EKS-EQC-00148
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-EQC-00148
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/FGFR528.14.0E-159467743277
StatusUnreviewed
Ensembl ProteinENSECAP00000019112
UniProt AccessionF6WLS1;
Protein NameFibroblast growth factor receptor
Protein Synonyms/Alias
Gene NameFGFR4
Gene Synonyms/Alias FGFR4;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSECAG00000020869ENSECAP00000019112ENSECAT00000023089
OrganismEquus caballus
Functional Description
Protein Length801
Protein Sequence
(FASTA)
MWLLLALLGV LLGVPGSPAL SLEVSEEMEL EPCLAPSPEQ QEQKLTVVLG QAVRLCCGRA 60
ERGGHWYKEG SRLAPAGRVR GWRGRLEIAS SLLEDAGHYL CLARGSMLVL HNVTLVVDDS 120
LTSSNDDEDR KAHRGPSNGH VYPQQAPYWT HPQRMEKKLH AVPAGNTVKF RCPAAGNPTP 180
TIRWLKDGQD FHGEHRIGGI RLRHQHWSLV MESVVPSDRG TYTCLVENSL GSIRYSYLLD 240
VLERSPHRPI LQAGLPANTT AVAGSDVELL CKVYSDAQPH IQWLKHIVIN GSSFGADGFP 300
YVQVLKTADI NSSEVEVLYL RNVSAEDAGE YTCLAGNSIG LSYQSAWLTV LPEEDFAWAA 360
AAPEARYTDI ILYASGSLAL VVLLLLAGLY RGQVLHGRHP RQPATVQKLS RFPLARQFSL 420
ESGSSAKSSL SLVRGVHLSS NGPPLLAGLV SLDLPLDPLW EFPRDRLVLG KPLGEGCFGQ 480
VVRAEAFGMD PAQPDQASTV AVKMLKDNAS DKDLADLVSE MEVMKLIGRH KNIINLLGVC 540
TQEGPLYVIV ECAAKGNLRE FLRARRPPGP DLSPDGPRSS EGPLSFPALV SCAYQVARGM 600
QYLESRKCIH RDLAARNVLV TEDNVMKIAD FGLARGVHHI DYYKKTSNGR LPVKWMAPEA 660
LFDRVYTHQS DVWSFGILLW EIFTLGGSPY PGIPVEELFS LLREGHRMDR PPNCPPELYG 720
LMRECWHAAP SQRPTFKQLV EALDKVLLAV SEEYLDLRLT FGPYSPASGD ASSTCSSSDS 780
VFSHDPLPLG PSSYPFPRVQ T 801
Nucleotide Sequence
(FASTA)
ATGTGGCTGC TGTTGGCCCT GTTGGGGGTC CTGCTGGGGG TGCCCGGGTC TCCAGCTTTG 60
TCCCTTGAGG TCTCTGAGGA AATGGAGCTG GAGCCCTGCC TGGCCCCTAG CCCAGAGCAG 120
CAAGAGCAGA AGCTGACCGT GGTCCTTGGG CAGGCTGTGC GGTTATGCTG TGGGCGGGCT 180
GAGCGTGGTG GCCACTGGTA CAAGGAGGGC AGTCGCCTGG CACCTGCTGG CCGAGTACGA 240
GGCTGGAGGG GCCGCTTGGA GATTGCCAGC TCTCTACTGG AGGATGCTGG CCATTACCTC 300
TGCCTGGCAC GGGGCTCCAT GCTTGTCCTG CACAATGTCA CCTTGGTTGT GGATGATTCC 360
TTAACCTCCA GCAATGATGA TGAGGACCGC AAAGCCCACA GAGGCCCCTC GAATGGGCAT 420
GTGTACCCCC AGCAAGCACC CTACTGGACA CACCCTCAAC GCATGGAGAA GAAACTGCAT 480
GCAGTGCCTG CTGGGAACAC CGTCAAGTTC CGCTGCCCAG CTGCAGGCAA CCCCACGCCC 540
ACCATCCGCT GGCTCAAGGA TGGACAGGAC TTCCATGGGG AGCATCGCAT TGGAGGCATT 600
CGGCTGCGCC ACCAGCACTG GAGCCTGGTG ATGGAAAGCG TGGTGCCCTC GGACCGTGGC 660
ACGTATACCT GCCTTGTGGA GAATTCTCTG GGCAGCATCC GCTACAGCTA TCTGCTGGAC 720
GTGCTGGAGC GGTCCCCGCA CCGGCCCATC CTGCAGGCGG GGCTCCCGGC CAACACCACA 780
GCTGTGGCAG GCAGCGACGT GGAACTGCTG TGCAAGGTGT ACAGCGATGC CCAGCCCCAC 840
ATCCAATGGC TGAAGCACAT CGTCATCAAT GGCAGCAGCT TCGGTGCTGA CGGCTTCCCA 900
TATGTGCAAG TCCTGAAGAC AGCAGACATC AATAGCTCAG AGGTGGAGGT CCTGTACCTT 960
CGGAACGTGT CGGCTGAGGA TGCAGGCGAG TACACCTGCC TGGCAGGCAA CTCCATCGGC 1020
