EKS-EQC-00330
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-EQC-00330
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
Other/PEK404.82.3E-121490974485
StatusUnreviewed
Ensembl ProteinENSECAP00000018602
UniProt AccessionF6USB3;
Protein Name
Protein Synonyms/Alias
Gene NameEIF2AK3
Gene Synonyms/Alias EIF2AK3;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSECAG00000020856ENSECAP00000018602ENSECAT00000022505
OrganismEquus caballus
Functional Description
Protein Length1013
Protein Sequence
(FASTA)
RSLVIISTLD GRIAALDPEN HGKKQWDLDV GSGSLVSSSL SKPEVFGNKM IIPSLDGDLF 60
QWDRDRESME TVPFTVESLL ESSYKFGDDV VLVGGKSLTT YGLSAYSGKV RYICSALGCR 120
RWDNDEMEQE DILLLQRTQK TVRAVGPRSG NEKWNFSVGH FELRYIPDME TRAGFIESTL 180
KPSGSKEESK IISDLEEQEA AMLDTVIKVS VADWKVMAFS KKGGHLEWEY QFCTPIASAW 240
LVKDGKVIPI SLFDDTSYTS NNEVLEDEED IVEAARGATE NSVYLGMYRG QLYLQSSVRI 300
SEKFPTSPKA LENVNDENAI IPLPTIKWKP LIHSPSRTPV LVGSDEFDKC LSNDKFSHEE 360
YSNGALSILQ YPYDNGYYLP YYKRERNKRS TQITVRFLDN PNYSKTIRKK DPVLLLPWWK 420
EIVATILFCI IATTFIVRRL FHPHPHRQRK ESETQCQTEN KYDSLSGEVN DSGSNDVKNS 480
GYVSRYLTDF EPVQCMGRGG FGVVFEAKNK VDDCNYAIKR IRLPNRELAR EKVMREVKAL 540
AKLEHPGIVR YFNAWLEAPP EKWQEEMDEI WLKDESTDWP PSSPSPMDAP SVKIRRMDPF 600
STKEHIEIIA PSPKRSRSFS VGISCGQTSS SESQFSPLEF SGTDHGDISG SVDAVYNLQD 660
SCLTDCDVGD GTIDGNDEGH SFELCPSEAS PYVRSRERTS SSIVFEDSGC DNASSKEELK 720
TNPLHIGSHD ADKLTALKHS SSNSPSEPTL SVSPPRPTTL SLDLTKNTTE KLQPSSPKVY 780
LYIQMQLCRK ENLKDWMNSR CTIEERERSM CLHIFLQIAE AVEFLHSKGL MHRDLKPSNI 840
FFTMDDVVKI GDFGLVTAMD QDEEEQMVLT PMPAYARHTG QVGTKLYMSP EQIHGNNYSH 900
KVDIFSLGLI LFELLYPFGT QMERVRILTD VRNLKFPPLF TQKYPREHVM VQDMLSPSPM 960
ERPEATNIIE NAVFEDLEFP GKTVLRQRSR SVSSSGTKPS RQPSNSQSPL PSS 1013
Nucleotide Sequence
(FASTA)
AGATCGTTAG TGATTATCAG CACTTTAGAT GGGCGAATTG CTGCCTTGGA TCCTGAGAAT 60
CATGGTAAAA AGCAGTGGGA TTTGGATGTG GGATCCGGTT CCTTGGTTTC ATCAAGCCTT 120
AGCAAACCAG AGGTATTTGG GAATAAGATG ATCATTCCTT CCCTGGATGG AGACCTCTTC 180
CAGTGGGACC GAGACCGTGA GAGCATGGAA ACAGTTCCTT TTACCGTTGA GTCACTTCTT 240
GAATCTTCTT ATAAATTTGG AGATGATGTT GTTTTGGTTG GAGGAAAGTC TCTCACTACA 300
TATGGACTCA GTGCATATAG TGGAAAGGTG AGGTATATCT GTTCAGCTTT GGGTTGTCGC 360
CGATGGGATA ATGATGAAAT GGAACAAGAG GACATCCTGC TTCTGCAGCG CACCCAGAAA 420
ACCGTTCGAG CTGTTGGACC TCGTAGTGGC AATGAGAAGT GGAATTTCAG TGTTGGCCAC 480
TTTGAACTTC GGTATATTCC AGACATGGAA ACTAGAGCCG GATTTATTGA AAGCACCCTA 540
AAACCCAGTG GAAGCAAAGA AGAGTCTAAA ATTATTTCAG ATCTGGAAGA ACAGGAAGCT 600
GCCATGTTGG ACACAGTGAT AAAGGTCTCA GTTGCTGATT GGAAGGTTAT GGCGTTTAGT 660
AAAAAGGGCG GACATCTGGA ATGGGAGTAC CAGTTTTGTA CTCCCATTGC ATCTGCCTGG 720
TTGGTTAAGG ATGGCAAAGT CATTCCCATC AGTCTTTTTG ATGATACGAG TTATACATCT 780
