EPS-EQC-00012

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EPS-EQC-00012

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
DSP/aDSP	118.1	3.1E-34	29	169	141

Status

Unreviewed

Ensembl Protein

ENSECAP00000019334

UniProt Accession

F6WZR5;

Protein Name

Protein Synonyms/Alias

Gene Name

DUSP12

Gene Synonyms/Alias

DUSP12;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSECAG00000021937	ENSECAP00000019334	ENSECAT00000023350

Organism

Equus caballus

Functional Description

Protein Length

340

Protein Sequence
(FASTA)

MLEAQGGSHG CERPMRSQSG ASSVGRMLEV QPGLYLGGAA AVAEPDHLRE VGITAVLTVD 60

SEEPDFKAGA GVEGLLRFFV PALDKPETDL LSHLDRCVAF IGQARAEGRA VLVHCHAGVS 120

RSVAVVTAFM MKIDQLTFEK AYEKLQTIKP DAKMNEGFEW QLKLYQAMGY EVDTSSAVYK 180

QYRLQKVTEK YPELQNLPQE LFAVDPTAIS QGLNDDILYK CRKCRRSLFR SSSILDHNEG 240

SGPIAFAHKR VTPSFLLTTG SQAQCTSYFI EPVQWMESAL LGVMDGQLLC PKCSAKLGSF 300

NWYGEQCSCG RWITPAFQIH KNRVDEMKML PVLGSQTRKI 340

Nucleotide Sequence
(FASTA)

ATGTTGGAGG CGCAGGGCGG GAGCCATGGT TGCGAGCGTC CGATGCGCAG CCAGAGCGGG 60

GCCAGCTCCG TGGGGCGGAT GCTGGAAGTG CAGCCGGGGC TGTACCTGGG TGGAGCCGCG 120

GCCGTCGCGG AGCCAGACCA CCTGAGGGAG GTGGGCATCA CGGCCGTGCT AACGGTGGAC 180

TCGGAGGAAC CCGATTTCAA GGCGGGGGCT GGGGTCGAGG GTCTGCTGCG CTTCTTCGTG 240

CCAGCGCTGG ACAAACCCGA GACCGACCTG CTCAGCCATT TGGACCGGTG CGTGGCCTTC 300

ATCGGCCAGG CCCGTGCCGA GGGCCGGGCA GTGTTGGTGC ACTGTCATGC AGGAGTCAGT 360

CGAAGTGTGG CTGTAGTGAC TGCTTTTATG ATGAAGATTG ACCAACTTAC CTTTGAAAAA 420

GCCTATGAAA AACTCCAGAC TATCAAACCA GATGCTAAGA TGAATGAGGG GTTTGAGTGG 480

CAACTGAAAT TATACCAGGC AATGGGATAT GAAGTAGATA CCTCTAGTGC AGTTTATAAG 540

CAATATCGTT TACAGAAGGT TACAGAGAAG TATCCAGAAT TGCAGAACTT ACCTCAAGAG 600

CTCTTTGCTG TTGACCCGAC CGCCATTTCA CAAGGATTGA ACGATGATAT TCTCTACAAA 660

TGCAGAAAGT GCAGGCGATC TTTGTTTCGA AGTTCTAGTA TTTTGGATCA TAACGAAGGA 720

AGTGGTCCTA TAGCCTTTGC CCACAAGAGA GTGACACCAT CTTTCCTGCT TACCACAGGG 780

AGTCAGGCTC AATGTACATC TTATTTCATT GAACCTGTAC AGTGGATGGA ATCAGCTTTG 840

CTGGGAGTGA TGGATGGACA GCTTCTTTGC CCCAAATGCA GTGCCAAATT GGGTTCTTTC 900

AACTGGTATG GTGAACAGTG CTCGTGTGGT AGATGGATAA CACCTGCTTT TCAAATACAC 960

AAAAATAGAG TGGATGAAAT GAAAATGCTG CCGGTTTTGG GGTCACAGAC AAGAAAAATA 1020

TGA 1023

Domain Profile

S: 4     eilpglylgdqataldrreLsklgitvvinaslsvikvqviPeylikkgityknipvdDs  63

         e+ pglylg++a + +  +L+++git v+++  +   ++++  +    g     +p+ D+

Q: 29    EVQPGLYLGGAAAVAEPDHLREVGITAVLTVDSEEPDFKAGAGVE---GLLRFFVPALDK  85

         799*******************************99998887664...777778******

S: 64    dvtdllqyfdeaaefideakekggkvlvHCaaGvsRSatlvlaYLmkveglslsdAieav  123

         ++tdll+++d++++fi +a+ +g++vlvHC+aGvsRS+++v+a++mk  +l++++A+e++

Q: 86    PETDLLSHLDRCVAFIGQARAEGRAVLVHCHAGVSRSVAVVTAFMMKIDQLTFEKAYEKL  145

         ************************************************************

S: 124   krkrpsiepnegfleQLlelekkl  147

         ++ +p +++negf +QL +++ ++

Q: 146   QTIKPDAKMNEGFEWQLKLYQAMG  169

         ********************9886

Domain Sequence
(FASTA)

EVQPGLYLGG AAAVAEPDHL REVGITAVLT VDSEEPDFKA GAGVEGLLRF FVPALDKPET 60

DLLSHLDRCV AFIGQARAEG RAVLVHCHAG VSRSVAVVTA FMMKIDQLTF EKAYEKLQTI 120

KPDAKMNEGF EWQLKLYQAM G 141

Keyword

Complete proteome; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Choloepus hoffmanni"; ?>Danio rerio"; ?>Dasypus novemcinctus"; ?>Drosophila melanogaster"; ?>Echinops telfairi"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Takifugu rubripes"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>Saccharomyces cerevisiae"; ?>Schizosaccharomyces pombe"; ?>

Gene Ontology

GO:0005634	; C:nucleus
GO:0008138	; F:protein tyrosine/serine/threonine phosphatase activity
GO:0006470	; P:protein dephosphorylation

KEGG

InterPros

IPR000340	; Dual-sp_phosphatase_cat-dom.
IPR020422	; Dual-sp_phosphatase_subgr_cat.
IPR024950	; DUSP.
IPR016278	; DUSP12.
IPR000387	; Tyr/Dual-specificity_Pase.

Pfam

PF00782

; DSPc; 1.

SMARTs

SM00195

; DSPc; 1.

Prosites

PS50056	; TYR_PHOSPHATASE_2; 1.
PS50054	; TYR_PHOSPHATASE_DUAL; 1.

Prints

Created Date

20-Feb-2013