CTCTCCTATC AGTCGGCCTG GCTCACGGTG CTGCCAGAGG AGGACTTCGC GTGGGCAGCA 1080
GCAGCGCCCG AGGCCAGGTA CACAGACATC ATCCTGTACG CGTCGGGCTC TCTGGCTTTG 1140
GTGGTGCTCC TGCTGCTGGC TGGGCTGTAT CGTGGGCAGG TGCTCCACGG CCGGCACCCC 1200
CGGCAGCCGG CCACTGTGCA GAAGTTGTCC CGCTTCCCTC TGGCCCGACA GTTCTCTCTG 1260
GAGTCGGGCT CCTCAGCCAA GTCAAGCTTG TCACTGGTGC GGGGTGTCCA TCTCTCCTCC 1320
AACGGCCCCC CCTTGCTTGC TGGCCTTGTG AGCCTAGACC TACCTCTTGA CCCGCTGTGG 1380
GAGTTTCCCC GAGACAGGCT GGTGCTCGGG AAGCCTCTGG GTGAGGGCTG CTTCGGGCAG 1440
GTGGTGCGTG CAGAGGCCTT CGGCATGGAC CCTGCCCAGC CTGACCAGGC CAGCACCGTG 1500
GCCGTCAAGA TGCTCAAGGA CAATGCCTCT GACAAGGATT TGGCAGACCT GGTCTCTGAG 1560
ATGGAGGTGA TGAAGCTGAT TGGCCGACAC AAGAACATTA TCAACCTGCT GGGTGTCTGC 1620
ACCCAGGAAG GGCCTCTGTA CGTGATTGTA GAGTGTGCCG CCAAGGGAAA CCTGCGGGAG 1680
TTCCTGCGGG CCCGGCGCCC CCCAGGCCCC GACCTGAGCC CTGACGGGCC ACGGAGCAGT 1740
GAGGGACCAC TCTCCTTTCC CGCCCTGGTC TCCTGTGCCT ACCAGGTGGC CCGAGGCATG 1800
CAGTACCTGG AGTCTCGGAA GTGCATCCAC CGGGACCTGG CTGCTCGCAA CGTGCTGGTG 1860
ACTGAGGACA ATGTGATGAA GATCGCTGAC TTTGGGCTGG CCCGCGGCGT CCACCACATT 1920
GACTACTACA AGAAAACCAG CAACGGCCGC CTGCCTGTCA AGTGGATGGC ACCTGAGGCC 1980
TTATTTGACC GAGTCTACAC ACACCAGAGT GATGTGTGGT CATTTGGGAT CCTGCTGTGG 2040
GAGATCTTCA CCCTCGGGGG CTCCCCATAT CCCGGCATCC CAGTGGAGGA GCTCTTCTCA 2100
CTGCTGCGGG AGGGCCATCG GATGGACCGG CCCCCGAACT GCCCCCCAGA GCTGTACGGC 2160
CTGATGCGTG AGTGCTGGCA CGCAGCACCC TCTCAGAGGC CCACTTTCAA GCAGCTAGTG 2220
GAGGCGCTGG ACAAGGTCCT GCTGGCCGTC TCTGAGGAGT ACCTTGACCT CCGCCTCACC 2280
TTTGGACCCT ACTCCCCTGC CAGTGGGGAT GCCAGCAGCA CCTGCTCTTC CAGCGACTCT 2340
GTCTTCAGCC ACGATCCCCT GCCACTGGGG CCCAGCTCCT ACCCCTTCCC CAGGGTGCAG 2400
ACATGA 2406
Domain Profile
S: 1     lvlgkllGeGafGqvvkaeaigldkdkekkevtvavkmlkedatdkdladlvsemevlkl  60
         lvlgk+lGeG+fGqvv+aea+g+d  ++++++tvavkmlk++a+dkdladlvsemev+kl
Q: 467   LVLGKPLGEGCFGQVVRAEAFGMDPAQPDQASTVAVKMLKDNASDKDLADLVSEMEVMKL  526
         79**********************************************************
S: 61    iGkhkniinllGactqeGplyviveyaakGnlreflrarrpkgeeaskdkskaseeqlte  120
         iG+hkniinllG+ctqeGplyvive+aakGnlreflrarrp+g + s d +++se  l++
Q: 527   IGRHKNIINLLGVCTQEGPLYVIVECAAKGNLREFLRARRPPGPDLSPDGPRSSEGPLSF  586
         ************************************************************
S: 121   kdlvsfayqvarGmeylaskkcihrdlaarnvlvtednvlkiadfGlardvheidyykkt  180
           lvs+ayqvarGm+yl+s+kcihrdlaarnvlvtednv+kiadfGlar+vh+idyykkt
Q: 587   PALVSCAYQVARGMQYLESRKCIHRDLAARNVLVTEDNVMKIADFGLARGVHHIDYYKKT  646
         ************************************************************
S: 181   tnGrlpvkwmapealfdrvytsqsdvwsfGvllweiltlGgspypgiaveelfkllkeGh  240
         +nGrlpvkwmapealfdrvyt+qsdvwsfG+llwei+tlGgspypgi+veelf+ll+eGh
Q: 647   SNGRLPVKWMAPEALFDRVYTHQSDVWSFGILLWEIFTLGGSPYPGIPVEELFSLLREGH  706
