EKS-EQC-00091

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-EQC-00091

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
Atypical/PIKK	413.2	9.1E-124	2688	3018	331

Status

Unreviewed

Ensembl Protein

ENSECAP00000019300

UniProt Accession

F6X5V1;

Protein Name

Protein Synonyms/Alias

Gene Name

ATM

Gene Synonyms/Alias

ATM;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSECAG00000021147	ENSECAP00000019300	ENSECAT00000023313
ENSECAG00000021147	ENSECAP00000019305	ENSECAT00000023320

Organism

Equus caballus

Functional Description

Protein Length

3060

Protein Sequence
(FASTA)

MSLALNDLLI CCHQLGHDRA TERRKEVEKF KRLIRDPETV KQLDQHLDNK QGKYLNWDAV 60

FRFLQKYIQK EIEHLRTAKP NVSASTQAGR QKKMQEISSL VKYFIKCANK RAPKLKCQEL 120

LNYIMDTMKD SSNGAISGAD CSNILLKDIL SVRKYWCEIS QQQWLELLSV YFRLYLKPSQ 180

DINRVLVARI IQAVTKGCCS QTDGLNSKFL EYFSKAIQHA RQEKSSAGLS HILAAFILFL 240

KTLAVNFRIQ VCELGDEILP TLLYVWTQHR LNDSLKEVMI ELFQLQIYIH HPKGAKTQEK 300

GAYESRKWKS ILYNLYDLLV NEISRIGSRG KYSSGSRNIA VKENLIELMA DICHQVFSED 360

TKSLEISQSY ATTQRECNDS SVSCKKRKIE LGWEVINDRL QKSQNDFDLV PWLQIATQLI 420

SKYPASLPNC ELSPLLMITM PALPQQRRGE RTPYVLRCLM EVALCQGKKS NLESSQKSDL 480

LKLWNKIWCI TFRGISSEQI QAENFGLLGA IIQGSLIEVD REFWKLFTGS ACKPSFPAVC 540

CLTLALTICV VPETVKTGME QNICEVNRSS SLKELIMKWL LFYQLEDDFE DSTELPPILH 600

SNFPHLALEK ILVSLTMKNC QAAMSFFQSV PECEKHQKDQ DEPSFSEVED LFLQTTFDKM 660

DFLTIGKEHA TEKQQPSIGF SVHQNLKESL NRCLLGLSEQ LLNNYSSETT NSETLVRCSS 720

LLVGVLGCYR YVGVIAEEEA YKSELFQKAK SLMQCAGESI TLFKNKTNEE SRIVSLRNMM 780

HLCTSCLCNC TKHSPNKIAS GFFLRLLTSK LMNDIADICR SLASFTKKPF DYGEVESMRD 840

DTDKNLMETE DQSSMNLFDD CPTVSVGDAN ESGENQSTVG AINPLAEEHL SKQDLLFLDM 900

LKFLCMCVTS AQTNTVSFRA ADIRRKLLML LDSSMLDPAK SLHLHMYLVL LKELPGEEYS 960

LPMEDVVELL KPLSNVCSFY RRDQDVCKTV LNHVLHVVMN LRQGNMDAEN TKDAQEQFLR 1020

VIEVFWRLTK EGKYAFSVRM ALVKCLKTLL EADPYSKWAI LKVKGNNFPV NEIFPQFLAD 1080

DHHQVRMLAA ESINRLFQDM EQGSSSRLLK ALPLKLQQTA FENAYLKAQE GMRQVSQRAE 1140

NPELLDDIYN RKAVLLMMIA VVLCCSPVCE KQALFALCKS VKDDGLEPHL VKKVLEKVSE 1200

TFGYRNLEDF MASHLDYLIL EWLNLRDNEY SLSSFPFILL NYANVEDFYR SCYKVLIPHL 1260

VIRSDFDEVK SIANQIQEDW KSLLTDCFPK ILVNILPYFA YEDTGDSGMA QQRETATKVY 1320