AATAATGAAG TTTTAGAAGA TGAAGAAGAC ATTGTGGAAG CTGCCCGAGG AGCCACAGAG 840
AACAGCGTTT ACTTGGGAAT GTACAGAGGC CAGCTGTATC TGCAGTCGTC AGTCAGAATT 900
TCAGAAAAGT TTCCCACAAG CCCCAAGGCC TTGGAAAACG TCAATGATGA AAATGCGATT 960
ATCCCTTTGC CAACAATCAA ATGGAAACCC TTAATTCATT CTCCTTCCAG AACTCCTGTC 1020
TTGGTAGGGT CTGATGAATT TGACAAATGT CTTAGTAATG ATAAGTTTTC TCATGAAGAG 1080
TACAGTAATG GAGCACTTTC AATCTTGCAG TATCCATATG ATAATGGTTA CTATCTACCA 1140
TACTACAAGA GGGAGAGGAA CAAGCGGAGC ACTCAGATCA CAGTCAGGTT TCTTGACAAC 1200
CCAAACTACA GCAAGACCAT CCGCAAAAAG GATCCGGTTC TCCTCTTGCC CTGGTGGAAA 1260
GAAATAGTTG CAACTATTCT GTTTTGTATC ATAGCAACAA CTTTTATCGT GCGCAGACTT 1320
TTCCATCCTC ATCCTCACAG GCAAAGGAAA GAATCTGAAA CTCAGTGTCA AACTGAAAAT 1380
AAATATGACT CTTTAAGTGG AGAAGTTAAT GACAGTGGCT CGAATGACGT AAAAAATTCT 1440
GGCTACGTAT CACGGTATCT GACAGATTTT GAACCGGTTC AGTGCATGGG TCGTGGCGGG 1500
TTTGGAGTTG TCTTTGAAGC TAAAAACAAA GTAGATGACT GCAATTATGC TATCAAGAGA 1560
ATCCGTCTCC CCAACAGGGA ATTGGCTCGG GAAAAGGTAA TGCGAGAGGT TAAAGCCTTA 1620
GCCAAGCTTG AACACCCAGG AATTGTTAGA TATTTCAATG CTTGGTTGGA AGCACCACCA 1680
GAGAAGTGGC AAGAAGAAAT GGACGAAATT TGGCTGAAAG ATGAAAGCAC AGACTGGCCA 1740
CCCAGCTCTC CTAGCCCAAT GGATGCACCA TCAGTTAAAA TACGCAGAAT GGATCCTTTC 1800
TCAACAAAAG AACATATTGA AATCATAGCT CCTTCGCCAA AAAGGAGCAG GTCTTTTTCA 1860
GTAGGCATTT CCTGTGGCCA GACAAGTTCA TCTGAGAGCC AGTTCTCTCC ACTGGAATTT 1920
TCAGGAACGG ACCATGGAGA CATCAGTGGG TCGGTGGACG CAGTGTACAA TCTCCAAGAC 1980
AGTTGCCTTA CAGACTGTGA TGTGGGAGAT GGTACTATAG ATGGCAATGA TGAGGGGCAC 2040
TCCTTTGAAC TTTGTCCTTC TGAAGCTTCT CCTTATGTCA GGTCAAGGGA GAGAACATCC 2100
TCTTCTATAG TATTTGAAGA TTCTGGCTGT GATAATGCGT CCAGTAAAGA AGAGCTCAAA 2160
ACTAACCCAC TGCATATCGG CAGCCATGAT GCTGATAAAC TGACTGCTTT GAAGCATTCC 2220
AGTAGCAACT CTCCTTCTGA ACCTACTTTA TCTGTTTCTC CTCCAAGACC AACCACTTTA 2280
AGTTTAGATC TCACTAAAAA CACTACGGAA AAACTCCAGC CCAGTTCGCC GAAAGTGTAT 2340
CTTTACATTC AGATGCAGCT ATGCAGAAAG GAAAACCTCA AAGACTGGAT GAACAGTCGA 2400
TGCACCATAG AGGAGAGAGA GAGGAGCATG TGTTTGCACA TCTTCCTGCA GATCGCGGAG 2460
GCAGTAGAAT TTCTGCACAG TAAAGGGCTC ATGCACAGGG ACCTCAAGCC TTCCAACATA 2520
TTCTTTACAA TGGACGACGT GGTCAAGATC GGAGACTTTG GGTTAGTGAC TGCAATGGAC 2580
CAGGACGAGG AAGAGCAGAT GGTTCTGACC CCAATGCCAG CATACGCCAG ACACACAGGA 2640
CAAGTGGGGA CCAAACTTTA TATGAGCCCA GAGCAGATTC ATGGAAACAA CTACTCTCAC 2700
AAAGTGGACA TCTTTTCTTT AGGCCTCATC CTATTTGAAT TGCTATACCC ATTTGGCACT 2760
CAGATGGAGA GAGTCAGGAT CTTAACCGAT GTAAGAAATC TCAAATTTCC ACCACTATTT 2820
ACTCAGAAAT ATCCTCGTGA GCACGTGATG GTTCAAGACA TGCTGTCTCC ATCCCCCATG 2880
GAACGGCCTG AAGCTACAAA CATCATTGAA AATGCTGTGT TTGAGGACTT GGAGTTTCCA 2940
