EKS-EQC-00243
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-EQC-00243
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
CAMK/CAMKL317.56.3E-953237235
StatusUnreviewed
Ensembl ProteinENSECAP00000020185
UniProt AccessionQ2LGG0;
Protein Name
Protein Synonyms/Alias AMPK-activated protein kinase alpha-1 subunit;
Gene NamePRKAA1
Gene Synonyms/Alias
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSECAG00000022617ENSECAP00000020185ENSECAT00000024304
OrganismEquus caballus
Functional Description
Protein Length517
Protein Sequence
(FASTA)
VGKHELTGHK VAVKILNRQK IRSLDVVGKI RREIQNLKLF RHPHIIKLYQ VISTPSDIFM 60
VMEYVSGGEL FDYICKNGRL DEKESRRLFQ QILSGVDYCH RHMVVHRDLK PENVLLDAHM 120
NAKIADFGLS NMMSDGEFLR TSCGSPNYAA PEVISGRLYA GPEVDIWSSG VILYALLCGT 180
LPFDDDHVPT LFKKICDGIF YTPQYLNPSV ISLLKHMLQV DPMKRATIKD IREHEWFKQD 240
LPKYLFPEDP SYSSTMIDDE ALKEVCEKFE CSEEEVLSCL YNRNHQDPLA VAYHLIIDNR 300
RIMNEAKDFY LATSPPDSFL DDHHLTRPHP ERVPFLVAET PRARHTLDEL NPQKSKHQGV 360
RKAKWHLGIR SQSRPNDIMA EVCRAIKQLD YEWKVVNPYY LRVRRKNPVT STYSKMSLQL 420
YQVDSRTYLL DFRSIDDEIT EAKSGTATPQ RSGSVSNYRS CQRSDSDAEA QGKSSEASLT 480
SSVTSLDSSP VDLTPRPGSH TIEFFEMCAN LIKILAQ 517
Nucleotide Sequence
(FASTA)
GTTGGCAAAC ATGAATTGAC TGGGCATAAA GTTGCTGTGA AGATACTCAA TCGCCAGAAG 60
ATTCGAAGCC TCGATGTGGT TGGAAAAATC CGCAGAGAAA TTCAGAACCT CAAGCTTTTC 120
AGGCATCCTC ATATAATTAA ACTGTACCAG GTCATCAGTA CACCATCTGA TATTTTCATG 180
GTGATGGAAT ATGTCTCAGG AGGAGAGCTA TTTGATTATA TCTGTAAAAA TGGAAGGCTC 240
GATGAAAAAG AAAGTCGACG TCTGTTCCAA CAGATCCTTT CTGGTGTGGA TTATTGTCAC 300
AGGCATATGG TGGTCCATAG AGACTTGAAA CCTGAAAACG TCCTGCTTGA TGCACACATG 360
AATGCAAAGA TAGCTGATTT TGGTCTTTCA AACATGATGT CAGATGGTGA ATTTTTAAGA 420
ACGAGTTGTG GCTCACCCAA CTATGCTGCC CCAGAGGTCA TTTCAGGAAG ATTGTATGCA 480
GGCCCAGAGG TAGACATATG GAGCAGCGGG GTTATTCTCT ATGCTTTATT ATGTGGAACC 540
CTTCCATTTG ATGATGATCA TGTGCCAACT CTTTTTAAGA AGATATGTGA TGGGATCTTT 600
TATACCCCTC AGTATTTAAA TCCATCCGTG ATTAGCCTTT TGAAACATAT GCTGCAGGTG 660
GATCCCATGA AGCGGGCCAC AATCAAAGAT ATCAGGGAAC ATGAATGGTT TAAACAAGAC 720
CTTCCAAAAT ATCTCTTTCC TGAGGACCCA TCATATAGTT CAACTATGAT TGATGATGAA 780
GCCTTAAAAG AAGTATGTGA AAAATTTGAA TGCTCAGAAG AGGAGGTTCT CAGCTGCCTT 840
TATAACCGAA ATCACCAGGA CCCTTTGGCA GTGGCCTACC ACCTCATCAT AGATAACAGG 900
AGAATAATGA ATGAAGCCAA AGATTTTTAC TTGGCGACAA GCCCACCTGA TTCTTTTCTT 960
GATGATCACC ATTTGACTCG GCCCCATCCT GAAAGAGTAC CATTCTTGGT TGCTGAAACA 1020
CCAAGGGCAC GCCATACTCT CGATGAATTA AATCCACAGA AATCCAAACA CCAAGGTGTA 1080
AGAAAAGCCA AATGGCATTT GGGAATTAGA AGTCAAAGTC GACCAAATGA TATCATGGCA 1140
GAAGTTTGTA GAGCAATTAA ACAACTGGAT TATGAATGGA AGGTTGTAAA CCCATATTAC 1200
TTGCGTGTTC GAAGGAAGAA TCCTGTGACA AGTACCTACT CCAAAATGAG TCTACAGTTA 1260
TACCAAGTGG ACAGTAGAAC ATACTTACTG GATTTCCGTA GTATTGATGA TGAAATTACT 1320
GAAGCCAAAT CCGGGACTGC TACTCCACAA AGATCGGGAT CCGTTAGCAA CTATCGATCT 1380
TGTCAGAGGA GTGATTCGGA TGCTGAGGCT CAAGGAAAAT CCTCAGAAGC TTCTCTTACC 1440
TCATCGGTGA CCTCACTTGA CTCTTCTCCT GTTGACTTAA CTCCAAGACC TGGAAGTCAC 1500
ACAATAGAGT TTTTTGAGAT GTGTGCGAAT CTAATTAAAA TTCTTGCACA GTAA 1554
Domain Profile
S: 19    khketkekvavKiikkkkl.seeslekikrEieilkklkhpniikllevietkkklylvl  77
         kh++t++kvavKi++++k+ s + + ki+rEi+ lk ++hp+iikl++vi+t +++++v+
