EKS-EQC-00139

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-EQC-00139

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
Other/CDC7	541.7	5.6E-163	59	571	513

Status

Unreviewed

Ensembl Protein

ENSECAP00000020547

UniProt Accession

F6TBX9;

Protein Name

Protein Synonyms/Alias

Gene Name

CDC7

Gene Synonyms/Alias

CDC7;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSECAG00000022964	ENSECAP00000020547	ENSECAT00000024718

Organism

Equus caballus

Functional Description

Protein Length

576

Protein Sequence
(FASTA)

MEASLGIQMD DPLAFSPLRD RFQADGSLKK HEQNFKLPGM HKKDIEKLYE AVPQLGSVFK 60

IKDKIGEGTF SSVYLATAHL QVGPEEKIAL KHLIPTSHPI RIAAELQCLT VAGGQDNVMG 120

VKYCFRKNDH VVIAMPYLEH ESFLDILNSL SFQEVREYMF NLFKALKRIH QFGIVHRDVK 180

PSNFLYNRRL KKYALVDFGL AQGTHDTKIE LLKFVQSEAQ QESCLQNKSH VITGNKISLS 240

GLAAPKELDQ QPTTKTSVKR PYTNAQIQIK HGKDGKEGSV GLSVQRSVFG ERNFNIHSSI 300

SHESPAVKLM KQSKTVDVLS RKLATKKKAV STKVMNSGVM RKTASSCPAS LTCDCYATDK 360

VCSICLSRRQ QVAPRAGTPG FRAPEVLTKC PNQTTAIDMW SAGVIFLSLL SGRYPFYKAS 420

DDLTALAQIM TIRGSRETIQ AAKTFGKSIL CSKEVPAQDL RKLCEKLRGI DSKTSKLTSD 480

IQGPASHDPT VSEKTDHKAS HLIQTPQAQP SGTSVCKGDS NGCGGHFDVC STNLEGWDEV 540

PDEAYDLLDK LLDLNPASRI TAGEALLHPF FKDMSL 576

Nucleotide Sequence
(FASTA)

