EKS-EQC-00162
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-EQC-00162
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
CAMK/RSKb442.07.1E-133393653261
StatusUnreviewed
Ensembl ProteinENSECAP00000021585
UniProt AccessionF6XUU5;
Protein NameRibosomal protein S6 kinase
Protein Synonyms/Alias
Gene NameRPS6KA5
Gene Synonyms/Alias RPS6KA5;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSECAG00000023892ENSECAP00000021585ENSECAT00000025919
OrganismEquus caballus
Functional Description
Protein Length765
Protein Sequence
(FASTA)
ANLTGHAEKV GIENFELLKV LGTGAYGKVF LVRKISGHDT GKLYAMKVLK KATIVQKAKT 60
TEHTRTERQV LEHIRQSPFL VTLHYAFQTE TKLHLILDYI NGGELFTHLS QRERFTEHEV 120
QIYVGEIVLA LEHLHKLGII YRDIKLENIL LDSNGHVVLT DFGLSKEFVA DEGERAYSFC 180
GTIEYMAPDI VRGGDSGHDK AVDWWSLGVL MYELLTGASP FTVDGEKNSQ AEISRRILKS 240
EPPYPQEMSA LAKDLIQRLL MKDPKKRLGC GPRDADEIKE HLFFQKINWD DLAAKKVPAP 300
FKPVIRDELD VSNFAEEFTE MDPTYSPAAL PQSSERLFQG YSFVAPSILF KRNAAVTDPL 360
QVHMGVERPG VTHVARSAMM KDSPFYQHYD LDLKDKPLGE GSFSICRKCI HKKSNQAFAV 420
KIISKRLEAN TQKEITALKL CEGHPNIVKL HEVFHDQLHS FLVMELLNGG ELFERIKKKK 480
HFSETEASYI MRKLVSAVSH MHDVGVVHRD LKPENLLFTD ENDNLEIKVI DFGFARLKPP 540
DNQPLKTPCF TLHYAAPELL NHSGYDESCD LWSLGVILYT MLSGQVPFQS HDKSLTCTSA 600
VEIMKKIKKG DFSFEGEAWR NVSQEAKDLI QGLLTVDPNK RLKMSGLRYN EWLQDGSQLS 660
SNPLMTPDIL GSSGAAVHTC VKATFHAFNK YKREGFCLQN VDKAPLAKRR KMKKTSTSTE 720
TRSSSSESSH SSSSHSHGKT TPTKTLQPSN PADGNNPETL FQFSD 765
Nucleotide Sequence
(FASTA)
GCTAATTTAA CAGGACATGC AGAGAAGGTG GGGATTGAAA ATTTTGAGCT CTTGAAGGTC 60
CTAGGAACTG GAGCTTATGG AAAAGTATTT CTAGTTCGTA AAATAAGTGG TCACGATACT 120
GGAAAACTGT ATGCCATGAA AGTCTTGAAA AAGGCAACAA TAGTTCAAAA GGCCAAAACC 180
ACAGAGCATA CACGGACGGA GCGACAAGTC TTGGAGCACA TTAGGCAGTC ACCGTTTTTG 240
GTGACATTGC ACTATGCTTT CCAAACAGAA ACCAAACTTC ATCTCATTTT AGATTATATA 300
AATGGTGGAG AACTTTTTAC CCATCTTTCT CAAAGAGAGC GTTTCACAGA GCACGAGGTG 360
CAGATCTACG TTGGAGAGAT TGTGCTCGCC CTCGAACATC TCCACAAGTT GGGGATTATA 420
TACCGTGACA TTAAGCTTGA GAATATTCTG CTTGATTCTA ATGGCCATGT GGTGCTGACA 480
GATTTTGGTC TGAGTAAGGA GTTTGTGGCT GATGAAGGTG AAAGAGCATA TTCCTTTTGT 540
GGAACTATTG AATACATGGC ACCAGATATT GTCAGAGGGG GAGATTCAGG ACATGACAAG 600
GCAGTTGACT GGTGGAGTTT AGGTGTTCTA ATGTATGAAC TACTAACTGG AGCATCTCCT 660
TTCACTGTTG ATGGAGAGAA GAATTCCCAA GCTGAGATAT CTAGGAGAAT ATTAAAAAGC 720
GAGCCTCCGT ACCCCCAAGA AATGAGTGCT TTAGCTAAGG ACCTAATTCA GCGTCTTTTG 780
ATGAAAGATC CCAAGAAAAG ATTGGGATGT GGTCCACGCG ATGCAGATGA AATCAAAGAA 840
CATCTCTTTT TTCAGAAAAT AAATTGGGAT GATTTAGCTG CCAAAAAAGT TCCTGCACCA 900
TTCAAGCCGG TCATCCGAGA TGAATTAGAT GTGAGCAACT TTGCAGAAGA GTTCACGGAA 960
ATGGATCCCA CCTACTCTCC TGCAGCGCTG CCCCAGAGCT CCGAGAGGCT GTTCCAGGGC 1020
