EKS-EQC-00430

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-EQC-00430

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
AGC/DMPK	496.2	2.4E-149	18	284	267

Status

Unreviewed

Ensembl Protein

ENSECAP00000019152

UniProt Accession

F6YZG2;

Protein Name

Protein Synonyms/Alias

Gene Name

CDC42BPB

Gene Synonyms/Alias

CDC42BPB;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSECAG00000021040	ENSECAP00000019152	ENSECAT00000023138

Organism

Equus caballus

Functional Description

Protein Length

1654

Protein Sequence
(FASTA)

AKPFTQLVKD MQLHREDFEI IKVIGRGAFG EVAVVKMKNT ERIYAMKILN KWEMLKRAET 60

ACFREERDVL VNGDCQWITT LHYAFQDENY LYLVMDYYVG GDLLTLLSKF EDKLPEDMAR 120

FYIGEMVLAI DSIHQLHYVH RDIKPDNVLL DVNGHIRLAD FGSCLKMNDD GTVQSSVAVG 180

TPDYISPEIL QAMEDGMGKY GPECDWWSLG VCMYEMLYGE TPFYAESLVE TYGKIMNHEE 240

RFQFPSHVTD VSEEAKDLIQ RLICSRERRL GQNGIEDFKK HAFFEGLNWE NIRNLEAPYI 300

PDVSSPSDTS NFDVDDDVLR NIEILPPGSH TGFSGLHLPF IGFTFTTESS FSDRGSLKSI 360

MQSNTLTKDE GVQRDLENSL QVEAYERRIR RLEQEKLELS RKLQESTQTV QSLHGSTRAL 420

GSSAREKEIR KLNEEIERLK NKIADSNRLE RQLEDTVTLR QEHEDSTHRL KGLEKQYRMV 480

RQEKEDFHKQ LVEASERLKS QARELKDAHQ QRKLALQEFS ELNERMAELR SQKQKVSRQL 540

RDKEEEMEVA MQKIDSMRQE IRKSDKFRKE LEAQLEDAIA EASKERKLRE HSENFSKQIE 600

SELEALKMKQ GGRGQGATLE HQQEISKIKS ELEKKVLFYE EELVRREASH VLEVKNVKKE 660

VHDSESHQLA LQKEILMLKD KLEKSKRERH NEMEEAVGTV KDKYERERAM LFEENKKLTA 720

ENERLCSFVD KLTAQNRQQE EELQGLAAKK ESVAHWEAQI AEIIQWVSDE KDARGYLQAL 780

ASKMTEELET LRSSSLGSRT LDPLWKVRRS QKLDMSARLE LQSALEAEIR AKQLVQEELR 840

KVKDTNLSFE SKLKDSEAKN RELLEEMEIL KKKMEEKFRA DTGLKLPDFQ DSIFEYFNTA 900

PLAHDLTFRT SSASEQETQA PKPEVSPSIS VGASTEQQED MGRAPQRPPA VPLPTTQALA 960

LAGPKPKAHQ FSIKSFSSPT QCSHCTSLMV GLIRQGYACD VCSFACHVSC KDSAPQVCPI 1020

PPEQSKRPLG VDVQRGIGTA YKGYVKVPKP TGVKKGWQRA YAVVCDCKLF LYDLPEGKST 1080

QPGVIASQVL DLRDEEFSVS SVLASDVIHA SRRDIPCIFR VTASLLGTPS KTSSLLILTE 1140

NENEKRKWVG ILEGLQSILH KNRLRNQLVH IPQEAYDSSL PLIKAVLTAA IVDGDRIAVG 1200

LEEGLYVIEV TRDVILRVAD YKKVYQIELA PKERIAVLLC GRNHHVHLCP WSSFDGGESN 1260

VDIKLPETKG CQLIATATLK KSSSTCLFVA VKRLVLCYEI LRTKPFHRKF NEIGAPGNVQ 1320

WMAVVKDKLC VGYPSGFSLL STQGDGQALN LVNPNDPSLT FLSQQSFDAL CAVELKSEEY 1380

LLCFSHMGLY VDPQGRRSRM QELMWPAAPV ACSCSPSHVT VYSEYGVDVF DVRTMEWVQT 1440

IGLRRIRPLN SEGTLNLLNC EPPRLIYFKS KFSGAVLNVP DTSDNSKKQM LRTRSKRRFV 1500

FKVPEEERLQ QRREMLRDPE LRSKMISNPT NFNHVAHMGP GDGMQVLMDL PLSAVPPAQE 1560

ERPGPAPASL SRQPLPRNKP YISWPSSGGS EPGVAVPLRS MSDPDQDFDK EPDSDSTKHS 1620

TPSNSSNPSG PPSPNSPHRS QLPLEGLEQP AYDA 1654

Nucleotide Sequence
(FASTA)

