EKS-EQC-00003
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-EQC-00003
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/Eph516.88.4E-156622879258
StatusUnreviewed
Ensembl ProteinENSECAP00000021136
UniProt AccessionF7C3U9;
Protein Name
Protein Synonyms/Alias
Gene NameEPHA3
Gene Synonyms/Alias EPHA3;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSECAG00000023211ENSECAP00000021136ENSECAT00000025408
OrganismEquus caballus
Functional Description
Protein Length984
Protein Sequence
(FASTA)
MDCHLSVLLL LSCSALGCSG EVTVPPSNEV NLLDSKTVQG ELGWISYPSH GWEEISGVDE 60
HYTPIRTYQV CNVMDHSQNN WLRTNWVSRN SAQKIYVELK FTLRDCNSIP LVSGTCKETF 120
NLYYMESDDD HGVKFREHQF TKIDTIAADE SFTQMDLGDR ILKLNTEVRE VGPVNKKGFY 180
LAFQDVGACV ALVSVRVYFK KCPFTVKNLA MFPDTVPMDS QSLVEVRGSC VNNSKEEDAP 240
RMYCSTEGEW LVPIGKCSCN AGYEEGGLMC RACRPGFYKA SDGGMKCAKC PPHSSTPEDG 300
SVNCRCENNY FRADRDPPSM ACTRPPSAPR NVISNINETS VILDWSWPLD TGGRKDVTFN 360
IICKKCGWNI KQCEPCSPNV RFLPRQFGLT NTTVTVTDLL AHTNYTFEID AINGVSELSS 420
PPRQFAAVSI TTNQAAPSPV ITIKKDRTSR NSISLSWQEP EHPNGIILDY EVKYYEKQEQ 480
ETSYTILRAR GTNVTISSLK PDTTYVFQIR ARTAAGYGTN SRKFEFETSP DSFSISGENS 540
QVVMIAVSAA GAILLLSGVA YVLIGRFCGY NKSKHGAEEK RLHFGNGHLK LPGLRTYVDP 600
HTYEDPTQAV HEFAKELDAT NISIDKVVGA GEFGEVCSGR LKLPSKKEIS VAIKTLKVGY 660
TEKQRRDFLG EASIMGQFDH PNIIRLEGVV TKSKPVMIVT EYMENGSLDG FLRKHDAQFT 720
VIQLVGMLRG IASGMKYLSD MGYVHRDLAA RNILINSNLV CKVSDFGLSR VLEDDPEAAY 780
TTRGGKIPIR WTSPEAIAYR KFTSASDVWS YGIVLWEVMS YGERPYWEMS NQDVIKAVDE 840
GYRLPPPMDC PAALYQLMLD CWQKDRNNRP KFEQIVSILD KLIRNPGSLK VVTSAAARPS 900
NLLLDQSNVD VPTFRTPGDW LNGVRTAQCK EIFTGVEYSS CDTIAKISTD DMKKVGVTVV 960
GPQKKIISSI KALETQSKNG PVPV 984
Nucleotide Sequence
(FASTA)
ATGGATTGTC ACCTCTCCGT CCTCCTCCTC CTCAGCTGCT CTGCTCTCGG CTGCTCCGGG 60
GAAGTGACTG TCCCTCCCTC CAACGAAGTC AATCTGCTGG ATTCGAAGAC AGTCCAAGGG 120
GAGCTGGGCT GGATCTCCTA CCCATCACAT GGGTGGGAAG AGATCAGTGG TGTTGATGAA 180
CATTACACAC CCATCAGGAC TTACCAGGTG TGCAATGTCA TGGATCACAG TCAAAATAAT 240
TGGCTGAGGA CAAACTGGGT CTCCAGGAAC TCGGCTCAGA AGATCTACGT GGAGCTCAAG 300
TTCACTCTGA GGGACTGCAA TAGCATTCCA CTGGTTTCGG GAACTTGCAA GGAGACTTTC 360
AACCTGTATT ACATGGAGTC AGATGATGAT CATGGGGTCA AATTCCGAGA GCATCAGTTT 420
ACAAAGATAG ACACCATTGC AGCTGATGAA AGTTTCACTC AAATGGATCT CGGGGACAGA 480
