EKS-EQC-00222

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-EQC-00222

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
STE/STE7	318.5	3.8E-95	168	409	242

Status

Unreviewed

Ensembl Protein

ENSECAP00000019856

UniProt Accession

F7BQY5;

Protein Name

Protein Synonyms/Alias

Gene Name

MAP2K5

Gene Synonyms/Alias

MAP2K5;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSECAG00000022411	ENSECAP00000019856	ENSECAT00000023929

Organism

Equus caballus

Functional Description

Protein Length

463

Protein Sequence
(FASTA)

MLWLALGPFR AMENQVLVIR IKIPNSGAVD WTVHSGPQLL FRDVLDVIGQ VLPEATTTAF 60

EYEDEDGDRI TVRSDEEMKA MLSYYYSTVM EQQVNGQLIE PLQIFPRACK PPGERNIHGL 120

KVNTRAGPSQ HSSPAVSDSL PSNSLKKSSA ELKKILANGQ MNEQDIRYRD TLGHGNGGTV 180

YKAYHVPSGK ILAVKVILLD ITLELQKQIM SELEILYKCD SSYIIGFYGA FFVENRISIC 240

TEFMDGGSLD VYRKIPEHVL GRIAVAVVKG LTYLWSLKIL HRDVKPSNML VNTSGQVKLC 300

DFGVSTQLVN SIAKTYVGTN AYMAPERISG EQYGIHSDVW SLGISFMEIQ KNQGSLMPLQ 360

LLQCIVDEDS PVLPVGEFSE PFVHFITQCM RKQPKERPAP EELMGHPFIV QFNDGNAAVV 420

SMWVCRALEE RRSQQKVCSA LSSLPEAVLC LSGGLAWTLP CLS 463

Nucleotide Sequence
(FASTA)

