EKS-EQC-00064

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-EQC-00064

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CMGC/CDK	372.0	2.0E-111	478	771	294

Status

Unreviewed

Ensembl Protein

ENSECAP00000019089

UniProt Accession

F6XVV6;

Protein Name

Protein Synonyms/Alias

Gene Name

CDK12

Gene Synonyms/Alias

CDK12;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSECAG00000021449	ENSECAP00000019089	ENSECAT00000023062

Organism

Equus caballus

Functional Description

Protein Length

1240

Protein Sequence
(FASTA)

PRSHTSSNYD SYKKSPGSTS RRQSISPPYK EPSAYQSSTR SPSPYGRRQR SVSPYSRRRS 60

SSYERSGSYS GRSPSPYGRR RSSSPFMTKR SLSRSPLPSR KSMKSRSRSP AYSRHSSSHS 120

KKKRSGSRSR HSSISPVRLP LNSSLGAELS RKKKERAAAA AAAKMDGKES KGSPTFLPRK 180

ENSSVESKDS GLESKKLPRG VKVEKSAPDT ELVNVTHLNT EVKNSLDTGK VKLDENSEKH 240

PVLKDSKAQG TRDSKLVALK EEIVTPKETE TSEKETPPPL PTVISPPPPL PTTTPPPQTP 300

PLPPLPPLPA IPQQPPLPPP QPAFSQVLAS SSSTLAPSTH PRTSAVSSQA NSQPPVQVSV 360

KTQVSLTAAI PHLKTSTLPP LPLPPLLPGD DDMDSPKETL PSKPVKKEKE QRPRHLLTDL 420

PLPPELPGGD PSPPDSPEPK AITPPQQPYK KRPKICCPRY GERRQTESDW GKRCVDKFDI 480

IGIIGEGTYG QVYKAKDKDT GELVALKKVR LDNEKEGFPI TAIREIKILR QLIHRSVVNM 540

KEIVTDKQDA LDFKKDKGAF YLVFEYMDHD LMGLLESGLV HFSEDHIKSF MKQLMEGLDY 600

CHKKNFLHRD IKCSNILLNN SGQIKLADFG LARLYNSEES RPYTNKVITL WYRPPELLLG 660

EERYTPAIDV WSCGCILGEL FTKKPIFQAN LELAQLELIS RLCGSPCPAV WPDVIKLPYF 720

NTMKPKKQYR RRLREEFSFI PSAALDLLDH MLTLDPSKRC TAEQTLQSDF LKDVELSKMD 780

PPDLPHWQDC HELWSKKRRR QRQSGVVVEE PPPSKASRKE TTSGTSAEPV KNSSPAPPQP 840

APGKVEPGAG DAIGLGDITQ QLNQSELAVL LNLLQSQTDL SIPQMAQLLN IHSNPEMQQQ 900

LEALNQSISA LTEATSQQQN SEPVAPEESL KEAPPAPVVQ PSAEQTTPET SSTPADMQNM 960

LAVLLSQLMK TQEPSGNLEE NNSDKNSGSQ GPRRTPTMPQ EEAAACPPHI LPPEKRPPEP 1020

PGPPPPPPPP PLVEGDLSSA PQELNPAVTA ALLQLLTQPE AEPSGHLPHE HQALRSMEYS 1080

TRPHPNRTYG NTDGPETGFS ATDTDERNSG PALTESLAQT LVKNRTFSGS VSHLGESSSY 1140

QGTGSVQFPG DQDLRFARVP LALPSVVGQP FLKAEGSSNS VVHAETKLQN YGELGPGPTG 1200

ASSSGAGLNW GAPAQSSYGK LYRGPTRVPP RGGRGRGVPY 1240

Nucleotide Sequence
(FASTA)