ATTCTTAAAC TCAACACTGA GGTTAGAGAA GTAGGTCCTG TCAACAAAAA GGGATTTTAT 540
TTGGCTTTTC AAGATGTTGG TGCTTGTGTT GCCTTGGTGT CTGTGAGAGT ATACTTCAAA 600
AAGTGCCCAT TTACGGTGAA GAATCTGGCT ATGTTTCCAG ACACAGTACC CATGGATTCC 660
CAATCCCTGG TGGAAGTCAG AGGTTCTTGT GTTAACAATT CTAAGGAGGA AGATGCTCCC 720
AGGATGTACT GCAGCACAGA AGGAGAATGG CTTGTACCCA TCGGCAAGTG CTCTTGCAAT 780
GCTGGCTACG AAGAAGGAGG TTTGATGTGC CGAGCTTGTC GTCCCGGTTT CTACAAGGCC 840
TCGGATGGTG GTATGAAGTG TGCCAAGTGC CCCCCTCACA GCTCCACTCC GGAAGATGGT 900
TCAGTGAACT GCAGGTGTGA GAATAATTAC TTCCGGGCAG ACAGAGACCC TCCATCCATG 960
GCTTGTACCC GACCTCCATC TGCACCAAGA AATGTTATCT CTAATATAAA CGAGACCTCG 1020
GTTATCCTGG ACTGGAGTTG GCCCCTGGAC ACAGGAGGCC GGAAAGATGT TACCTTCAAC 1080
ATTATATGTA AAAAGTGTGG GTGGAATATA AAACAATGTG AGCCTTGCAG CCCCAATGTC 1140
CGCTTCCTCC CTCGACAGTT TGGACTCACC AACACGACAG TGACAGTGAC AGACCTCCTG 1200
GCACACACTA ACTACACCTT TGAGATCGAT GCCATTAATG GGGTGTCAGA GCTGAGCTCA 1260
CCACCAAGAC AGTTTGCTGC CGTCAGCATC ACAACTAACC AGGCTGCTCC ATCACCTGTC 1320
ATCACGATTA AGAAGGATCG AACATCCAGA AACAGTATCT CTTTATCTTG GCAAGAACCT 1380
GAACACCCTA ATGGGATCAT ATTGGACTAC GAGGTCAAAT ACTATGAAAA GCAGGAACAA 1440
GAGACAAGTT ATACCATTCT GAGAGCAAGA GGCACGAATG TGACCATCAG TAGCCTCAAG 1500
CCTGACACGA CATACGTCTT CCAAATCAGA GCCCGAACAG CAGCTGGATA CGGGACCAAC 1560
AGTCGCAAGT TTGAGTTTGA AACTAGCCCA GACTCTTTCT CCATCTCGGG TGAGAATAGC 1620
CAGGTGGTCA TGATCGCCGT CTCAGCGGCG GGAGCCATCC TCCTCCTCAG CGGTGTCGCC 1680
TACGTTTTGA TCGGGAGGTT TTGTGGCTAC AACAAGTCGA AACATGGTGC AGAGGAAAAA 1740
AGACTTCATT TTGGAAATGG ACATTTAAAA CTGCCAGGTC TCAGGACTTA TGTTGACCCA 1800
CACACGTATG AAGACCCGAC CCAAGCAGTT CACGAGTTTG CTAAGGAACT GGACGCCACT 1860
AACATATCCA TTGACAAAGT TGTTGGAGCA GGTGAATTTG GAGAGGTGTG CAGTGGTCGC 1920
TTAAAACTTC CGTCAAAAAA AGAGATTTCA GTGGCCATTA AGACCCTGAA AGTGGGGTAC 1980
ACGGAAAAGC AGAGGAGAGA CTTCCTGGGA GAAGCAAGCA TTATGGGACA ATTTGACCAT 2040
CCCAACATCA TCCGACTAGA GGGAGTCGTT ACTAAAAGTA AACCAGTTAT GATTGTCACA 2100
GAATACATGG AGAATGGTTC CTTGGACGGT TTCTTACGTA AACACGATGC CCAGTTTACC 2160
GTCATCCAGC TAGTGGGGAT GCTCCGAGGG ATAGCGTCTG GCATGAAGTA CCTCTCAGAC 2220
ATGGGCTATG TTCACCGGGA CCTCGCTGCT CGGAACATCT TGATCAACAG TAATTTGGTG 2280
TGTAAGGTTT CTGATTTTGG ACTTTCACGT GTTCTGGAGG ATGACCCAGA AGCTGCCTAC 2340
