EKS-EQC-00361
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-EQC-00361
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/Src436.14.0E-131246495250
StatusUnreviewed
Ensembl ProteinENSECAP00000020913
UniProt AccessionF6USJ9;
Protein Name
Protein Synonyms/Alias
Gene NameLCK
Gene Synonyms/Alias LCK;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSECAG00000023256ENSECAP00000020913ENSECAT00000025147
OrganismEquus caballus
Functional Description
Protein Length510
Protein Sequence
(FASTA)
MGCSCSSNPE DDWMENIDVC ENCHYPIVPL DGKATLPMRN GSEVRDPLVT YEGSNPPASP 60
LQDNLVIALH RYEPSHDGDL GFEKGEQLRI LEQSGEWWKA QSLTTGQEGF IPFNFVAKAN 120
SLEPEPGPRD DGPSLSALRS WLLAPGNTHG SFLIRESEST AGSFSLSVRD FDQNQGEVVK 180
HYKIRNLDKG GFYISPRITF PGLHELVRHY TNASDGLCTR LSRPCQTQKP QKPWWEDEWE 240
VPRETLKLVE RLGAGQFGEV WMGYYNGHTK VAVKSLKQGS MSPDAFLAEA NLMKQLQHQR 300
LVRLYAVVTQ EPIYIITEYM ENGSLVDFLK TSTGIKLTIN KLLDMAAQIA EGMAFIEERN 360
YIHRDLRAAN ILVSDTLSCK IADFGLARLI EDNEYTAREG AKFPIKWTAP EAINYGTFTI 420
KSDVWSFGIL LTEIVTHGRI PYPGMTNPEV IQNLERGYRM VRPDNCPEEL YQLMMLCWKE 480
RPEDRPTFDY LRSVLEDFFT ATEGQYQPQP 510
Nucleotide Sequence
(FASTA)
ATGGGCTGTA GCTGCAGCTC AAACCCCGAA GATGACTGGA TGGAAAACAT CGATGTATGT 60
GAGAACTGCC ATTACCCCAT AGTCCCACTG GATGGCAAGG CCACGCTGCC TATGCGGAAT 120
GGCTCTGAGG TGCGGGATCC ACTGGTAACC TATGAGGGCT CCAACCCCCC AGCCTCCCCT 180
CTGCAAGACA ACCTGGTTAT CGCCCTGCAC AGATACGAGC CCTCCCACGA TGGAGACCTG 240
GGCTTCGAGA AGGGCGAACA GCTCCGTATC CTGGAGCAGA GCGGCGAGTG GTGGAAGGCA 300
CAGTCCCTGA CCACGGGCCA GGAAGGTTTC ATCCCCTTCA ACTTCGTGGC CAAAGCGAAC 360
AGCCTGGAGC CCGAACCGGG ACCAAGAGAT GACGGCCCTT CGCTTTCTGC CTTGCGCAGC 420
TGGCTCCTGG CGCCCGGGAA CACGCACGGC TCCTTCCTGA TCCGGGAGAG CGAGAGTACC 480
GCGGGATCGT TTTCACTGTC CGTCCGGGAC TTCGACCAGA ACCAGGGAGA GGTGGTGAAA 540
CATTACAAGA TCCGTAACCT GGACAAGGGT GGCTTCTACA TCTCCCCCCG CATCACCTTT 600
CCCGGCCTGC ATGAGCTGGT CCGCCATTAC ACCAATGCTT CGGATGGGCT GTGCACGCGG 660
TTGAGCCGCC CCTGCCAGAC CCAGAAGCCC CAGAAGCCAT GGTGGGAGGA CGAGTGGGAG 720
GTTCCCAGGG AGACGCTGAA GTTGGTGGAG CGGCTGGGGG CTGGCCAGTT CGGGGAGGTG 780
TGGATGGGAT ACTACAACGG GCACACGAAG GTGGCAGTGA AGAGCCTGAA GCAGGGCAGC 840
ATGTCCCCCG ATGCCTTCCT GGCAGAGGCC AACCTCATGA AGCAGCTGCA ACACCAGCGG 900
CTGGTCCGGC TCTACGCGGT GGTCACCCAG GAGCCCATCT ACATCATCAC GGAATACATG 960
GAGAACGGGA GCCTGGTGGA TTTTCTCAAG ACCTCCACAG GCATCAAGCT GACCATCAAC 1020
AAACTCCTGG ACATGGCAGC CCAAATTGCA GAGGGTATGG CATTCATTGA AGAGCGGAAT 1080
TATATCCACC GTGACCTGAG GGCTGCCAAC ATCCTGGTGT CTGACACCCT GAGCTGCAAG 1140
ATCGCAGACT TTGGCCTAGC ACGCCTCATT GAGGACAACG AGTACACAGC CAGGGAGGGG 1200
GCCAAGTTTC CCATTAAGTG GACAGCACCA GAAGCCATTA ACTATGGGAC ATTCACCATC 1260
AAGTCGGATG TGTGGTCTTT TGGGATCCTG CTGACGGAGA TTGTCACCCA TGGCCGCATC 1320
CCTTACCCAG GGATGACCAA TCCTGAGGTG ATTCAGAACC TGGAGCGAGG TTACCGCATG 1380
GTGCGACCTG ACAACTGTCC AGAGGAGCTG TACCAACTCA TGATGCTGTG CTGGAAGGAA 1440
CGCCCAGAGG ACCGGCCCAC CTTTGACTAC CTGCGCAGTG TGCTGGAGGA CTTCTTCACG 1500
GCCACAGAGG GCCAGTACCA GCCCCAGCCC TGA 1533
Domain Profile
S: 1     lklvkklGeGqfGevwlgkwkgsvkvavktlkegtlspeafleeaqilkklrheklvkly  60
         lklv++lG+GqfGevw+g+++g++kvavk+lk+g++sp+afl+ea+++k+l+h++lv+ly
Q: 246   LKLVERLGAGQFGEVWMGYYNGHTKVAVKSLKQGSMSPDAFLAEANLMKQLQHQRLVRLY  305
         6899********************************************************