TATTCCTTTG TTGCCCCTTC CATTCTGTTC AAGCGCAATG CAGCCGTCAC AGACCCTCTT 1080
CAGGTCCACA TGGGAGTTGA ACGTCCTGGG GTAACACATG TTGCTAGGAG TGCGATGATG 1140
AAGGACTCTC CGTTCTATCA ACACTATGAC CTAGATCTGA AGGACAAACC ATTGGGAGAA 1200
GGAAGTTTTT CAATTTGTCG AAAGTGCATA CACAAAAAAA GTAACCAGGC ATTTGCAGTC 1260
AAAATAATCA GCAAAAGGTT GGAAGCCAAT ACTCAAAAAG AAATAACAGC TCTGAAACTC 1320
TGTGAAGGAC ACCCCAATAT TGTGAAATTG CATGAAGTTT TTCATGATCA GCTTCACTCC 1380
TTTCTAGTGA TGGAACTTCT GAACGGCGGA GAGCTGTTTG AACGAATTAA GAAAAAGAAA 1440
CACTTCAGTG AGACCGAAGC CAGCTACATC ATGCGGAAGC TGGTTTCGGC CGTGAGCCAC 1500
ATGCATGACG TCGGAGTGGT TCATAGAGAC TTGAAACCCG AGAATTTGTT GTTCACTGAT 1560
GAAAATGACA ACTTGGAAAT TAAAGTAATT GATTTCGGGT TTGCCCGCCT AAAGCCGCCT 1620
GATAACCAGC CTCTGAAGAC GCCCTGCTTC ACCCTTCACT ATGCCGCCCC CGAGCTCTTG 1680
AATCACAGCG GCTACGATGA GTCCTGCGAC CTCTGGAGCC TGGGCGTCAT TTTGTATACA 1740
ATGTTGTCAG GGCAAGTTCC ATTCCAATCT CATGACAAAA GTTTGACGTG TACCAGTGCA 1800
GTGGAAATCA TGAAGAAAAT TAAAAAGGGA GATTTCTCCT TTGAAGGAGA AGCCTGGAGG 1860
AATGTATCCC AAGAGGCTAA AGATTTGATC CAAGGTCTTC TCACAGTTGA TCCAAATAAA 1920
AGGCTTAAAA TGTCTGGCTT GAGATACAAT GAATGGCTTC AAGATGGCAG TCAGCTGTCC 1980
TCAAATCCTC TGATGACTCC AGACATTCTG GGATCTTCAG GAGCTGCTGT GCATACCTGT 2040
GTGAAAGCAA CCTTCCATGC CTTTAACAAG TACAAGAGAG AGGGGTTTTG CCTTCAGAAT 2100
GTTGATAAGG CACCTTTGGC GAAGAGAAGA AAAATGAAAA AGACCAGCAC CAGCACGGAG 2160
ACGCGCAGCA GCTCAAGTGA AAGTTCTCAT TCCTCTTCCT CTCATTCTCA TGGCAAAACT 2220
ACACCTACAA AGACACTGCA GCCCAGCAAT CCTGCCGACG GCAATAACCC AGAGACCCTC 2280
TTCCAGTTCT CCGACTGA 2298
Domain Profile
S: 2     evkedlGvGsysvckrcvhkatnqefavkiidks.krdtseeieillryeqhpnivtlkd  60
         +++++lG+Gs+s+c++c+hk++nq+favkii+k+ +++t++ei++l+++e+hpniv+l++
Q: 393   LKDKPLGEGSFSICRKCIHKKSNQAFAVKIISKRlEANTQKEITALKLCEGHPNIVKLHE  452
         5789********************************************************
S: 61    vyddgkyvylvlellkGGelldrikkkkffsereasailrtlvkaveylheqGvvhrdlk  120
         v++d+++ +lv+ell+GGel++rikkkk+fse+eas+i+r+lv+av+++h++Gvvhrdlk
Q: 453   VFHDQLHSFLVMELLNGGELFERIKKKKHFSETEASYIMRKLVSAVSHMHDVGVVHRDLK  512
         ************************************************************
S: 121   penilyvdesdnaesikiidfGfaklkraengllktpcytlnfvapevlkrqGydeacdl  180
         pen+l++de+dn+e ik+idfGfa+lk+++n++lktpc+tl+++ape+l++ Gyde+cdl
Q: 513   PENLLFTDENDNLE-IKVIDFGFARLKPPDNQPLKTPCFTLHYAAPELLNHSGYDESCDL  571
         **************.*********************************************
S: 181   wslGvllytmlaGyvpf....angpedtaeeilakikeGkfslsGeawdsvseeakdlvs  236
         wslGv+lytml+G+vpf    +++++++a+ei++kik+G+fs++Geaw++vs+eakdl++
Q: 572   WSLGVILYTMLSGQVPFqshdKSLTCTSAVEIMKKIKKGDFSFEGEAWRNVSQEAKDLIQ  631
         *****************98888899***********************************
