM KKLKEEMEGV VKELAENNHI LERFGALTMD 720

GGLRNVDCL 729

Nucleotide Sequence
(FASTA)

ATGCAGAGCA CTTCTAATCA CCTCTGGCTC TTGTCGGATA TTTTAGGCCA AGGAGCTACT 60

GCAAATGTCT TTCGAGGAAG ACATAAGAAA ACTGGTGACT TGTTTGCTAT CAAAGTGTTT 120

AATAACATAA GCTTCCTTCG TCCAGTGGAT GTTCAAATGA GAGAATTTGA AGTGTTAAAA 180

AAACTCAATC ACAAAAATAT TGTCAAATTA TTTGCTATTG AAGAGGAGAC AACAACAAGG 240

CATAAAGTAC TTGTTATGGA ATTCTGTCCA TGTGGGAGTT TATACACTGT CCTAGAGGAG 300

CCGTCTAATG CCTATGGACT GCCAGAGTCT GAATTTCTGA TTGTTTTGCG AGATGTGGTG 360

GGTGGAATGA ATCATCTCCG AGAGAATGGC ATAGTGCACC GTGACATCAA GCCAGGAAAT 420

ATCATGCGTG TGATAGGGGA AGACGGCCAG TCTGTGTACA AACTCACAGA TTTCGGTGCA 480

GCTAGAGAAT TAGAAGATGA TGAGCAGTTT GTTTCTCTGT ATGGCACAGA AGAATACTTG 540

CATCCTGATA TGTATGAGCG AGCCGTGCTG CGGAAAGACC ATCAGAAGAA GTATGGAGCC 600

ACGGTCGACC TTTGGAGCAT CGGGGTAACG TTTTACCACG CAGCCACCGG GTCACTGCCG 660

TTCAGACCGT TTGAAGGGCC ACGCAGGAAT AAGGAAGTGA TGTATAAAAT ACTTACTGGA 720

AAGCCTTCTG GCGCAATATC TGGAGTACAG AAAGCAGAGA ATGGCCCGAT CGACTGGAGT 780

GGGGACATGC CTGTGTCCTG CAGTCTTTCA CGGGGTCTTC AGGTTCTGCT CACCCCTGTT 840

CTGGCAAACA TCCTCGAGGC AGACCAGGAG AAGTGTTGGG GTTTTGACCA GTTTTTTGCA 900

GAAACTAGTG ATATTCTTCA CCGAATGATA ATTCATGTTT TTTCACTACA ACAAATGACA 960

GCTCATAAGA TTTATATTCA TAGCTATAAT ACTGCTGCTG TATTTCATGA ACTGGTGTAT 1020

AAACAAACCA AAATTATTTC TTCAAATCAA GAACTTATCT ATGAAGGACG ACGCTTAGTT 1080

CTAGAACCTG GAAGACTGGC ACAGCATTTG CCCAAAACGA CTGAGGACAA TCCCATCTTC 1140

GTAGTAAGCC AAGAGCCTCT GAGTGCTGTG GGACTGATAT ATGAAAAAAT TTCCCTCCCT 1200

AAAGTGCATC CCCGTTATGA TTTAGATGGG GATGCCAGCA TGGCGAAGGC AATAACAGGA 1260

GTTGTGTGTT ATGCCTGTAG AGTTACCAGT ACGTTGCTGC TTTATCAAGA ATTAATGCGA 1320

AAGGGGATAC GATGGTTGAT AGAATTAGTT AAAGATGATT ATAATGAAAC TGTTCACAAA 1380

AAGACAGAAG TTGTGATCAC ATTGGATTTC TGCATCAGAA ACATTGAAAA AACTATGAAA 1440

GTATATGAAA AGTTGATAGA AATCAACCTA GAAGCAGCAG AGTTAGGTGA AATTTCAGAC 1500

ATACACACCA AATTGTTGAG ACTTTCCAGT TCTCAGGGAA CAATAGAAAC CAGTCTTCAG 1560

GATATCGAAA GCAAATTATC TCCGAGTGGC CTGCTGACAG ACGCCTGGGC CCATCAAGAA 1620

GGCACTCATC CAAAAGACAG ACACGTAGAA AAGCTACAAG TCCTGTTAAG TTGCATCACA 1680

GAGATTTACT ATCAGTTCAA AAAAGACAAA GCAGAACGTA GACTAGCTTA TAATGAAGAA 1740

CAAATTCACA AATTTGATAA ACAAAAACTG TATTACCATG CGACAAAAGC TATGACCCAC 1800

TTTACGGATG AATGTGTTAA AAAGTATGAG GTGTTTTTGG ATAAGTCAGA AGAATGGATG 1860

CGAAAGATGC TTCATCTCAG GAAACAGTTA CTAGCCCTGA CGAATCAGTG TTTTGACATT 1920

GAAGAAGAAG TTTCAAAGTA CCAAGACTAC ACCAGTGAGT TACAAGAAAC GTTGCCTCAG 1980

AAAATGTTTG CGGCCTCCAG TGGAATGAAA CATGCCATGA CCCCGGTTTA TCCATGTTCT 2040

AACACTTTAG TGGAAATGAC TCTAGGCATG AAGAAATTAA AAGAAGAAAT GGAAGGAGTA 2100

GTTAAGGAAC TTGCTGAAAA TAATCATATT TTAGAAAGGT TTGGCGCTTT AACCATGGAT 2160

GGCGGCCTTC GCAATGTTGA CTGTCTTTAA 2190

Domain Profile

