EKS-EQC-00288
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-EQC-00288
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/EGFR502.82.0E-151579836258
StatusUnreviewed
Ensembl ProteinENSECAP00000020578
UniProt AccessionF6T440;
Protein Name
Protein Synonyms/Alias
Gene NameERBB4
Gene Synonyms/Alias ERBB4;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSECAG00000022865ENSECAP00000020578ENSECAT00000024752
ENSECAG00000022865ENSECAP00000020577ENSECAT00000024751
OrganismEquus caballus
Functional Description
Protein Length1153
Protein Sequence
(FASTA)
TEILNGGVYV DQNKFLCYTD TIHWQDIVRN PWPSNLTLVS TNGSSGCGRC HKSCTGRCWG 60
PTENHCQTLT RTVCAEQCDG RCYGPYVSDC CHRECAGGCS GPKDTDCFAC MNFNDSGACV 120
TQCPQTFVYN PTTFQLEHNF NAKYTYGAFC VKKCPHNFVV DSSSCVRACP SSKMEVEENG 180
IKMCKPCTDI CPKACDGIGT GSLLSAQTVD SSNIDKFINC TKINGNLIFL VTGIHGDPYN 240
AIEAIDPEKL NVFRTVREIT GFLNIQSWPP NMTDFSVFSN LVTIGGRVLY SGLSLLILKQ 300
QGITSLQFQS LKEISAGNIY ITDNSNLCYY HTINWTTLFS TINQRIVIRD NRKAENCTAE 360
GMVCNHLCSS NGCWGPGPDQ CLSCRRFSRG RTCIESCNLF DGEFREFENG SICVECDPQC 420
EKMEDGILTC HGPGPDNCTK CSHFKDGPNC VEKCPDGLQG ANSFIFKYAD QDRECHPCHP 480
NCTQGCSGPT SHDCIYYPWT GHSTLPQHAR TPLIAAGVIG GLFIMVIMAL TFAVYVRRKS 540
IKKKRALRRF LETELVEPLT PSGTAPNQAQ LRILKETELK RVKVLGSGAF GTVYKGIWVP 600
EGETVKIPVA IKILNETTGP KANVEFMDEA LIMASMDHPH LVRLLGVCLS PTIQLVTQLM 660
PHGCLLDYVH EHKDNIGSQL LLNWCVQIAK GMMYLEERRL VHRDLAARNV LVKSPNHVKI 720
TDFGLARLLE GDEKEYNADG GKMPIKWMAL ECIHYRKFTH QSDVWSYGVT IWELMTFGGK 780
PYDGIPTREI PDLLEKGERL PQPPICTIDV YMVMVKCWMI DADSRPKFKE LAAEFSRMAR 840
DPQRYLVIQG DDRMKLPSPN DSKFFQNLLD EEDLEDMMDA EEYLVPQAFN IPPPIYTSRA 900
RIDSNRNQFV YRDGGFAAEQ GVPVPYRATT STIPEAPVAQ GATPEIFDDS CCNGTLRKPV 960
APHVQEDSST QRYSADPTVF ATERSPRGEL DEEGYMTPMR DKPKQEYLHP VEENPFVSRR 1020
KNGDLQALDN PEYHSASNGP PKAEDEYVNE PLYLNTFANA LGNAEYLKNN VLSVPEKAKK 1080
AFDNPDYWNH SLPPRSTLQH PDYLQEYSTK YFYKQNGRIR PIVAENPEYL SEFSLKPGTV 1140
LPPPPYRHRN TVV 1153
Nucleotide Sequence
(FASTA)
ACAGAAATCC TAAATGGTGG AGTCTATGTA GACCAGAACA AATTCCTTTG TTACACAGAC 60
ACAATTCATT GGCAAGACAT TGTTCGGAAT CCATGGCCTT CCAACTTGAC TCTGGTGTCA 120
ACAAATGGTA GCTCAGGATG TGGACGTTGC CATAAGTCCT GTACTGGCCG ATGCTGGGGA 180
CCCACAGAGA ATCATTGCCA GACTTTGACA AGGACAGTGT GTGCAGAACA ATGTGATGGC 240
AGGTGCTACG GACCCTACGT CAGTGACTGC TGTCATCGAG AATGTGCTGG GGGCTGCTCG 300
GGACCCAAGG ACACCGACTG CTTTGCCTGC ATGAATTTCA ATGACAGTGG AGCATGTGTT 360
ACTCAGTGTC CCCAAACTTT TGTCTACAAT CCAACCACCT TTCAGTTGGA GCATAACTTC 420
AATGCAAAGT ACACGTATGG AGCATTTTGT GTCAAGAAGT GCCCACATAA CTTTGTGGTC 480
GATTCCAGTT CTTGTGTGCG TGCCTGTCCT AGTTCCAAGA TGGAAGTAGA AGAAAATGGT 540
