EKS-EQC-00296

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-EQC-00296

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
Atypical/Alpha	277.3	9.6E-83	121	318	198

Status

Unreviewed

Ensembl Protein

ENSECAP00000020572

UniProt Accession

F6T489;

Protein Name

Protein Synonyms/Alias

Gene Name

EEF2K

Gene Synonyms/Alias

EEF2K;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSECAG00000022924	ENSECAP00000020572	ENSECAT00000024745

Organism

Equus caballus

Functional Description

Protein Length

725

Protein Sequence
(FASTA)

MADEDLIFRL EGVDGGQTSR AGPDGDSDAD SDDDEGYFIC PITDDPRSHQ NVNSKVNNYY 60

SNLMKSEQYS SSGSPASSFH FKEAWKHAIE KAKHMPDPWA EFHLEDIATE CATRHRYNAV 120

TGEWLEDEVL IKMASQPFGR GAMRECFRTK KLSNFLHTQQ WKGASNYVAK RYIESVDRDV 180

YFEDVCLQME AKLWGEEYNR HKPPKQVDIM QMCVVELKER PGKTLFHLEH YIEGKYIKYN 240

SNSGFVRDDN VRLTPQAFSH FTFERSGHQL IVVDIQGVGD LYTDPQIHTE KGTDFGDGNL 300

GVRGMALFFH SHACNRICKS MGLTPFDLSP REKDAVNQNT KLLQSAKTIL RGTEEKCGSP 360

RVRTLSGSRP PLLLRLSENS GDENMSDVTF DSLPSSPSSA TPHSQKLDHL HWPVFSDLDN 420

MTPRDHDHLD NHRDSENSGD SGYPSEKRGE LDDPEPQEHG HSNGTRRYES DEDSLGSCGR 480

VCVEKWNLLN SSRLHLPRPS TVALEMQRLN ALDLEKKIGK SILGKVHLAM VRYHEGGRFC 540

EKDEEWDRES AVFHLEHAAD LGELEAIVGL GLMYSQLPHH ILADVSLKET EENKTKGFNY 600

LLKAAEAGDR QSMILVARAF DTGQNLSPDR SQNWPEALHW YNTALETTDC DEGGEYDGMQ 660

DEPRYTLLAR EAEMLFTGGC GLEKDPQRSG DLYTRAAEAA MAAMKGRLAN QYYQKAEEAW 720

AQMEE 725

Nucleotide Sequence
(FASTA)