Q: 3     KHELTGHKVAVKILNRQKIrSLDVVGKIRREIQNLKLFRHPHIIKLYQVISTPSDIFMVM  62
         7999**************96667788**********************************
S: 78    eyasggeLfdyieekgrlkekearklfkqlvsavkYlhskgivHrDlKpeNllldkkeni  137
         ey+sggeLfdyi ++grl+eke+r+lf+q++s+v+Y+h++ +vHrDlKpeN+lld+++n 
Q: 63    EYVSGGELFDYICKNGRLDEKESRRLFQQILSGVDYCHRHMVVHRDLKPENVLLDAHMNA  122
         ************************************************************
S: 138   kiaDFGlanlfkegklletfcGsppYaaPellkgkkYegpkvDvWslGvvLyalvtgklP  197
         kiaDFGl+n++++g+ l+t+cGsp+YaaPe+++g+ Y gp+vD+Ws Gv+Lyal++g+lP
Q: 123   KIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSSGVILYALLCGTLP  182
         ************************************************************
S: 198   fdeenlkellekilkgkleipkklskelesLlrklLvvdpekRatieeilkhewl  252
         fd++++ +l++ki +g + +p++l+++++sLl+++L+vdp kRati++i++hew+
Q: 183   FDDDHVPTLFKKICDGIFYTPQYLNPSVISLLKHMLQVDPMKRATIKDIREHEWF  237
         ******************************************************7
Domain Sequence
(FASTA)
KHELTGHKVA VKILNRQKIR SLDVVGKIRR EIQNLKLFRH PHIIKLYQVI STPSDIFMVM 60
EYVSGGELFD YICKNGRLDE KESRRLFQQI LSGVDYCHRH MVVHRDLKPE NVLLDAHMNA 120
KIADFGLSNM MSDGEFLRTS CGSPNYAAPE VISGRLYAGP EVDIWSSGVI LYALLCGTLP 180
FDDDHVPTLF KKICDGIFYT PQYLNPSVIS LLKHMLQVDP MKRATIKDIR EHEWF 235
KeywordATP-binding; Kinase; Nucleotide-binding; Transferase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Choloepus hoffmanni"; ?>Danio rerio"; ?>Echinops telfairi"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>Schizosaccharomyces pombe"; ?>
EKS-AIM-00227
EKS-ANC-00241
EKS-BOT-00244
EKS-CAJ-00254
EKS-CAF-00257
EKS-CAP-00269
EKS-CHH-00009
EKS-DAR-00564
EKS-ECT-00008
EKS-FEC-00232
EKS-GAM-00145
EKS-GAG-00212
EKS-GAA-00302
EKS-GOG-00243
EKS-HOS-00256
EKS-ICT-00235
EKS-LAC-00255
EKS-LOA-00248
EKS-MAM-00244
EKS-MEG-00198
EKS-MOD-00245
EKS-MUM-00254
EKS-MUP-00247
EKS-MYL-00250
EKS-NOL-00227
EKS-OCP-00014
EKS-ORN-00319
EKS-ORA-00216
EKS-ORC-00218
EKS-ORL-00299
EKS-OTG-00251
EKS-PAT-00234
EKS-PES-00217
EKS-POA-00241
EKS-RAN-00244
EKS-SAH-00229
EKS-SUS-00212
EKS-TAG-00260
EKS-TAR-00312
EKS-TEN-00307
EKS-TUT-00024
EKS-XET-00319
EKS-XIM-00310
EKS-SCP-00014
Gene Ontology
GO:0005737; C:cytoplasm
GO:0005634; C:nucleus
GO:0004679; F:AMP-activated protein kinase activity
GO:0005524; F:ATP binding
GO:0003682; F:chromatin binding
GO:0035174; F:histone serine kinase activity
GO:0042149; P:cellular response to glucose starvation
GO:0019395; P:fatty acid oxidation
GO:0042593; P:glucose homeostasis
GO:0006006; P:glucose metabolic process
GO:0008610; P:lipid biosynthetic process
GO:0043066; P:negative regulation of apoptotic process
GO:0050995; P:negative regulation of lipid catabolic process
GO:0032007; P:negative regulation of TOR signaling cascade
GO:0010508; P:positive regulation of autophagy
GO:0042752; P:regulation of circadian rhythm
KEGG
ecb:100009710;
InterPros
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR002290; Ser/Thr_dual-sp_kinase_dom.
IPR008271; Ser/Thr_kinase_AS.
Pfam
PF00069; Pkinase; 1.
SMARTs
SM00220; S_TKc; 1.
Prosites
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00108; PROTEIN_KINASE_ST; 1.
Prints
Created Date20-Feb-2013