EKS-EQC-00424

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-EQC-00424

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
Other/ULK	348.1	3.8E-104	8	260	253

Status

Unreviewed

Ensembl Protein

ENSECAP00000018672

UniProt Accession

F6U4R5;

Protein Name

Protein Synonyms/Alias

Gene Name

ULK3

Gene Synonyms/Alias

ULK3;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSECAG00000021084	ENSECAP00000018672	ENSECAT00000022587

Organism

Equus caballus

Functional Description

Protein Length

462

Protein Sequence
(FASTA)

PRLDGFILER LGSGTYAHFK AYAKKDTREV VAIKCVAKKS LNKASVENLL TEIEILKGIQ 60

HPHIVQLKDF QWDSDNIYLI MEFCAGGDLS RFIHTRRILP EKVARVFMQQ LASALQFLHQ 120

QNISHLDLKP QNILLSSLEK PHLKLADFGF AQHMSPWDEK HVLRGSPLYM APEMVCQRQY 180

DARVDLWSVG VILYEALFGQ PPFASRSFSE LEEKIRSNRV IELPLRPPLS RDCRDLLQRL 240

LERDPSRRIS FQDFFAHPWV DLEHMPSGES LAQATALVVQ AVKKDQEGDA AAALSLYCKA 300

LDFFVPALHY EVDAQRKEAI KAKVGQYVSR AEELKAIVSS SNRALLRQGA SARDLLREMA 360

RDKPRLLAAL EVASAAMAKE EEAGGEQDAL ALYQHGLEEL LLLLAAEPPG RRRELLHTEV 420

QNLMARAEYL KEQVKMRESR WEAETLDKEG LLESVRSSCT LQ 462

Nucleotide Sequence
(FASTA)