ACAACAAGAG GAGGGAAGAT CCCAATCCGG TGGACGTCAC CAGAAGCCAT AGCCTACCGC 2400
AAATTCACAT CAGCCAGCGA CGTGTGGAGT TACGGGATTG TTCTCTGGGA GGTGATGTCC 2460
TATGGAGAGA GACCATACTG GGAGATGTCC AATCAGGACG TAATTAAAGC TGTGGATGAG 2520
GGCTACCGCC TGCCGCCTCC CATGGACTGC CCAGCTGCAT TGTACCAGCT GATGCTGGAC 2580
TGCTGGCAGA AAGACAGGAA CAACAGGCCC AAGTTTGAGC AGATCGTCAG CATCCTGGAC 2640
AAGCTGATCC GGAACCCGGG AAGTCTGAAG GTCGTCACCA GCGCAGCGGC AAGGCCATCA 2700
AACCTTCTTC TGGACCAAAG CAATGTCGAC GTCCCTACCT TCCGCACACC AGGTGACTGG 2760
CTTAATGGTG TCCGGACAGC ACAGTGCAAG GAAATCTTCA CAGGAGTGGA GTACAGTTCT 2820
TGTGACACCA TAGCCAAGAT TTCCACAGAT GACATGAAAA AAGTTGGTGT CACTGTGGTT 2880
GGGCCACAAA AGAAGATCAT CAGTAGTATT AAAGCTCTAG AAACTCAATC AAAAAATGGT 2940
CCAGTTCCAG TGTAA 2955
Domain Profile
S: 1     vkiekviGaGefGevcsGrlklpgkreiavaiktlkagstekqrrdflseasilGqfdhp  60
         ++i+kv+GaGefGevcsGrlklp+k+ei+vaiktlk g+tekqrrdfl easi+Gqfdhp
Q: 622   ISIDKVVGAGEFGEVCSGRLKLPSKKEISVAIKTLKVGYTEKQRRDFLGEASIMGQFDHP  681
         689*********************************************************
S: 61    niirleGvvtkskpvmivteymengaldsflrkkdgqftviqlvgmlrGiasgmkylsdm  120
         niirleGvvtkskpvmivteymeng+ld flrk+d qftviqlvgmlrGiasgmkylsdm
Q: 682   NIIRLEGVVTKSKPVMIVTEYMENGSLDGFLRKHDAQFTVIQLVGMLRGIASGMKYLSDM  741
         ************************************************************
S: 121   gyvhrdlaarnilvnsnlvckvsdfGlsrvleddseaayttsggkipirwtapeaiayrk  180
         gyvhrdlaarnil+nsnlvckvsdfGlsrvledd+eaaytt+ggkipirwt+peaiayrk
Q: 742   GYVHRDLAARNILINSNLVCKVSDFGLSRVLEDDPEAAYTTRGGKIPIRWTSPEAIAYRK  801
         ************************************************************
S: 181   ftsasdvwsyGivlwevlsyGerpywdmsnqdvikaieegyrlpppmdcpaalyqlmldc  240
         ftsasdvwsyGivlwev+syGerpyw+msnqdvika++egyrlpppmdcpaalyqlmldc
Q: 802   FTSASDVWSYGIVLWEVMSYGERPYWEMSNQDVIKAVDEGYRLPPPMDCPAALYQLMLDC  861
         ************************************************************
S: 241   wqkdraerpkfeqivsil  258
         wqkdr++rpkfeqivsil
Q: 862   WQKDRNNRPKFEQIVSIL  879
         ***************986
Domain Sequence
(FASTA)
ISIDKVVGAG EFGEVCSGRL KLPSKKEISV AIKTLKVGYT EKQRRDFLGE ASIMGQFDHP 60
NIIRLEGVVT KSKPVMIVTE YMENGSLDGF LRKHDAQFTV IQLVGMLRGI ASGMKYLSDM 120
GYVHRDLAAR NILINSNLVC KVSDFGLSRV LEDDPEAAYT TRGGKIPIRW TSPEAIAYRK 180
