EKS-EQC-00166

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-EQC-00166

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
Other/TTK	485.5	4.7E-146	524	790	267

Status

Unreviewed

Ensembl Protein

ENSECAP00000021429

UniProt Accession

F6WLR2;

Protein Name

Protein Synonyms/Alias

Gene Name

TTK

Gene Synonyms/Alias

TTK;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSECAG00000023776	ENSECAP00000021429	ENSECAT00000025743

Organism

Equus caballus

Functional Description

Protein Length

857

Protein Sequence
(FASTA)

MEAEDLSGRE LTIDSIMNKV RDIKNKFKNE DLTDELSLNK VSADTTDNSG TVNQIIMMAN 60

NPEDWLNLLL KLEKNSVPLN DALLNKLIVR YSQAIEALPP DKYGQNESFA QIQVRFAELK 120

AIQEPDDARD CFQMARANCK KFAFVHVSFA QFELSQGNFK KSKQLLHKAL ECGAVPLEML 180

EIAIRNLNLQ KKQLLSEEEK KSLSASTVST AQESFPSSLG HLQNKKVSGD SRGQPAKARF 240

FYGENMPPQD AEIGHGNPLK RSNKTKRSCP FGRVPVNLLN SPDYHVKTEG AVVPSFTKRQ 300

TSGSESRDMI VPGSKSSGND SCELRNLKSV QNIRSKEALM SDGKSSELST DSITLKNKTE 360

SSLLTKLEET KEHQEPKFPE SNQKQGQSKR KLECVKQNPA ASSNQWQIPE ITRKADSEQK 420

QTTFEQPGFS ISKQSPPISA PKWIDPKSVC KTPSSSSLDD YMSCFRTPVV KNDFPSACQL 480

STPYSQLACF QQPPGQIPIT PLQHLQISAS SSTNECISVK GRIYSILKQI GSGGSSKVFQ 540

VLTENKQIHA IKYVNLEEAD NQTIESYRNE IAYLNKLQQH SDKIIRLYDY EITDQYIYMV 600

MECGNIDLNT WLKKKKSINP WERKSYWKNM LEAVYTIHQH GIVHSDLKPA NFLIVDGMLK 660

LIDFGIANQM QPDTTSIVKD SQVGTVNYMP PEAIKDMSSS RENGKSKSKI SPKSDVWSLG 720

CILYYMTYGK TPFQHIINQI SKLHAIIDPN HEIEFPDIPE KDLQDVLKCC LIRDPKQRIS 780

IPELLAHPYV QIQTHPGNQM TKGTTEEMKH VLGQLVGLNS PNSILKAAKT LYEHYSSGDR 840

HDSSSSSKTF EKKWEKK 857

Nucleotide Sequence
(FASTA)

