EKS-EQC-00158

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-EQC-00158

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
Other/TLK	615.9	8.6E-186	410	688	279

Status

Unreviewed

Ensembl Protein

ENSECAP00000020562

UniProt Accession

F6T4Z9;

Protein Name

Protein Synonyms/Alias

Gene Name

TLK1

Gene Synonyms/Alias

TLK1;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSECAG00000022790	ENSECAP00000020562	ENSECAT00000024734

Organism

Equus caballus

Functional Description

Protein Length

720

Protein Sequence
(FASTA)

GAMDELHSLD PRRQELLEAR FTGVASGSTG STGSCSVGAK ASTNNESSNH SFGSLGSLSD 60

KESETPEKKQ SESSRGRKRK AENQNESSQG KSIGGRGHKI SDYFEYQGGN GSSPVRGIPP 120

AIRSPQNSHS HSTPSSSVRP NSPSPTALAF GDHSIVQPKQ LSFKITQTDL TMLKLAALES 180

NKNQDLEKKE GRIDDLLRAN CDLRRQIDEQ QKLLEKYKER LNKCISMSKK LLIEKSTQEK 240

LSSREKSMQD RLRLGHFTTV RHGASFTEQW TDGFAFQNLV KQQEWVNQQR EDIERQRKLL 300

AKRKPPTANN SQAPSTNSEP KQRKNKAVNG AENDPFVRPN LPQLLTLAEY HEQEEIFKLR 360

LGHLKKEEAE IQAELERLER VRNLHIRELK RINNEDNSQF KDHPTLNERY LLLHLLGRGG 420

FSEVYKAFDL YEQRYAAVKI HQLNKSWRDE KKENYHKHAC REYRIHKELD HPRIVKLYDY 480

FSLDTDTFCT VLEYCEGNDL DFYLKQHKLM SEKEARSIVM QIVNALRYLN EIKPPIIHYD 540

LKPGNILLVD GTACGEIKIT DFGLSKIMDD DSYGVDGMDL TSQGAGTYWY LPPECFVVGK 600

EPPKISNKVD VWSVGVIFFQ CLYGRKPFGH NQSQQDILQE NTILKATEVQ FPVKPVVSSE 660

AKAFIRRCLA YRKEDRFDVH QLANDPYLLP HMRRSNSSGN LHMAGLTASP TPPSSSIITY 720

Nucleotide Sequence
(FASTA)

