EKS-EQC-00234

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-EQC-00234

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CAMK/CAMKL	387.0	3.7E-116	25	276	252

Status

Unreviewed

Ensembl Protein

ENSECAP00000019672

UniProt Accession

F6YPV5;

Protein Name

Protein Synonyms/Alias

Gene Name

MARK2

Gene Synonyms/Alias

MARK2;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSECAG00000021754	ENSECAP00000019672	ENSECAT00000023728

Organism

Equus caballus

Functional Description

Protein Length

761

Protein Sequence
(FASTA)

SSKSNMLRGR NSATSADEQP HIGNYRLLKT IGKGNFAKVK LARHILTGKE VAVKIIDKTQ 60

LNSSSLQKLF REVRIMKVLN HPNIVKLFEV IETEKTLYLV MEYASGGEVF DYLVAHGRMK 120

EKEARAKFRQ IVSAVQYCHQ KFIVHRDLKA ENLLLDADMN IKIADFGFSN EFTFGNKLDT 180

FCGSPPYAAP ELFQGKKYDG PEVDVWSLGV ILYTLVSGSL PFDGQNLKEL RERVLRGKYR 240

IPFYMSTDCE NLLKKFLILN PSKRGTLEQI MKDRWMNVGH EDDELKPYVE PLPDYKDPRR 300

TELMVSMGYT REEIQDSLVG QRYNEVMATY LLLGYKSSEL EGDTITLKPR PPADLTNSSA 360

PSPSHKVQRS VSANPKQRRF SDQAGPAIPT SNSYSKKTQS NNAENKRPEE DRESGRKASS 420

TAKVPASPLP GLERKKTTPT PSTNSVLSTS TNRSRNSPLL ERASLGQASI QNGKDSLTMP 480

GSRASTASAS AAVSAARPRQ HQKSMSASVH PNKATGLPPT DSNCEVPRPR QVTAPQRVPV 540

ASPSAHNISS SGGAPDRTNF PRGVSSRSTF HAGQLRQVRD QQNLPYGVTP ASPSGNSQGR 600

RGASGSIFSK FTSKFVRRNL SFRFARRNLN EPESKDRVET LRPHVVGSGG NDKEKEEFRE 660

AKPRSLRFTW SMKTTSSMEP NEMMREIRKV LDANSCQSEL HEKYMLLCMH GTPGHENFVQ 720

WEMEVCKLPR LSLNGVRFKR ISGTSMAFKN IASKIANELK L 761

Nucleotide Sequence
(FASTA)