S: 1     WelkelLGeGafgnvikarnkktgekiavkvikeesslrprevqvrelevlrklnhkniv  60

         W l+++LG+Ga++nv+++r+kktg+ +a+kv++++s+lrp++vq+re+evl+klnhkniv

Q: 9     WLLSDILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQMREFEVLKKLNHKNIV  68

         999*********************************************************

S: 61    klvdveeelnlasarlkvlvleyCsgGdlrkvLeepenayGLkesevlvvLsdvvaglry  120

         kl+++eee   +++r+kvlv+e+C +G+l++vLeep+nayGL+ese+l+vL+dvv g+++

Q: 69    KLFAIEEE---TTTRHKVLVMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNH  125

         ********...*************************************************

S: 121   LrenkivhRDlkPenivllkgedgksiykltDlGaareldddekvvslvGteeYlaPely  180

         Lren+ivhRD+kP+ni++++gedg+s+ykltD+Gaarel+dde++vsl+GteeYl+P++y

Q: 126   LRENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEYLHPDMY  185

         ************************************************************

S: 181   e........qkkytatvDlWsiGvllyeaitGslPflpfegprr....lykkitkkpaka  228

         e        qkky+atvDlWsiGv++y+a+tGslPf+pfegprr    +yk++t kp++a

Q: 186   EravlrkdhQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRnkevMYKILTGKPSGA  245

         ************************************************************

S: 229   iagteka.ngevefssslPlsaslssglqeklekllanllevdeekrw  275

         i+g++ka ng++++s ++P+s+sls+glq  l+++lan+le+d+ek+w

Q: 246   ISGVQKAeNGPIDWSGDMPVSCSLSRGLQVLLTPVLANILEADQEKCW  293

         *******9***************************************9

Domain Sequence
(FASTA)

WLLSDILGQG ATANVFRGRH KKTGDLFAIK VFNNISFLRP VDVQMREFEV LKKLNHKNIV 60

KLFAIEEETT TRHKVLVMEF CPCGSLYTVL EEPSNAYGLP ESEFLIVLRD VVGGMNHLRE 120

NGIVHRDIKP GNIMRVIGED GQSVYKLTDF GAARELEDDE QFVSLYGTEE YLHPDMYERA 180

VLRKDHQKKY GATVDLWSIG VTFYHAATGS LPFRPFEGPR RNKEVMYKIL TGKPSGAISG 240

VQKAENGPID WSGDMPVSCS LSRGLQVLLT PVLANILEAD QEKCW 285

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Drosophila melanogaster"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Taeniopygia guttata"; ?>Tetraodon nigroviridis"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0003676	; F:nucleic acid binding
GO:0004672	; F:protein kinase activity
GO:0002218	; P:activation of innate immune response
GO:0050830	; P:defense response to Gram-positive bacterium
GO:0010629	; P:negative regulation of gene expression
GO:0043123	; P:positive regulation of I-kappaB kinase/NF-kappaB cascade
GO:0032727	; P:positive regulation of interferon-alpha production
GO:0045359	; P:positive regulation of interferon-beta biosynthetic process
GO:0032728	; P:positive regulation of interferon-beta production
GO:0045944	; P:positive regulation of transcription from RNA polymerase II promoter

KEGG

ecb:100051650

;

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.

Prints

Created Date

20-Feb-2013