ATTAAAATGT GTAAACCTTG CACTGATATT TGCCCAAAAG CTTGCGATGG CATTGGCACG 600
GGATCACTGC TGTCAGCTCA GACTGTGGAT TCCAGTAACA TTGACAAATT CATAAACTGC 660
ACCAAAATCA ATGGGAATTT GATCTTCCTT GTCACTGGTA TTCATGGGGA CCCTTACAAT 720
GCAATTGAAG CCATAGACCC AGAGAAACTG AATGTCTTTC GGACCGTCCG AGAGATAACA 780
GGTTTCTTGA ACATACAATC ATGGCCCCCA AACATGACCG ACTTCAGTGT TTTTTCTAAC 840
CTGGTGACCA TTGGTGGAAG AGTACTCTAT AGTGGCCTCT CCTTGCTTAT CCTCAAGCAA 900
CAGGGCATCA CTTCTCTCCA ATTCCAGTCC CTGAAGGAAA TCAGTGCAGG AAACATCTAT 960
ATTACAGACA ACAGCAACCT GTGCTATTAT CACACCATTA ACTGGACAAC GCTCTTCAGC 1020
ACTATCAACC AAAGAATAGT GATCCGGGAC AACAGGAAAG CTGAAAACTG TACTGCTGAA 1080
GGAATGGTAT GTAACCATCT GTGCTCAAGC AATGGCTGCT GGGGACCCGG GCCAGACCAG 1140
TGCCTGTCCT GCCGTCGCTT CAGCAGGGGG AGGACCTGCA TAGAGTCCTG TAACCTCTTT 1200
GATGGCGAAT TTCGGGAGTT TGAGAATGGC TCCATCTGTG TGGAGTGTGA CCCCCAGTGT 1260
GAGAAGATGG AAGATGGCAT CCTCACATGC CATGGACCGG GACCTGACAA CTGTACCAAG 1320
TGCTCCCATT TTAAGGATGG CCCGAACTGT GTGGAAAAAT GTCCAGATGG CCTGCAGGGT 1380
GCAAACAGTT TCATCTTCAA GTATGCTGAT CAGGATCGGG AGTGCCACCC ATGCCATCCA 1440
AACTGCACCC AAGGGTGTAG CGGTCCCACT AGTCATGACT GCATTTACTA CCCTTGGACG 1500
GGCCATTCCA CTTTACCACA ACATGCTAGG ACTCCTCTAA TTGCAGCGGG AGTTATCGGC 1560
GGGCTCTTCA TCATGGTCAT CATGGCTCTA ACATTCGCAG TTTATGTTAG AAGGAAGAGC 1620
ATCAAAAAGA AAAGAGCCTT GAGAAGGTTC CTGGAAACAG AGCTGGTAGA ACCCTTAACT 1680
CCCAGTGGCA CAGCCCCCAA TCAAGCTCAA CTTCGCATTT TGAAAGAAAC TGAGCTCAAA 1740
AGAGTGAAAG TACTTGGCTC GGGTGCTTTT GGAACTGTTT ATAAAGGTAT TTGGGTCCCT 1800
GAAGGAGAAA CAGTGAAGAT TCCTGTAGCT ATTAAGATTC TTAATGAAAC AACTGGTCCC 1860
AAAGCCAATG TGGAGTTTAT GGATGAAGCT CTGATCATGG CAAGTATGGA CCATCCACAC 1920
TTAGTCCGGT TATTGGGTGT CTGTCTGAGC CCAACTATCC AGCTGGTTAC ACAGCTTATG 1980
CCCCATGGCT GCCTGTTGGA TTACGTCCAT GAACACAAGG ATAACATTGG ATCACAGCTG 2040
TTACTTAACT GGTGTGTCCA GATAGCGAAG GGAATGATGT ACCTGGAAGA AAGGCGGCTC 2100
GTTCATCGGG ACTTGGCAGC CCGTAATGTC TTAGTGAAAT CTCCAAACCA TGTGAAAATC 2160
ACAGATTTTG GACTAGCCAG ACTCTTGGAA GGAGACGAAA AAGAGTATAA CGCTGACGGA 2220
GGAAAGATGC CAATTAAGTG GATGGCTCTG GAGTGTATAC ACTATAGGAA ATTCACCCAC 2280
CAGAGTGATG TTTGGAGCTA TGGAGTCACT ATTTGGGAAC TGATGACCTT TGGAGGAAAA 2340
CCCTACGATG GAATTCCAAC CCGAGAAATC CCTGATTTAT TAGAGAAAGG AGAACGTTTG 2400
CCCCAGCCTC CCATCTGCAC TATTGATGTC TACATGGTCA TGGTCAAATG TTGGATGATT 2460
GATGCTGACA GTAGACCTAA ATTTAAAGAA CTGGCCGCTG AATTTTCGAG GATGGCTCGA 2520
GACCCTCAGA GATATCTAGT TATTCAGGGT GATGATCGTA TGAAACTTCC CAGTCCAAAC 2580
GACAGCAAGT TCTTTCAGAA TCTCTTGGAT GAAGAGGATT TAGAGGATAT GATGGATGCT 2640
GAGGAATACC TGGTCCCTCA GGCTTTCAAC ATCCCACCTC CCATCTATAC TTCCAGAGCA 2700