AGCAGTAAGT CCAACATGCT GCGGGGCCGC AACTCAGCCA CCTCTGCTGA CGAGCAGCCC 60

CATATTGGCA ACTATCGACT CCTCAAGACC ATTGGCAAGG GTAACTTCGC TAAGGTGAAG 120

CTGGCTCGGC ACATCCTAAC TGGGAAAGAG GTAGCTGTGA AGATCATTGA CAAGACTCAG 180

TTGAACTCCT CCAGCCTCCA GAAACTCTTC CGGGAAGTAA GAATAATGAA GGTTTTGAAT 240

CACCCCAACA TAGTTAAATT ATTTGAAGTG ATCGAAACTG AAAAAACTCT CTACCTTGTC 300

ATGGAGTACG CCAGTGGAGG AGAGGTGTTT GACTACCTAG TGGCTCATGG CAGGATGAAA 360

GAAAAAGAGG CTCGAGCCAA ATTCCGCCAG ATAGTGTCTG CTGTGCAGTA CTGTCACCAG 420

AAGTTTATTG TTCATAGAGA CCTAAAGGCA GAAAACCTGC TTTTGGATGC TGATATGAAC 480

ATCAAGATTG CAGACTTTGG CTTCAGCAAC GAGTTCACCT TTGGGAACAA GCTGGACACC 540

TTCTGTGGCA GCCCTCCTTA TGCCGCCCCG GAGCTCTTCC AGGGCAAAAA GTACGATGGC 600

CCCGAGGTGG ACGTGTGGAG CCTGGGTGTT ATCCTGTATA CACTGGTCAG CGGATCCCTG 660

CCTTTTGACG GACAGAACCT CAAGGAGCTG CGGGAGCGGG TACTGAGGGG AAAATACCGT 720

ATTCCGTTCT ACATGTCCAC GGACTGTGAA AACCTGCTTA AGAAATTTCT CATTCTCAAT 780

CCCAGCAAGA GAGGCACTTT AGAGCAAATC ATGAAAGATC GATGGATGAA CGTGGGTCAC 840

GAAGATGATG AATTAAAGCC TTATGTGGAG CCACTCCCTG ACTACAAGGA CCCCCGGCGG 900

ACAGAGTTGA TGGTGTCCAT GGGTTACACA CGGGAAGAGA TCCAGGACTC GCTGGTGGGC 960

CAGAGGTACA ACGAGGTGAT GGCCACCTAT CTGCTCCTGG GCTACAAGAG CTCCGAGCTG 1020

GAGGGCGACA CCATCACCTT GAAGCCCCGG CCTCCAGCTG ATCTGACCAA TAGCAGCGCC 1080

CCTTCCCCCT CCCACAAGGT ACAGCGCAGC GTCTCAGCCA ACCCCAAGCA GCGGCGCTTC 1140

AGTGACCAGG CTGGTCCTGC CATTCCCACC TCGAATTCCT ACTCTAAGAA GACTCAGAGT 1200

AACAACGCAG AAAATAAGCG GCCGGAGGAG GACCGGGAGT CAGGGCGGAA GGCCAGCAGC 1260

ACAGCCAAAG TGCCTGCCAG CCCCCTGCCC GGCCTGGAGA GGAAGAAGAC CACCCCCACC 1320

CCCTCCACGA ACAGTGTCCT CTCCACCAGC ACAAATCGAA GCAGGAATTC CCCACTTTTG 1380

GAGAGGGCCA GCCTTGGCCA GGCCTCCATC CAGAATGGCA AAGACAGCCT AACCATGCCA 1440

GGGTCCCGGG CCTCCACGGC TTCTGCTTCC GCCGCAGTCT CTGCGGCCCG GCCCCGCCAG 1500

CACCAGAAAT CCATGTCGGC CTCCGTGCAC CCCAACAAGG CCACTGGGCT GCCCCCCACG 1560

GACAGTAACT GTGAGGTGCC GCGGCCCAGG CAAGTCACAG CCCCCCAGCG TGTCCCTGTC 1620

GCCTCCCCCT CCGCCCACAA CATCAGCAGC AGTGGTGGAG CCCCAGACCG AACTAATTTC 1680

CCCCGGGGTG TGTCCAGTCG AAGCACCTTC CACGCTGGGC AGCTCCGGCA GGTGCGGGAC 1740

CAGCAGAATT TGCCCTACGG TGTGACCCCA GCCTCTCCCT CGGGCAACAG CCAGGGCCGG 1800

CGGGGCGCCT CTGGGAGCAT CTTCAGCAAA TTCACCTCCA AGTTTGTACG CAGAAATCTG 1860

TCTTTCAGGT TTGCCAGAAG GAACCTGAAT GAACCTGAAA GCAAAGACCG AGTGGAGACG 1920

CTCAGACCTC ACGTAGTGGG CAGCGGAGGT AATGACAAAG AAAAGGAGGA GTTTCGGGAG 1980

GCCAAGCCCC GCTCCCTGCG CTTCACGTGG AGTATGAAGA CCACGAGCTC CATGGAGCCG 2040

AACGAGATGA TGCGGGAGAT CCGCAAGGTG CTGGACGCAA ACAGCTGCCA GAGCGAGCTG 2100

CACGAGAAGT ACATGCTGCT GTGCATGCAC GGCACGCCGG GCCACGAGAA CTTCGTGCAG 2160

TGGGAGATGG AGGTGTGCAA ACTGCCGCGG CTCTCTCTCA ACGGTGTTCG ATTTAAGCGG 2220

ATATCGGGCA CCTCCATGGC CTTCAAAAAC ATTGCCTCCA AAATAGCCAA CGAGCTGAAG 2280

CTTTAA 2286

Domain Profile

