EKS-EQC-00379

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-EQC-00379

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
STE/STE11	365.2	2.6E-109	365	624	260

Status

Unreviewed

Ensembl Protein

ENSECAP00000019177

UniProt Accession

F6YY53;

Protein Name

Protein Synonyms/Alias

Gene Name

MAP3K2

Gene Synonyms/Alias

MAP3K2;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSECAG00000021505	ENSECAP00000019177	ENSECAT00000023172

Organism

Equus caballus

Functional Description

Protein Length

629

Protein Sequence
(FASTA)

MDDQQALNSI MQDLAVLHKA SRPALSLQET RKTKSSSPKK QNDVRVKFEH RGEKRILQFP 60

RPVKLEDLRS KAKIAFGQSM DLHYTNNELV IPLTTQDDLD KAVELLDRSI HMKSLKILLV 120

INGSTQGRST AQLCVSSSIS LRCSSATEKS QLICEPPKTL SYFMTTSFQV RDRSSPPPGY 180

IPDELHQVAR NGSFTSINSE GEFIPESMDQ VCMLDPLSLS SPENSGSGSC PSLDSPLDGE 240

SYPKSRMPRA QSYPDNHQEF SDYDNPIFEK FGKGGTYPRR YHVSYHHQDY NDGRKTFPRA 300

RRTQGTSFRF SPTDHSLSTS SGSSIFTPEY DDTRIRRRGS DIDNPTLTVM DISPPSRSPR 360

APTNWRLGKL LGQGAFGRVY LCYDVDTGRE LAVKQVQFDP DSPETSKEVN ALECEIQLLK 420

NLLHERIVQY YGCLRDPQEK TLSIFMEYMP GGSIKDQLKA YGALTENVTR KYTRQILEGV 480

HYLHSNMIVH RDIKGANILR DSTGNVKLGD FGASKRLQTI CLSGTGMKSV TGTPYWMSPE 540

VISGEGYGRK ADVWSVGCTV VEMLTEKPPW AEFEAMAAIF KIATQPTNPK LPPHVSDYTR 600

DFLKRIFVEA KLRPSADELL RHMFKKMMY 629

Nucleotide Sequence
(FASTA)

