EKS-EQC-00012
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-EQC-00012
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/Eph435.55.3E-131598852255
StatusUnreviewed
Ensembl ProteinENSECAP00000021660
UniProt AccessionF6WYP6;
Protein Name
Protein Synonyms/Alias
Gene NameEPHA1
Gene Synonyms/Alias EPHA1;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSECAG00000023882ENSECAP00000021660ENSECAT00000026000
OrganismEquus caballus
Functional Description
Protein Length949
Protein Sequence
(FASTA)
VTLMDTSTAQ GELGWLLDPP EDGWSEVQQM LNGTPLYMYQ DCPVQEGGDT DHWLRSNWIY 60
RGEEASRVHV ELQFTVRDCK SFPGGARPLG CKETFNLLYM ESDQDVGIQL RRPLFQKVTT 120
VAADQSFTIR DLASGSVKLN VEHCSLGLLT RRGLYLAFHN PGACVALVSV RVFYQRCPEA 180
VHGLAQFPDT LPRLGGLVEV AGTCLPHAQA SPGPSGAARM HCSPDGEWLV PVGRCHCEPG 240
YEEGGDGEGC LACPGGSYRA DMGAPHCLQC PQHSTAETEG ATICTCEDGH YRAPGEGPQA 300
ACTRPPSAPQ NLSFSVLGTK LSLSWQPPAD TGGRQDVRYS VGCSQCRGAA LDGGPCQPCG 360
GSVRFSPSAD GLAAPAVRVD GLEPYANYTF NIAAQNGVSG LDTSKPASAL LSISMGHAES 420
LSGLSLRLVK KEPRQLELTW AGSWPRSPGG NLSYELHVLN QDEERHQMVL EPRVLLTELQ 480
PDTTYIVRVR MLTPLGPGPF SPDQEFRTSP PVSRSLTGGE IVAVIFGLLL GVGLLLGILV 540
FRSRKSKRRR QQRPRDHVTS VNREDKLWLK PYVDLQAYED PAQGALDFTQ ELDPTWLIVD 600
TVIGEGEFGE VYRGTLRIPS QDCKTVAIKT LKDTSPDGQW WNFLREATIM GQFNHPHILH 660
LEGVITKRKP IMIITEFMEN GALDAFLRER EDQLIPGQLV AMLQGIASGM NYLSDHNYVH 720
RDLAARNILV SQNLCCKVSD FGLTRFLDNS DGTYETQGGK IPIRWTAPEA IAHRIFTTAS 780
DVWSFGIVMW EVLSFGDKPY GEMSNQEVMK SIEDGYRLPP PVDCPAPLYE LMKNCWAYDR 840
ARRPHFHQLK AHLDHLLANP HSLRTIANFD PRVTLRLPSL SGSDGIPYRS VPEWLESIRM 900
KRYILHFHSA GLDTMECVLE LTAEDLVQMG ITLPGHQKRI LCSIQGFKD 949
Nucleotide Sequence
(FASTA)
GTCACCCTGA TGGACACAAG CACGGCACAG GGAGAGTTGG GCTGGCTGCT GGATCCCCCA 60
GAGGATGGGT GGAGTGAGGT GCAGCAGATG CTGAATGGGA CACCCCTGTA CATGTACCAG 120
GACTGCCCAG TGCAAGAAGG CGGAGACACT GACCACTGGC TTCGCTCCAA TTGGATCTAC 180
CGGGGGGAGG AGGCGTCACG TGTCCACGTG GAGCTGCAGT TCACCGTGCG GGATTGCAAG 240
AGCTTCCCCG GGGGAGCCAG GCCCCTGGGC TGCAAGGAGA CCTTCAACCT CCTGTACATG 300
GAGAGTGACC AGGACGTGGG CATTCAGCTC CGACGGCCCT TGTTCCAGAA GGTAACCACG 360
GTGGCCGCAG ACCAGAGCTT CACCATCCGA GACCTTGCAT CCGGCTCAGT GAAACTGAAC 420
GTGGAGCACT GCTCCTTGGG CCTCCTGACC CGCCGTGGAC TCTACCTTGC TTTCCACAAC 480