DMLKDENVLG KQIDHLFRSN LPEIVVELLM TLHEPATSGA SQSTDLCDFS GDLDPAPNPP 1380

HFPSHVIKAT FAYISSCHKT KLKSIVEILS KSPDSYQKIL LAICVQAAET NNIYKKHRIL 1440

KIYHLFVSLL LKDIKSGLGG AWAFVLRDVI YTLIHYINKR PSRFRDVSLR SFSLCCDLLS 1500

QVCHTAVTYC KDALESHLHV IVGTLIPLVD DQMEVQKQVL DLLKYLVIDN KDNENLYMTI 1560

KLLDPFPDHV VFKDLRITQQ KIKYSGGPFS LLEEINHFLS VSKYDALPLT RLEGLKDLRR 1620

QLEQHKDQMM DLMRASQDNP QGGIMVKLVV GLLQLSKMAI NHTGEREVLE AVGSCLGELG 1680

PIDFSTIAVQ HSKDTSYTKA LELFEDKELQ WTFIMLTYLN NTLVEDCVKV RSAAVTCLKN 1740

ILATKTGHSF WEIYKKTTDP MLIYLHPFRT SRKKFLEVPR IDKENPLEGL DDTSLWIPQS 1800

KNHDIWIKTL TCAVLDSGGT KSEILQLLKP MCEVKTDFCQ TVLPYLIHDI LLQDTNESWR 1860

NLLSTHIQGF FTNCFRHSSQ TSRSTTPANL DSESEHIFRG CLDKKSQRTM LAIVDYMRRQ 1920

KRPSSGTVFD EAFWLELNYL EVAKVAQSCA AHFTALLYAE IYADKKSMED QEKRSLTFEE 1980

GSQSTTISSL SEKSKEETGI SLQDLLLEIY RSIGEPDSLY GCGGGKMLQP LTRLRTYEHE 2040

AMWGKALVTY DLETAISSST RQAGIIQALQ NLGLCHILSV YLKGLDHENK EWCAELQELH 2100

YQAAWRNMQW DHCICVNKGA EGASYHKSLY NALQSLRDRE FSTFYESLKY ASMFLVKEVE 2160

ELCKGSLESV YSLYPTLSRL QTIGELENIG ELFSRSVTDR QPSEVYIKWR KHSQLLKDSD 2220

FSFQEPIMAL RTVILEILME KEMESSQRQC FKDILTKHLV ELSTLARTFK NTQLPERAIF 2280

QIKQYNSASC GVSEWQLEEA QVFWAKEEQS LALSILKQMI KKLDASCTEN DPNLKLMYTE 2340

CLRICGNWLA ETCLENPAVI MQTYLEKAVE VAGNCDGESN DELRNGKMKA FLSLARFSDT 2400

QYQRIENYMK SSEFENKQAL LKRAKEEVGL LREHKIQTNR YTIKVQRELE LDECALRALK 2460

EDRKRFLCKA VENYISCLLS GEGHDMWIFR LCSLWLENSG VSEVNGMMKA NGIKIPSYKF 2520

LPLMYQLAAR MGTKMMGGLG FHEVLNNLIS RISMDHPHHT LFIILALANA NKDEFLTKPE 2580

AARRSRITKS APKQSSQLDE DRTEAANKII HTIRTRRPQM IRSVEALCDA YIILANLDAT 2640

QWRTQRQGIN IPADQPITKL QNLEDVVVPT MEIKVDPTGE YENLVTIQSF KAEFRLAGGL 2700

NLPKIIDCLG SDGKERRQLV KGRDDLRQDA VMQQVFQMCN TLLQRNTETR KRKLTICTYK 2760

VVPLSQRSGV LEWCTGTVPI GEFLVNNENG AHKRYRPEDF SALQCQKKMM DVQKKSFEEK 2820

YATFMDICQN FQPVFRYFCM EKFLDPAVWF EKRLAYTRSV ATSSIVGYIL GLGDRHVQNI 2880

LINEQSAELV HIDLGVAFEQ GKILPTPETV PFRLTRDIVD GMGITGVEGV FRRCCEKTME 2940

VMRNSQETLL TIVEVLLYDP LFDWTMNPLK ALYLQQRPED ETELHSTPHA DDQECKRNLS 3000

DVDQSFNKVA ERVLMRLQEK LKGVEEGTVL SVGGQVNLLI QQAMDPKNLS RLFPGWKAWV 3060

Nucleotide Sequence
(FASTA)

