EKS-EQC-00055

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-EQC-00055

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CMGC/CDK	450.4	2.5E-135	4	286	283

Status

Unreviewed

Ensembl Protein

ENSECAP00000018603

UniProt Accession

F6US96;

Protein Name

Protein Synonyms/Alias

Gene Name

CDK2

Gene Synonyms/Alias

CDK2;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSECAG00000021177	ENSECAP00000018603	ENSECAT00000022506

Organism

Equus caballus

Functional Description

Protein Length

298

Protein Sequence
(FASTA)

MENFQKVEKI GEGTYGVVYK AKNKLTGEVV ALKKIRLDTE TEGVPSTAIR EISLLKELNH 60

PNIVKLLDVI HTENKLYLVF EFLHQDLKKF MDASALTGIP LPLIKSYLFQ LLQGLAFCHS 120

HRVLHRDLKP QNLLINAEGA IKLADFGLAR AFGVPVRTYT HEVVTLWYRA PEILLGCKYY 180

STAVDIWSLG CIFAEMVTRR ALFPGDSEID QLFRIFRTLG TPDDSVWPGV TSMPDYKPSF 240

PKWARQDFSK VVPPLDEDGR SLLSQMLHYD PNKRISAKAA LTHPFFQDVT KPVPHLRL 298

Nucleotide Sequence
(FASTA)

ATGGAGAACT TCCAAAAAGT GGAAAAGATC GGAGAGGGCA CGTACGGAGT TGTGTACAAA 60

GCCAAAAACA AGTTGACGGG AGAAGTGGTC GCGCTTAAAA AAATCCGCCT GGACACTGAG 120

ACGGAGGGTG TACCCAGTAC TGCCATCCGG GAGATCTCTC TGCTTAAGGA GCTTAACCAC 180

CCTAATATTG TCAAGCTGCT GGATGTCATC CACACAGAAA ACAAACTCTA CCTGGTTTTT 240

GAGTTTCTGC ACCAGGATCT CAAGAAATTC ATGGATGCCT CTGCTCTCAC TGGCATTCCT 300

CTTCCCCTCA TCAAGAGCTA TCTGTTCCAG CTGCTCCAGG GCCTAGCTTT CTGCCATTCT 360

CATCGGGTCC TGCACCGAGA CCTCAAACCT CAGAATCTGC TTATCAACGC AGAGGGGGCC 420

ATCAAGCTAG CAGACTTTGG ACTAGCCAGA GCCTTTGGAG TCCCTGTTCG TACTTATACT 480

CATGAGGTGG TGACCCTGTG GTACCGAGCA CCTGAAATCC TTTTGGGTTG CAAATACTAC 540

TCCACAGCTG TGGACATCTG GAGCCTGGGC TGCATCTTTG CTGAGATGGT GACCCGGCGG 600

GCCCTATTCC CTGGAGATTC TGAGATTGAC CAACTCTTCC GGATCTTTCG AACTCTGGGG 660

ACCCCAGATG ACTCGGTTTG GCCAGGAGTT ACTTCCATGC CTGATTATAA GCCAAGTTTC 720

CCCAAGTGGG CCCGGCAAGA TTTTAGCAAA GTTGTGCCTC CCCTGGATGA AGATGGACGG 780

AGCTTGTTAT CGCAAATGCT GCACTACGAC CCCAACAAGC GGATTTCGGC AAAGGCAGCT 840

CTGACTCACC CTTTCTTCCA GGATGTGACC AAGCCAGTAC CCCACCTTCG ACTCTGA 897

Domain Profile

S: 1     yeklekigeGtygkvykakdketgevvAlKkirlekekegvpitalrEisllkelkhkni  60

         ++k+ekigeGtyg+vykak+k tgevvAlKkirl++e+egvp+ta+rEisllkel+h+ni

Q: 4     FQKVEKIGEGTYGVVYKAKNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPNI  63

         89**********************************************************

S: 61    vkLlevvakdkkklyLvfefleqdLkkllkkkkkkklsleevkslllqlleglaylHsnk  120

         vkLl+v++ +++klyLvfefl+qdLkk++++++ ++++l  +ks+l+qll+gla++Hs++

Q: 64    VKLLDVIH-TENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSHR  122

         ********.99*************************************************

S: 121   ilHRDlKpqNlLiskegklklaDfGlarafssplktytkevvTlwYraPelLlgakeYst  180

         +lHRDlKpqNlLi++eg +klaDfGlaraf++p++tyt+evvTlwYraPe+Llg+k+Yst

Q: 123   VLHRDLKPQNLLINAEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYYST  182

         ************************************************************

S: 181   avDiWsvgcilaelltrkplfqgkseidqlerifkllgtpsekvwpevsklpeykksfpk  240

         avDiWs+gci+ae++tr++lf+g+seidql+rif++lgtp+++vwp+v+++p+yk sfpk

Q: 183   AVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDDSVWPGVTSMPDYKPSFPK  242

         ************************************************************

S: 241   kkkkklkekvkklkekaldllekllaldpkkRisakealqhkyf  284

         +++++++++v+ l+e++++ll+++l++dp+kRisak+al+h++f

Q: 243   WARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALTHPFF  286

         ******************************************98

Domain Sequence
(FASTA)

FQKVEKIGEG TYGVVYKAKN KLTGEVVALK KIRLDTETEG VPSTAIREIS LLKELNHPNI 60

VKLLDVIHTE NKLYLVFEFL HQDLKKFMDA SALTGIPLPL IKSYLFQLLQ GLAFCHSHRV 120

LHRDLKPQNL LINAEGAIKL ADFGLARAFG VPVRTYTHEV VTLWYRAPEI LLGCKYYSTA 180

VDIWSLGCIF AEMVTRRALF PGDSEIDQLF RIFRTLGTPD DSVWPGVTSM PDYKPSFPKW 240

ARQDFSKVVP PLDEDGRSLL SQMLHYDPNK RISAKAALTH PFF 283

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Erinaceus europaeus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tupaia belangeri"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>Schizosaccharomyces pombe"; ?>

Gene Ontology

GO:0015030	; C:Cajal body
GO:0000781	; C:chromosome, telomeric region
GO:0000793	; C:condensed chromosome
GO:0000307	; C:cyclin-dependent protein kinase holoenzyme complex
GO:0005768	; C:endosome
GO:0005667	; C:transcription factor complex
GO:0000805	; C:X chromosome
GO:0000806	; C:Y chromosome
GO:0005524	; F:ATP binding
GO:0004693	; F:cyclin-dependent protein kinase activity
GO:0035173	; F:histone kinase activity
GO:0032298	; P:positive regulation of DNA-dependent DNA replication initiation
GO:0045893	; P:positive regulation of transcription, DNA-dependent
GO:0006813	; P:potassium ion transport
GO:0007265	; P:Ras protein signal transduction
GO:0060968	; P:regulation of gene silencing

KEGG

ecb:100051790

;

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013