EKS-EQC-00174

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-EQC-00174

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
AGC/PKC	369.7	1.0E-110	348	598	251

Status

Unreviewed

Ensembl Protein

ENSECAP00000021032

UniProt Accession

F7CQM8;

Protein Name

Protein Synonyms/Alias

Gene Name

PRKCD

Gene Synonyms/Alias

PRKCD;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSECAG00000023172	ENSECAP00000021032	ENSECAT00000025287

Organism

Equus caballus

Functional Description

Protein Length

671

Protein Sequence
(FASTA)

MAPFLRIAFN SYELGSLQAE DEASQPFCAV KMKEALSTDR GKTLVQKKPT MYPEWKSTFD 60

AHIYEGRVIQ IVLMRAAEEP VSEVTVGVSV LAERCKKNNG KAEFWLDLQP QAKVLMSVQY 120

FLEDIDCKQS VRAEDEAKFP TMNRRGAIKQ AKIHYIKNHE FIATFFRQPT FCSVCKDFVW 180

GLNKQGYKCR QCNAAIHKKC IDKIIGRCTG TAANSRDTIF QKERFNIDMP HRFKVYNYMS 240

PTFCDHCGSL LWGLVKQGLK CEDCGMNVHH KCQKKVANLC GINQKLLAEA LNQVSQRPTR 300

KSESGPPEHF GIYQNFEKKP GVSGDDAPDH STYGKIWEGS NRCNIENFTF HKVLGKGSFG 360

KVLLAELKGK KEFFAIKLKK DVALIDDDGT VVPLFLLGLA QRPSMKEPLA GSYASDHLFF 420

VMEFLNGGDL MYHIQDKGRF ELYRATFYAA EIICGLQFLH NKGIIYRDLK LDNVMLDQDG 480

HIKIADFGMC KENIFGEKQA STFCGTPDYI APEILQGLKY SFSVDWWSFG VLLYEMLIGQ 540

SPFHGDDEDE LFESIRMDTP HYPRWITKES KDILEKLLER DPTKRLGVTG NIKAHSFFKT 600

INWTLLEKRA VEPPFKPKVK SPGDYSNFDQ EFLNEKPRLS YSDKNLIDSM DQAAFAGFSF 660

VNPKFERLLE K 671

Nucleotide Sequence
(FASTA)