ATGGAGGCGT CTTTGGGGAT TCAGATGGAT GACCCGCTGG CTTTTTCTCC CCTGCGTGAC 60

CGGTTTCAGG CGGATGGCTC GTTAAAAAAA CATGAGCAGA ATTTTAAACT ACCAGGTATG 120

CATAAAAAAG ATATTGAGAA GCTTTATGAA GCTGTACCAC AGCTTGGCAG TGTGTTTAAG 180

ATTAAGGACA AAATTGGAGA AGGCACTTTC AGCTCTGTTT ATTTGGCTAC AGCACACTTA 240

CAAGTAGGAC CTGAAGAGAA AATTGCTCTA AAACACTTAA TTCCAACAAG TCATCCTATA 300

AGAATTGCAG CTGAACTTCA GTGCCTAACA GTGGCTGGGG GGCAAGACAA TGTCATGGGA 360

GTTAAATACT GCTTTAGGAA AAATGATCAT GTGGTTATTG CTATGCCATA TCTGGAGCAT 420

GAGTCCTTTT TGGACATTTT GAATTCTCTT TCCTTTCAAG AAGTACGTGA ATATATGTTT 480

AATCTGTTCA AAGCTTTGAA ACGCATTCAT CAGTTTGGTA TTGTTCACCG TGATGTTAAG 540

CCCAGCAATT TTTTATATAA TAGGCGTCTG AAAAAGTATG CCTTGGTAGA CTTTGGTTTG 600

GCCCAGGGAA CCCATGATAC AAAAATAGAG CTGCTCAAAT TTGTCCAATC GGAAGCTCAG 660

CAAGAAAGTT GTTTACAAAA TAAATCCCAC GTGATCACAG GAAACAAGAT TTCATTGAGT 720

GGCCTAGCAG CACCTAAGGA GCTGGATCAG CAGCCCACCA CAAAAACTTC TGTTAAAAGG 780

CCCTACACAA ATGCGCAAAT TCAGATTAAA CATGGAAAAG ATGGAAAGGA GGGATCTGTA 840

GGCCTTTCTG TCCAGCGCTC TGTTTTTGGA GAAAGAAATT TCAATATACA CAGCTCCATT 900

TCACATGAGA GCCCTGCAGT GAAACTTATG AAGCAGTCAA AGACTGTGGA TGTACTCTCT 960

AGAAAGTTAG CAACAAAAAA GAAGGCTGTT TCTACAAAAG TTATGAATAG TGGTGTGATG 1020

AGGAAAACTG CCAGTTCTTG CCCAGCTAGC CTGACCTGTG ACTGTTATGC AACAGATAAA 1080

GTTTGCAGTA TTTGCCTTTC AAGGCGGCAA CAGGTTGCCC CTCGGGCAGG TACACCGGGA 1140

TTCAGAGCAC CAGAGGTCTT GACAAAGTGC CCCAATCAGA CTACAGCAAT TGACATGTGG 1200

TCTGCAGGTG TGATATTCCT TTCTTTGCTT AGTGGACGAT ATCCATTTTA TAAAGCAAGT 1260

GATGATTTAA CTGCTTTGGC TCAAATTATG ACAATTCGTG GATCCAGGGA AACTATCCAG 1320

GCTGCTAAAA CTTTTGGCAA ATCAATATTA TGTAGCAAAG AAGTCCCTGC ACAAGACTTG 1380

AGAAAACTCT GTGAGAAGCT CAGAGGTATA GATTCTAAGA CTTCCAAATT AACCAGTGAT 1440

ATACAGGGGC CTGCTTCTCA TGACCCAACT GTTTCAGAGA AGACTGACCA TAAAGCTTCT 1500

CACCTTATAC AAACACCTCA AGCACAGCCC TCAGGGACTT CAGTGTGTAA AGGGGACAGT 1560

AATGGTTGTG GGGGTCATTT TGATGTGTGT TCTACCAACT TAGAGGGCTG GGATGAGGTG 1620

CCTGATGAAG CTTATGACCT ACTTGATAAA CTTCTTGATC TAAATCCAGC GTCAAGAATA 1680

ACAGCAGGAG AAGCTTTGTT GCATCCTTTT TTTAAAGATA TGAGTTTGTG A 1731

Domain Profile

S: 1     fkikdkiGeGtfssvylataqleegleekialkhliptshPeriaaeLelltvlgGqenv  60

         fkikdkiGeGtfssvylata+l++g+eekialkhliptshP+riaaeL++ltv+gGq+nv

Q: 59    FKIKDKIGEGTFSSVYLATAHLQVGPEEKIALKHLIPTSHPIRIAAELQCLTVAGGQDNV  118

         9***********************************************************

S: 61    vglkecfrkndsvvivlpylehesfldllrslsfqevreYlrnLlvalkrvhkfgivhrD  120

         +g+k+cfrknd+vvi++pylehesfld+l+slsfqevreY++nL++alkr+h+fgivhrD

Q: 119   MGVKYCFRKNDHVVIAMPYLEHESFLDILNSLSFQEVREYMFNLFKALKRIHQFGIVHRD  178

         ************************************************************

S: 121   vkpsnfLynrrlkkfaLvDfGLaq..............seaqkeecsrn.........ll  157

         vkpsnfLynrrlkk+aLvDfGLaq              seaq+e+c +n

Q: 179   VKPSNFLYNRRLKKYALVDFGLAQgthdtkiellkfvqSEAQQESCLQNkshvitgnkI-  237

         *************************************************6666666650.

S: 158   saavekevd...................................................  166

Q: 238   --------Slsglaapkeldqqpttktsvkrpytnaqiqikhgkdgkegsvglsvqrsvf  289

         ........3444444444458899999*********************************

S: 167   ............................................................  166

Q: 290   gernfnihssishespavklmkqsktvdvlsrklatkkkavstkvmnsgvmrktasscpa  349

         ************************************************************

S: 167   ..tcdcygtdkvcsvclsrrqqvanraGtpGfraPevLlkipdqttaiDiwsaGvilLsl  224

           tcdcy+tdkvcs+clsrrqqva+raGtpGfraPevL+k+p+qttaiD+wsaGvi+Lsl

Q: 350   slTCDCYATDKVCSICLSRRQQVAPRAGTPGFRAPEVLTKCPNQTTAIDMWSAGVIFLSL  409

         ************************************************************

S: 225   lsgryPffkasddlealaeivtilGsreiikaakafgksvllskevp.............  271

         lsgryPf+kasddl+ala+i+ti+Gsre+i+aak+fgks+l+skevp

Q: 410   LSGRYPFYKASDDLTALAQIMTIRGSRETIQAAKTFGKSILCSKEVPaqdlrklceklrg  469

         ************************************************************

S: 272   .................................................dsdsye.....  277

                                                          ds+++

Q: 470   idsktskltsdiqgpashdptvsektdhkashliqtpqaqpsgtsvckgDSNGCGghfdv  529

         ************************999999999999999999999999955555566666

S: 278   ...........PdeaydlldkllelnPakritaeealkhpff  308

                    Pdeaydlldkll+lnPa+rita eal+hpff

Q: 530   cstnlegwdevPDEAYDLLDKLLDLNPASRITAGEALLHPFF  571

         66777788899******************************8

Domain Sequence
(FASTA)

FKIKDKIGEG TFSSVYLATA HLQVGPEEKI ALKHLIPTSH PIRIAAELQC LTVAGGQDNV 60

MGVKYCFRKN DHVVIAMPYL EHESFLDILN SLSFQEVREY MFNLFKALKR IHQFGIVHRD 120

VKPSNFLYNR RLKKYALVDF GLAQGTHDTK IELLKFVQSE AQQESCLQNK SHVITGNKIS 180

LSGLAAPKEL DQQPTTKTSV KRPYTNAQIQ IKHGKDGKEG SVGLSVQRSV FGERNFNIHS 240

SISHESPAVK LMKQSKTVDV LSRKLATKKK AVSTKVMNSG VMRKTASSCP ASLTCDCYAT 300

DKVCSICLSR RQQVAPRAGT PGFRAPEVLT KCPNQTTAID MWSAGVIFLS LLSGRYPFYK 360

ASDDLTALAQ IMTIRGSRET IQAAKTFGKS ILCSKEVPAQ DLRKLCEKLR GIDSKTSKLT 420

SDIQGPASHD PTVSEKTDHK ASHLIQTPQA QPSGTSVCKG DSNGCGGHFD VCSTNLEGWD 480

EVPDEAYDLL DKLLDLNPAS RITAGEALLH PFF 513

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Choloepus hoffmanni"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Dasypus novemcinctus"; ?>Dipodomys ordii"; ?>Drosophila melanogaster"; ?>Echinops telfairi"; ?>Erinaceus europaeus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Macropus eugenii"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>Saccharomyces cerevisiae"; ?>Schizosaccharomyces pombe"; ?>

Gene Ontology

GO:0005737	; C:cytoplasm
GO:0005634	; C:nucleus
GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0008284	; P:positive regulation of cell proliferation
GO:0033261	; P:regulation of S phase

KEGG

ecb:100060468

;

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 2.

SMARTs

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013