EKS-EQC-00104
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-EQC-00104
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/Tec489.51.9E-147402652251
StatusUnreviewed
Ensembl ProteinENSECAP00000018848
UniProt AccessionF6S5Q6;
Protein Name
Protein Synonyms/Alias
Gene NameBTK
Gene Synonyms/Alias BTK;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSECAG00000020984ENSECAP00000018848ENSECAT00000022788
OrganismEquus caballus
Functional Description
Protein Length659
Protein Sequence
(FASTA)
MAAVILESIF LKRSQQKKKT SPLNFKKRLF LLTVQKLSYY EYDFERGRRG SKKGSIDVEK 60
ITCVETVVPE KNPPPERQIP RRGEESSEME QISIIERFPY PFQVVYDEGP LYVFSPTEEL 120
RKRWIHQLKN VIRYNSDLVQ KYHPCFWIDG QYLCCSQTAK NAMGCQILEN RNGSLKPGSS 180
HRKTKKPLPP TPEEDQILKK PLPPEPTAAP VSTSELKKVV ALYDYMPMNA NDLQLRKGNE 240
YFILEESNLP WWRARDKNGQ EGYIPSNYVT EAEDSIEMYE WYSKHMTRSQ AEQLLKQEGK 300
EGGFIVRDSS KAGKYTVSVF AKSTGDPQGV IRHYVVCSTP QSQYYLAEKH LFSTIPELIN 360
YHQHNSAGLI SRLKYPVSQQ NKNAPSTAGL GYGSWEIDPK DLTFLKELGT GQFGVVKYGK 420
WRGQYDVAIK MIKEGSMSED EFIEEAKVMM NLSHEKLVQL YGVCTKQRPI FIITEYMANG 480
CLLNYLREMR HRFQTQQLLE MCKDVCEAME YLESKQFLHR DLAARNCLVN DQGVVKVSDF 540
GLSRYVLDDE YTSSVGSKFP VRWSPPEVLM YSKFSSKSDI WAFGVLMWEI YSLGKMPYER 600
FTNSETAEHI AQGLRLYRPH LASERVYTIM YSCWHEKADE RPTFKILLSN ILDVMDEES 659
Nucleotide Sequence
(FASTA)
ATGGCTGCAG TGATACTGGA GAGCATCTTT CTGAAGCGAT CACAGCAGAA AAAGAAAACA 60
TCACCTTTAA ACTTCAAGAA GCGCCTCTTT CTCTTGACCG TGCAAAAACT TTCCTACTAT 120
GAGTATGACT TTGAACGTGG GAGAAGAGGC AGTAAGAAGG GTTCAATAGA TGTTGAGAAG 180
ATCACCTGCG TTGAAACAGT GGTTCCTGAA AAAAATCCAC CCCCCGAAAG ACAGATTCCG 240
AGAAGGGGTG AAGAGTCCAG TGAAATGGAG CAGATTTCAA TCATTGAAAG GTTCCCTTAC 300
CCCTTCCAGG TTGTATATGA TGAAGGGCCT CTCTATGTCT TCTCCCCAAC TGAAGAACTG 360
AGGAAGCGTT GGATTCACCA GCTCAAAAAT GTAATCCGGT ACAACAGTGA TCTGGTACAG 420
AAATACCACC CTTGCTTCTG GATCGATGGG CAGTATCTCT GCTGCTCTCA GACAGCCAAA 480
AATGCTATGG GCTGCCAAAT TCTGGAGAAC AGGAATGGAA GCTTAAAACC TGGGAGTTCT 540
CACCGAAAGA CAAAAAAGCC TCTTCCTCCC ACGCCTGAGG AGGACCAGAT CTTGAAAAAG 600
CCGCTGCCCC CTGAGCCGAC AGCAGCACCC GTCTCCACCA GCGAGCTGAA AAAGGTGGTA 660
GCCCTTTATG ATTACATGCC AATGAATGCC AATGATCTAC AGCTGCGGAA GGGCAACGAG 720
TATTTTATCC TGGAGGAAAG CAACTTACCC TGGTGGCGAG CACGGGATAA AAATGGGCAG 780
GAAGGCTACA TCCCTAGTAA CTATGTCACT GAAGCAGAAG ACTCCATAGA AATGTATGAG 840
TGGTATTCCA AACACATGAC CCGAAGTCAA GCTGAGCAAC TGCTAAAGCA AGAGGGGAAA 900