ATGCTGTGGC TGGCCCTTGG CCCCTTCCGT GCCATGGAGA ACCAGGTGCT GGTGATTCGT 60

ATCAAGATTC CAAATAGTGG CGCGGTGGAC TGGACAGTGC ACTCCGGGCC GCAGCTACTC 120

TTCAGGGATG TGCTGGATGT GATAGGACAG GTTCTGCCTG AAGCAACAAC CACAGCATTT 180

GAATATGAAG ATGAAGATGG TGATCGAATT ACAGTGAGAA GTGATGAAGA AATGAAGGCA 240

ATGCTGTCAT ATTATTATTC CACAGTAATG GAACAGCAAG TAAATGGACA GTTAATAGAG 300

CCTCTGCAGA TATTTCCAAG AGCCTGCAAG CCTCCTGGGG AACGGAACAT ACATGGCCTG 360

AAGGTGAATA CCCGGGCTGG ACCTTCTCAA CACAGCAGCC CAGCAGTCTC AGATTCACTT 420

CCAAGCAATA GCTTAAAGAA GTCTTCTGCT GAACTGAAAA AAATACTAGC CAATGGCCAG 480

ATGAATGAAC AAGACATACG GTATCGAGAC ACTCTTGGTC ATGGCAACGG AGGCACAGTC 540

TACAAAGCCT ATCATGTCCC AAGTGGGAAA ATATTAGCTG TAAAGGTCAT ACTACTAGAT 600

ATTACACTGG AACTTCAGAA ACAAATTATG TCTGAGTTGG AAATTCTTTA TAAGTGTGAT 660

TCATCATATA TCATAGGGTT TTATGGTGCA TTTTTTGTAG AAAACAGAAT TTCGATATGT 720

ACAGAATTCA TGGATGGGGG ATCTTTGGAT GTATATAGAA AAATTCCAGA GCATGTCCTT 780

GGAAGAATTG CAGTAGCAGT TGTTAAAGGC CTTACCTATT TGTGGAGTTT AAAGATTTTA 840

CATAGAGATG TGAAGCCCTC CAATATGCTA GTAAACACAA GCGGACAGGT CAAGCTGTGT 900

GATTTTGGAG TTAGCACTCA GCTGGTGAAT TCTATAGCCA AGACGTATGT TGGAACAAAT 960

GCTTATATGG CGCCTGAAAG AATTTCAGGG GAGCAGTATG GAATCCATTC TGACGTCTGG 1020

AGCTTAGGAA TCTCTTTCAT GGAGATTCAG AAAAACCAGG GATCTTTAAT GCCTCTCCAG 1080

CTTCTGCAGT GCATTGTTGA TGAGGATTCG CCCGTCCTTC CGGTTGGAGA GTTCTCCGAG 1140

CCATTTGTAC ATTTCATCAC TCAGTGCATG CGAAAACAGC CAAAAGAAAG GCCAGCTCCT 1200

GAGGAATTGA TGGGCCACCC GTTCATCGTG CAGTTCAATG ACGGAAACGC CGCTGTGGTG 1260

TCCATGTGGG TGTGCAGGGC CCTGGAAGAG AGGCGGAGCC AGCAGAAAGT TTGCTCTGCA 1320

TTATCCAGTC TACCAGAGGC CGTTCTCTGC CTCTCCGGCG GTCTTGCCTG GACCTTGCCT 1380

TGCCTCTCA 1389

Domain Profile

S: 3     kleelGaGnggvVekvlhkksgkilavKtirleikkeeqkqilrelevlkkssnspyivk  62

           ++lG+Gngg+V+k+ h +sgkilavK i l+i+ e qkqi++ele+l k+ +s+yi++

Q: 168   YRDTLGHGNGGTVYKAYHVPSGKILAVKVILLDITLELQKQIMSELEILYKC-DSSYIIG  226

         5679************************************************.*******

S: 63    fyGafvsegdvsicmelmdgtsldkvlkkvlekkkripekvlgkiavavvkaleylkekl  122

         fyGaf+ e+++sic+e+mdg+sld v++k       ipe+vlg+iavavvk+l+yl+ +l

Q: 227   FYGAFFVENRISICTEFMDGGSLD-VYRK-------IPEHVLGRIAVAVVKGLTYLW-SL  277

         ************************.6876.......9********************.78

S: 123   kiiHRDvKPsNiLvnskGevKlCDFGvsgqlvdsiAksavGtksYmaPEriegkkkYsvk  182

         ki+HRDvKPsN+Lvn++G+vKlCDFGvs+qlv+siAk++vGt++YmaPEri+g ++Y ++

Q: 278   KILHRDVKPSNMLVNTSGQVKLCDFGVSTQLVNSIAKTYVGTNAYMAPERISG-EQYGIH  336

         *****************************************************.******

S: 183   sdvWslGltlvelatgrypyeklkeilellkaivneeppklpeeefseefqefvskClkk  242

         sdvWslG++++e+  ++       ++l+ll++iv+e++p+lp  efse f++f+++C++k

Q: 337   SDVWSLGISFMEIQKNQG----SLMPLQLLQCIVDEDSPVLPVGEFSEPFVHFITQCMRK  392

         ***************975....55689*********************************

S: 243   dekeRpklkellkhafi  259

         ++keRp  +el+ h+fi

Q: 393   QPKERPAPEELMGHPFI  409

         ****************7

Domain Sequence
(FASTA)

YRDTLGHGNG GTVYKAYHVP SGKILAVKVI LLDITLELQK QIMSELEILY KCDSSYIIGF 60

YGAFFVENRI SICTEFMDGG SLDVYRKIPE HVLGRIAVAV VKGLTYLWSL KILHRDVKPS 120

NMLVNTSGQV KLCDFGVSTQ LVNSIAKTYV GTNAYMAPER ISGEQYGIHS DVWSLGISFM 180

EIQKNQGSLM PLQLLQCIVD EDSPVLPVGE FSEPFVHFIT QCMRKQPKER PAPEELMGHP 240

FI 242

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005819	; C:spindle
GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0007507	; P:heart development
GO:0000165	; P:MAPK cascade

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000270	; OPR_PB1.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00564	; PB1; 1.
PF00069	; Pkinase; 1.

SMARTs

SM00666

; PB1; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013