ATGGAGGCCG AGGATTTAAG TGGCAGAGAA TTGACAATTG ATTCCATAAT GAACAAAGTG 60

AGAGACATTA AAAATAAATT TAAAAATGAA GACCTTACTG ATGAGCTAAG CTTGAATAAA 120

GTCTCTGCTG ATACTACAGA TAACTCAGGA ACTGTTAACC AAATTATAAT GATGGCGAAC 180

AACCCAGAGG ACTGGTTGAA TTTGTTGCTC AAACTAGAGA AAAACAGTGT CCCCCTAAAT 240

GACGCCCTTT TAAATAAGCT GATTGTTCGT TACAGTCAAG CAATTGAAGC ACTTCCTCCT 300

GATAAATATG GGCAAAATGA GAGTTTTGCT CAAATTCAAG TGAGATTTGC TGAATTAAAA 360

GCGATTCAGG AGCCGGATGA TGCCCGTGAC TGCTTTCAGA TGGCCAGAGC AAACTGCAAG 420

AAGTTTGCTT TCGTACATGT ATCTTTTGCA CAATTTGAAC TATCGCAAGG TAACTTTAAA 480

AAAAGTAAAC AACTTCTTCA TAAAGCTCTG GAATGTGGAG CAGTACCACT AGAAATGCTA 540

GAAATTGCCA TTCGGAATTT AAACCTCCAA AAAAAGCAGC TGCTTTCAGA GGAAGAAAAG 600

AAGAGCTTAT CAGCATCTAC AGTATCAACT GCCCAGGAAT CATTCCCCAG TTCACTTGGC 660

CATCTACAGA ATAAGAAGGT CAGCGGTGAC TCCAGAGGAC AGCCTGCTAA AGCCAGGTTT 720

TTCTATGGAG AGAACATGCC CCCTCAAGAT GCAGAGATAG GTCATGGAAA TCCTTTGAAA 780

CGATCAAACA AAACTAAACG GTCGTGCCCA TTTGGAAGAG TCCCTGTTAA CCTTCTGAAT 840

AGCCCGGATT ATCACGTGAA GACAGAAGGT GCAGTTGTTC CAAGTTTTAC AAAAAGACAG 900

ACCTCTGGAT CAGAATCCCG AGATATGATT GTGCCCGGAT CTAAATCAAG TGGAAATGAT 960

TCCTGTGAAT TGAGAAATTT AAAGTCTGTT CAAAATATCC GTTCCAAGGA GGCCCTGATG 1020

TCAGATGGGA AGAGTTCTGA ACTTAGTACT GATTCTATAA CCCTGAAGAA TAAAACTGAA 1080

TCAAGTCTTC TAACGAAATT GGAAGAAACT AAAGAGCATC AAGAACCAAA GTTTCCAGAA 1140

AGTAACCAGA AACAAGGGCA ATCTAAGAGA AAGTTGGAAT GTGTAAAGCA GAATCCTGCT 1200

GCCTCTTCAA ATCAGTGGCA GATTCCGGAG ATAACCCGAA AGGCTGATTC AGAGCAGAAA 1260

CAAACCACTT TTGAGCAACC TGGCTTTTCC ATTTCAAAGC AGTCACCCCC AATATCAGCA 1320

CCTAAATGGA TTGATCCAAA ATCTGTTTGT AAGACGCCCA GCAGCAGCAG CTTGGATGAT 1380

TACATGAGCT GTTTTAGAAC TCCAGTTGTA AAGAATGACT TTCCATCTGC TTGTCAGTTG 1440

TCAACACCTT ACAGCCAACT CGCCTGTTTC CAGCAGCCAC CGGGGCAGAT CCCCATTACG 1500

CCACTTCAGC ATTTACAGAT TTCAGCATCC TCTTCAACAA ATGAGTGCAT TTCAGTTAAA 1560

GGAAGAATTT ATTCCATATT GAAGCAGATA GGAAGTGGAG GTTCAAGTAA GGTATTTCAG 1620

GTGTTGACTG AAAATAAACA GATACATGCT ATAAAGTATG TGAACCTGGA GGAAGCAGAT 1680

AATCAAACTA TTGAGAGTTA CCGGAATGAA ATCGCTTATC TGAATAAACT ACAACAACAC 1740

AGTGATAAGA TCATCCGACT TTATGATTAT GAAATCACAG ACCAGTACAT CTACATGGTA 1800

ATGGAGTGTG GAAATATTGA TCTTAATACT TGGCTTAAAA AGAAAAAATC CATCAATCCC 1860

TGGGAACGCA AGAGTTACTG GAAAAATATG TTGGAGGCAG TTTACACAAT TCATCAACAT 1920

GGCATTGTTC ACAGTGATCT GAAACCTGCT AACTTTCTGA TAGTTGATGG AATGCTAAAG 1980

CTAATTGATT TTGGAATTGC AAACCAAATG CAGCCAGATA CAACAAGTAT CGTTAAAGAC 2040

TCTCAGGTTG GTACAGTGAA TTATATGCCA CCAGAAGCAA TCAAAGATAT GTCTTCCTCA 2100

AGAGAGAATG GGAAATCCAA ATCAAAGATA AGCCCCAAAA GTGATGTTTG GTCCTTAGGA 2160