CCGAGATCTC ACACCTCTAG CAATTATGAC TCCTACAAGA AGAGTCCTGG AAGTACCTCA 60

AGGAGGCAGT CCATCAGCCC ACCTTACAAG GAGCCTTCGG CGTACCAGTC CAGCACCCGG 120

TCCCCCAGTC CCTACGGTAG GCGACAGAGG TCTGTGAGTC CTTACAGCCG GAGACGTTCG 180

TCCAGCTATG AAAGGAGCGG CTCGTACAGC GGGAGATCCC CCAGTCCCTA CGGTCGAAGG 240

CGCTCCAGCA GCCCTTTCAT GACCAAACGG TCTCTGAGTC GGAGCCCGCT CCCCAGTAGG 300

AAATCTATGA AGTCTAGAAG TAGAAGTCCC GCATATTCAA GACACTCATC TTCTCATAGT 360

AAAAAGAAGA GATCCGGGTC ACGCAGTCGA CATTCCAGTA TCTCACCTGT CAGGCTTCCA 420

TTGAACTCCA GCTTGGGAGC TGAACTCAGT AGGAAAAAGA AGGAAAGAGC AGCTGCTGCT 480

GCAGCAGCAA AAATGGATGG AAAGGAATCC AAGGGTTCAC CTACATTTTT GCCTAGAAAA 540

GAGAACAGTT CAGTAGAGTC TAAGGATTCA GGCTTGGAAT CTAAAAAGTT ACCCAGAGGT 600

GTAAAAGTGG AAAAATCTGC CCCAGATACT GAACTGGTGA ATGTAACACA TCTAAACACA 660

GAGGTCAAAA ATTCTTTAGA TACAGGGAAA GTAAAGTTGG ATGAGAACTC TGAGAAGCAT 720

CCTGTTCTTA AAGATTCGAA AGCACAGGGA ACAAGAGACT CTAAACTCGT AGCATTGAAA 780

GAGGAGATTG TTACTCCGAA AGAGACAGAG ACATCAGAAA AGGAGACCCC TCCACCTCTC 840

CCCACAGTTA TTTCTCCTCC ACCTCCTTTA CCAACTACTA CCCCTCCACC TCAGACACCC 900

CCTTTGCCAC CTTTGCCACC ACTACCAGCT ATTCCACAGC AACCACCTCT GCCTCCTCCC 960

CAGCCAGCAT TTAGTCAGGT TCTTGCTTCT AGTAGTTCAA CTTTGGCTCC TTCTACTCAC 1020

CCAAGGACAT CTGCTGTGTC CTCTCAGGCA AATTCTCAGC CCCCTGTACA GGTTTCTGTG 1080

AAGACTCAAG TATCTTTAAC AGCTGCTATT CCACACTTAA AAACTTCAAC GTTGCCTCCT 1140

CTGCCCCTCC CACCCTTATT ACCGGGAGAT GATGACATGG ATAGTCCAAA AGAAACTCTA 1200

CCTTCAAAAC CTGTGAAGAA AGAGAAGGAA CAAAGGCCAC GTCACTTACT CACGGACCTC 1260

CCTCTCCCTC CAGAGCTCCC TGGTGGGGAT CCATCTCCCC CAGACTCTCC AGAACCAAAG 1320

GCAATCACAC CACCTCAGCA ACCATATAAA AAGAGACCAA AAATTTGTTG TCCTCGTTAT 1380

GGAGAAAGAA GACAAACAGA AAGCGACTGG GGGAAACGCT GTGTGGACAA ATTTGACATT 1440

ATTGGGATTA TTGGAGAGGG AACCTATGGC CAAGTATATA AAGCCAAGGA CAAAGATACA 1500

GGAGAGCTGG TGGCCCTGAA GAAGGTGAGG CTAGACAATG AGAAAGAGGG CTTCCCAATC 1560

ACAGCCATTC GTGAAATCAA AATCCTTCGT CAGCTAATCC ACCGAAGTGT TGTTAACATG 1620

AAGGAAATTG TCACAGATAA ACAAGATGCA CTGGATTTCA AGAAGGACAA AGGTGCCTTT 1680

TACCTTGTAT TTGAGTATAT GGACCACGAT TTAATGGGAC TGCTAGAATC TGGTTTGGTG 1740

CACTTTTCTG AGGACCATAT CAAGTCATTC ATGAAACAGC TAATGGAAGG ATTGGATTAT 1800

TGTCACAAAA AGAATTTCCT GCATCGGGAT ATTAAGTGTT CTAACATTTT GCTGAATAAC 1860

AGTGGGCAAA TCAAGCTGGC AGATTTTGGA CTTGCTCGGC TCTATAACTC TGAAGAGAGT 1920