GCTAAACCAT TTACACAACT GGTGAAGGAC ATGCAACTTC ATCGAGAAGA CTTCGAAATA 60

ATTAAAGTAA TTGGAAGAGG TGCTTTTGGT GAGGTTGCTG TTGTCAAAAT GAAGAACACT 120

GAACGAATTT ATGCAATGAA AATCCTCAAC AAGTGGGAAA TGCTTAAAAG AGCAGAGACT 180

GCTTGTTTCC GAGAAGAACG TGACGTGCTG GTGAACGGCG ACTGTCAGTG GATCACCACG 240

TTGCACTATG CCTTTCAAGA TGAAAATTAT CTGTACTTAG TCATGGATTA CTATGTGGGT 300

GGTGATCTAC TGACCCTGCT CAGTAAATTT GAAGACAAGC TTCCAGAAGA TATGGCAAGA 360

TTCTACATTG GTGAAATGGT GTTGGCCATT GATTCCATCC ATCAACTTCA TTATGTGCAC 420

AGAGACATTA AGCCTGACAA TGTCCTTTTG GACGTGAATG GTCATATCCG CCTGGCCGAC 480

TTTGGATCTT GTTTGAAGAT GAATGATGAT GGAACTGTTC AGTCCTCTGT GGCCGTGGGC 540

ACACCTGACT ACATCTCACC GGAGATTCTG CAGGCGATGG AGGACGGCAT GGGCAAGTAC 600

GGCCCCGAGT GTGACTGGTG GTCTCTGGGC GTCTGTATGT ACGAAATGCT GTATGGAGAA 660

ACACCGTTTT ATGCAGAATC ACTTGTGGAG ACCTATGGAA AGATCATGAA CCATGAAGAG 720

CGATTTCAGT TCCCTTCCCA TGTCACGGAT GTATCTGAAG AAGCAAAAGA CCTCATTCAG 780

AGACTAATCT GCAGCAGAGA GCGCCGGCTA GGGCAGAATG GAATAGAGGA CTTCAAAAAG 840

CATGCGTTCT TTGAAGGACT AAATTGGGAA AATATACGAA ACCTAGAAGC ACCTTACATT 900

CCTGATGTGA GCAGTCCTTC TGACACATCC AACTTCGATG TGGATGATGA TGTGCTAAGA 960

AATATTGAAA TATTACCTCC TGGTTCTCAT ACAGGCTTTT CTGGATTACA TTTGCCATTC 1020

ATCGGTTTTA CGTTCACAAC GGAAAGCTCT TTTTCTGATC GAGGCTCTCT GAAGAGTATA 1080

ATGCAGTCCA ACACATTGAC CAAAGATGAG GGTGTGCAGC GGGATTTAGA GAACAGCTTG 1140

CAGGTTGAAG CTTATGAAAG GAGGATACGG AGACTGGAAC AAGAGAAGCT AGAGCTGAGC 1200

AGAAAGCTGC AAGAGTCCAC CCAGACCGTG CAGTCCCTCC ACGGCTCAAC TCGGGCCCTC 1260

GGCAGCTCAG CCCGAGAGAA AGAAATCAGA AAGCTGAATG AGGAAATTGA ACGTTTGAAG 1320

AATAAAATAG CAGATTCAAA TAGGCTTGAG CGACAACTTG AGGACACTGT GACACTTCGT 1380

CAGGAGCACG AAGACTCTAC ACATAGACTA AAAGGCCTGG AAAAGCAGTA CCGCATGGTG 1440

CGACAGGAGA AGGAGGACTT TCACAAGCAA TTGGTTGAAG CTTCAGAACG GTTGAAATCC 1500

CAAGCCAGAG AACTCAAAGA TGCCCACCAG CAGCGAAAGC TGGCCCTGCA GGAGTTCTCG 1560

GAGCTCAATG AGCGCATGGC AGAACTCCGC TCCCAGAAGC AAAAGGTTTC TCGGCAGCTC 1620

CGGGACAAAG AGGAAGAAAT GGAGGTGGCC ATGCAGAAAA TCGACTCGAT GCGGCAGGAA 1680

ATCCGCAAAT CCGATAAGTT CAGGAAAGAG CTGGAAGCTC AGCTCGAGGA TGCCATCGCC 1740

GAGGCCTCCA AGGAGCGCAA ACTTCGAGAG CACAGTGAGA ACTTCTCCAA GCAAATAGAA 1800

AGTGAGCTTG AGGCCCTCAA GATGAAGCAA GGAGGCCGGG GCCAAGGTGC CACCTTAGAA 1860

CATCAGCAGG AGATTTCCAA GATAAAATCT GAGCTTGAGA AGAAAGTCTT GTTTTATGAA 1920