S: 237   klltvdpakrlkleqllkhswl  258
         +lltvdp+krlk+++l++++wl
Q: 632   GLLTVDPNKRLKMSGLRYNEWL  653
         *********************7
Domain Sequence
(FASTA)
LKDKPLGEGS FSICRKCIHK KSNQAFAVKI ISKRLEANTQ KEITALKLCE GHPNIVKLHE 60
VFHDQLHSFL VMELLNGGEL FERIKKKKHF SETEASYIMR KLVSAVSHMH DVGVVHRDLK 120
PENLLFTDEN DNLEIKVIDF GFARLKPPDN QPLKTPCFTL HYAAPELLNH SGYDESCDLW 180
SLGVILYTML SGQVPFQSHD KSLTCTSAVE IMKKIKKGDF SFEGEAWRNV SQEAKDLIQG 240
LLTVDPNKRL KMSGLRYNEW L 261
KeywordATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.
Sequence SourceEnsembl
Orthology
Ortholog group
Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Drosophila melanogaster"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Sarcophilus harrisii"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>
EKS-ANC-00159
EKS-BOT-00163
EKS-CAE-00125
EKS-CAJ-00167
EKS-CAF-00170
EKS-CAP-00162
EKS-CII-00093
EKS-CIS-00194
EKS-DAR-00452
EKS-DIO-00087
EKS-DRM-00077
EKS-FEC-00153
EKS-GAG-00140
EKS-GAA-00192
EKS-GOG-00163
EKS-HOS-00169
EKS-ICT-00158
EKS-LAC-00173
EKS-LOA-00162
EKS-MAM-00160
EKS-MEG-00130
EKS-MOD-00162
EKS-MUP-00167
EKS-MYL-00173
EKS-NOL-00156
EKS-ORN-00202
EKS-ORA-00141
EKS-ORC-00151
EKS-ORL-00189
EKS-OTG-00170
EKS-PAT-00153
EKS-PES-00145
EKS-PEM-00087
EKS-POA-00160
EKS-SAH-00157
EKS-TAG-00191
EKS-TAR-00209
EKS-TEN-00202
EKS-XET-00152
EKS-XIM-00197
Gene Ontology
GO:0005737; C:cytoplasm
GO:0005634; C:nucleus
GO:0005524; F:ATP binding
GO:0000287; F:magnesium ion binding
GO:0004674; F:protein serine/threonine kinase activity
GO:0043990; P:histone H2A-S1 phosphorylation
GO:0043987; P:histone H3-S10 phosphorylation
GO:0043988; P:histone H3-S28 phosphorylation
GO:0070498; P:interleukin-1-mediated signaling pathway
GO:0007243; P:intracellular protein kinase cascade
GO:0045892; P:negative regulation of transcription, DNA-dependent
GO:0035066; P:positive regulation of histone acetylation
GO:0033129; P:positive regulation of histone phosphorylation
GO:0051092; P:positive regulation of NF-kappaB transcription factor activity
GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter
GO:0009605; P:response to external stimulus
GO:0006950; P:response to stress
KEGG
InterPros
IPR000961; AGC-kinase_C.
IPR011009; Kinase-like_dom.
IPR017892; Pkinase_C.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR016239; Ribosomal_S6_kinase_II.
IPR002290; Ser/Thr_dual-sp_kinase_dom.
IPR008271; Ser/Thr_kinase_AS.
Pfam
PF00069; Pkinase; 2.
PF00433; Pkinase_C; 1.
SMARTs
SM00133; S_TK_X; 1.
SM00220; S_TKc; 2.
Prosites
PS51285; AGC_KINASE_CTER; 1.
PS00107; PROTEIN_KINASE_ATP; 2.
PS50011; PROTEIN_KINASE_DOM; 2.
PS00108; PROTEIN_KINASE_ST; 2.
Prints
Created Date20-Feb-2013