EKS-EQC-00177

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-EQC-00177

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
AGC/PKA	483.3	1.7E-145	47	301	255

Status

Unreviewed

Ensembl Protein

ENSECAP00000020287

UniProt Accession

F6TVJ6;

Protein Name

Protein Synonyms/Alias

Gene Name

PRKACB

Gene Synonyms/Alias

PRKACB;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSECAG00000022585	ENSECAP00000020287	ENSECAT00000024421

Organism

Equus caballus

Functional Description

Protein Length

354

Protein Sequence
(FASTA)

MSARKSSEAS ACSSSEVSVK EFLAKAKEDF LKKWENPAQN NAGLEDFERK KTLGTGSFGR 60

VMLVKHKATE QYYAMKILDK QKVVKLKQIE HTLNEKRILQ AVNFPFLVRL EYSFKDNSNL 120

YMVMEYVPGG EMFSHLRRIG RFSEPHARFY AAQIVLTFEY LHSLDLIYRD LKPENLLIDH 180

QGYIQVTDFG FAKRVKGRTW TLCGTPEYLA PEIILSKGYN KAVDWWALGV LIYEMAAGYP 240

PFFADQPIQI YEKIVSGKVR FPSHFSSDLK DLLRNLLQVD LTKRFGNLKN GVSDIKTHKW 300

FATTDWIAIY QRKVEAPFIP KFRGSGDTSN FDDYEEEDIR VSITEKCAKE FCEF 354

Nucleotide Sequence
(FASTA)

ATGAGTGCAC GCAAATCATC AGAAGCATCT GCTTGCTCCT CTTCAGAAGT ATCTGTGAAA 60

GAGTTTCTAG CTAAAGCCAA AGAAGACTTT TTAAAAAAAT GGGAAAATCC TGCTCAGAAT 120

AATGCCGGGC TGGAGGATTT TGAAAGGAAA AAAACCCTTG GAACAGGTTC ATTTGGAAGA 180

GTCATGTTGG TGAAACATAA AGCCACTGAA CAGTATTATG CCATGAAGAT CTTAGATAAG 240

CAGAAGGTTG TTAAACTGAA GCAAATAGAG CATACTTTGA ATGAGAAAAG AATATTACAG 300

GCAGTGAATT TTCCTTTTCT TGTTCGACTG GAGTATTCTT TTAAGGATAA TTCTAATTTA 360

TACATGGTTA TGGAATATGT CCCCGGGGGT GAAATGTTTT CACATTTAAG AAGAATTGGA 420

AGGTTCAGTG AACCCCATGC ACGGTTCTAT GCAGCTCAGA TAGTGCTAAC ATTCGAGTAC 480

CTCCATTCAC TAGACCTCAT CTACAGAGAT CTAAAACCTG AAAATCTCTT AATTGACCAC 540

CAAGGTTATA TCCAGGTCAC AGACTTTGGG TTTGCCAAAA GAGTTAAAGG CAGAACTTGG 600

ACATTATGTG GCACTCCAGA ATATTTAGCT CCAGAAATAA TCCTCAGCAA GGGTTACAAT 660

AAGGCAGTGG ATTGGTGGGC CTTAGGAGTG TTAATCTATG AAATGGCAGC TGGCTACCCC 720

CCGTTCTTTG CAGATCAACC AATTCAAATT TATGAAAAGA TTGTTTCTGG AAAGGTCCGA 780

TTCCCATCAC ACTTCAGTTC AGATCTCAAG GACCTCCTAA GGAACCTACT GCAGGTGGAT 840

TTGACAAAGC GGTTTGGAAA TCTAAAGAAT GGTGTGAGTG ACATAAAAAC TCACAAGTGG 900

TTTGCCACAA CAGATTGGAT TGCGATTTAC CAGAGGAAGG TTGAAGCTCC ATTCATACCA 960

AAGTTCAGAG GCTCTGGAGA TACCAGCAAC TTTGATGACT ATGAAGAAGA AGATATCCGT 1020

GTCTCTATAA CAGAAAAATG TGCAAAAGAA TTTTGTGAAT TTTGA 1065

Domain Profile

S: 1     ferlktlGtGsfGrvelvrekeskkyyalkvlskekvvklkqvehvknekrvlkavefpf  60

         fer+ktlGtGsfGrv+lv++k++++yya+k+l+k+kvvklkq+eh+ nekr+l+av+fpf

Q: 47    FERKKTLGTGSFGRVMLVKHKATEQYYAMKILDKQKVVKLKQIEHTLNEKRILQAVNFPF  106

         799*********************************************************

S: 61    lvkllasfkdesnlylvleyveGGelfsylrkvrrfsekaarfyaaeivlaleylhsldl  120

         lv+l++sfkd+snly+v+eyv+GGe+fs+lr+++rfse++arfyaa+ivl++eylhsldl

Q: 107   LVRLEYSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHSLDL  166

         ************************************************************

S: 121   iyrdlkpenllldkeGyikvtdfGfakkvkdrtwtlcGtpeylapeiiqskgynkavdww  180

         iyrdlkpenll+d++Gyi+vtdfGfak+vk+rtwtlcGtpeylapeii skgynkavdww

Q: 167   IYRDLKPENLLIDHQGYIQVTDFGFAKRVKGRTWTLCGTPEYLAPEIILSKGYNKAVDWW  226

         ************************************************************

S: 181   alGvliyellaGyppffddqpikiyekivsgklkfpsklssdlkdllkkllqvdltkrlg  240

         alGvliye++aGyppff+dqpi+iyekivsgk++fps++ssdlkdll++llqvdltkr+g

Q: 227   ALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRFPSHFSSDLKDLLRNLLQVDLTKRFG  286

         ************************************************************

S: 241   nlkngvedikehkwf  255

         nlkngv+dik+hkwf

Q: 287   NLKNGVSDIKTHKWF  301

         **************9

Domain Sequence
(FASTA)

FERKKTLGTG SFGRVMLVKH KATEQYYAMK ILDKQKVVKL KQIEHTLNEK RILQAVNFPF 60

LVRLEYSFKD NSNLYMVMEY VPGGEMFSHL RRIGRFSEPH ARFYAAQIVL TFEYLHSLDL 120

IYRDLKPENL LIDHQGYIQV TDFGFAKRVK GRTWTLCGTP EYLAPEIILS KGYNKAVDWW 180

ALGVLIYEMA AGYPPFFADQ PIQIYEKIVS GKVRFPSHFS SDLKDLLRNL LQVDLTKRFG 240

NLKNGVSDIK THKWF 255

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Felis catus"; ?>Gallus gallus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Taeniopygia guttata"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Saccharomyces cerevisiae"; ?>Schizosaccharomyces pombe"; ?>

Gene Ontology

GO:0005813	; C:centrosome
GO:0005524	; F:ATP binding
GO:0004691	; F:cAMP-dependent protein kinase activity
GO:0000287	; F:magnesium ion binding

KEGG

InterPros

IPR000961	; AGC-kinase_C.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00133	; S_TK_X; 1.
SM00220	; S_TKc; 1.

Prosites

PS51285	; AGC_KINASE_CTER; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013