ATGAGTCTAG CACTTAATGA TCTGCTTATT TGCTGCCATC AACTAGGACA TGATAGAGCT 60

ACAGAACGAA GGAAAGAAGT TGAGAAATTT AAGCGCCTGA TTCGCGATCC TGAAACTGTT 120

AAACAGTTAG ATCAGCATTT AGATAACAAA CAAGGAAAAT ATTTGAATTG GGATGCTGTT 180

TTTAGATTTT TACAGAAATA TATTCAGAAA GAAATAGAAC ATCTGAGAAC AGCAAAACCA 240

AATGTATCAG CCTCAACACA AGCCGGCAGG CAGAAAAAGA TGCAAGAAAT CAGTAGTTTG 300

GTCAAATACT TCATCAAATG TGCAAATAAA AGAGCACCCA AGCTAAAATG TCAAGAACTC 360

TTGAATTATA TCATGGATAC TATGAAAGAT TCATCTAATG GTGCCATTTC TGGAGCTGAC 420

TGTAGCAACA TACTGCTCAA GGACATTCTT TCAGTGAGAA AATATTGGTG TGAAATATCT 480

CAGCAACAGT GGCTAGAATT GCTCTCTGTG TACTTCAGGC TGTATCTTAA ACCTTCACAA 540

GACATTAATA GGGTTTTAGT GGCTAGAATA ATTCAAGCTG TGACTAAAGG ATGCTGTTCG 600

CAAACTGATG GATTAAATTC TAAATTTTTG GAATATTTTT CCAAGGCTAT TCAGCATGCA 660

AGACAAGAAA AGAGTTCTGC AGGTCTAAGT CATATCTTAG CAGCATTTAT TCTCTTCCTC 720

AAGACTTTGG CTGTTAACTT TCGAATTCAA GTGTGTGAAT TAGGAGATGA AATTCTTCCT 780

ACCTTGCTTT ATGTTTGGAC TCAACATAGA CTTAATGATT CCTTAAAAGA AGTAATGATT 840

GAATTATTTC AACTGCAAAT TTATATCCAT CATCCAAAGG GAGCAAAAAC CCAAGAAAAA 900

GGTGCTTATG AATCAAGGAA ATGGAAAAGT ATCTTATACA ACTTATATGA TCTGCTAGTT 960

AATGAGATAA GTCGTATAGG AAGCAGAGGG AAATATTCTT CAGGATCTCG TAATATTGCT 1020

GTCAAGGAAA ACCTGATTGA ATTGATGGCA GATATTTGTC ACCAGGTTTT CAGTGAAGAT 1080

ACCAAATCTT TGGAGATTTC TCAGTCTTAT GCCACCACAC AAAGAGAATG TAATGATTCC 1140

AGTGTATCTT GCAAAAAGAG GAAAATAGAA TTAGGCTGGG AAGTAATAAA CGATCGTCTT 1200

CAGAAGTCAC AGAATGATTT TGATCTTGTG CCTTGGTTAC AGATTGCAAC CCAGTTAATA 1260

TCAAAATATC CTGCAAGTTT ACCTAATTGT GAGCTGTCAC CATTACTGAT GATTACTATG 1320

CCAGCTCTGC CTCAACAGCG ACGTGGGGAG CGCACACCAT ATGTGTTACG ATGCCTTATG 1380

GAAGTTGCGT TATGTCAAGG CAAGAAATCA AACCTAGAAA GCTCACAAAA GTCAGATTTA 1440

TTGAAACTCT GGAATAAAAT TTGGTGTATT ACCTTTCGTG GTATAAGTTC TGAACAAATA 1500

CAAGCTGAAA ACTTTGGTTT ACTTGGAGCC ATAATTCAAG GCAGTTTAAT TGAGGTTGAT 1560

AGAGAATTCT GGAAGTTATT TACTGGGTCA GCCTGCAAAC CTTCATTTCC TGCAGTATGC 1620

TGTTTGACTT TGGCCCTGAC CATTTGTGTA GTTCCAGAAA CAGTAAAAAC AGGAATGGAA 1680

CAGAATATAT GTGAAGTAAA TAGAAGTTCT TCTTTAAAAG AATTGATAAT GAAATGGCTC 1740

TTATTCTATC AGTTAGAGGA TGACTTTGAA GACAGTACAG AGCTGCCTCC AATTCTTCAC 1800

AGTAATTTTC CTCATCTTGC ACTGGAGAAG ATTCTTGTGA GTCTCACTAT GAAAAACTGT 1860

CAAGCTGCAA TGAGTTTTTT CCAAAGTGTG CCAGAATGTG AAAAACACCA AAAAGATCAA 1920

GATGAGCCTT CATTCTCAGA AGTTGAAGAC CTATTTCTTC AGACAACTTT TGACAAGATG 1980

GATTTTTTAA CCATTGGGAA AGAACATGCT ACAGAAAAGC AGCAACCCAG TATAGGCTTT 2040

TCTGTCCACC AAAACCTCAA GGAATCACTG AATCGCTGTC TTTTGGGATT ATCAGAACAA 2100