TGCATTTTGT ACTATATGAC TTATGGGAAA ACACCATTTC AGCATATAAT TAATCAGATT 2220

TCTAAATTAC ATGCCATAAT TGACCCTAAT CATGAAATCG AATTTCCTGA TATTCCAGAG 2280

AAAGATCTTC AAGATGTGTT AAAGTGTTGT TTAATAAGGG ACCCTAAGCA GAGGATATCC 2340

ATTCCCGAGC TCCTGGCGCA TCCATATGTT CAGATTCAAA CTCATCCAGG TAACCAGATG 2400

ACTAAGGGAA CCACTGAAGA AATGAAACAT GTTCTGGGCC AACTTGTTGG TCTGAATTCT 2460

CCTAACTCCA TTTTGAAAGC TGCTAAAACA TTATATGAGC ACTATAGTAG TGGTGACAGG 2520

CATGATTCCT CTTCGTCATC CAAGACTTTT GAAAAAAAAT GGGAAAAAAA ATGA 2574

Domain Profile

S: 1     yeilkklGsGGsskvfkvksekkrvyalkvvdleaaddqtidgykneielleklqdqs.k  59

         y+ilk++GsGGsskvf+v++e+k+++a+k+v+le+ad+qti++y+nei++l+klq++s k

Q: 524   YSILKQIGSGGSSKVFQVLTENKQIHAIKYVNLEEADNQTIESYRNEIAYLNKLQQHSdK  583

         99********************************************************9*

S: 60    virlydyeledsllylvmecGdidlnkilkkkksiepdyelvsyykemleavkvihqhGi  119

         +irlydye++d+++y+vmecG+idln +lkkkksi+p +e++sy+k+mleav +ihqhGi

Q: 584   IIRLYDYEITDQYIYMVMECGNIDLNTWLKKKKSINP-WERKSYWKNMLEAVYTIHQHGI  642

         *************************************.**********************

S: 120   vhsdlkPanfllvdGilklidfGianavaedttsivkesqvGtvnylaPealkdmsssqs  179

         vhsdlkPanfl+vdG+lklidfGian++++dttsivk+sqvGtvny++Pea+kdmsss

Q: 643   VHSDLKPANFLIVDGMLKLIDFGIANQMQPDTTSIVKDSQVGTVNYMPPEAIKDMSSS--  700

         **********************************************************..

S: 180   sereaekskikvsrksdvwslGcilylllygktPfgsirnqvskllaiinPdveiefPei  239

           re++ksk+k+s+ksdvwslGcily+++ygktPf++i+nq+skl+aii+P++eiefP+i

Q: 701   --RENGKSKSKISPKSDVWSLGCILYYMTYGKTPFQHIINQISKLHAIIDPNHEIEFPDI  758

         ..**********************************************************

S: 240   tsniekslvellkaclkrnPkkrisvdellsspfv  274

         +   ek+l+++lk+cl r+Pk+ris++ell++p+v

Q: 759   P---EKDLQDVLKCCLIRDPKQRISIPELLAHPYV  790

         *...*****************************96

Domain Sequence
(FASTA)

YSILKQIGSG GSSKVFQVLT ENKQIHAIKY VNLEEADNQT IESYRNEIAY LNKLQQHSDK 60

IIRLYDYEIT DQYIYMVMEC GNIDLNTWLK KKKSINPWER KSYWKNMLEA VYTIHQHGIV 120

HSDLKPANFL IVDGMLKLID FGIANQMQPD TTSIVKDSQV GTVNYMPPEA IKDMSSSREN 180

GKSKSKISPK SDVWSLGCIL YYMTYGKTPF QHIINQISKL HAIIDPNHEI EFPDIPEKDL 240

QDVLKCCLIR DPKQRISIPE LLAHPYV 267

Keyword

Complete proteome; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>Saccharomyces cerevisiae"; ?>Schizosaccharomyces pombe"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity

KEGG

ecb:100069586

;

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.
IPR011990	; TPR-like_helical.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013