GAAGGAGGTT TCATTGTCAG AGACTCCAGC AAAGCTGGAA AATATACCGT GTCTGTGTTT 960
GCTAAATCTA CAGGGGACCC TCAAGGGGTG ATACGCCATT ATGTTGTGTG TTCCACACCT 1020
CAGAGCCAGT ATTACCTGGC TGAGAAGCAC CTTTTCAGCA CCATCCCTGA GCTCATTAAC 1080
TACCATCAGC ATAACTCTGC AGGACTCATA TCAAGGCTCA AATATCCAGT GTCTCAACAA 1140
AACAAGAATG CGCCTTCCAC TGCAGGCCTG GGCTACGGCT CATGGGAAAT CGATCCAAAG 1200
GACCTGACCT TCTTGAAGGA GCTGGGGACC GGACAATTTG GGGTAGTGAA GTATGGGAAA 1260
TGGAGAGGCC AGTATGATGT GGCCATCAAG ATGATCAAAG AAGGCTCCAT GTCCGAGGAT 1320
GAGTTCATTG AAGAAGCCAA AGTCATGATG AATCTTTCCC ATGAGAAGCT GGTGCAGTTG 1380
TATGGCGTCT GCACCAAACA GCGCCCCATC TTCATCATCA CTGAGTACAT GGCCAATGGC 1440
TGCCTCCTGA ACTACCTGAG GGAGATGCGC CACCGCTTCC AGACTCAGCA GCTCCTGGAG 1500
ATGTGCAAGG ATGTCTGCGA AGCCATGGAA TACCTGGAGT CAAAGCAGTT CCTTCACCGA 1560
GACCTGGCTG CTCGAAACTG TTTGGTAAAC GATCAAGGAG TTGTTAAAGT ATCTGACTTC 1620
GGCCTGTCCA GGTATGTTCT GGATGACGAA TACACAAGCT CAGTAGGCTC CAAATTTCCA 1680
GTCCGGTGGT CTCCACCAGA AGTCCTGATG TACAGCAAGT TCAGCAGCAA ATCTGACATC 1740
TGGGCTTTTG GGGTTTTGAT GTGGGAAATT TACTCTCTGG GGAAGATGCC ATATGAAAGA 1800
TTTACTAACA GTGAAACAGC CGAACACATT GCCCAAGGCC TCCGTCTCTA CAGGCCTCAT 1860
CTAGCTTCAG AGAGGGTATA TACCATCATG TACAGCTGCT GGCATGAGAA AGCAGATGAA 1920
CGTCCCACTT TCAAAATTCT TCTGAGCAAC ATTCTAGATG TCATGGATGA AGAATCCTGA 1980
Domain Profile
S: 1     ltllkelgsgqfgvvklgkwrakidvaikaikegamseedfieeakvmmklshpklvqly  60
         lt+lkelg+gqfgvvk+gkwr+++dvaik+ikeg+mse++fieeakvmm+lsh+klvqly
Q: 402   LTFLKELGTGQFGVVKYGKWRGQYDVAIKMIKEGSMSEDEFIEEAKVMMNLSHEKLVQLY  461
         79**********************************************************
S: 61    gvclkqkpiyivteylengcllnylrekkkklekelllemckdvcegmeylerksfihrd  120
         gvc+kq+pi+i+tey++ngcllnylre+++++++++llemckdvce+meyle+k+f+hrd
Q: 462   GVCTKQRPIFIITEYMANGCLLNYLREMRHRFQTQQLLEMCKDVCEAMEYLESKQFLHRD  521
         ************************************************************
S: 121   laarnclvdeelvvkvsdfglaryvlddqyvssvgakfpvkwsppevlsyskyssksdvw  180
         laarnclv+++ vvkvsdfgl+ryvldd+y+ssvg+kfpv+wsppevl+ysk+ssksd+w
Q: 522   LAARNCLVNDQGVVKVSDFGLSRYVLDDEYTSSVGSKFPVRWSPPEVLMYSKFSSKSDIW  581
         ************************************************************
S: 181   afgvlmwevfsegklpyekksnsevvekvsrglrlyrpklaskkvyevmkscwkekpeer  240
         afgvlmwe++s+gk+pye+++nse++e++++glrlyrp+las++vy++m+scw+ek++er
Q: 582   AFGVLMWEIYSLGKMPYERFTNSETAEHIAQGLRLYRPHLASERVYTIMYSCWHEKADER  641