CGCCCTTATA CAAACAAAGT CATTACTCTT TGGTACCGAC CTCCAGAACT TCTGCTGGGA 1980

GAGGAGCGTT ATACACCAGC CATAGATGTT TGGAGCTGTG GATGCATCCT TGGGGAACTG 2040

TTCACAAAGA AGCCTATTTT TCAAGCCAAT CTGGAACTGG CTCAGCTAGA ACTGATCAGT 2100

CGACTCTGTG GTAGCCCTTG TCCAGCTGTG TGGCCTGATG TTATCAAGCT GCCCTACTTC 2160

AATACCATGA AACCGAAGAA GCAATATAGA AGGCGTCTGC GAGAAGAATT CTCTTTCATT 2220

CCTTCAGCAG CACTTGATTT ACTGGACCAC ATGCTGACAC TAGATCCTAG CAAACGTTGC 2280

ACAGCTGAAC AGACCCTACA GAGTGACTTC CTTAAAGATG TCGAGCTCAG CAAAATGGAT 2340

CCTCCAGACC TCCCGCACTG GCAGGATTGC CATGAATTAT GGAGTAAGAA ACGGCGACGG 2400

CAGCGACAAA GTGGTGTTGT AGTGGAAGAG CCACCTCCAT CCAAAGCCTC TCGAAAAGAG 2460

ACAACCTCAG GGACAAGTGC TGAGCCTGTG AAGAACAGCA GCCCAGCACC ACCTCAGCCT 2520

GCTCCTGGCA AGGTGGAGCC TGGGGCTGGG GATGCAATAG GCCTTGGTGA CATCACACAG 2580

CAGTTGAATC AAAGTGAATT GGCAGTGTTA TTGAACCTGC TGCAGAGCCA AACTGACCTG 2640

AGCATCCCTC AAATGGCACA GCTGCTTAAT ATCCACTCCA ACCCAGAGAT GCAGCAGCAG 2700

CTGGAGGCCT TGAACCAATC CATCAGTGCC CTAACAGAAG CCACTTCTCA GCAGCAGAAC 2760

TCAGAGCCTG TGGCCCCAGA GGAATCTTTG AAGGAGGCAC CCCCTGCCCC GGTGGTCCAG 2820

CCTTCAGCAG AACAGACGAC CCCTGAAACT TCAAGCACAC CAGCTGACAT GCAGAATATG 2880

TTGGCAGTTC TCTTGAGTCA GCTGATGAAA ACCCAGGAGC CATCAGGCAA CCTGGAGGAA 2940

AACAACAGTG ACAAGAACAG TGGGTCACAG GGGCCCCGAA GAACTCCCAC AATGCCACAG 3000

GAGGAGGCAG CAGCGTGTCC TCCTCACATT CTTCCACCAG AGAAGAGGCC CCCTGAGCCC 3060

CCCGGACCTC CACCGCCGCC ACCTCCACCC CCTCTGGTTG AAGGCGATCT TTCCAGCGCC 3120

CCCCAGGAGT TGAACCCAGC CGTGACAGCC GCCTTGCTGC AACTTTTAAC CCAGCCTGAA 3180

GCAGAGCCTT CTGGCCACCT GCCACATGAG CACCAGGCCT TGAGATCAAT GGAATACTCC 3240

ACCCGACCCC ATCCCAACAG GACTTATGGA AACACTGATG GGCCTGAAAC AGGGTTCAGT 3300

GCCACTGACA CTGACGAACG CAACTCTGGT CCAGCCTTGA CAGAATCCTT GGCCCAGACC 3360

CTGGTGAAGA ACAGGACCTT CTCAGGCTCT GTGAGCCACC TTGGGGAGTC CAGCAGTTAC 3420

CAGGGCACAG GGTCAGTGCA GTTCCCAGGG GACCAGGACC TCCGTTTTGC CAGGGTCCCC 3480

TTAGCATTAC CCTCAGTGGT CGGGCAACCA TTCCTGAAGG CTGAGGGAAG CAGCAACTCT 3540

GTGGTACATG CAGAGACCAA ATTGCAAAAC TATGGGGAAC TGGGGCCAGG ACCTACTGGG 3600

GCCAGCAGCT CAGGAGCAGG CCTTAACTGG GGGGCCCCAG CTCAGTCTTC TTACGGAAAA 3660

CTCTATCGGG GGCCTACAAG AGTCCCGCCA AGAGGGGGAA GAGGGAGAGG AGTTCCTTAC 3720

TAG 3723

Domain Profile

S: 1     yeklekigeGtygkvykakdketgevvAlKkirlekekegvpitalrEisllkelkhkni  60

