EKS-EQC-00115

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-EQC-00115

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
Other/NAK	344.5	4.6E-103	1	265	265

Status

Unreviewed

Ensembl Protein

ENSECAP00000021630

UniProt Accession

F6X5Q8;

Protein Name

Protein Synonyms/Alias

Gene Name

GAK

Gene Synonyms/Alias

GAK;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSECAG00000023832	ENSECAP00000021630	ENSECAT00000025969
ENSECAG00000023832	ENSECAP00000021619	ENSECAT00000025958

Organism

Equus caballus

Functional Description

Protein Length

1258

Protein Sequence
(FASTA)

GGFAFVYEAQ DLGSGREYAL KRLLSNEEEK NRAIIQEVCF MKKLSGHPNI VQFCSAASIG 60

KEESDTGQAE FLLLTELCRG QLVEFLKKVE SKGPLSCDTI LKIFYQTCRA VQHMHRQKPP 120

IVHRDLKVEN LLLSNQGTIK LCDFGSATTT LHYPDYSWSA QKRALVEDEI TRNTTPMYRT 180

PEIVDLYSNF PISEKQDIWA LGCILYLLCF GQHPFEDGAK LRIVNGKYSI PPNDTRYSVF 240

HGLIRAMLKV NPEERLSITE LVNQLQEIAA ARNVNPKSPI TELLEQNGGC GNAALSRGLS 300

PPGGPTSSSY SGGLVVAEYD QPYGGLLDIL RGGTERLFTN IKDTSSKVIQ SVANYAKGDL 360

DISYITSRIA VMSFPAEGVE SAIKNNIEDV RLFLDSKHPG HYAVYNLSPR MYRPSKFHNR 420

VSECGWAARR APSLHSLYSI CRNMHSWLRQ DHKNVCVVHC MDGRAASAVA VCSFLCFCRL 480

FSTAEAAVYM FSMKRCPPGI WPSHKRYIEY MCDMVAEEPI TPHSKPILVK AVVMTPVPLF 540

SKQRNGCRPF CEVYVGDERV TTTSQEYDRM RDFKIEDGKA VIPLGITVQG DVLIIIYHAR 600

STLGGRLQAK MASMKMFQIQ FHTGFVPRNA TTVKFAKYDL DACDIQEKYP DLFQVNLEVE 660

VEPRDRPSRE APPWESASLR GLNPKILFSS REEQQDILSK FGKPELPRQP GSTAQYDAEA 720

GSPDTEPTES DSPQSSSADT PHFLHTLDWH EERDSETGPG SNIAKESQSA PTEDGGESEP 780

SDEEAVPSST ESRELPDEDS SGPPARTQES ELIFDVDAPA APQEPALQED GVDLLGLHSE 840

AGLAPPLQTC NVPPSNADLL SCLLGAPVAA PGSSPGDLLG SEVPPLFASP APPLSARSTP 900

REEPAVSADP FDPLLLPADP DAQPSSKPDL FGEFLNSDSL AAPPASFPST HSAPPPACSP 960

DFLHLGDLPA EPGKMAASTS HPDLLGGWDA WAEAPAPTPA TEGPLLAPGG QPAPPGPSAS 1020

RTKSQSLDPF ADLGDLSPGL PGSTAGFAPG AFGPKAAPPP KGGGSWQTSR PPAQGAPWPP 1080

QARPPPKTSA QPRPNYTTNF SVIGGREERG VRAPSFAQKP RVSENDFEDL LSNQGFSSKS 1140

DKKGPRTIAE MRRQDQARDT DPLKLKLLDW TEGKEKNIRA LLSTLHTVLW DGESRWTPVG 1200

MADLVTPGQV KKQYRRAVLV VHPDKAAGQP YEQYARMIFM ELSDAWAEFE SQGSRPLF 1258

Nucleotide Sequence
(FASTA)