         ************************************************************
S: 241   rmekpakctkelyvlmrecwhakaserptfkqlvedl  277
         rm++p +c+ ely lmrecwha++s+rptfkqlve+l
Q: 707   RMDRPPNCPPELYGLMRECWHAAPSQRPTFKQLVEAL  743
         **********************************986
Domain Sequence
(FASTA)
LVLGKPLGEG CFGQVVRAEA FGMDPAQPDQ ASTVAVKMLK DNASDKDLAD LVSEMEVMKL 60
IGRHKNIINL LGVCTQEGPL YVIVECAAKG NLREFLRARR PPGPDLSPDG PRSSEGPLSF 120
PALVSCAYQV ARGMQYLESR KCIHRDLAAR NVLVTEDNVM KIADFGLARG VHHIDYYKKT 180
SNGRLPVKWM APEALFDRVY THQSDVWSFG ILLWEIFTLG GSPYPGIPVE ELFSLLREGH 240
RMDRPPNCPP ELYGLMRECW HAAPSQRPTF KQLVEAL 277
KeywordATP-binding; Complete proteome; Immunoglobulin domain; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Receptor; Reference proteome; Repeat; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Felis catus"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Oryctolagus cuniculus"; ?>Pan troglodytes"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Xenopus tropicalis"; ?>
EKS-AIM-00141
EKS-ANC-00141
EKS-BOT-00149
EKS-CAF-00157
EKS-CAP-00150
EKS-FEC-00139
EKS-ICT-00143
EKS-LAC-00159
EKS-LOA-00148
EKS-MOD-00149
EKS-MUM-00154
EKS-MUP-00154
EKS-MYL-00158
EKS-ORC-00140
EKS-PAT-00140
EKS-RAN-00148
EKS-SAH-00144
EKS-SUS-00130
EKS-TAG-00178
EKS-XET-00138
Gene Ontology
GO:0005911; C:cell-cell junction
GO:0005783; C:endoplasmic reticulum
GO:0005887; C:integral to plasma membrane
GO:0005634; C:nucleus
GO:0005524; F:ATP binding
GO:0005007; F:fibroblast growth factor-activated receptor activity
GO:0008201; F:heparin binding
GO:0061144; P:alveolar secondary septum development
GO:0016477; P:cell migration
GO:0042593; P:glucose homeostasis
GO:0001759; P:organ induction
GO:0018108; P:peptidyl-tyrosine phosphorylation
GO:0055062; P:phosphate ion homeostasis
GO:0008284; P:positive regulation of cell proliferation
GO:2000573; P:positive regulation of DNA biosynthetic process
GO:0070374; P:positive regulation of ERK1 and ERK2 cascade
GO:0048554; P:positive regulation of metalloenzyme activity
GO:0045862; P:positive regulation of proteolysis
GO:0046777; P:protein autophosphorylation
GO:0070857; P:regulation of bile acid biosynthetic process
GO:2000188; P:regulation of cholesterol homeostasis
GO:0010715; P:regulation of extracellular matrix disassembly
KEGG
ecb:100068679;
InterPros
IPR007110; Ig-like.
IPR013783; Ig-like_fold.
IPR013098; Ig_I-set.
IPR003598; Ig_sub2.
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
IPR016248; Tyr_kinase_fibroblast_GF_rcpt.
Pfam
PF07679; I-set; 2.
PF07714; Pkinase_Tyr; 1.
SMARTs
SM00408; IGc2; 3.
SM00219; TyrKc; 1.
Prosites
PS50835; IG_LIKE; 2.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
Prints
PR00109; TYRKINASE.
Created Date20-Feb-2013