GGGAAAACAG TGCTCAGACA GAGGTCTCGC TCCGTGAGCT CATCAGGAAC AAAACCTTCC 3000
AGACAGCCCA GCAACTCCCA GAGCCCTTTG CCGAGCAGTT AG 3042
Domain Profile
S: 1     feeikvlGkGgfgvVlkaknkldkkeyaikriklnkakkelekverevkaLaklehpniv  60
         fe ++++G+GgfgvV++aknk+d+++yaikri+l++++ ++ekv+revkaLaklehp+iv
Q: 490   FEPVQCMGRGGFGVVFEAKNKVDDCNYAIKRIRLPNRELAREKVMREVKALAKLEHPGIV  549
         799*********************************************************
S: 61    rYfaawleekeesl..............................................  74
         rYf+awle ++e++                                              
Q: 550   RYFNAWLEAPPEKWqeemdeiwlkdestdwppsspspmdapsvkirrmdpfstkehieii  609
         ************************************************************
S: 75    ............................................................  74
                                                                     
Q: 610   apspkrsrsfsvgiscgqtsssesqfsplefsgtdhgdisgsvdavynlqdscltdcdvg  669
         ************************************************************
S: 75    ..td.sseveaeaeleesesseesdtk.................................  98
           t  ++++ +++el++se+s++++++                                 
Q: 670   dgTIdGNDEGHSFELCPSEASPYVRSRertsssivfedsgcdnasskeelktnplhigsh  729
         *9555999999999999999999999999999999999999999999999999*******
S: 99    ..................................................llyiqmelce  108
                                                           +lyiqm+lc+
Q: 730   dadkltalkhsssnspseptlsvspprpttlsldltkntteklqpsspkvYLYIQMQLCR  789
         ************************************************************
S: 109   ketLkdwiderkllesrselvm.rlfkqllegleylHskgliHrdLkpsniFldsddqvK  167
         ke+Lkdw+++r+++e+r++ ++ ++f q++e++e+lHskgl+HrdLkpsniF+++dd vK
Q: 790   KENLKDWMNSRCTIEERERSMClHIFLQIAEAVEFLHSKGLMHRDLKPSNIFFTMDDVVK  849
         ************************************************************
S: 168   igDFgLatalaealkedvkqdaqskeakhtgqvgtklymsPeqleksqYnkkvDifsLGl  227
         igDFgL+ta++++++e+++ ++++++a+htgqvgtklymsPeq+++++Y++kvDifsLGl
Q: 850   IGDFGLVTAMDQDEEEQMVLTPMPAYARHTGQVGTKLYMSPEQIHGNNYSHKVDIFSLGL  909
         ************************************************************
S: 228   ilfeLlypfstemervetltelrdgkipedfddkvpkekkllqkllsrdpkeRpsasell  287
         ilfeLlypf t+merv++lt++r++k+p  f++k+p e+ ++q++ls +p+eRp+a++++
Q: 910   ILFELLYPFGTQMERVRILTDVRNLKFPPLFTQKYPREHVMVQDMLSPSPMERPEATNII  969
         ************************************************************
S: 288   ksell  292
         +++++
Q: 970   ENAVF  974
         *9875
Domain Sequence
(FASTA)
FEPVQCMGRG GFGVVFEAKN KVDDCNYAIK RIRLPNRELA REKVMREVKA LAKLEHPGIV 60