GGAGGGTTTG CATTTGTATA TGAAGCTCAA GATCTGGGAA GTGGCAGAGA GTATGCATTA 60

AAGAGACTAT TGTCCAATGA AGAGGAAAAG AACAGAGCCA TCATTCAGGA AGTTTGTTTC 120

ATGAAAAAGC TTTCTGGCCA TCCCAATATT GTCCAGTTTT GTTCTGCAGC TTCAATAGGA 180

AAAGAAGAGT CGGACACTGG GCAGGCCGAG TTCCTGCTGC TCACCGAGCT CTGCAGAGGA 240

CAGCTGGTGG AGTTTTTAAA GAAAGTTGAG TCTAAAGGTC CGCTCTCATG CGACACCATC 300

CTGAAGATCT TCTATCAGAC GTGTAGGGCG GTGCAGCACA TGCACAGGCA GAAGCCACCC 360

ATCGTCCACA GAGACCTCAA GGTTGAAAAC TTGCTGCTTA GCAACCAGGG GACCATTAAG 420

CTGTGTGACT TCGGCAGTGC CACGACCACA TTGCACTACC CGGACTACAG CTGGAGTGCC 480

CAGAAGCGGG CCCTGGTGGA GGACGAGATC ACCAGGAACA CAACACCCAT GTACAGGACG 540

CCAGAAATTG TGGACTTGTA CTCGAACTTC CCGATCAGCG AGAAGCAGGA CATCTGGGCT 600

CTGGGCTGCA TCTTGTACCT GCTGTGCTTT GGGCAGCACC CTTTTGAAGA TGGGGCAAAA 660

CTTCGAATAG TCAACGGGAA GTACTCAATC CCTCCTAACG ACACCCGCTA CTCCGTGTTC 720

CACGGCCTCA TCCGCGCCAT GCTGAAGGTC AACCCAGAGG AGCGGCTGTC CATCACGGAG 780

CTGGTGAACC AGCTCCAGGA AATTGCAGCG GCCAGGAACG TGAACCCAAA GTCACCCATC 840

ACCGAGCTCC TGGAGCAGAA TGGAGGCTGT GGGAATGCTG CCCTGTCCCG AGGGCTGTCC 900

CCTCCTGGGG GCCCGACAAG CAGCAGCTAC AGTGGAGGCC TGGTGGTTGC CGAGTATGAC 960

CAGCCCTACG GTGGACTCCT GGACATCTTG CGTGGGGGCA CTGAGCGCCT TTTCACAAAC 1020

ATCAAGGACA CCTCCTCCAA GGTCATCCAG TCTGTCGCCA ATTATGCAAA GGGAGATTTG 1080

GACATATCTT ACATCACATC CAGAATTGCT GTGATGTCCT TCCCAGCGGA AGGTGTGGAG 1140

TCGGCCATCA AAAACAACAT AGAGGACGTG CGGCTGTTTC TGGACTCCAA GCACCCAGGA 1200

CATTACGCGG TCTACAACCT GTCCCCGAGG ATGTACCGGC CCTCCAAGTT TCACAACCGA 1260

GTCTCCGAGT GCGGCTGGGC GGCCAGGCGA GCCCCAAGCC TTCACAGCCT GTACAGCATT 1320

TGTAGGAATA TGCACTCCTG GCTCCGGCAG GACCACAAGA ACGTCTGCGT CGTGCACTGC 1380

ATGGATGGGA GAGCCGCGTC CGCTGTGGCC GTCTGCTCCT TCCTATGCTT CTGCCGACTC 1440

TTCAGCACCG CAGAGGCTGC CGTGTACATG TTCAGTATGA AGCGCTGCCC GCCGGGCATC 1500

TGGCCATCCC ACAAAAGGTA CATCGAGTAC ATGTGCGACA TGGTGGCAGA GGAGCCCATC 1560

ACACCACACA GCAAGCCAAT CCTGGTGAAG GCTGTAGTCA TGACGCCGGT GCCGCTGTTC 1620

AGCAAGCAGA GGAACGGCTG CAGGCCCTTC TGCGAGGTGT ACGTGGGCGA CGAGCGCGTG 1680

ACCACCACGT CCCAAGAGTA TGACAGGATG AGGGATTTTA AAATCGAGGA TGGCAAAGCG 1740

GTCATTCCCC TGGGCATAAC AGTCCAAGGA GACGTGCTCA TTATCATCTA TCACGCCAGG 1800

TCCACCCTGG GAGGAAGGCT GCAGGCCAAG ATGGCATCCA TGAAGATGTT CCAGATCCAG 1860

TTCCACACTG GGTTTGTGCC TCGGAACGCA ACTACTGTGA AATTCGCAAA GTATGACCTG 1920