CTTCTAAATA ACTACTCATC TGAGACTACA AATTCAGAAA CGCTTGTCCG GTGTTCAAGT 2160

CTTTTGGTGG GTGTTCTTGG CTGCTATCGT TATGTGGGTG TAATAGCTGA AGAGGAAGCA 2220

TATAAATCAG AATTATTCCA GAAAGCCAAG TCTCTAATGC AGTGTGCAGG AGAAAGTATC 2280

ACTCTGTTTA AAAATAAGAC AAATGAAGAA TCTAGAATTG TTTCACTGAG AAATATGATG 2340

CATCTATGTA CAAGTTGCTT GTGTAACTGT ACCAAGCACA GTCCAAATAA GATTGCATCT 2400

GGCTTTTTCC TACGATTGTT AACATCAAAG CTAATGAATG ATATTGCTGA TATTTGTAGA 2460

AGTTTAGCAT CTTTTACCAA AAAGCCATTT GACTATGGAG AAGTAGAATC AATGCGAGAT 2520

GATACTGATA AAAATCTGAT GGAGACGGAG GATCAGTCCT CCATGAATCT ATTTGATGAT 2580

TGCCCTACTG TTAGTGTTGG TGATGCAAAT GAATCTGGAG AGAACCAAAG TACTGTCGGT 2640

GCCATAAATC CTTTAGCTGA AGAACATCTG TCAAAGCAAG ATCTACTTTT TTTAGACATG 2700

CTCAAGTTCT TGTGTATGTG TGTAACTAGT GCTCAGACCA ATACTGTGTC ATTTAGAGCA 2760

GCTGATATTC GGAGGAAATT GTTGATGTTA CTTGATTCTA GCATGCTAGA CCCTGCTAAA 2820

TCTCTCCACC TACACATGTA TCTAGTGCTT TTAAAGGAGC TGCCCGGAGA AGAATATTCC 2880

TTGCCAATGG AAGATGTTGT TGAACTTCTG AAACCACTAT CCAATGTGTG TTCTTTTTAT 2940

CGCCGTGACC AAGATGTTTG TAAGACAGTT TTAAACCATG TTCTTCATGT AGTGATGAAC 3000

CTACGTCAAG GCAATATGGA TGCTGAGAAC ACAAAGGATG CTCAAGAACA GTTTCTAAGA 3060

GTGATTGAAG TATTTTGGCG CTTAACAAAG GAGGGGAAAT ACGCATTCTC TGTAAGAATG 3120

GCACTGGTAA AATGCCTTAA AACCTTGCTT GAGGCCGATC CTTATTCAAA ATGGGCTATT 3180

CTTAAGGTAA AGGGAAACAA CTTTCCTGTA AATGAAATAT TTCCACAATT TCTTGCTGAT 3240

GATCATCACC AAGTTCGCAT GTTGGCTGCA GAGTCAATCA ACAGATTATT CCAGGATATG 3300

GAACAAGGAA GTTCTTCCAG GTTATTGAAA GCACTTCCTT TGAAGCTTCA GCAAACAGCT 3360

TTTGAAAATG CATACTTGAA AGCTCAAGAA GGAATGAGAC AAGTGTCCCA GAGAGCTGAG 3420

AACCCTGAAC TTTTGGATGA TATTTATAAT AGAAAAGCTG TTTTACTGAT GATGATAGCT 3480

GTGGTTTTAT GCTGTAGCCC TGTCTGTGAA AAACAGGCTT TGTTTGCCCT ATGCAAGTCT 3540

GTGAAAGACG ATGGATTAGA ACCTCACCTT GTTAAAAAGG TTTTAGAGAA AGTTTCTGAA 3600

ACTTTTGGAT ATAGAAATTT AGAAGACTTC ATGGCTTCTC ATTTGGATTA TCTAATTTTG 3660

GAATGGCTAA ATCTTCGAGA TAATGAATAC AGTTTATCTT CTTTTCCTTT TATCTTATTA 3720

AACTACGCAA ATGTTGAGGA TTTCTATAGA TCTTGTTACA AAGTTTTGAT TCCACATCTG 3780

GTGATTAGAA GTGATTTTGA TGAGGTGAAG TCCATTGCTA ATCAGATTCA AGAGGATTGG 3840

AAAAGTCTTC TAACAGACTG CTTTCCAAAG ATTCTTGTAA ATATTCTGCC TTACTTTGCC 3900

TATGAGGATA CTGGAGACAG TGGGATGGCA CAGCAAAGAG AGACTGCTAC CAAAGTCTAT 3960

GATATGCTTA AAGATGAAAA TGTATTAGGA AAACAGATTG ATCATTTATT CAGGAGTAAT 4020

TTACCAGAGA TTGTGGTGGA GTTATTGATG ACCTTACATG AACCAGCAAC TTCTGGTGCC 4080

AGCCAAAGCA CTGACCTCTG TGACTTTTCA GGGGATTTGG ATCCTGCTCC TAATCCACCT 4140

CATTTTCCGT CACATGTGAT TAAAGCAACA TTTGCCTATA TCAGCAGTTG CCATAAAACC 4200