ATGGCAGACG AAGACCTCAT CTTCCGCCTC GAAGGCGTTG ATGGCGGCCA GACCTCCAGG 60

GCTGGCCCCG ACGGTGATTC TGACGCAGAC AGCGACGATG ACGAAGGTTA CTTTATCTGC 120

CCCATCACCG ATGACCCCAG GTCACACCAG AATGTCAATT CCAAGGTTAA TAACTACTAC 180

AGCAACCTAA TGAAGAGTGA GCAGTACAGC TCCAGCGGGT CACCCGCGAG CTCCTTCCAT 240

TTTAAGGAAG CCTGGAAGCA CGCAATCGAG AAGGCCAAGC ACATGCCTGA CCCCTGGGCT 300

GAGTTCCACC TGGAGGACAT TGCCACGGAA TGTGCCACGC GTCACAGGTA CAACGCTGTT 360

ACTGGGGAGT GGCTGGAAGA TGAAGTTCTG ATCAAGATGG CGTCTCAGCC CTTTGGCCGT 420

GGAGCGATGA GGGAGTGCTT CAGGACGAAG AAGCTCTCCA ACTTCCTGCA CACCCAGCAG 480

TGGAAGGGTG CCTCCAACTA CGTGGCAAAG CGCTACATTG AGTCGGTGGA CAGGGACGTG 540

TACTTTGAGG ATGTGTGTCT ACAGATGGAG GCCAAGCTCT GGGGAGAGGA GTATAATCGG 600

CACAAGCCCC CCAAGCAGGT GGACATCATG CAGATGTGCG TCGTGGAGCT GAAGGAGAGG 660

CCGGGCAAGA CGCTCTTCCA CCTGGAGCAC TATATCGAGG GCAAGTACAT CAAGTACAAC 720

TCCAACTCGG GCTTTGTCCG CGACGACAAC GTGCGCCTGA CACCACAGGC CTTCAGCCAC 780

TTCACGTTTG AGCGTTCTGG CCATCAGCTG ATTGTGGTGG ACATCCAGGG TGTGGGCGAC 840

CTCTACACTG ACCCACAGAT CCACACCGAG AAGGGCACTG ACTTTGGAGA TGGCAACCTA 900

GGTGTCCGGG GGATGGCTCT CTTCTTCCAC TCTCATGCCT GCAACCGGAT TTGCAAGAGC 960

ATGGGCCTCA CGCCCTTCGA CCTCTCGCCG AGAGAGAAGG ATGCAGTGAA TCAGAACACC 1020

AAGCTGCTGC AATCTGCCAA GACCATCTTG AGGGGAACAG AGGAAAAGTG TGGAAGCCCC 1080

CGAGTAAGGA CCCTGTCTGG GAGCCGGCCT CCACTGCTCC TTCGCCTTTC AGAGAACTCC 1140

GGAGACGAGA ACATGAGCGA CGTGACCTTC GACTCTCTCC CTTCCTCCCC ATCTTCGGCC 1200

ACGCCACACA GCCAGAAACT GGACCACCTC CATTGGCCTG TGTTCAGTGA CCTCGATAAC 1260

ATGACACCCC GAGACCACGA CCATCTGGAC AACCACCGGG ACTCTGAGAA CAGTGGGGAC 1320

AGCGGATACC CCAGTGAGAA GCGGGGTGAG CTGGATGACC CAGAGCCCCA AGAACACGGC 1380

CACTCAAACG GCACCCGGAG GTATGAGTCG GATGAAGACA GCCTGGGCAG CTGCGGACGG 1440

GTCTGTGTGG AGAAGTGGAA TCTCCTCAAC TCCTCCCGCC TCCACCTGCC GAGGCCTTCA 1500

ACTGTGGCCC TGGAGATGCA AAGGCTTAAT GCTCTGGACC TTGAAAAGAA AATCGGGAAG 1560

TCCATTTTGG GGAAGGTCCA TCTGGCCATG GTACGCTACC ATGAGGGTGG GCGCTTCTGT 1620

GAGAAGGATG AGGAGTGGGA CCGCGAGTCG GCCGTCTTCC ATCTGGAACA TGCAGCCGAC 1680

CTGGGTGAGC TGGAGGCCAT CGTGGGCCTG GGACTCATGT ACTCACAGCT GCCCCACCAC 1740

ATCCTGGCTG ACGTCTCTTT GAAGGAGACG GAAGAGAATA AAACCAAAGG ATTCAATTAT 1800

CTACTGAAGG CAGCTGAAGC TGGTGACAGA CAGTCCATGA TCCTGGTGGC ACGGGCTTTT 1860

GACACTGGCC AGAACCTTAG CCCAGACAGG TCCCAAAACT GGCCGGAGGC CCTGCACTGG 1920

TACAACACTG CCCTGGAGAC GACAGATTGT GATGAGGGCG GTGAGTATGA TGGGATGCAA 1980

GACGAACCCC GGTACACGCT GCTGGCCAGG GAGGCTGAGA TGCTGTTCAC AGGTGGCTGC 2040

GGGCTAGAGA AGGACCCGCA GAGATCAGGC GACTTGTACA CCCGGGCAGC CGAGGCAGCG 2100

ATGGCAGCCA TGAAGGGCCG GCTGGCCAAC CAGTACTATC AGAAGGCGGA GGAGGCCTGG 2160

GCCCAGATGG AGGAATAA 2178

Domain Profile

S: 2     sesWsqqetivlikvlskeekkGalRkalrvkkgslflvkeelkevvryvakiykeqkvl  61

         +++W+++e  vlik++s+++++Ga+R+++r+kk+s+fl+ +++k++++yvak+y+e++++

Q: 121   TGEWLEDE--VLIKMASQPFGRGAMRECFRTKKLSNFLHTQQWKGASNYVAKRYIESVDR  178

         789*****..**************************************************

S: 62    hlylrdverqraaqklvtefnqvkPkkivyiprlievfLkdrtsknqlltvEeyllGefv  121

         ++y++dv  q++a+ +++e+n++kP+k+v+i++++ v+Lk+r++k  l+++E+y++G+++

Q: 179   DVYFEDVCLQMEAKLWGEEYNRHKPPKQVDIMQMCVVELKERPGK-TLFHLEHYIEGKYI  237

         *********************************************.**************

S: 122   KynnnngdeikrenkleelmlafsHftyeytngellVvDlqGvgeklTDpqiatksrgtk  181

         Kyn+n+g  ++r+++++ +++afsHft+e+++++l+VvD+qGvg+ +TDpqi+t ++gt+

Q: 238   KYNSNSG--FVRDDNVRLTPQAFSHFTFERSGHQLIVVDIQGVGDLYTDPQIHT-EKGTD  294

         *******..*********************************************.*****

S: 182   fgkanlgeraiknFfakhhCNeiC  205

         fg++nlg+r+++ Ff +h+CN+iC

Q: 295   FGDGNLGVRGMALFFHSHACNRIC  318

         ************************

Domain Sequence
(FASTA)

TGEWLEDEVL IKMASQPFGR GAMRECFRTK KLSNFLHTQQ WKGASNYVAK RYIESVDRDV 60

YFEDVCLQME AKLWGEEYNR HKPPKQVDIM QMCVVELKER PGKTLFHLEH YIEGKYIKYN 120

SNSGFVRDDN VRLTPQAFSH FTFERSGHQL IVVDIQGVGD LYTDPQIHTE KGTDFGDGNL 180

GVRGMALFFH SHACNRIC 198

Keyword

Complete proteome; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0005509	; F:calcium ion binding
GO:0004686	; F:elongation factor-2 kinase activity
GO:0046777	; P:protein autophosphorylation
GO:0031952	; P:regulation of protein autophosphorylation

KEGG

ecb:100058387

;

InterPros

IPR017400	; Elongation_factor_2_kinase.
IPR011009	; Kinase-like_dom.
IPR004166	; MHCK_EF2_kinase.
IPR006597	; Sel1-like.
IPR011990	; TPR-like_helical.

Pfam

PF02816	; Alpha_kinase; 1.
PF08238	; Sel1; 4.

SMARTs

SM00811

; Alpha_kinase; 1.

Prosites

PS51158

; ALPHA_KINASE; 1.

Prints

Created Date

20-Feb-2013