CCGGGTGCCT GTGTGGCCCT GGTGTCCGTA CGGGTGTTCT ACCAGCGCTG TCCCGAGGCT 540
GTGCATGGCT TGGCCCAATT TCCTGACACT CTCCCCAGAC TGGGCGGGTT GGTGGAAGTG 600
GCAGGGACCT GCTTGCCCCA TGCCCAGGCC AGCCCTGGCC CCTCAGGTGC CGCCCGCATG 660
CACTGCAGCC CCGACGGCGA GTGGTTGGTA CCGGTGGGGC GGTGCCACTG TGAGCCTGGC 720
TATGAGGAAG GTGGCGATGG CGAGGGATGC CTTGCCTGCC CTGGCGGCTC CTACCGGGCT 780
GACATGGGTG CACCCCATTG TCTCCAGTGC CCCCAGCACA GCACAGCTGA GACTGAGGGG 840
GCCACCATCT GTACCTGTGA GGACGGCCAT TACCGAGCCC CTGGGGAGGG CCCCCAGGCA 900
GCATGTACAC GTCCCCCCTC AGCCCCCCAA AACCTGAGCT TCTCTGTTTT GGGGACCAAG 960
CTCTCCCTGA GTTGGCAACC CCCAGCGGAT ACGGGGGGTC GCCAGGACGT CAGATACAGT 1020
GTGGGGTGTT CTCAGTGTCG GGGAGCAGCG CTGGATGGAG GGCCCTGCCA GCCCTGTGGG 1080
GGAAGTGTGC GCTTCTCCCC CTCGGCCGAC GGGCTCGCTG CTCCTGCTGT GCGTGTTGAC 1140
GGCCTTGAAC CCTACGCCAA CTACACCTTT AACATCGCAG CCCAAAATGG AGTGTCAGGG 1200
CTGGACACCT CCAAGCCAGC CAGCGCCTTG CTCAGCATCA GCATGGGGCA TGCAGAGTCA 1260
CTGTCAGGCC TGTCCCTGAG GCTGGTAAAG AAGGAACCGC GACAGCTGGA GCTGACCTGG 1320
GCGGGATCCT GGCCTCGCAG CCCTGGGGGG AACCTAAGCT ATGAGCTGCA CGTGCTGAAC 1380
CAGGACGAAG AACGGCATCA GATGGTTCTA GAACCCAGGG TCTTGCTGAC TGAACTGCAG 1440
CCAGACACCA CGTACATCGT CAGAGTCCGA ATGCTGACCC CACTGGGCCC TGGCCCTTTC 1500
TCCCCTGATC AGGAGTTTCG GACCAGCCCA CCAGTTTCCA GGAGCCTGAC TGGAGGCGAG 1560
ATCGTGGCCG TCATCTTTGG GCTGCTGCTG GGTGTAGGTC TGCTGCTCGG GATACTTGTC 1620
TTCCGCTCAA GGAAATCTAA GCGGCGACGG CAGCAGAGGC CGCGTGATCA TGTCACCAGC 1680
GTGAACCGAG AGGACAAGCT GTGGCTGAAG CCGTATGTGG ACCTCCAGGC ATATGAGGAC 1740
CCTGCCCAGG GAGCCCTGGA CTTCACCCAG GAGCTCGATC CAACCTGGCT GATTGTAGAC 1800
ACCGTCATAG GGGAAGGAGA GTTTGGGGAA GTGTATCGAG GGACCCTGAG AATCCCCAGC 1860
CAGGACTGCA AGACTGTGGC CATTAAGACG TTGAAAGATA CATCTCCAGA TGGTCAGTGG 1920
TGGAACTTCC TTCGAGAGGC AACTATCATG GGCCAGTTCA ACCACCCACA CATTCTGCAC 1980
CTGGAAGGCG TCATCACAAA GAGAAAGCCC ATCATGATCA TCACAGAGTT TATGGAGAAC 2040
GGAGCCCTGG ATGCCTTCTT GAGGGAGCGG GAGGACCAGC TGATCCCTGG ACAGCTAGTG 2100
GCCATGCTGC AGGGCATTGC ATCTGGTATG AACTACCTCA GTGACCACAA TTATGTCCAC 2160
CGGGACCTGG CCGCCAGGAA CATCTTAGTG AGTCAGAACC TATGTTGCAA GGTGTCTGAC 2220
TTCGGCCTGA CCCGCTTCCT AGACAACTCT GATGGCACCT ATGAAACCCA GGGAGGAAAG 2280
ATCCCCATCC GTTGGACAGC CCCTGAAGCC ATTGCCCATC GGATCTTTAC CACGGCCAGC 2340