AAGCTTAAAA GCATTGTAGA AATTCTTTCC AAAAGCCCTG ATTCCTATCA GAAAATTCTT 4260

CTAGCCATAT GTGTGCAAGC AGCTGAGACA AATAATATTT ATAAAAAGCA CAGAATTCTT 4320

AAAATATATC ACCTGTTTGT TAGCTTATTA CTGAAAGATA TAAAAAGTGG CTTAGGAGGA 4380

GCTTGGGCCT TTGTTCTTCG AGATGTTATT TATACTTTGA TTCACTATAT CAACAAAAGG 4440

CCTTCTCGTT TCAGGGATGT GTCATTACGC AGCTTCTCTC TTTGCTGTGA CCTGTTAAGC 4500

CAGGTTTGCC ACACAGCAGT AACTTACTGT AAGGATGCTT TAGAAAGTCA CCTCCATGTT 4560

ATTGTTGGTA CACTCATACC CCTTGTGGAC GATCAGATGG AGGTTCAGAA GCAGGTATTG 4620

GACTTGTTGA AATACTTAGT GATAGATAAC AAGGATAATG AAAACCTCTA TATGACAATT 4680

AAACTTTTAG ATCCTTTTCC TGACCATGTT GTCTTTAAGG ATTTGCGTAT TACTCAGCAG 4740

AAAATCAAAT ACAGTGGAGG ACCTTTTTCA CTCTTGGAGG AAATTAACCA TTTTCTCTCA 4800

GTAAGTAAGT ATGATGCACT TCCGCTGACA AGGCTTGAAG GATTGAAGGA TCTTCGGAGA 4860

CAGCTGGAAC AACATAAAGA TCAGATGATG GATCTTATGA GAGCGTCCCA GGATAACCCA 4920

CAAGGTGGCA TAATGGTGAA GTTGGTTGTC GGCTTGTTGC AGTTATCCAA GATGGCAATA 4980

AACCACACTG GCGAAAGGGA AGTTTTAGAG GCTGTTGGAA GCTGCTTGGG AGAACTGGGT 5040

CCTATAGATT TCTCTACCAT AGCTGTACAG CATAGTAAAG ATACATCTTA TACCAAGGCC 5100

CTCGAGTTAT TTGAAGATAA AGAACTTCAG TGGACCTTCA TAATGTTGAC CTACCTGAAT 5160

AATACACTGG TAGAAGATTG TGTCAAAGTG CGATCAGCTG CTGTTACCTG TTTGAAAAAC 5220

ATTTTAGCCA CAAAGACTGG ACATAGTTTC TGGGAGATTT ATAAGAAGAC AACTGACCCC 5280

ATGCTGATCT ATCTACACCC TTTTAGAACA TCAAGAAAAA AGTTTTTAGA AGTACCCAGA 5340

ATTGACAAAG AAAACCCTTT AGAAGGCCTG GATGATACAA GCCTGTGGAT TCCTCAAAGT 5400

AAAAATCATG ACATTTGGAT AAAGACACTG ACTTGTGCTG TTTTGGATAG TGGAGGCACA 5460

AAAAGTGAAA TTCTTCAGTT ATTGAAGCCA ATGTGTGAAG TGAAAACTGA CTTTTGTCAG 5520

ACTGTGCTTC CATACTTGAT TCATGATATT TTACTCCAAG ATACAAATGA ATCATGGAGA 5580

AATCTGCTTT CTACACACAT TCAGGGATTT TTTACTAACT GTTTCAGACA TTCTTCACAA 5640

ACAAGTCGAT CCACGACCCC TGCAAATTTG GATTCAGAGT CAGAGCACAT TTTCCGAGGC 5700

TGTTTGGATA AAAAATCACA AAGAACAATG CTTGCTATTG TGGACTACAT GAGGAGACAA 5760

AAGAGACCTT CCTCAGGAAC AGTTTTTGAT GAGGCCTTCT GGCTGGAGTT GAATTATCTT 5820

GAAGTTGCCA AGGTAGCTCA GTCTTGTGCT GCTCACTTTA CAGCATTGCT CTATGCCGAA 5880

ATCTACGCAG ACAAGAAAAG CATGGAGGAT CAAGAGAAAA GAAGTCTTAC ATTTGAAGAA 5940

GGGAGCCAAA GTACAACTAT TTCTAGTTTG AGTGAAAAAA GTAAAGAAGA AACTGGAATA 6000

AGTTTACAGG ATCTGCTGTT AGAGATCTAC AGAAGTATAG GAGAGCCAGA CAGTCTGTAT 6060

GGCTGTGGGG GAGGAAAAAT GTTACAACCC CTTACTAGAC TACGAACATA TGAACATGAA 6120

GCAATGTGGG GAAAAGCCCT AGTAACATAC GACCTTGAGA CAGCAATCTC CTCATCAACC 6180

CGCCAGGCAG GGATAATTCA GGCCTTGCAG AATTTGGGAC TCTGCCACAT TCTTTCTGTC 6240

TATTTAAAAG GATTAGATCA TGAAAATAAA GAGTGGTGTG CTGAACTACA AGAACTTCAT 6300