AGAATTGACT CAAATAGGAA CCAGTTTGTG TACCGAGACG GAGGTTTTGC CGCAGAACAA 2760
GGAGTGCCCG TGCCCTACAG AGCCACCACC AGCACCATCC CAGAAGCTCC CGTTGCTCAG 2820
GGGGCTACCC CCGAGATTTT CGATGACTCC TGCTGTAACG GCACCCTGCG CAAGCCAGTG 2880
GCACCCCATG TCCAAGAGGA TAGCAGCACC CAGAGGTACA GCGCCGACCC CACAGTGTTT 2940
GCCACAGAAC GGAGCCCACG AGGAGAGCTG GATGAGGAAG GTTACATGAC CCCTATGCGA 3000
GACAAACCCA AACAAGAGTA CCTGCACCCT GTGGAAGAGA ACCCTTTTGT TTCTCGAAGA 3060
AAAAATGGAG ACCTTCAAGC TTTGGATAAT CCTGAATATC ACAGTGCTTC CAACGGTCCG 3120
CCCAAGGCAG AGGATGAGTA TGTGAATGAG CCACTGTACC TCAACACCTT TGCCAACGCC 3180
TTGGGGAATG CCGAGTACCT GAAGAACAAC GTACTGTCTG TGCCAGAGAA GGCCAAGAAG 3240
GCATTCGACA ACCCTGACTA CTGGAACCAC AGCCTGCCGC CTCGGAGCAC CCTTCAGCAC 3300
CCAGACTACC TGCAGGAGTA CAGCACAAAA TATTTTTATA AACAAAATGG ACGGATCCGG 3360
CCTATTGTGG CAGAGAATCC TGAATACCTC TCTGAGTTCT CATTGAAGCC AGGCACTGTG 3420
CTGCCTCCTC CACCCTACAG ACACCGAAAT ACTGTGGTGT AA 3462
Domain Profile
S: 1     lkklkvlGsGafGtvykGiwipegenvkipvaikvleektgkkankelldealvlasldh  60
         lk++kvlGsGafGtvykGiw+pege+vkipvaik+l+e+tg+kan e++deal++as+dh
Q: 579   LKRVKVLGSGAFGTVYKGIWVPEGETVKIPVAIKILNETTGPKANVEFMDEALIMASMDH  638
         699*********************************************************
S: 61    anlvrllglclsstlqlvtqllplGclldyvrehkdklGsqellnwcvqiakGmsyleek  120
         ++lvrllg+cls t+qlvtql+p+Gclldyv+ehkd++Gsq llnwcvqiakGm+ylee+
Q: 639   PHLVRLLGVCLSPTIQLVTQLMPHGCLLDYVHEHKDNIGSQLLLNWCVQIAKGMMYLEER  698
         ************************************************************
S: 121   rlvhrdlaarnvlvkspnhvkitdfGlaklleadekelkaeggkvpikwlalesilkrky  180
         rlvhrdlaarnvlvkspnhvkitdfGla+lle deke++a+ggk+pikw+ale+i++rk+
Q: 699   RLVHRDLAARNVLVKSPNHVKITDFGLARLLEGDEKEYNADGGKMPIKWMALECIHYRKF  758
         ************************************************************
S: 181   thqsdvwsyGvtvwelltfGakpydgipakeipdllekGerlaqppictidvymvlvkcw  240
         thqsdvwsyGvt+wel+tfG kpydgip++eipdllekGerl+qppictidvymv+vkcw
Q: 759   THQSDVWSYGVTIWELMTFGGKPYDGIPTREIPDLLEKGERLPQPPICTIDVYMVMVKCW  818
         ************************************************************
S: 241   midaesrpkfkelaeefs  258
         mida+srpkfkela+efs
Q: 819   MIDADSRPKFKELAAEFS  836
         ****************96
Domain Sequence
(FASTA)
LKRVKVLGSG AFGTVYKGIW VPEGETVKIP VAIKILNETT GPKANVEFMD EALIMASMDH 60
PHLVRLLGVC LSPTIQLVTQ LMPHGCLLDY VHEHKDNIGS QLLLNWCVQI AKGMMYLEER 120
RLVHRDLAAR NVLVKSPNHV KITDFGLARL LEGDEKEYNA DGGKMPIKWM ALECIHYRKF 180
THQSDVWSYG VTIWELMTFG GKPYDGIPTR EIPDLLEKGE RLPQPPICTI DVYMVMVKCW 240
MIDADSRPKF KELAAEFS 258