         ************************************************************
S: 241   ptfkellsale  251
         ptfk lls++ 
Q: 642   PTFKILLSNIL  652
         ********996
Domain Sequence
(FASTA)
LTFLKELGTG QFGVVKYGKW RGQYDVAIKM IKEGSMSEDE FIEEAKVMMN LSHEKLVQLY 60
GVCTKQRPIF IITEYMANGC LLNYLREMRH RFQTQQLLEM CKDVCEAMEY LESKQFLHRD 120
LAARNCLVND QGVVKVSDFG LSRYVLDDEY TSSVGSKFPV RWSPPEVLMY SKFSSKSDIW 180
AFGVLMWEIY SLGKMPYERF TNSETAEHIA QGLRLYRPHL ASERVYTIMY SCWHEKADER 240
PTFKILLSNI L 251
KeywordATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; SH3 domain; Transferase; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sorex araneus"; ?>Sus scrofa"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00098
EKS-ANC-00100
EKS-BOT-00108
EKS-CAJ-00109
EKS-CAF-00109
EKS-CAP-00103
EKS-DAR-00355
EKS-FEC-00102
EKS-GAM-00052
EKS-GAG-00088
EKS-GAA-00127
EKS-GOG-00108
EKS-HOS-00110
EKS-ICT-00102
EKS-LAC-00112
EKS-LOA-00102
EKS-MAM-00103
EKS-MEG-00083
EKS-MOD-00109
EKS-MUM-00109
EKS-MUP-00110
EKS-MYL-00121
EKS-NOL-00100
EKS-ORN-00132
EKS-ORA-00087
EKS-ORC-00099
EKS-ORL-00124
EKS-OTG-00109
EKS-PAT-00098
EKS-PES-00092
EKS-PEM-00054
EKS-POA-00100
EKS-PTV-00097
EKS-RAN-00109
EKS-SAH-00100
EKS-SOA-00057
EKS-SUS-00094
EKS-TAR-00136
EKS-TEN-00126
EKS-XET-00090
EKS-XIM-00130
Gene Ontology
GO:0031410; C:cytoplasmic vesicle
GO:0005829; C:cytosol
GO:0045121; C:membrane raft
GO:0005634; C:nucleus
GO:0005886; C:plasma membrane
GO:0005524; F:ATP binding
GO:0005547; F:phosphatidylinositol-3,4,5-trisphosphate binding
GO:0004713; F:protein tyrosine kinase activity
GO:0048469; P:cell maturation
GO:0007249; P:I-kappaB kinase/NF-kappaB cascade
GO:0018108; P:peptidyl-tyrosine phosphorylation
KEGG
ecb:100057626;
InterPros
IPR011009; Kinase-like_dom.
IPR011993; PH_like_dom.
IPR001849; Pleckstrin_homology.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR000980; SH2.
IPR001452; SH3_domain.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
IPR001562; Znf_Btk_motif.
Pfam
PF00779; BTK; 1.
PF00169; PH; 1.
PF07714; Pkinase_Tyr; 1.
PF00017; SH2; 1.
PF00018; SH3_1; 1.
SMARTs
SM00107; BTK; 1.
SM00233; PH; 1.
SM00252; SH2; 1.
SM00326; SH3; 1.
SM00219; TyrKc; 1.
Prosites
PS50003; PH_DOMAIN; 1.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
PS50001; SH2; 1.
PS50002; SH3; 1.
PS51113; ZF_BTK; 1.
Prints
PR00401; SH2DOMAIN.
PR00452; SH3DOMAIN.
PR00402; TECBTKDOMAIN.
PR00109; TYRKINASE.
Created Date20-Feb-2013