TACCAAGCAG CATGGAGGAA TATGCAATGG GACCACTGCA TTTGTGTCAA CAAAGGAGCA 6360

GAAGGAGCCA GTTACCACAA GTCGTTGTAC AATGCTCTGC AGTCTCTAAG AGACAGAGAA 6420

TTCTCCACGT TTTATGAAAG TCTCAAATAT GCCAGCATGT TTTTAGTGAA AGAAGTGGAA 6480

GAATTGTGTA AAGGTAGCCT TGAGTCTGTG TATTCACTCT ACCCCACACT TAGCAGATTG 6540

CAGACCATTG GAGAGCTCGA AAACATTGGG GAGCTTTTCT CAAGATCAGT CACAGATAGG 6600

CAACCCTCTG AAGTCTACAT TAAGTGGCGA AAGCACTCCC AGCTTCTCAA AGACAGTGAT 6660

TTTAGTTTTC AGGAGCCTAT CATGGCTCTA CGCACAGTCA TTTTGGAGAT CTTGATGGAA 6720

AAGGAAATGG AGAGCTCCCA AAGACAGTGT TTCAAGGACA TTCTCACCAA GCATCTTGTA 6780

GAACTCTCCA CACTAGCCCG AACTTTCAAG AACACTCAGC TCCCTGAAAG GGCAATATTT 6840

CAAATTAAAC AGTATAATTC AGCTAGTTGT GGAGTCTCTG AGTGGCAGCT GGAGGAAGCG 6900

CAAGTATTCT GGGCAAAAGA GGAGCAGAGC CTTGCCCTGA GTATTCTCAA GCAAATGATC 6960

AAGAAGTTGG ATGCCAGTTG TACAGAGAAT GATCCCAACC TAAAACTTAT GTACACAGAA 7020

TGTCTGAGGA TTTGTGGCAA CTGGTTAGCA GAAACTTGCT TAGAAAATCC TGCAGTCATC 7080

ATGCAGACCT ATCTGGAAAA GGCAGTAGAA GTTGCTGGAA ATTGTGATGG AGAAAGCAAT 7140

GATGAGCTCA GAAATGGAAA AATGAAGGCC TTTCTCTCTT TAGCACGGTT CTCAGATACT 7200

CAGTACCAAA GAATTGAAAA CTACATGAAA TCATCAGAAT TTGAAAACAA GCAAGCTCTC 7260

CTGAAAAGGG CCAAAGAGGA AGTGGGCCTT CTTAGGGAAC ATAAAATTCA GACCAACAGA 7320

TACACAATAA AGGTTCAGCG AGAGCTGGAG CTGGATGAAT GTGCGCTCCG TGCACTGAAG 7380

GAGGATCGTA AACGTTTCTT ATGTAAAGCA GTTGAAAACT ACATCAGTTG CTTATTAAGT 7440

GGAGAAGGGC ATGATATGTG GATATTCCGT CTTTGTTCCC TCTGGCTTGA AAATTCTGGA 7500

GTATCTGAAG TCAATGGCAT GATGAAGGCA AATGGAATAA AGATTCCATC GTATAAATTT 7560

TTGCCTCTTA TGTACCAATT GGCTGCTAGA ATGGGGACCA AGATGATGGG AGGCCTAGGA 7620

TTTCATGAAG TCCTCAATAA CCTCATCTCT AGAATTTCAA TGGATCACCC CCATCATACT 7680

TTGTTTATTA TACTTGCATT AGCAAATGCA AACAAAGATG AATTTTTGAC CAAACCAGAG 7740

GCAGCAAGAA GGAGTAGAAT AACTAAAAGT GCACCTAAAC AAAGCTCTCA GCTTGATGAG 7800

GATCGAACTG AGGCTGCAAA CAAAATAATA CATACTATCA GGACTAGAAG ACCTCAGATG 7860

ATCAGAAGTG TTGAGGCGCT TTGTGATGCT TATATTATAT TAGCAAACTT AGATGCCACT 7920

CAGTGGAGGA CTCAGAGACA AGGCATAAAT ATTCCAGCAG ACCAGCCAAT TACTAAACTT 7980

CAGAACTTAG AAGATGTTGT TGTCCCTACT ATGGAAATTA AGGTGGACCC CACAGGAGAA 8040

TATGAAAATC TGGTGACTAT ACAATCATTT AAAGCAGAAT TTCGTTTAGC AGGAGGTCTC 8100

AATTTACCAA AAATAATAGA TTGTTTGGGC TCTGATGGCA AAGAAAGGAG ACAGCTTGTC 8160

AAGGGCCGTG ATGACCTGAG ACAAGATGCT GTCATGCAGC AGGTTTTCCA GATGTGCAAT 8220

ACATTACTGC AGAGAAACAC TGAAACCAGG AAGAGGAAAT TGACCATCTG CACATATAAG 8280

GTGGTTCCCC TCTCTCAGCG AAGTGGTGTT CTTGAGTGGT GCACAGGAAC GGTCCCTATT 8340

GGTGAATTTC TTGTTAACAA CGAGAATGGT GCCCATAAAA GATACAGGCC AGAGGATTTC 8400