CCGCGACTGG ACGGCTTCAT TCTCGAGCGC CTGGGCAGTG GCACGTATGC CCACTTCAAG 60

GCCTACGCCA AGAAGGACAC TCGTGAGGTG GTAGCCATCA AGTGCGTGGC CAAGAAGAGT 120

CTGAACAAGG CATCTGTGGA AAACCTCCTG ACAGAGATTG AGATCCTCAA GGGCATTCAA 180

CACCCCCACA TCGTACAGCT GAAAGACTTC CAGTGGGACA GTGACAACAT CTACCTCATC 240

ATGGAATTCT GCGCAGGGGG TGACCTGTCT CGCTTCATTC ACACCCGCAG GATTCTGCCT 300

GAGAAGGTGG CTCGTGTCTT CATGCAGCAG TTGGCTAGTG CCCTGCAGTT CCTGCACCAA 360

CAGAACATCT CTCACCTGGA TCTGAAGCCA CAGAACATTC TCCTGAGCTC CTTGGAGAAG 420

CCCCACCTTA AACTGGCAGA CTTCGGCTTT GCACAGCACA TGTCCCCCTG GGATGAGAAG 480

CATGTGCTCC GTGGCTCCCC CCTCTACATG GCCCCTGAGA TGGTGTGTCA GCGGCAGTAC 540

GACGCCCGTG TGGACCTCTG GTCTGTGGGG GTCATCCTAT ATGAAGCCCT CTTCGGGCAG 600

CCCCCCTTTG CCTCCAGGTC GTTCTCGGAG CTGGAAGAGA AGATCCGGAG CAACCGGGTT 660

ATTGAGCTCC CCCTGCGGCC TCCGCTCTCC CGAGACTGCC GGGACCTGTT GCAGAGGCTC 720

CTAGAACGGG ACCCCAGCCG TCGCATCTCC TTCCAGGACT TCTTCGCCCA CCCCTGGGTG 780

GACCTGGAAC ACATGCCCAG TGGGGAGAGC CTGGCACAAG CAACCGCCCT GGTGGTGCAG 840

GCTGTGAAGA AGGACCAGGA GGGGGATGCT GCAGCTGCCT TGTCTCTCTA CTGTAAGGCT 900

CTGGACTTCT TCGTGCCTGC ACTGCACTAC GAAGTGGATG CCCAGCGGAA GGAGGCAATT 960

AAGGCAAAGG TGGGGCAGTA CGTGTCCCGG GCTGAGGAGC TCAAGGCCAT CGTCTCCTCC 1020

TCCAATCGGG CCCTGCTGAG GCAAGGGGCC TCTGCCCGAG ACCTGCTCAG AGAGATGGCC 1080

CGGGACAAGC CACGCCTCCT TGCTGCTCTA GAAGTGGCTT CAGCTGCCAT GGCCAAGGAG 1140

GAGGAAGCTG GTGGGGAGCA GGATGCCCTG GCCCTATACC AGCATGGCCT GGAGGAGCTG 1200

CTGCTGCTGC TGGCAGCGGA GCCCCCAGGC CGGAGGCGGG AGCTGCTTCA CACTGAGGTT 1260

CAGAACCTCA TGGCTCGAGC TGAATACTTG AAGGAGCAGG TCAAGATGAG GGAGTCTCGC 1320

TGGGAAGCCG AGACCCTGGA CAAAGAGGGG CTGTTAGAGT CTGTTCGTAG CTCTTGCACC 1380

CTGCAGTGA 1389

Domain Profile

S: 4     eeeiGkGsfavvykgrlrkktsqvvAikvvekkkl.kkslenlekeikilkelkheniva  62

          e++G+G++a  +k++++k+t++vvAik+v+kk+l k+s+enl +ei+ilk ++h++iv+

Q: 8     LERLGSGTYAH-FKAYAKKDTREVVAIKCVAKKSLnKASVENLLTEIEILKGIQHPHIVQ  66

         589******97.9**********************999**********************

S: 63    lldveetskevylvmeycaggdLakllkqkkeLsedtvreflqqlasalkaLhskkivhr  122

         l+d++++s+++yl+me+caggdL++++++++ L+e+++r+f+qqlasal++Lh+++i+h

Q: 67    LKDFQWDSDNIYLIMEFCAGGDLSRFIHTRRILPEKVARVFMQQLASALQFLHQQNISHL  126

         ************************************************************

S: 123   DlkPqniLlsyadakkelkkvtlkladFglarvlkeesmaatlkGsplYmaPEvvkeqqy  182

         DlkPqniLls      +l+k +lkladFg+a++++ +++++ l+GsplYmaPE+v+++qy

Q: 127   DLKPQNILLS------SLEKPHLKLADFGFAQHMSPWDEKHVLRGSPLYMAPEMVCQRQY  180

         **********......89******************************************

S: 183   dakaDlWSiGtilyellvGkpPfaaesiseLvekiekndvleppipkeisselkdllqsL  242

         da++DlWS+G+ilye+l+G+pPfa++s+seL+eki++n+v+e+p++  +s++++dllq+L

Q: 181   DARVDLWSVGVILYEALFGQPPFASRSFSELEEKIRSNRVIELPLRPPLSRDCRDLLQRL  240

         ************************************************************

S: 243   LqrdpkkRisfeelfahpfl  262

         L+rdp++Risf+++fahp++

Q: 241   LERDPSRRISFQDFFAHPWV  260

         ******************96

Domain Sequence
(FASTA)

LERLGSGTYA HFKAYAKKDT REVVAIKCVA KKSLNKASVE NLLTEIEILK GIQHPHIVQL 60

KDFQWDSDNI YLIMEFCAGG DLSRFIHTRR ILPEKVARVF MQQLASALQF LHQQNISHLD 120

LKPQNILLSS LEKPHLKLAD FGFAQHMSPW DEKHVLRGSP LYMAPEMVCQ RQYDARVDLW 180

SVGVILYEAL FGQPPFASRS FSELEEKIRS NRVIELPLRP PLSRDCRDLL QRLLERDPSR 240

RISFQDFFAH PWV 253

Keyword

Complete proteome; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Dasypus novemcinctus"; ?>Drosophila melanogaster"; ?>Felis catus"; ?>Gadus morhua"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Macropus eugenii"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tupaia belangeri"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>Saccharomyces cerevisiae"; ?>

Gene Ontology

GO:0005737	; C:cytoplasm
GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0045879	; P:negative regulation of smoothened signaling pathway
GO:0045880	; P:positive regulation of smoothened signaling pathway
GO:0046777	; P:protein autophosphorylation

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR007330	; MIT.
IPR000719	; Prot_kinase_cat_dom.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF04212	; MIT; 2.
PF00069	; Pkinase; 1.

SMARTs

SM00745	; MIT; 2.
SM00220	; S_TKc; 1.

Prosites

PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013