GAAGAATTGG TCAGGCGTGA GGCCTCCCAT GTGCTAGAAG TGAAAAATGT GAAAAAGGAG 1980

GTGCATGATT CCGAAAGCCA CCAGCTGGCA CTGCAGAAAG AAATCTTAAT GTTAAAAGAT 2040

AAATTAGAGA AGTCAAAACG AGAACGGCAC AATGAAATGG AGGAGGCAGT GGGTACCGTG 2100

AAAGATAAAT ATGAACGAGA AAGGGCAATG CTGTTTGAGG AAAACAAGAA ATTAACTGCT 2160

GAAAATGAAA GGCTTTGTTC CTTTGTGGAT AAACTCACAG CTCAAAACAG ACAACAGGAG 2220

GAGGAACTGC AGGGTCTGGC AGCCAAGAAG GAGTCAGTTG CCCACTGGGA AGCTCAGATT 2280

GCGGAAATCA TTCAGTGGGT CAGCGACGAG AAAGATGCCC GGGGTTACCT TCAAGCTCTT 2340

GCTTCTAAGA TGACTGAAGA GCTTGAGACT TTGAGGAGTT CTAGTCTCGG ATCAAGAACA 2400

CTGGATCCCC TTTGGAAAGT TCGTCGTAGT CAGAAGCTGG ACATGTCTGC ACGGCTAGAA 2460

TTGCAGTCTG CTCTTGAAGC AGAGATCCGG GCCAAGCAGC TTGTTCAGGA GGAGCTGAGG 2520

AAAGTCAAAG ACACGAATCT CTCCTTTGAA AGTAAACTAA AGGATTCTGA AGCCAAAAAT 2580

AGAGAACTAT TAGAAGAAAT GGAAATTCTG AAGAAGAAGA TGGAAGAAAA ATTTAGAGCA 2640

GATACTGGAC TCAAACTTCC AGATTTTCAA GATTCTATTT TTGAGTATTT CAACACTGCA 2700

CCTCTTGCAC ATGATCTGAC ATTTAGAACC AGCTCAGCTA GTGAGCAAGA AACACAAGCT 2760

CCAAAACCAG AAGTGTCCCC ATCCATTTCT GTGGGTGCAA GCACAGAACA GCAAGAAGAC 2820

ATGGGTCGGG CCCCCCAGAG GCCGCCCGCT GTGCCGCTGC CCACCACACA GGCCCTTGCT 2880

CTGGCTGGAC CAAAGCCAAA AGCTCACCAG TTCAGCATCA AGTCCTTCTC CAGCCCCACT 2940

CAGTGCAGCC ACTGCACCTC CCTGATGGTG GGGCTGATCC GGCAGGGCTA CGCCTGCGAC 3000

GTGTGCTCAT TTGCTTGCCA TGTATCCTGC AAAGACAGCG CTCCCCAGGT GTGCCCCATA 3060

CCTCCTGAGC AGTCCAAGCG TCCTCTTGGT GTGGATGTAC AGAGAGGCAT AGGAACAGCC 3120

TACAAGGGCT ATGTCAAGGT CCCAAAGCCT ACGGGGGTGA AGAAAGGATG GCAGCGGGCT 3180

TACGCTGTGG TCTGTGACTG TAAGCTCTTT CTGTACGATT TGCCTGAAGG AAAATCCACC 3240

CAGCCTGGTG TCATCGCAAG CCAAGTCTTG GATCTCAGAG ATGAAGAATT CTCCGTGAGC 3300

TCAGTCCTGG CTTCAGATGT CATACATGCT TCACGCCGAG ATATTCCGTG CATATTCAGG 3360

GTGACAGCCT CTCTCTTAGG TACACCTTCT AAGACCAGCT CACTGCTCAT TCTGACAGAA 3420

AATGAGAATG AAAAGAGGAA GTGGGTTGGG ATACTAGAAG GACTCCAGTC TATCCTTCAT 3480

AAGAACCGCC TAAGGAATCA GCTCGTGCAT ATTCCACAGG AGGCCTACGA CAGCTCGCTG 3540

CCTCTCATCA AGGCCGTCCT CACAGCTGCC ATCGTGGATG GAGACAGGAT TGCAGTTGGC 3600

TTGGAAGAAG GGCTCTATGT CATAGAGGTG ACCCGCGATG TGATCCTCCG TGTTGCTGAC 3660

TACAAGAAAG TGTACCAGAT TGAGCTTGCT CCCAAAGAAA GGATCGCCGT CCTCCTCTGC 3720

GGCCGGAACC ACCACGTCCA TCTCTGTCCC TGGTCTTCCT TTGATGGCGG GGAAAGTAAT 3780