KeywordATP-binding; Complete proteome; Kinase; Nucleotide-binding; Phosphoprotein; Reference proteome; Transferase; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00279
EKS-ANC-00288
EKS-BOT-00300
EKS-CAE-00255
EKS-CAJ-00303
EKS-CAF-00303
EKS-CAP-00332
EKS-DAR-00650
EKS-GAG-00250
EKS-GAA-00369
EKS-GOG-00294
EKS-HOS-00303
EKS-LAC-00313
EKS-LOA-00307
EKS-MAM-00300
EKS-MEG-00242
EKS-MOD-00291
EKS-MUM-00328
EKS-MUP-00294
EKS-MYL-00299
EKS-NOL-00273
EKS-ORN-00387
EKS-ORA-00263
EKS-ORC-00279
EKS-ORL-00356
EKS-OTG-00306
EKS-PES-00266
EKS-PEM-00164
EKS-POA-00290
EKS-RAN-00313
EKS-SUS-00266
EKS-TAG-00313
EKS-TAR-00389
EKS-TEN-00384
EKS-VIP-00031
EKS-XET-00370
EKS-XIM-00381
Gene Ontology
GO:0016323; C:basolateral plasma membrane
GO:0005739; C:mitochondrion
GO:0005524; F:ATP binding
GO:0044212; F:transcription regulatory region DNA binding
GO:0004714; F:transmembrane receptor protein tyrosine kinase activity
GO:0006915; P:apoptotic process
GO:0061026; P:cardiac muscle tissue regeneration
GO:0045165; P:cell fate commitment
GO:0021551; P:central nervous system morphogenesis
GO:0009880; P:embryonic pattern specification
GO:0007507; P:heart development
GO:0007595; P:lactation
GO:0060749; P:mammary gland alveolus development
GO:0060644; P:mammary gland epithelial cell differentiation
GO:0043066; P:negative regulation of apoptotic process
GO:0008285; P:negative regulation of cell proliferation
GO:0001755; P:neural crest cell migration
GO:0021889; P:olfactory bulb interneuron differentiation
GO:0018108; P:peptidyl-tyrosine phosphorylation
GO:0060045; P:positive regulation of cardiac muscle cell proliferation
GO:0070374; P:positive regulation of ERK1 and ERK2 cascade
GO:0043552; P:positive regulation of phosphatidylinositol 3-kinase activity
GO:2000366; P:positive regulation of STAT protein import into nucleus
GO:0045893; P:positive regulation of transcription, DNA-dependent
GO:0042523; P:positive regulation of tyrosine phosphorylation of Stat5 protein
GO:0046777; P:protein autophosphorylation
GO:0030334; P:regulation of cell migration
GO:0007169; P:transmembrane receptor protein tyrosine kinase signaling pathway
KEGG
InterPros
IPR000494; EGF_rcpt_L.
IPR006211; Furin-like_Cys-rich_dom.
IPR006212; Furin_repeat.
IPR009030; Growth_fac_rcpt.
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
Pfam
PF00757; Furin-like; 1.
PF07714; Pkinase_Tyr; 1.
PF01030; Recep_L_domain; 1.
SMARTs
SM00261; FU; 5.
SM00219; TyrKc; 1.
Prosites
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
Prints
PR00109; TYRKINASE.
Created Date20-Feb-2013