ATGGATGATC AGCAAGCTTT GAACTCAATC ATGCAAGATT TGGCTGTTCT TCATAAGGCC 60

AGTCGACCAG CATTATCGTT ACAGGAAACC AGAAAAACAA AATCTTCATC ACCAAAAAAG 120

CAGAATGATG TCCGAGTCAA ATTTGAACAT AGAGGAGAAA AAAGAATCCT TCAGTTCCCC 180

AGACCAGTTA AACTGGAAGA TCTGAGGTCT AAAGCTAAAA TTGCCTTTGG ACAGTCTATG 240

GATCTCCATT ATACCAATAA CGAGTTGGTA ATCCCATTAA CTACCCAAGA TGACTTGGAC 300

AAAGCTGTGG AACTGCTGGA TCGTAGTATT CATATGAAGA GCCTCAAGAT ATTACTTGTA 360

ATAAATGGAA GTACACAGGG GCGCTCTACT GCCCAGTTGT GTGTATCTTC TTCAATTTCA 420

TTACGTTGCT CAAGCGCCAC TGAAAAGAGC CAATTGATCT GTGAACCACC AAAAACTCTA 480

AGCTATTTTA TGACTACTTC CTTCCAAGTT AGAGATAGAA GCTCCCCTCC CCCAGGATAC 540

ATTCCGGATG AATTACACCA GGTTGCCCGG AATGGGTCAT TCACCAGTAT CAACAGTGAA 600

GGAGAGTTCA TCCCAGAGAG CATGGACCAA GTGTGTATGT TGGACCCATT ATCTTTAAGC 660

AGCCCTGAAA ATTCTGGCTC AGGAAGTTGT CCATCACTTG ATAGTCCTTT GGATGGAGAG 720

AGCTATCCGA AATCACGAAT GCCTAGGGCA CAGAGCTACC CAGATAATCA TCAGGAATTT 780

TCAGACTATG ATAACCCTAT CTTTGAGAAA TTTGGAAAAG GAGGAACATA TCCACGAAGG 840

TATCATGTTT CATATCACCA TCAAGACTAT AATGATGGTC GTAAAACTTT TCCAAGAGCT 900

AGAAGAACCC AGGGGACCAG CTTCCGTTTC AGTCCTACTG ATCACTCCTT AAGCACTAGT 960

AGTGGGAGCA GCATCTTTAC CCCAGAGTAT GATGACACTC GAATAAGAAG AAGGGGAAGT 1020

GACATAGACA ACCCTACTTT GACTGTAATG GACATCAGCC CGCCCAGCCG CTCACCTCGT 1080

GCTCCAACCA ACTGGAGATT GGGCAAACTG CTTGGCCAGG GAGCCTTTGG CAGGGTCTAC 1140

CTCTGTTATG ATGTCGATAC AGGAAGAGAA TTGGCTGTTA AGCAAGTTCA ATTTGACCCT 1200

GATAGTCCTG AGACCAGCAA GGAAGTAAAT GCACTTGAGT GTGAAATTCA GTTGTTGAAA 1260

AACTTGCTGC ATGAACGAAT TGTTCAGTAT TATGGCTGTT TGAGGGATCC CCAGGAAAAA 1320

ACACTTTCCA TATTTATGGA GTATATGCCA GGGGGTTCAA TTAAGGACCA ATTAAAAGCA 1380

TATGGAGCTC TTACTGAGAA TGTGACTAGG AAATACACTC GTCAGATTCT GGAGGGTGTC 1440

CATTATTTGC ACAGTAATAT GATTGTTCAT AGAGATATCA AAGGCGCAAA TATTCTGCGA 1500

GATTCAACAG GCAATGTCAA ACTAGGAGAT TTTGGGGCCA GCAAACGGCT TCAAACCATC 1560

TGTCTTTCGG GGACAGGAAT GAAGTCTGTC ACAGGCACAC CATACTGGAT GAGCCCTGAA 1620

GTGATTAGTG GGGAAGGCTA TGGCCGAAAA GCAGATGTCT GGAGTGTGGG CTGTACTGTG 1680

GTAGAAATGC TAACTGAAAA GCCTCCTTGG GCAGAATTTG AAGCAATGGC TGCAATCTTT 1740

AAAATTGCCA CTCAGCCAAC AAATCCAAAG CTGCCACCTC ATGTCTCAGA CTACACTCGA 1800

GATTTCCTCA AACGGATCTT TGTAGAGGCC AAACTGAGGC CTTCAGCTGA TGAACTCCTA 1860

CGGCACATGT TTAAGAAAAT GATGTAT 1887

Domain Profile

S: 1     wqkrevigkGsfgsvyaaldvdtgellavKeveikpekksekkevkalkeEikllkelkH  60

         w+ ++++g+G+fg+vy+++dvdtg+ lavK+v+++p++ +++kev+al++Ei+llk+l H

Q: 365   WRLGKLLGQGAFGRVYLCYDVDTGRELAVKQVQFDPDSPETSKEVNALECEIQLLKNLLH  424

         78899*******************************************************

S: 61    enivkyyGv..eveeeelkiflEyvegGslssllekygkleesvikkytkqileglayLH  118

         e+iv+yyG+  + +e++l+if+Ey++gGs++++l++yg+l+e+v++kyt+qileg++yLH

Q: 425   ERIVQYYGClrDPQEKTLSIFMEYMPGGSIKDQLKAYGALTENVTRKYTRQILEGVHYLH  484

         *********777899*********************************************

S: 119   ekkivHRDiKgaNilldssgvvklsDFGaskrlaelntkaaelesltGtlaymaPEvikk  178

         +++ivHRDiKgaNil ds+g+vkl+DFGaskrl++++ + + ++s+tGt+++m+PEvi++

Q: 485   SNMIVHRDIKGANILRDSTGNVKLGDFGASKRLQTICLSGTGMKSVTGTPYWMSPEVISG  544

         **********************************************************99

S: 179   kekgygrkaDiWslgcvviemltgkrPfaeldeelaimfkvgakktkPeipeklseegkd  238

         +  gygrkaD+Ws+gc+v+emlt+k+P+ae+ e++a++fk++++ t+P++p ++s+ ++d

Q: 545   E--GYGRKADVWSVGCTVVEMLTEKPPWAEF-EAMAAIFKIATQPTNPKLPPHVSDYTRD  601

         8..****************************.9***************************

S: 239   flekcleldpkkrpsaeeLLkhef  262

         fl++++ +++k rpsa+eLL+h+f

Q: 602   FLKRIF-VEAKLRPSADELLRHMF  624

         ******.899************98

Domain Sequence
(FASTA)

WRLGKLLGQG AFGRVYLCYD VDTGRELAVK QVQFDPDSPE TSKEVNALEC EIQLLKNLLH 60

ERIVQYYGCL RDPQEKTLSI FMEYMPGGSI KDQLKAYGAL TENVTRKYTR QILEGVHYLH 120

SNMIVHRDIK GANILRDSTG NVKLGDFGAS KRLQTICLSG TGMKSVTGTP YWMSPEVISG 180

EGYGRKADVW SVGCTVVEML TEKPPWAEFE AMAAIFKIAT QPTNPKLPPH VSDYTRDFLK 240

RIFVEAKLRP SADELLRHMF 260

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Echinops telfairi"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004672	; F:protein kinase activity
GO:0071260	; P:cellular response to mechanical stimulus
GO:0045893	; P:positive regulation of transcription, DNA-dependent

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000270	; OPR_PB1.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.

Pfam

PF00564	; PB1; 1.
PF00069	; Pkinase; 1.

SMARTs

SM00666	; PB1; 1.
SM00220	; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.

Prints

Created Date

20-Feb-2013