GTTGACATCA AGCTTCCGGA AACAAAAGGC TGTCAGCTCA TAGCAACAGC GACACTGAAG 3840

AAGAGCTCTT CCACCTGCCT GTTTGTAGCA GTGAAACGGC TGGTCCTTTG CTATGAGATC 3900

CTGAGAACTA AGCCTTTCCA CAGGAAGTTC AATGAAATTG GGGCCCCTGG CAATGTACAG 3960

TGGATGGCCG TGGTCAAGGA CAAGCTCTGT GTTGGCTACC CTTCTGGGTT CTCTCTGTTG 4020

AGCACCCAGG GAGATGGGCA GGCTCTAAAC CTGGTAAATC CCAATGACCC CTCGCTTACG 4080

TTCCTCTCAC AACAGTCTTT TGATGCCCTT TGTGCTGTGG AGCTCAAAAG TGAGGAGTAC 4140

CTGCTTTGCT TCAGCCACAT GGGACTGTAC GTGGACCCAC AAGGTCGGAG GTCACGCATG 4200

CAGGAGCTCA TGTGGCCTGC AGCGCCTGTT GCCTGTAGTT GCAGCCCCTC GCACGTCACG 4260

GTGTACAGCG AGTACGGCGT GGATGTCTTT GACGTGCGCA CCATGGAGTG GGTTCAGACC 4320

ATCGGCCTGC GGAGGATAAG ACCCCTGAAC TCTGAGGGCA CCCTCAACCT CCTCAACTGT 4380

GAGCCTCCCC GCTTGATCTA CTTCAAGAGC AAGTTCTCCG GAGCAGTTCT CAACGTGCCC 4440

GACACCTCCG ATAACAGCAA GAAGCAGATG CTCAGGACCA GAAGCAAGAG GCGATTTGTG 4500

TTCAAGGTGC CGGAGGAGGA GAGACTGCAG CAGCGGCGAG AGATGCTTAG AGACCCAGAA 4560

TTGAGATCCA AAATGATATC CAACCCAACC AACTTCAACC ACGTGGCTCA CATGGGCCCT 4620

GGTGACGGGA TGCAGGTGCT CATGGACCTG CCTCTGAGTG CTGTGCCCCC TGCCCAGGAG 4680

GAAAGGCCTG GCCCTGCTCC TGCCAGCCTG TCCCGGCAGC CTCTGCCCAG GAACAAGCCC 4740

TACATCTCGT GGCCCTCGTC AGGTGGATCA GAGCCTGGAG TGGCTGTGCC TCTGAGAAGT 4800

ATGTCCGATC CCGACCAGGA CTTTGACAAA GAGCCCGATT CGGATTCCAC CAAACACTCA 4860

ACTCCATCAA ACAGCTCCAA CCCCAGTGGC CCGCCGAGCC CCAACTCCCC CCACAGGAGC 4920

CAGCTCCCCC TCGAAGGCCT GGAGCAGCCA GCCTATGACG CCTAA 4965

Domain Profile

S: 1     feilkviGrGafgevavvrekatekvyamkilkklellkraesaffreerdvlvkadsew  60

         fei+kviGrGafgevavv++k+te++yamkil+k+e+lkrae+a+freerdvlv++d++w

Q: 18    FEIIKVIGRGAFGEVAVVKMKNTERIYAMKILNKWEMLKRAETACFREERDVLVNGDCQW  77

         89**********************************************************

S: 61    ivqlqyafqdekylylvmeylvGGdlltllskyedklpeelarfylaelvlaldsvhelg  120

         i++l+yafqde+ylylvm+y+vGGdlltllsk+edklpe++arfy+ e+vla+ds+h+l+

Q: 78    ITTLHYAFQDENYLYLVMDYYVGGDLLTLLSKFEDKLPEDMARFYIGEMVLAIDSIHQLH  137

         ************************************************************

S: 121   yvhrdikpdnilldksGhikladfGsclklnedgtvkssvavGtpdyispevlkaleegk  180

         yvhrdikpdn+lld++Ghi+ladfGsclk+n+dgtv+ssvavGtpdyispe+l+a+e+g+

Q: 138   YVHRDIKPDNVLLDVNGHIRLADFGSCLKMNDDGTVQSSVAVGTPDYISPEILQAMEDGM  197

         ************************************************************