ATGGCGCCGT TCCTGCGCAT TGCCTTCAAC TCCTACGAGC TGGGCTCCCT GCAGGCTGAG 60

GATGAGGCAA GCCAACCCTT CTGTGCCGTG AAGATGAAGG AGGCGCTCAG CACAGACCGT 120

GGGAAGACGC TGGTGCAGAA GAAGCCCACC ATGTATCCTG AGTGGAAGTC GACGTTCGAT 180

GCCCACATCT ACGAGGGCCG CGTCATCCAG ATTGTGCTGA TGCGGGCCGC CGAGGAGCCG 240

GTGTCCGAGG TGACCGTGGG CGTGTCAGTG CTGGCCGAGC GCTGCAAGAA GAACAATGGC 300

AAGGCCGAGT TCTGGCTGGA CCTGCAACCC CAGGCCAAAG TATTGATGTC TGTGCAGTAT 360

TTCCTGGAAG ACATAGATTG CAAGCAGTCT GTTCGGGCTG AAGACGAGGC CAAGTTCCCA 420

ACAATGAACC GCCGTGGAGC CATCAAACAG GCCAAAATCC ACTACATCAA GAACCATGAG 480

TTTATCGCCA CCTTCTTTAG GCAGCCCACC TTCTGTTCTG TGTGCAAAGA CTTTGTCTGG 540

GGTCTCAACA AGCAAGGCTA CAAATGCAGG CAATGCAATG CTGCCATCCA CAAGAAATGC 600

ATCGACAAGA TCATCGGTCG GTGCACTGGC ACCGCGGCCA ACAGCCGGGA CACCATATTC 660

CAGAAAGAAC GTTTCAACAT TGACATGCCG CACCGGTTCA AGGTTTACAA CTACATGAGC 720

CCCACCTTCT GTGACCATTG TGGCAGCCTG CTCTGGGGGC TGGTGAAGCA GGGATTAAAG 780

TGTGAAGACT GTGGCATGAA CGTGCACCAT AAGTGCCAGA AGAAGGTGGC CAACCTCTGC 840

GGCATCAACC AGAAGCTCTT GGCTGAGGCA CTGAACCAAG TCAGCCAGAG ACCCACCCGG 900

AAGTCGGAGT CTGGGCCTCC GGAGCATTTC GGGATCTACC AGAATTTTGA GAAGAAGCCA 960

GGAGTCTCTG GAGATGATGC CCCAGACCAC AGTACCTACG GCAAGATCTG GGAGGGCAGC 1020

AACAGATGCA ACATTGAGAA CTTCACCTTC CACAAGGTCC TGGGCAAAGG CAGCTTCGGG 1080

AAGGTGCTGC TTGCAGAGCT GAAGGGCAAA AAGGAGTTCT TCGCCATCAA GCTCAAGAAG 1140

GATGTGGCTC TGATTGATGA TGACGGCACA GTGGTCCCCC TTTTCCTCTT GGGGCTTGCC 1200

CAGCGGCCCT CAATGAAGGA GCCTCTCGCT GGTTCCTATG CCTCTGACCA CCTGTTCTTC 1260

GTGATGGAGT TCCTCAACGG GGGAGACCTG ATGTACCACA TCCAGGATAA AGGCCGCTTT 1320

GAACTCTACC GTGCCACGTT TTATGCAGCT GAGATAATCT GTGGACTACA GTTTCTACAC 1380

AACAAGGGGA TCATTTACAG GGACCTCAAG CTGGACAATG TGATGCTGGA CCAGGATGGC 1440

CACATCAAGA TTGCCGACTT TGGGATGTGC AAGGAGAACA TATTCGGGGA GAAACAGGCC 1500

AGCACCTTCT GCGGCACCCC TGACTATATC GCCCCCGAGA TCCTGCAGGG CCTGAAGTAC 1560

TCGTTCTCCG TGGACTGGTG GTCCTTTGGA GTCCTTCTCT ATGAGATGCT CATTGGTCAG 1620

TCCCCCTTCC ACGGTGACGA TGAGGATGAA CTCTTCGAGT CCATCCGTAT GGACACACCA 1680

CATTATCCCC GCTGGATCAC CAAGGAGTCC AAGGACATTC TGGAGAAGCT GCTTGAAAGG 1740

GATCCAACCA AGAGGCTGGG AGTGACAGGG AACATCAAAG CCCACTCCTT CTTCAAGACC 1800

ATCAACTGGA CGCTGCTGGA GAAACGTGCG GTGGAGCCGC CCTTCAAGCC CAAAGTGAAG 1860

TCCCCTGGAG ACTACAGCAA CTTCGACCAG GAGTTCCTGA ACGAGAAGCC ACGCCTCTCC 1920

TACAGCGACA AGAACCTCAT TGACTCCATG GACCAAGCAG CCTTTGCTGG CTTCTCCTTC 1980

GTGAACCCCA AATTTGAGAG GCTCCTGGAA AAGTGA 2016

Domain Profile

S: 1     fellkvlGkGsfgkvllaelkktdelyaikvlkkdvvlqdddveltlvekrvlalaskkp  60

         f+++kvlGkGsfgkvllaelk+++e++aik lkkdv l ddd   t+v   +l la++++

Q: 348   FTFHKVLGKGSFGKVLLAELKGKKEFFAIK-LKKDVALIDDDG--TVVPLFLLGLAQRPS  404

         89****************************.7*******9985..566778999999988

S: 61    flvqlfscfqtedrlffvleyvnGGdlmfhiqkarklkeerarfyaaeiilalkflhekg  120

         +   l  ++ ++d+lffv+e++nGGdlm+hiq++++++  ra+fyaaeii++l+flh+kg

Q: 405   MKEPLAGSY-ASDHLFFVMEFLNGGDLMYHIQDKGRFELYRATFYAAEIICGLQFLHNKG  463

         888888887.689***********************************************

S: 121   iiyrdlkldnvlldaeGhikladfGlckeeilegkttstfcGtPdyiaPeilkeeeygks  180

         iiyrdlkldnv+ld++Ghik+adfG+cke+i+ +k++stfcGtPdyiaPeil++ +y++s

Q: 464   IIYRDLKLDNVMLDQDGHIKIADFGMCKENIFGEKQASTFCGTPDYIAPEILQGLKYSFS  523

         ************************************************************

S: 181   vdwwalGvllyemlagqsPfegededelfesilekevlyPkslskeaveilkglltkdpe  240

         vdww++Gvllyeml+gqsPf+g+dedelfesi++++++yP++++ke+++il++ll++dp+

Q: 524   VDWWSFGVLLYEMLIGQSPFHGDDEDELFESIRMDTPHYPRWITKESKDILEKLLERDPT  583

         ************************************************************

S: 241   krlGvkeegeedikehaff  259

         krlGv  +g  +ik+h+ff

Q: 584   KRLGV--TG--NIKAHSFF  598

         *****..56..79999998

Domain Sequence
(FASTA)

