EKS-EQC-00358

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-EQC-00358

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/Src	444.0	1.6E-133	275	524	250

Status

Unreviewed

Ensembl Protein

ENSECAP00000019686

UniProt Accession

F6YPC4;

Protein Name

Protein Synonyms/Alias

Gene Name

YES1

Gene Synonyms/Alias

YES1;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSECAG00000021666	ENSECAP00000019686	ENSECAT00000023742

Organism

Equus caballus

Functional Description

Protein Length

541

Protein Sequence
(FASTA)

MGCIKSKENK SPAIKYRPEN TPEPVSTSVS HYGAEHTAVA PSSSAKGTSV NFSNLSVTPF 60

GGSSGVTPFG GASSSFSVVP SSYPAGLTGG VTIFVALYDY EARTTEDLSF KKGERFQIIN 120

NTEGDWWEAR SIATGKNGYI PSNYVAPADS IQAEEWYFGK MGRKDAERLL LNPGNQRGIF 180

LVRESETTKG AYSLSIRDWD EVRGDNVKHY KIRKLDNGGY YITTRAQFDT LQKLVKHYTE 240

HADGLCHKLT TVCPTVKPQT QGLAKDAWEI PRESLRLEVK LGQGCFGEVW MGTWNGTTKV 300

AIKTLKPGTM MPEAFLQEAQ IMKKLRHDKL VPLYAVVSEE PIYIVTEFMS KGILLDFLKE 360

GDGKYLKLPQ LVDMAAQIAD GMAYIERMNY IHRDLRAANI LVGENLVCKI ADFGLARLIE 420

DNEYTARQGA KFPIKWTAPE AALYGRFTIK SDVWSFGILQ TELVTKGRVP YPGMVNREVL 480

EQVERGYRMP CPQGCPESLH DLMNLCWKKD PDERPTFEYI QSFLEDYFTA TEPQYQPGEN 540

L 541

Nucleotide Sequence
(FASTA)