RYFNAWLEAP PEKWQEEMDE IWLKDESTDW PPSSPSPMDA PSVKIRRMDP FSTKEHIEII 120
APSPKRSRSF SVGISCGQTS SSESQFSPLE FSGTDHGDIS GSVDAVYNLQ DSCLTDCDVG 180
DGTIDGNDEG HSFELCPSEA SPYVRSRERT SSSIVFEDSG CDNASSKEEL KTNPLHIGSH 240
DADKLTALKH SSSNSPSEPT LSVSPPRPTT LSLDLTKNTT EKLQPSSPKV YLYIQMQLCR 300
KENLKDWMNS RCTIEERERS MCLHIFLQIA EAVEFLHSKG LMHRDLKPSN IFFTMDDVVK 360
IGDFGLVTAM DQDEEEQMVL TPMPAYARHT GQVGTKLYMS PEQIHGNNYS HKVDIFSLGL 420
ILFELLYPFG TQMERVRILT DVRNLKFPPL FTQKYPREHV MVQDMLSPSP MERPEATNII 480
ENAVF 485
KeywordComplete proteome; Reference proteome.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00317
EKS-ANC-00330
EKS-BOT-00338
EKS-CAE-00275
EKS-CAJ-00347
EKS-CAF-00346
EKS-CAP-00372
EKS-CII-00189
EKS-CIS-00091
EKS-DAR-00702
EKS-DRM-00166
EKS-FEC-00329
EKS-GAG-00285
EKS-GAA-00421
EKS-GOG-00335
EKS-HOS-00345
EKS-ICT-00322
EKS-LAC-00353
EKS-LOA-00350
EKS-MAM-00344
EKS-MEG-00279
EKS-MOD-00334
EKS-MUM-00373
EKS-MUP-00333
EKS-MYL-00337
EKS-NOL-00309
EKS-ORN-00442
EKS-ORA-00297
EKS-ORC-00317
EKS-ORL-00409
EKS-OTG-00343
EKS-PES-00298
EKS-PEM-00179
EKS-POA-00331
EKS-PTV-00079
EKS-RAN-00353
EKS-SAH-00317
EKS-SUS-00302
EKS-TAG-00414
EKS-TAR-00445
EKS-TEN-00441
EKS-VIP-00041
EKS-XET-00434
EKS-XIM-00430
Gene Ontology
GO:0005789; C:endoplasmic reticulum membrane
GO:0005524; F:ATP binding
GO:0004674; F:protein serine/threonine kinase activity
GO:0006919; P:activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0030282; P:bone mineralization
GO:0019722; P:calcium-mediated signaling
GO:0002063; P:chondrocyte development
GO:0031018; P:endocrine pancreas development
GO:0007029; P:endoplasmic reticulum organization
GO:0030968; P:endoplasmic reticulum unfolded protein response
GO:0006983; P:ER overload response
GO:0045444; P:fat cell differentiation
GO:0030073; P:insulin secretion
GO:0048009; P:insulin-like growth factor receptor signaling pathway
GO:0007595; P:lactation
GO:0031642; P:negative regulation of myelination
GO:0017148; P:negative regulation of translation
GO:0032092; P:positive regulation of protein binding
GO:0009967; P:positive regulation of signal transduction
GO:0046777; P:protein autophosphorylation
GO:0051260; P:protein homooligomerization
GO:0019217; P:regulation of fatty acid metabolic process
GO:0032933; P:SREBP signaling pathway
GO:0006412; P:translation
GO:0006926; P:virus-infected cell apoptotic process
KEGG
InterPros
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR011047; Quinonprotein_ADH-like.
IPR008271; Ser/Thr_kinase_AS.
Pfam
PF00069; Pkinase; 2.
SMARTs
Prosites
PS50011; PROTEIN_KINASE_DOM; 1.
PS00108; PROTEIN_KINASE_ST; 1.
Prints
Created Date20-Feb-2013