S: 181   geygkecdwwslGvilyellvgetpfyaeslvetyskilnhkeslkfpede.kvseeakd  239

         g+yg+ecdwwslGv++ye+l+getpfyaeslvety+ki+nh+e+++fp+++ +vseeakd

Q: 198   GKYGPECDWWSLGVCMYEMLYGETPFYAESLVETYGKIMNHEERFQFPSHVtDVSEEAKD  257

         **************************************************99********

S: 240   likklltsreerlgregiedlkkhpff  266

         li++l++sre+rlg++gied+kkh+ff

Q: 258   LIQRLICSRERRLGQNGIEDFKKHAFF  284

         **************************9

Domain Sequence
(FASTA)

FEIIKVIGRG AFGEVAVVKM KNTERIYAMK ILNKWEMLKR AETACFREER DVLVNGDCQW 60

ITTLHYAFQD ENYLYLVMDY YVGGDLLTLL SKFEDKLPED MARFYIGEMV LAIDSIHQLH 120

YVHRDIKPDN VLLDVNGHIR LADFGSCLKM NDDGTVQSSV AVGTPDYISP EILQAMEDGM 180

GKYGPECDWW SLGVCMYEML YGETPFYAES LVETYGKIMN HEERFQFPSH VTDVSEEAKD 240

LIQRLICSRE RRLGQNGIED FKKHAFF 267

Keyword

ATP-binding; Complete proteome; Kinase; Metal-binding; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase; Zinc; Zinc-finger.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0042641	; C:actomyosin
GO:0005524	; F:ATP binding
GO:0046872	; F:metal ion binding
GO:0005543	; F:phospholipid binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0005083	; F:small GTPase regulator activity
GO:0031532	; P:actin cytoskeleton reorganization
GO:0031032	; P:actomyosin structure organization
GO:0016477	; P:cell migration
GO:0035556	; P:intracellular signal transduction

KEGG

InterPros

IPR000961	; AGC-kinase_C.
IPR001180	; Citron.
IPR020454	; DAG/PE-bd.
IPR011009	; Kinase-like_dom.
IPR014930	; Myotonic_dystrophy_kinase_coil.
IPR000095	; PAK_box_Rho-bd.
IPR011993	; PH_like_dom.
IPR017892	; Pkinase_C.
IPR001849	; Pleckstrin_homology.
IPR002219	; Prot_Kinase_C-like_PE/DAG-bd.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.
IPR026611	; Ser/Thr_kinase_MRCK.

Pfam

PF00130	; C1_1; 1.
PF00780	; CNH; 1.
PF08826	; DMPK_coil; 1.
PF00069	; Pkinase; 1.
PF00433	; Pkinase_C; 1.

SMARTs

SM00109	; C1; 1.
SM00285	; PBD; 1.
SM00233	; PH; 1.
SM00133	; S_TK_X; 1.
SM00220	; S_TKc; 1.

Prosites

PS51285	; AGC_KINASE_CTER; 1.
PS50219	; CNH; 1.
PS50108	; CRIB; 1.
PS50003	; PH_DOMAIN; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.
PS00479	; ZF_DAG_PE_1; 1.
PS50081	; ZF_DAG_PE_2; 1.

Prints

PR00008

; DAGPEDOMAIN.

Created Date

20-Feb-2013