GACGCTTGCG ACATTCAGGA GAAATACCCG GATTTATTCC AAGTGAACCT GGAAGTAGAG 1980

GTGGAGCCCA GAGACAGGCC TAGCCGGGAG GCCCCACCCT GGGAGAGCGC GAGCCTGAGG 2040

GGGCTGAATC CCAAAATCCT GTTTTCTAGC CGGGAGGAGC AGCAAGACAT TCTGTCTAAA 2100

TTTGGCAAAC CGGAGCTCCC CAGGCAGCCT GGCTCCACCG CGCAGTACGA CGCTGAGGCG 2160

GGGTCTCCAG ACACTGAGCC CACGGAGTCC GACTCGCCGC AGAGCAGCAG CGCAGACACC 2220

CCCCACTTCC TGCACACACT GGACTGGCAC GAAGAGAGAG ACTCAGAGAC GGGCCCAGGC 2280

AGTAACATTG CCAAGGAGAG TCAGTCTGCC CCCACTGAGG ATGGAGGAGA GAGTGAGCCG 2340

TCTGATGAGG AGGCAGTGCC GTCCTCAACT GAGAGCAGGG AGCTGCCCGA CGAGGACTCA 2400

TCAGGCCCAC CAGCAAGGAC GCAAGAGTCA GAGTTGATAT TTGATGTGGA TGCACCAGCC 2460

GCGCCACAGG AGCCCGCGCT GCAGGAGGAT GGTGTCGACC TCCTTGGGCT GCACTCCGAG 2520

GCGGGTCTGG CGCCCCCTCT GCAGACCTGT AATGTTCCCC CCAGCAATGC TGACCTGCTC 2580

AGCTGCCTCC TGGGGGCCCC TGTGGCTGCT CCAGGGAGCT CCCCGGGTGA CCTGCTTGGC 2640

AGTGAGGTCC CCCCGCTCTT TGCAAGCCCT GCTCCTCCCC TGAGTGCACG GAGCACACCT 2700

CGAGAGGAGC CTGCTGTGTC CGCTGACCCC TTTGACCCTC TCCTGCTGCC CGCTGATCCA 2760

GATGCCCAGC CCAGCTCCAA GCCTGATCTC TTTGGCGAAT TTCTAAATTC GGACTCTCTG 2820

GCCGCCCCGC CCGCATCCTT CCCCTCCACC CACAGCGCCC CACCCCCAGC CTGCAGCCCT 2880

GACTTCCTGC ACCTGGGGGA TCTGCCAGCA GAGCCCGGCA AGATGGCAGC TTCAACCAGC 2940

CACCCAGATC TGCTGGGAGG ATGGGATGCC TGGGCCGAAG CTCCAGCCCC CACACCAGCC 3000

ACAGAAGGCC CCCTCCTCGC TCCTGGAGGC CAGCCGGCCC CTCCCGGTCC CTCAGCCAGC 3060

CGGACCAAGT CTCAGAGCCT GGACCCATTT GCAGACCTTG GTGACCTCAG TCCCGGCCTC 3120

CCAGGCTCAA CCGCTGGATT TGCTCCTGGA GCCTTCGGTC CCAAAGCAGC CCCCCCGCCC 3180

AAGGGTGGTG GTTCCTGGCA GACGAGTCGG CCCCCAGCCC AGGGTGCCCC GTGGCCCCCC 3240

CAGGCTAGGC CTCCCCCCAA AACCTCTGCA CAGCCGAGGC CTAACTACAC CACGAACTTC 3300

AGCGTGATCG GCGGCCGAGA GGAGAGGGGC GTCCGCGCCC CCAGCTTTGC TCAAAAGCCC 3360

AGAGTGTCGG AGAATGACTT TGAAGACCTG TTGTCCAATC AGGGCTTCTC CTCCAAGTCT 3420

GACAAGAAGG GGCCGAGGAC CATCGCCGAG ATGAGGAGGC AGGACCAGGC GAGGGACACA 3480

GATCCGCTCA AGCTGAAGCT GCTGGACTGG ACTGAGGGCA AGGAGAAGAA CATCCGAGCC 3540

CTGCTGTCCA CGTTGCACAC CGTGCTGTGG GACGGCGAGA GCCGCTGGAC GCCCGTGGGC 3600

ATGGCCGACC TGGTGACTCC TGGGCAGGTG AAGAAGCAGT ACCGCCGCGC CGTGCTGGTG 3660

GTCCATCCGG ACAAGGCCGC AGGGCAGCCG TACGAGCAGT ACGCCAGGAT GATCTTCATG 3720

GAGCTGAGCG ACGCCTGGGC CGAGTTCGAG AGTCAGGGCT CCCGGCCCCT CTTCTGA 3777

Domain Profile