         ++ +  igeGtyg+vykakdk+tge+vAlKk+rl++ekeg+pita+rEi++l++l h+ +

Q: 478   FDIIGIIGEGTYGQVYKAKDKDTGELVALKKVRLDNEKEGFPITAIREIKILRQLIHRSV  537

         667889******************************************************

S: 61    vkLlevva.........kdkkklyLvfefleqdLkkllkkkkkkklsleevkslllqlle  111

         v+++e+v+         kdk  +yLvfe++++dL+ ll++    ++s++++ks+++ql+e

Q: 538   VNMKEIVTdkqdaldfkKDKGAFYLVFEYMDHDLMGLLESGLV-HFSEDHIKSFMKQLME  596

         ****************8899********************999.****************

S: 112   glaylHsnkilHRDlKpqNlLiskegklklaDfGlarafssplk.tytkevvTlwYraPe  170

         gl+y+H++++lHRD+K++N+L++++g++klaDfGlar ++s+++  yt++v+TlwYr+Pe

Q: 597   GLDYCHKKNFLHRDIKCSNILLNNSGQIKLADFGLARLYNSEESrPYTNKVITLWYRPPE  656

         ***************************************7766527**************

S: 171   lLlgakeYstavDiWsvgcilaelltrkplfqgkseidqlerifkllgtpsekvwpevsk  230

         lLlg+++Y+ a+D+Ws+gcil el+t+kp+fq++ e  qle i++l+g+p  +vwp+v k

Q: 657   LLLGEERYTPAIDVWSCGCILGELFTKKPIFQANLELAQLELISRLCGSPCPAVWPDVIK  716

         ************************************************************

S: 231   lpeykksfpkkkkk.klkekvkklkekaldllekllaldpkkRisakealqhkyf  284

         lp +++  pkk+++ +l+e+++ + ++aldll+++l+ldp+kR++a+++lq++++

Q: 717   LPYFNTMKPKKQYRrRLREEFSFIPSAALDLLDHMLTLDPSKRCTAEQTLQSDFL  771

         *****7777777777******9999**************************9985

Domain Sequence
(FASTA)

FDIIGIIGEG TYGQVYKAKD KDTGELVALK KVRLDNEKEG FPITAIREIK ILRQLIHRSV 60

VNMKEIVTDK QDALDFKKDK GAFYLVFEYM DHDLMGLLES GLVHFSEDHI KSFMKQLMEG 120

LDYCHKKNFL HRDIKCSNIL LNNSGQIKLA DFGLARLYNS EESRPYTNKV ITLWYRPPEL 180

LLGEERYTPA IDVWSCGCIL GELFTKKPIF QANLELAQLE LISRLCGSPC PAVWPDVIKL 240

PYFNTMKPKK QYRRRLREEF SFIPSAALDL LDHMLTLDPS KRCTAEQTLQ SDFL 294

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>Saccharomyces cerevisiae"; ?>Schizosaccharomyces pombe"; ?>

Gene Ontology

GO:0016607	; C:nuclear speck
GO:0005730	; C:nucleolus
GO:0005524	; F:ATP binding
GO:0008353	; F:RNA polymerase II carboxy-terminal domain kinase activity
GO:0070816	; P:phosphorylation of RNA polymerase II C-terminal domain
GO:0046777	; P:protein autophosphorylation
GO:0043405	; P:regulation of MAP kinase activity

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013