S: 1     ykllktlGegsfgkVklakhketkekvavKiikkkklseeslekikrEieilkklkhpni  60

         y+llkt+G+g+f+kVkla+h +t+++vavKii+k++l+++sl+k++rE++i+k l+hpni

Q: 25    YRLLKTIGKGNFAKVKLARHILTGKEVAVKIIDKTQLNSSSLQKLFREVRIMKVLNHPNI  84

         99**********************************************************

S: 61    ikllevietkkklylvleyasggeLfdyieekgrlkekearklfkqlvsavkYlhskgiv  120

         +kl+eviet+k+lylv+eyasgge+fdy++++gr+kekear+ f+q+vsav+Y+h+k iv

Q: 85    VKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQKFIV  144

         ************************************************************

S: 121   HrDlKpeNllldkkenikiaDFGlanlfkegklletfcGsppYaaPellkgkkYegpkvD  180

         HrDlK+eNllld+++nikiaDFG++n+f+ g++l+tfcGsppYaaPel++gkkY+gp+vD

Q: 145   HRDLKAENLLLDADMNIKIADFGFSNEFTFGNKLDTFCGSPPYAAPELFQGKKYDGPEVD  204

         ************************************************************

S: 181   vWslGvvLyalvtgklPfdeenlkellekilkgkleipkklskelesLlrklLvvdpekR  240

         vWslGv+Ly+lv+g+lPfd++nlkel+e++l+gk++ip+++s+++e+Ll+k+L  +p+kR

Q: 205   VWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKKFLILNPSKR  264

         ************************************************************

S: 241   atieeilkhewl  252

          t+e+i+k++w+

Q: 265   GTLEQIMKDRWM  276

         ***********8

Domain Sequence
(FASTA)

YRLLKTIGKG NFAKVKLARH ILTGKEVAVK IIDKTQLNSS SLQKLFREVR IMKVLNHPNI 60

VKLFEVIETE KTLYLVMEYA SGGEVFDYLV AHGRMKEKEA RAKFRQIVSA VQYCHQKFIV 120

HRDLKAENLL LDADMNIKIA DFGFSNEFTF GNKLDTFCGS PPYAAPELFQ GKKYDGPEVD 180

VWSLGVILYT LVSGSLPFDG QNLKELRERV LRGKYRIPFY MSTDCENLLK KFLILNPSKR 240

GTLEQIMKDR WM 252

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Erinaceus europaeus"; ?>Felis catus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Macropus eugenii"; ?>Microcebus murinus"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sus scrofa"; ?>Takifugu rubripes"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0045180	; C:basal cortex
GO:0016020	; C:membrane
GO:0005634	; C:nucleus
GO:0005524	; F:ATP binding
GO:0000287	; F:magnesium ion binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0030010	; P:establishment of cell polarity
GO:0045197	; P:establishment or maintenance of epithelial cell apical/basal polarity
GO:0007243	; P:intracellular protein kinase cascade
GO:0010976	; P:positive regulation of neuron projection development
GO:0050770	; P:regulation of axonogenesis
GO:0006979	; P:response to oxidative stress

KEGG

InterPros

IPR001772	; Kinase-assoc_KA1.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.
IPR015940	; UBA/transl_elong_EF1B_N_euk.

Pfam

PF02149	; KA1; 1.
PF00069	; Pkinase; 1.

SMARTs

SM00220	; S_TKc; 1.
SM00165	; UBA; 1.

Prosites

PS50032	; KA1; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.
PS50030	; UBA; 1.

Prints

Created Date

20-Feb-2013