GGTGCAATGG ATGAGCTTCA TAGTCTGGAT CCAAGAAGGC AAGAATTGTT GGAAGCTAGA 60

TTTACAGGAG TTGCAAGTGG GAGCACTGGG AGCACTGGCA GTTGCAGTGT TGGAGCTAAA 120

GCCTCAACAA ATAATGAAAG CTCTAATCAC AGTTTTGGAA GCTTGGGATC TTTAAGTGAC 180

AAAGAATCAG AGACACCAGA GAAGAAACAA TCGGAATCAT CTAGAGGAAG AAAGAGAAAA 240

GCAGAAAACC AGAATGAAAG TAGTCAGGGA AAAAGTATTG GGGGACGTGG CCACAAAATT 300

AGCGACTATT TTGAATACCA AGGTGGTAAT GGCTCAAGTC CAGTAAGAGG CATACCTCCT 360

GCGATCCGTT CTCCTCAGAA TTCACATTCA CATTCCACTC CTTCCTCATC TGTTCGGCCG 420

AATAGCCCTT CTCCTACTGC GTTAGCTTTT GGGGACCACT CTATTGTACA ACCAAAGCAG 480

TTATCCTTTA AAATTACTCA GACTGATCTC ACAATGCTGA AATTAGCAGC ACTAGAAAGT 540

AATAAAAACC AGGACCTGGA AAAGAAGGAA GGTCGTATAG ATGACTTGCT CAGGGCTAAC 600

TGTGATCTCA GACGGCAAAT AGATGAACAA CAAAAATTAC TTGAAAAATA CAAAGAACGA 660

TTAAATAAGT GCATATCAAT GAGCAAGAAA CTGCTTATTG AAAAGAGTAC ACAAGAGAAA 720

CTGTCAAGCC GAGAGAAGAG TATGCAAGAC AGATTACGCC TTGGGCACTT CACAACAGTT 780

AGACATGGTG CTTCATTTAC TGAACAATGG ACAGATGGTT TTGCATTTCA GAATCTTGTG 840

AAGCAGCAAG AATGGGTGAA TCAGCAAAGG GAAGATATTG AAAGGCAGAG GAAACTTCTA 900

GCCAAACGCA AACCTCCCAC AGCTAATAAT TCTCAGGCAC CTTCTACCAA TTCTGAACCA 960

AAACAAAGGA AAAACAAAGC AGTCAATGGA GCAGAAAATG ATCCCTTTGT TAGACCAAAT 1020

TTACCACAAC TGTTGACTTT GGCAGAATAT CATGAACAGG AAGAAATTTT CAAACTTAGA 1080

CTAGGACATC TCAAAAAGGA AGAGGCAGAA ATCCAGGCAG AACTTGAACG TTTGGAAAGA 1140

GTTAGAAATC TTCACATTCG AGAGCTCAAA AGAATTAATA ATGAAGATAA TTCGCAGTTC 1200

AAGGATCACC CAACGTTAAA TGAAAGATAT TTATTACTTC ATCTGCTTGG TAGAGGTGGC 1260

TTTAGTGAAG TATATAAGGC TTTTGACCTT TATGAACAAA GATATGCTGC TGTGAAGATC 1320

CATCAGCTTA ATAAAAGCTG GAGGGATGAG AAGAAGGAAA ACTACCACAA ACATGCCTGC 1380

AGAGAGTACA GAATACACAA AGAACTGGAT CACCCCAGAA TAGTTAAACT CTATGATTAT 1440

TTCTCCTTGG ATACAGATAC GTTTTGTACA GTGTTAGAAT ACTGTGAAGG CAATGACTTG 1500

GATTTCTATC TGAAGCAACA TAAATTAATG TCAGAGAAAG AAGCTAGGTC TATTGTAATG 1560

CAAATTGTAA ATGCACTAAG ATATCTCAAT GAAATCAAAC CACCTATTAT ACATTATGAT 1620

CTTAAGCCAG GAAACATCCT TCTGGTAGAT GGAACAGCAT GTGGAGAAAT CAAAATCACT 1680

GATTTCGGTC TGTCCAAGAT TATGGATGAT GATAGCTATG GTGTAGATGG AATGGATCTA 1740

ACTTCCCAAG GGGCAGGCAC TTACTGGTAT TTACCTCCTG AATGTTTTGT AGTTGGAAAA 1800

GAACCACCAA AGATTTCCAA CAAGGTTGAT GTGTGGTCAG TCGGAGTCAT CTTCTTTCAG 1860

TGTCTTTACG GTAGAAAGCC ATTTGGTCAC AATCAATCTC AACAAGACAT TCTTCAAGAA 1920

AACACAATAT TGAAAGCCAC AGAAGTCCAG TTCCCTGTAA AACCGGTTGT AAGCAGTGAG 1980

GCAAAGGCCT TTATAAGACG CTGTTTGGCA TACCGAAAAG AAGATCGATT TGATGTGCAC 2040

CAACTGGCAA ATGACCCATA CCTTCTCCCG CACATGAGAA GATCAAATTC TTCAGGAAAC 2100

TTACACATGG CTGGGCTGAC AGCATCCCCT ACACCCCCTT CTTCAAGCAT AATTACTTAC 2160

TGA 2163

Domain Profile

S: 1     ylllkllgkggfsevykafdlkeqryvavkihqlnkdwkdekkenyvkhalreyrihkel  60

         ylll+llg+ggfsevykafdl+eqry+avkihqlnk+w+dekkeny+kha+reyrihkel

Q: 410   YLLLHLLGRGGFSEVYKAFDLYEQRYAAVKIHQLNKSWRDEKKENYHKHACREYRIHKEL  469

         9***********************************************************

S: 61    dhprivklydllsldtdsfctvleyvegndldfylkqhkllsekearsiimqivsalkyl  120

         dhprivklyd++sldtd+fctvley+egndldfylkqhkl+sekearsi+mqiv+al+yl

Q: 470   DHPRIVKLYDYFSLDTDTFCTVLEYCEGNDLDFYLKQHKLMSEKEARSIVMQIVNALRYL  529

         ************************************************************

S: 121   neikppiihydlkpgnillvegtacgeikitdfglskimdddsydsddgleltsqgagty  180

         neikppiihydlkpgnillv+gtacgeikitdfglskimdddsy++d g++ltsqgagty

Q: 530   NEIKPPIIHYDLKPGNILLVDGTACGEIKITDFGLSKIMDDDSYGVD-GMDLTSQGAGTY  588

         *********************************************99.************

S: 181   wylppecfvvgkeppkisnkvdvwsvgvifyqclygkkpfghnqsqqdileentilkate  240

         wylppecfvvgkeppkisnkvdvwsvgvif+qclyg+kpfghnqsqqdil+entilkate

Q: 589   WYLPPECFVVGKEPPKISNKVDVWSVGVIFFQCLYGRKPFGHNQSQQDILQENTILKATE  648

         ************************************************************

S: 241   vqfpskpvvsseakafirrclayrkedridvqqlakdeyl  280

         vqfp+kpvvsseakafirrclayrkedr+dv+qla+d+yl

Q: 649   VQFPVKPVVSSEAKAFIRRCLAYRKEDRFDVHQLANDPYL  688

         **************************************97

Domain Sequence
(FASTA)

YLLLHLLGRG GFSEVYKAFD LYEQRYAAVK IHQLNKSWRD EKKENYHKHA CREYRIHKEL 60

DHPRIVKLYD YFSLDTDTFC TVLEYCEGND LDFYLKQHKL MSEKEARSIV MQIVNALRYL 120

NEIKPPIIHY DLKPGNILLV DGTACGEIKI TDFGLSKIMD DDSYGVDGMD LTSQGAGTYW 180

YLPPECFVVG KEPPKISNKV DVWSVGVIFF QCLYGRKPFG HNQSQQDILQ ENTILKATEV 240

QFPVKPVVSS EAKAFIRRCL AYRKEDRFDV HQLANDPYL 279

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005634	; C:nucleus
GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0006886	; P:intracellular protein transport
GO:0035556	; P:intracellular signal transduction
GO:0001672	; P:regulation of chromatin assembly or disassembly

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013