ATGGGCTGCA TTAAAAGTAA AGAGAACAAA AGTCCAGCCA TTAAATACCG ACCGGAAAAC 60

ACTCCAGAAC CTGTCAGTAC AAGTGTCAGC CATTATGGAG CAGAACACAC TGCAGTGGCA 120

CCATCATCTT CAGCAAAGGG AACATCTGTT AATTTTAGCA ATCTTTCCGT GACGCCATTT 180

GGAGGATCCT CAGGGGTGAC ACCTTTTGGG GGAGCGTCTT CCTCATTCTC AGTGGTGCCA 240

AGTTCATATC CTGCTGGTTT AACAGGTGGC GTTACTATAT TTGTGGCCTT ATATGATTAT 300

GAAGCTAGAA CTACAGAAGA CCTTTCATTT AAGAAGGGTG AAAGATTTCA AATAATCAAC 360

AATACGGAAG GAGACTGGTG GGAAGCAAGA TCAATTGCTA CAGGAAAGAA TGGCTATATC 420

CCTAGCAATT ATGTAGCCCC TGCAGACTCC ATTCAAGCAG AAGAATGGTA TTTTGGCAAA 480

ATGGGGAGAA AAGATGCTGA AAGATTACTG CTGAATCCTG GGAATCAACG AGGTATTTTC 540

TTAGTAAGAG AAAGTGAAAC TACTAAAGGT GCTTACTCCC TCTCTATTCG TGATTGGGAT 600

GAGGTAAGGG GAGACAATGT GAAACATTAC AAAATTAGGA AACTTGACAA CGGTGGATAC 660

TATATCACAA CTAGAGCACA ATTTGATACT CTGCAGAAAC TGGTAAAACA CTACACAGAA 720

CATGCTGATG GTTTATGCCA TAAGTTAACA ACTGTGTGTC CAACTGTGAA ACCCCAGACT 780

CAAGGTCTAG CAAAAGATGC TTGGGAAATC CCTCGAGAAT CTTTGCGACT AGAGGTTAAA 840

CTGGGACAAG GATGTTTTGG TGAAGTATGG ATGGGAACAT GGAATGGAAC CACAAAAGTA 900

GCAATCAAAA CACTAAAACC AGGTACAATG ATGCCAGAAG CTTTTCTTCA AGAGGCTCAG 960

ATAATGAAAA AATTGAGACA TGATAAACTT GTTCCACTAT ATGCTGTTGT TTCTGAAGAG 1020

CCAATTTACA TTGTCACTGA ATTTATGTCA AAAGGTATCT TATTAGATTT CCTGAAGGAG 1080

GGAGATGGAA AGTATTTGAA GCTCCCACAA CTGGTTGATA TGGCTGCTCA GATTGCTGAT 1140

GGTATGGCAT ATATTGAAAG GATGAACTAT ATTCACCGAG ATCTTCGGGC TGCTAATATT 1200

CTTGTAGGAG AAAATCTTGT GTGCAAAATA GCAGATTTTG GTTTAGCAAG GTTAATTGAA 1260

GACAATGAAT ATACGGCAAG ACAAGGTGCA AAATTTCCAA TCAAATGGAC AGCCCCTGAG 1320

GCTGCACTAT ATGGTCGATT TACAATAAAG TCTGATGTAT GGTCATTTGG AATTCTTCAG 1380

ACAGAATTGG TAACAAAAGG CAGAGTGCCA TATCCAGGTA TGGTAAACCG TGAGGTGCTG 1440

GAACAGGTGG AACGAGGGTA TAGGATGCCT TGCCCTCAGG GCTGTCCAGA ATCCCTACAT 1500

GATTTGATGA ATCTTTGTTG GAAGAAGGAC CCTGATGAAA GACCAACATT TGAATATATC 1560

CAGTCCTTCT TGGAAGACTA CTTCACTGCT ACAGAGCCAC AGTACCAGCC AGGAGAAAAT 1620

TTATAA 1626

Domain Profile

S: 1     lklvkklGeGqfGevwlgkwkgsvkvavktlkegtlspeafleeaqilkklrheklvkly  60

         l+l+ klG+G+fGevw+g+w+g++kva+ktlk+gt++peafl+eaqi+kklrh+klv ly

Q: 275   LRLEVKLGQGCFGEVWMGTWNGTTKVAIKTLKPGTMMPEAFLQEAQIMKKLRHDKLVPLY  334

         68999*******************************************************

S: 61    avvseeePiyivtelmakGslldflkeeegkklklpklvdlaaqvaeGmayleeknlihr  120

         avvse ePiyivte+m+kG lldflke +gk+lklp+lvd+aaq+a+Gmay+e++n+ihr

Q: 335   AVVSE-EPIYIVTEFMSKGILLDFLKEGDGKYLKLPQLVDMAAQIADGMAYIERMNYIHR  393

         ****9.******************************************************

S: 121   dlaarnvlvgeslvvkvadfGlarlieddeytakegaklPikWtaPeaiklgkftiksdv  180

         dl+a+n+lvge+lv+k+adfGlarlied+eyta++gak+PikWtaPea+ +g+ftiksdv

Q: 394   DLRAANILVGENLVCKIADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDV  453

         ************************************************************

S: 181   WsfGillteivtkGkvPypGmtneevleqvergyrlprpeecpeelyelllecwkkdpee  240

         WsfGil te+vtkG+vPypGm n+evleqvergyr+p+p+ cpe+l++l++ cwkkdp+e

Q: 454   WSFGILQTELVTKGRVPYPGMVNREVLEQVERGYRMPCPQGCPESLHDLMNLCWKKDPDE  513

         ************************************************************

S: 241   rPtfetlqevl  251

         rPtfe++q++l

Q: 514   RPTFEYIQSFL  524

         *******9986

Domain Sequence
(FASTA)

LRLEVKLGQG CFGEVWMGTW NGTTKVAIKT LKPGTMMPEA FLQEAQIMKK LRHDKLVPLY 60

AVVSEEPIYI VTEFMSKGIL LDFLKEGDGK YLKLPQLVDM AAQIADGMAY IERMNYIHRD 120

LRAANILVGE NLVCKIADFG LARLIEDNEY TARQGAKFPI KWTAPEAALY GRFTIKSDVW 180

SFGILQTELV TKGRVPYPGM VNREVLEQVE RGYRMPCPQG CPESLHDLMN LCWKKDPDER 240

PTFEYIQSFL 250

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; SH3 domain; Transferase; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Homo sapiens"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Rattus norvegicus"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tupaia belangeri"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005794	; C:Golgi apparatus
GO:0005886	; C:plasma membrane
GO:0005524	; F:ATP binding
GO:0004713	; F:protein tyrosine kinase activity
GO:0015758	; P:glucose transport

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR000980	; SH2.
IPR001452	; SH3_domain.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.

Pfam

PF07714	; Pkinase_Tyr; 1.
PF00017	; SH2; 1.
PF00018	; SH3_1; 1.

SMARTs

SM00252	; SH2; 1.
SM00326	; SH3; 1.
SM00219	; TyrKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.
PS50001	; SH2; 1.
PS50002	; SH3; 1.

Prints

PR00401	; SH2DOMAIN.
PR00452	; SH3DOMAIN.
PR00109	; TYRKINASE.

Created Date

20-Feb-2013