FTSASDVWSY GIVLWEVMSY GERPYWEMSN QDVIKAVDEG YRLPPPMDCP AALYQLMLDC 240
WQKDRNNRPK FEQIVSIL 258
KeywordATP-binding; Complete proteome; Kinase; Membrane; Nucleotide-binding; Receptor; Reference proteome; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Rattus norvegicus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>
EKS-AIM-00002
EKS-ANC-00002
EKS-BOT-00002
EKS-CAE-00001
EKS-CAJ-00002
EKS-CAF-00003
EKS-FEC-00004
EKS-GAG-00003
EKS-GAA-00003
EKS-GOG-00002
EKS-HOS-00003
EKS-ICT-00002
EKS-LOA-00002
EKS-MAM-00002
EKS-MEG-00002
EKS-MOD-00002
EKS-MUM-00002
EKS-MUP-00002
EKS-MYL-00003
EKS-NOL-00002
EKS-ORN-00002
EKS-ORA-00003
EKS-ORC-00002
EKS-ORL-00003
EKS-OTG-00001
EKS-PAT-00002
EKS-PES-00003
EKS-POA-00002
EKS-PRC-00002
EKS-RAN-00003
EKS-SUS-00002
EKS-TAG-00004
EKS-TAS-00002
EKS-TEN-00001
EKS-TUT-00001
EKS-XET-00001
Gene Ontology
GO:0005769; C:early endosome
GO:0005887; C:integral to plasma membrane
GO:0005524; F:ATP binding
GO:0005004; F:GPI-linked ephrin receptor activity
GO:0071300; P:cellular response to retinoic acid
GO:0010976; P:positive regulation of neuron projection development
GO:0032956; P:regulation of actin cytoskeleton organization
GO:0051893; P:regulation of focal adhesion assembly
GO:0070507; P:regulation of microtubule cytoskeleton organization
GO:0032319; P:regulation of Rho GTPase activity
KEGG
ecb:100054527;
InterPros
IPR001090; Ephrin_rcpt_lig-bd_dom.
IPR003961; Fibronectin_type3.
IPR008979; Galactose-bd-like.
IPR013783; Ig-like_fold.
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001660; SAM.
IPR013761; SAM/pointed.
IPR011510; SAM_2.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR011641; Tyr-kin_ephrin_A/B_rcpt-like.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
IPR016257; Tyr_kinase_ephrin_rcpt.
IPR001426; Tyr_kinase_rcpt_V_CS.
Pfam
PF01404; Ephrin_lbd; 1.
PF00041; fn3; 2.
PF07699; GCC2_GCC3; 1.
PF07714; Pkinase_Tyr; 1.
PF07647; SAM_2; 1.
SMARTs
SM00615; EPH_lbd; 1.
SM00060; FN3; 2.
SM00454; SAM; 1.
SM00219; TyrKc; 1.
Prosites
PS51550; EPH_LBD; 1.
PS50853; FN3; 2.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
PS00790; RECEPTOR_TYR_KIN_V_1; 1.
PS00791; RECEPTOR_TYR_KIN_V_2; 1.
PS50105; SAM_DOMAIN; 1.
Prints
PR00109; TYRKINASE.
Created Date20-Feb-2013