AGTGCCCTTC AATGCCAAAA GAAAATGATG GATGTGCAAA AGAAGTCTTT TGAAGAGAAG 8460

TATGCAACCT TCATGGATAT TTGCCAAAAT TTTCAACCAG TTTTCCGTTA CTTCTGCATG 8520

GAAAAATTCT TGGACCCAGC TGTTTGGTTT GAGAAACGAT TGGCTTATAC TCGCAGTGTG 8580

GCTACTTCTT CTATTGTTGG TTACATACTT GGACTTGGTG ATAGACATGT ACAGAATATC 8640

TTGATAAACG AGCAGTCAGC AGAACTTGTA CATATAGATT TAGGAGTTGC TTTTGAACAG 8700

GGTAAAATCC TTCCTACTCC TGAAACAGTT CCTTTTCGAC TCACCAGAGA TATTGTGGAT 8760

GGGATGGGCA TTACTGGTGT TGAAGGTGTC TTCAGAAGAT GCTGTGAGAA AACCATGGAG 8820

GTTATGAGAA ACTCTCAGGA AACCCTGTTA ACCATTGTAG AGGTCCTCCT GTATGATCCT 8880

CTCTTTGACT GGACCATGAA TCCTTTGAAA GCTTTGTATT TACAGCAGAG GCCAGAAGAT 8940

GAAACTGAGC TCCACTCCAC CCCACATGCA GATGACCAAG AATGCAAACG AAATCTCAGT 9000

GATGTTGACC AGAGTTTCAA CAAAGTAGCT GAACGGGTCT TGATGAGACT GCAAGAGAAG 9060

CTGAAAGGAG TGGAGGAAGG AACCGTGCTC AGTGTGGGTG GACAGGTGAA TCTGCTCATA 9120

CAACAGGCCA TGGACCCCAA AAATCTCAGC CGTCTTTTCC CAGGATGGAA AGCTTGGGTG 9180

TGA 9183

Domain Profile

S: 2     agfderveilaskqkpkklllrGsdgkeypyLvkgkeDlrqdervlqlfslvNtlLakdk  61

         ++f+ +  +   ++ pk +  +Gsdgke+++Lvkg++Dlrqd++++q+f+++NtlL++++

Q: 2688  QSFKAEFRLAGGLNLPKIIDCLGSDGKERRQLVKGRDDLRQDAVMQQVFQMCNTLLQRNT  2747

         566666666667788999******************************************

S: 62    etsrrkLkirtykVvplstrsgliewventvsLkellkklvekkavlldqpisyrykdls  121

         et++rkL+i+tykVvpls+rsg++ew+++tv+++e+l   v++++++++   +yr++d+s

Q: 2748  ETRKRKLTICTYKVVPLSQRSGVLEWCTGTVPIGEFL---VNNENGAHK---RYRPEDFS  2801

         *************************************...799999999...********

S: 122   tvqarkpklkhlkls....levfkevlenlvpkdllkklllekfpspeewfelrkaytrs  177

         + q++k++++++k+s    ++ f+++++n++p  +++++++ekf++p++wfe+r aytrs

Q: 2802  ALQCQKKMMDVQKKSfeekYATFMDICQNFQP--VFRYFCMEKFLDPAVWFEKRLAYTRS  2859

         ********************************..9*************************

S: 178   lAvislvgyiLgLgdrhlenllidqetgevvhidfgvafekaktqlkvpekvPFRLTrni  237

         +A++s+vgyiLgLgdrh++n+li+++++e+vhid+gvafe++k+ l++pe+vPFRLTr+i

Q: 2860  VATSSIVGYILGLGDRHVQNILINEQSAELVHIDLGVAFEQGKI-LPTPETVPFRLTRDI  2918

         ********************************************.***************

S: 238   vnalgvtgveGvfrasceavlrvlreskeklltiLevflydplvdwkk......kkktsk  291

         v+++g+tgveGvfr++ce++++v+r+s+e+llti+ev+lydpl+dw++      + ++++

Q: 2919  VDGMGITGVEGVFRRCCEKTMEVMRNSQETLLTIVEVLLYDPLFDWTMnplkalYLQQRP  2978

         ******************************************************9*****

S: 292   eteeelaekakaealkikkllskvekaenavatrdlllle  331

         e+e+el+++ +a+++++k++ls+v++++n+va+r+l++l+