FTFHKVLGKG SFGKVLLAEL KGKKEFFAIK LKKDVALIDD DGTVVPLFLL GLAQRPSMKE 60

PLAGSYASDH LFFVMEFLNG GDLMYHIQDK GRFELYRATF YAAEIICGLQ FLHNKGIIYR 120

DLKLDNVMLD QDGHIKIADF GMCKENIFGE KQASTFCGTP DYIAPEILQG LKYSFSVDWW 180

SFGVLLYEML IGQSPFHGDD EDELFESIRM DTPHYPRWIT KESKDILEKL LERDPTKRLG 240

VTGNIKAHSF F 251

Keyword

ATP-binding; Complete proteome; Kinase; Metal-binding; Nucleotide-binding; Reference proteome; Repeat; Serine/threonine-protein kinase; Transferase; Zinc; Zinc-finger.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005911	; C:cell-cell junction
GO:0005829	; C:cytosol
GO:0005783	; C:endoplasmic reticulum
GO:0016363	; C:nuclear matrix
GO:0005886	; C:plasma membrane
GO:0005524	; F:ATP binding
GO:0008047	; F:enzyme activator activity
GO:0046872	; F:metal ion binding
GO:0004697	; F:protein kinase C activity
GO:0006915	; P:apoptotic process
GO:0042100	; P:B cell proliferation
GO:0090398	; P:cellular senescence
GO:0016064	; P:immunoglobulin mediated immune response
GO:0032613	; P:interleukin-10 production
GO:0032615	; P:interleukin-12 production
GO:0035556	; P:intracellular signal transduction
GO:0030837	; P:negative regulation of actin filament polymerization
GO:0051490	; P:negative regulation of filopodium assembly
GO:0034351	; P:negative regulation of glial cell apoptotic process
GO:0046627	; P:negative regulation of insulin receptor signaling pathway
GO:0043407	; P:negative regulation of MAP kinase activity
GO:0050732	; P:negative regulation of peptidyl-tyrosine phosphorylation
GO:0090331	; P:negative regulation of platelet aggregation
GO:0042119	; P:neutrophil activation
GO:0018107	; P:peptidyl-threonine phosphorylation
GO:2000304	; P:positive regulation of ceramide biosynthetic process
GO:2000753	; P:positive regulation of glucosylceramide catabolic process
GO:1900163	; P:positive regulation of phospholipid scramblase activity
GO:0035307	; P:positive regulation of protein dephosphorylation
GO:2001022	; P:positive regulation of response to DNA damage stimulus
GO:2000755	; P:positive regulation of sphingomyelin catabolic process
GO:0032930	; P:positive regulation of superoxide anion generation
GO:0023021	; P:termination of signal transduction

KEGG

InterPros

IPR000961	; AGC-kinase_C.
IPR000008	; C2_Ca-dep.
IPR008973	; C2_Ca/lipid-bd_dom_CaLB.
IPR020454	; DAG/PE-bd.
IPR011009	; Kinase-like_dom.
IPR017892	; Pkinase_C.
IPR014376	; Prot_kin_PKC_delta.
IPR002219	; Prot_Kinase_C-like_PE/DAG-bd.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00130	; C1_1; 2.
PF00069	; Pkinase; 1.
PF00433	; Pkinase_C; 1.

SMARTs

SM00109	; C1; 2.
SM00239	; C2; 1.
SM00133	; S_TK_X; 1.
SM00220	; S_TKc; 1.

Prosites

PS51285	; AGC_KINASE_CTER; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.
PS00479	; ZF_DAG_PE_1; 2.
PS50081	; ZF_DAG_PE_2; 2.

Prints

PR00008

; DAGPEDOMAIN.

Created Date

20-Feb-2013