S: 61    avvseeePiyivtelmakGslldflkeeegkklklpklvdlaaqvaeGmayleeknlihr  120
         avv++ ePiyi+te+m++Gsl+dflk+++g kl+++kl+d+aaq+aeGma++ee+n+ihr
Q: 306   AVVTQ-EPIYIITEYMENGSLVDFLKTSTGIKLTINKLLDMAAQIAEGMAFIEERNYIHR  364
         ****9.******************************************************
S: 121   dlaarnvlvgeslvvkvadfGlarlieddeytakegaklPikWtaPeaiklgkftiksdv  180
         dl+a+n+lv+++l +k+adfGlarlied+eyta+egak+PikWtaPeai++g+ftiksdv
Q: 365   DLRAANILVSDTLSCKIADFGLARLIEDNEYTAREGAKFPIKWTAPEAINYGTFTIKSDV  424
         ************************************************************
S: 181   WsfGillteivtkGkvPypGmtneevleqvergyrlprpeecpeelyelllecwkkdpee  240
         WsfGillteivt+G++PypGmtn ev++++ergyr+ rp++cpeely+l++ cwk++pe+
Q: 425   WSFGILLTEIVTHGRIPYPGMTNPEVIQNLERGYRMVRPDNCPEELYQLMMLCWKERPED  484
         ************************************************************
S: 241   rPtfetlqevl  251
         rPtf++l++vl
Q: 485   RPTFDYLRSVL  495
         *******9876
Domain Sequence
(FASTA)
LKLVERLGAG QFGEVWMGYY NGHTKVAVKS LKQGSMSPDA FLAEANLMKQ LQHQRLVRLY 60
AVVTQEPIYI ITEYMENGSL VDFLKTSTGI KLTINKLLDM AAQIAEGMAF IEERNYIHRD 120
LRAANILVSD TLSCKIADFG LARLIEDNEY TAREGAKFPI KWTAPEAINY GTFTIKSDVW 180
SFGILLTEIV THGRIPYPGM TNPEVIQNLE RGYRMVRPDN CPEELYQLMM LCWKERPEDR 240
PTFDYLRSVL 250
KeywordATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; SH3 domain; Transferase; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Erinaceus europaeus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sorex araneus"; ?>Sus scrofa"; ?>Takifugu rubripes"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00347
EKS-BOT-00370
EKS-CAJ-00376
EKS-CAF-00371
EKS-CAP-00402
EKS-DAR-00750
EKS-DIO-00065
EKS-ERE-00004
EKS-FEC-00358
EKS-GAM-00223
EKS-GAA-00453
EKS-GOG-00391
EKS-HOS-00376
EKS-ICT-00351
EKS-LAC-00385
EKS-LOA-00383
EKS-MEG-00303
EKS-MIM-00060
EKS-MOD-00357
EKS-MUM-00403
EKS-MUP-00365
EKS-MYL-00368
EKS-NOL-00338
EKS-OCP-00080
EKS-ORN-00480
EKS-ORC-00349
EKS-ORL-00441
EKS-OTG-00374
EKS-PES-00333
EKS-POA-00359
EKS-RAN-00384
EKS-SAH-00340
EKS-SOA-00006
EKS-SUS-00324
EKS-TAR-00475
EKS-TUT-00115
EKS-XET-00485
EKS-XIM-00468
Gene Ontology
GO:0005794; C:Golgi apparatus
GO:0005524; F:ATP binding
GO:0004713; F:protein tyrosine kinase activity
GO:0050853; P:B cell receptor signaling pathway
GO:0018108; P:peptidyl-tyrosine phosphorylation
GO:0045588; P:positive regulation of gamma-delta T cell differentiation
GO:0010628; P:positive regulation of gene expression
GO:0042523; P:positive regulation of tyrosine phosphorylation of Stat5 protein
GO:0046777; P:protein autophosphorylation
GO:0050856; P:regulation of T cell receptor signaling pathway
GO:0051209; P:release of sequestered calcium ion into cytosol
KEGG
InterPros
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR000980; SH2.
IPR001452; SH3_domain.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
Pfam
PF07714; Pkinase_Tyr; 1.
PF00017; SH2; 1.
PF00018; SH3_1; 1.
SMARTs
SM00252; SH2; 1.
SM00326; SH3; 1.
SM00219; TyrKc; 1.
Prosites
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
PS50001; SH2; 1.
PS50002; SH3; 1.
Prints
PR00401; SH2DOMAIN.
PR00452; SH3DOMAIN.
PR00109; TYRKINASE.
Created Date20-Feb-2013