GATGTATGGA GCTTTGGGAT CGTGATGTGG GAGGTGCTGA GCTTTGGGGA TAAGCCCTAT 2400
GGGGAGATGA GCAATCAGGA GGTAATGAAG AGTATTGAGG ATGGGTACCG GTTGCCCCCT 2460
CCCGTGGACT GCCCTGCCCC TCTCTACGAG CTCATGAAGA ACTGTTGGGC CTACGACCGG 2520
GCCCGCCGGC CCCACTTCCA CCAGCTGAAG GCACACCTGG ATCATTTGCT TGCCAACCCC 2580
CACTCCCTGC GGACCATCGC TAACTTTGAT CCCAGGGTGA CTCTTCGCCT GCCCAGCTTG 2640
AGTGGCTCAG ATGGGATCCC CTATCGAAGC GTCCCTGAGT GGCTGGAGTC CATACGAATG 2700
AAACGCTACA TCCTGCACTT CCACTCAGCC GGGCTGGACA CCATGGAGTG TGTGCTGGAG 2760
CTGACGGCTG AGGACCTGGT GCAGATGGGG ATCACACTGC CGGGACACCA GAAGCGCATT 2820
CTTTGCAGTA TTCAAGGATT CAAGGACTGA 2850
Domain Profile
S: 2     kiekviGaGefGevcsGrlklpgkreiavaiktlkagstekqrrdflseasilGqfdhpn  61
          +++viG+GefGev++G+l++p++   +vaiktlk++s + q+++fl+ea+i+Gqf+hp+
Q: 598   IVDTVIGEGEFGEVYRGTLRIPSQDCKTVAIKTLKDTSPDGQWWNFLREATIMGQFNHPH  657
         5899******************999999********************************
S: 62    iirleGvvtkskpvmivteymengaldsflrkkdgqftviqlvgmlrGiasgmkylsdmg  121
         i++leGv+tk+kp+mi+te+mengald+flr++++q+   qlv+ml+Giasgm+ylsd++
Q: 658   ILHLEGVITKRKPIMIITEFMENGALDAFLREREDQLIPGQLVAMLQGIASGMNYLSDHN  717
         ************************************************************
S: 122   yvhrdlaarnilvnsnlvckvsdfGlsrvleddseaayttsggkipirwtapeaiayrkf  181
         yvhrdlaarnilv++nl+ckvsdfGl+r+l d+s+ +y+t+ggkipirwtapeaia+r f
Q: 718   YVHRDLAARNILVSQNLCCKVSDFGLTRFL-DNSDGTYETQGGKIPIRWTAPEAIAHRIF  776
         *****************************8.7889*************************
S: 182   tsasdvwsyGivlwevlsyGerpywdmsnqdvikaieegyrlpppmdcpaalyqlmldcw  241
         t+asdvws+Giv+wevls+G++py +msnq+v+k+ie+gyrlppp+dcpa ly+lm++cw
Q: 777   TTASDVWSFGIVMWEVLSFGDKPYGEMSNQEVMKSIEDGYRLPPPVDCPAPLYELMKNCW  836
         ************************************************************
S: 242   qkdraerpkfeqivsi  257
           dra+rp+f+q++++
Q: 837   AYDRARRPHFHQLKAH  852
         ************9986
Domain Sequence
(FASTA)
IVDTVIGEGE FGEVYRGTLR IPSQDCKTVA IKTLKDTSPD GQWWNFLREA TIMGQFNHPH 60
ILHLEGVITK RKPIMIITEF MENGALDAFL REREDQLIPG QLVAMLQGIA SGMNYLSDHN 120
YVHRDLAARN ILVSQNLCCK VSDFGLTRFL DNSDGTYETQ GGKIPIRWTA PEAIAHRIFT 180
TASDVWSFGI VMWEVLSFGD KPYGEMSNQE VMKSIEDGYR LPPPVDCPAP LYELMKNCWA 240