Q: 2979  EDETELHSTPHADDQECKRNLSDVDQSFNKVAERVLMRLQ  3018

         ***********************************99987

Domain Sequence
(FASTA)

QSFKAEFRLA GGLNLPKIID CLGSDGKERR QLVKGRDDLR QDAVMQQVFQ MCNTLLQRNT 60

ETRKRKLTIC TYKVVPLSQR SGVLEWCTGT VPIGEFLVNN ENGAHKRYRP EDFSALQCQK 120

KMMDVQKKSF EEKYATFMDI CQNFQPVFRY FCMEKFLDPA VWFEKRLAYT RSVATSSIVG 180

YILGLGDRHV QNILINEQSA ELVHIDLGVA FEQGKILPTP ETVPFRLTRD IVDGMGITGV 240

EGVFRRCCEK TMEVMRNSQE TLLTIVEVLL YDPLFDWTMN PLKALYLQQR PEDETELHST 300

PHADDQECKR NLSDVDQSFN KVAERVLMRL Q 331

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>Saccharomyces cerevisiae"; ?>Schizosaccharomyces pombe"; ?>

Gene Ontology

GO:0000781	; C:chromosome, telomeric region
GO:0005819	; C:spindle
GO:0016303	; F:1-phosphatidylinositol-3-kinase activity
GO:0005524	; F:ATP binding
GO:0004677	; F:DNA-dependent protein kinase activity
GO:0007420	; P:brain development
GO:0007050	; P:cell cycle arrest
GO:0071480	; P:cellular response to gamma radiation
GO:0006975	; P:DNA damage induced protein phosphorylation
GO:0006281	; P:DNA repair
GO:0007292	; P:female gamete generation
GO:0031572	; P:G2/M transition DNA damage checkpoint
GO:0007507	; P:heart development
GO:0071044	; P:histone mRNA catabolic process
GO:0016572	; P:histone phosphorylation
GO:0008630	; P:intrinsic apoptotic signaling pathway in response to DNA damage response
GO:0042159	; P:lipoprotein catabolic process
GO:0007094	; P:mitotic cell cycle spindle assembly checkpoint
GO:0043066	; P:negative regulation of apoptotic process
GO:0030889	; P:negative regulation of B cell proliferation
GO:0051402	; P:neuron apoptotic process
GO:0018105	; P:peptidyl-serine phosphorylation
GO:0043517	; P:positive regulation of DNA damage response, signal transduction by p53 class mediator
GO:0043525	; P:positive regulation of neuron apoptotic process
GO:0002331	; P:pre-B cell allelic exclusion
GO:0090399	; P:replicative senescence
GO:0001756	; P:somitogenesis
GO:0000723	; P:telomere maintenance

KEGG

InterPros

IPR016024	; ARM-type_fold.
IPR015519	; ATM/Tel1.
IPR003152	; FATC.
IPR011009	; Kinase-like_dom.
IPR000403	; PI3/4_kinase_cat_dom.
IPR018936	; PI3/4_kinase_CS.
IPR003151	; PIK-rel_kinase_FAT.
IPR014009	; PIK_FAT.
IPR021668	; TAN.

Pfam

PF02259	; FAT; 1.
PF02260	; FATC; 1.
PF00454	; PI3_PI4_kinase; 1.
PF11640	; TAN; 1.

SMARTs

SM00146

; PI3Kc; 1.

Prosites

PS51189	; FAT; 1.
PS51190	; FATC; 1.
PS00915	; PI3_4_KINASE_1; 1.
PS00916	; PI3_4_KINASE_2; 1.
PS50290	; PI3_4_KINASE_3; 1.

Prints

Created Date

20-Feb-2013