S: 10    GGfalvylaedastgekyalKrilvneeedleeikrEieimkklsghknivklv..dssv  67

         GGfa+vy a+d+ +g++yalKr+l+neee++++i++E+++mkklsgh+niv+++  +s

Q: 1     GGFAFVYEAQDLGSGREYALKRLLSNEEEKNRAIIQEVCFMKKLSGHPNIVQFCsaASIG  60

         9*****************************************************877888

S: 68    keekdngskevlllleyckkgslvdllnkrlekgelseaeilkilldvtravaalHalsv  127

         kee+d+g++e+lll+e+c+ g+lv++l+k ++kg ls+++ilki+++++rav+++H++++

Q: 61    KEESDTGQAEFLLLTELCR-GQLVEFLKKVESKGPLSCDTILKIFYQTCRAVQHMHRQKP  119

         999***************9.8***************************************

S: 128   pliHRDlkveNillsdegelvlcDlGSattaileve...skqelsalqeeieknttlsyr  184

         p++HRDlkveN+lls++g+++lcD+GSatt+ + ++   s+q+++ +++ei++ntt++yr

Q: 120   PIVHRDLKVENLLLSNQGTIKLCDFGSATTTLHYPDyswSAQKRALVEDEITRNTTPMYR  179

         ***********************************99999********************

S: 185   sPElidlysnlvideksDiWaLGcllYklcffesPfeesvklailngkysiPensrysek  244

         +PE++dlysn++i+ek+DiWaLGc+lY lcf+++Pfe+++kl+i+ngkysiP+n++ ++

Q: 180   TPEIVDLYSNFPISEKQDIWALGCILYLLCFGQHPFEDGAKLRIVNGKYSIPPNDTRYSV  239

         ************************************************************

S: 245   lkslikkmlevdpeeRptiaqvlell  270

         ++ li++ml+v+peeR++i++++++l

Q: 240   FHGLIRAMLKVNPEERLSITELVNQL  265

         **********************9986

Domain Sequence
(FASTA)

GGFAFVYEAQ DLGSGREYAL KRLLSNEEEK NRAIIQEVCF MKKLSGHPNI VQFCSAASIG 60

KEESDTGQAE FLLLTELCRG QLVEFLKKVE SKGPLSCDTI LKIFYQTCRA VQHMHRQKPP 120

IVHRDLKVEN LLLSNQGTIK LCDFGSATTT LHYPDYSWSA QKRALVEDEI TRNTTPMYRT 180

PEIVDLYSNF PISEKQDIWA LGCILYLLCF GQHPFEDGAK LRIVNGKYSI PPNDTRYSVF 240

HGLIRAMLKV NPEERLSITE LVNQL 265

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005794	; C:Golgi apparatus
GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity

KEGG

InterPros

IPR008973	; C2_Ca/lipid-bd_dom_CaLB.
IPR001623	; DnaJ_N.
IPR011009	; Kinase-like_dom.
IPR014019	; Phosphatase_tensin-typ.
IPR000719	; Prot_kinase_cat_dom.
IPR008271	; Ser/Thr_kinase_AS.
IPR014020	; Tensin_phosphatase_C2-dom.

Pfam

PF00226	; DnaJ; 1.
PF00069	; Pkinase; 1.
PF10409	; PTEN_C2; 1.

SMARTs

SM00271

; DnaJ; 1.

Prosites

PS51182	; C2_TENSIN; 1.
PS50076	; DNAJ_2; 1.
PS51181	; PPASE_TENSIN; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013