YDRARRPHFH QLKAH 255
KeywordATP-binding; Complete proteome; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Receptor; Reference proteome; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>
EKS-AIM-00011
EKS-ANC-00010
EKS-BOT-00011
EKS-CAJ-00011
EKS-CAF-00012
EKS-CAP-00009
EKS-FEC-00009
EKS-GAG-00011
EKS-GOG-00012
EKS-HOS-00012
EKS-ICT-00011
EKS-LAC-00015
EKS-LOA-00012
EKS-MAM-00010
EKS-MEG-00010
EKS-MOD-00011
EKS-MUM-00012
EKS-MUP-00012
EKS-MYL-00013
EKS-NOL-00011
EKS-OCP-00003
EKS-ORC-00011
EKS-OTG-00012
EKS-PAT-00010
EKS-PES-00009
EKS-POA-00009
EKS-RAN-00011
EKS-SAH-00009
EKS-SUS-00009
EKS-TAG-00011
Gene Ontology
GO:0005887; C:integral to plasma membrane
GO:0005524; F:ATP binding
GO:0004672; F:protein kinase activity
GO:0005005; F:transmembrane-ephrin receptor activity
GO:0032862; P:activation of Rho GTPase activity
GO:0030336; P:negative regulation of cell migration
GO:0006469; P:negative regulation of protein kinase activity
GO:0018108; P:peptidyl-tyrosine phosphorylation
GO:0045766; P:positive regulation of angiogenesis
GO:0030335; P:positive regulation of cell migration
GO:0008284; P:positive regulation of cell proliferation
GO:0001954; P:positive regulation of cell-matrix adhesion
GO:0051496; P:positive regulation of stress fiber assembly
GO:0046777; P:protein autophosphorylation
GO:0032314; P:regulation of Rac GTPase activity
GO:0034446; P:substrate adhesion-dependent cell spreading
KEGG
InterPros
IPR001090; Ephrin_rcpt_lig-bd_dom.
IPR003961; Fibronectin_type3.
IPR008979; Galactose-bd-like.
IPR013783; Ig-like_fold.
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001660; SAM.
IPR013761; SAM/pointed.
IPR021129; SAM_type1.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
IPR016257; Tyr_kinase_ephrin_rcpt.
IPR001426; Tyr_kinase_rcpt_V_CS.
Pfam
PF01404; Ephrin_lbd; 1.
PF00041; fn3; 2.
PF07714; Pkinase_Tyr; 1.
PF00536; SAM_1; 1.
SMARTs
SM00615; EPH_lbd; 1.
SM00060; FN3; 2.
SM00454; SAM; 1.
SM00219; TyrKc; 1.
Prosites
PS51550; EPH_LBD; 1.
PS50853; FN3; 2.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
PS00790; RECEPTOR_TYR_KIN_V_1; 1.
PS00791; RECEPTOR_TYR_KIN_V_2; 1.
PS50105; SAM_DOMAIN; 1.
Prints
PR00109; TYRKINASE.
Created Date20-Feb-2013