EKS-EQC-00051
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-EQC-00051
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TKL/RAF392.11.6E-117311568258
StatusUnreviewed
Ensembl ProteinENSECAP00000021602
UniProt AccessionF6XAS0;
Protein Name
Protein Synonyms/Alias
Gene NameARAF
Gene Synonyms/Alias ARAF;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSECAG00000023903ENSECAP00000021602ENSECAT00000025939
OrganismEquus caballus
Functional Description
Protein Length607
Protein Sequence
(FASTA)
MESPRGPPAN GAEPSRAVGT VKVYLPNKQR TVVTVRDGMS VYDSLDKALK VRGLNQDCCV 60
VYRLIKGRKT VTAWDTAIAP LDGEELIVEV LEDVPLTMHN FVRKTFFSLA FCDFCLKFLF 120
HGFRCQTCGY KFHQHCSSKV PTVCVDMSTN RRQFYHSVQD LSGGSRQHEA PSNRPLNEPL 180
TPQGPSSCTQ HRDPEHFPFP ASANAPLQRI RSTSTPNVHM VSTTAPMDSS LIQVGVGGHF 240
STDAAGGRSG GDGASRGSPS PASVSSGRKS PHSKSPSEQR ERKSLADDKK KVKNLGYRDS 300
GYYWEVPPSE VQLLKRIGTG SFGTVFRGRW HGDVAVKVLK VAQPTAEQAQ AFKNEMQVLR 360
KTRHVNILLF MGFMTRPGFA IITQWCEGSS LYHHLHVADT RFDMVQLIDV ARQTAQGMDY 420
LHAKNIIHRD LKSNSISLSL GLTVKIGDFG LATVKTRWSG AQPLEQPSGS VLWMAAEVIR 480
MQDPNPYSFQ SDVYAYGVVL YELMTGSLPY SHIGSRDQII FMVGRGYLSP DLSKISSNCP 540
KAMRRLLSDC LKFQREERPL FPQILATIEL LQRSLPKIER SASEPSLHRT QADELPACLL 600
SAARLVP 607
Nucleotide Sequence
(FASTA)
ATGGAGTCAC CACGGGGCCC CCCTGCCAAC GGGGCCGAGC CATCCCGGGC AGTGGGGACC 60
GTCAAAGTGT ACCTGCCCAA CAAGCAACGC ACGGTGGTGA CTGTCCGGGA TGGCATGAGT 120
GTCTACGATT CTCTAGACAA GGCCCTCAAG GTGCGAGGTC TCAATCAGGA TTGCTGTGTG 180
GTCTACCGGC TCATCAAGGG GCGAAAGACA GTTACTGCCT GGGACACGGC CATTGCCCCC 240
CTGGATGGCG AGGAGCTCAT CGTGGAGGTC CTCGAAGACG TCCCACTGAC CATGCACAAT 300
TTTGTACGGA AGACATTCTT CAGCCTGGCA TTCTGCGACT TCTGCCTTAA GTTTCTGTTC 360
CATGGCTTCC GCTGCCAAAC CTGTGGCTAC AAGTTCCACC AGCATTGTTC CTCCAAGGTC 420
CCCACAGTCT GTGTTGACAT GAGTACCAAC CGCCGACAGT TCTACCACAG TGTCCAGGAT 480
TTGTCCGGAG GCTCCAGACA GCACGAGGCT CCCTCGAACC GCCCCCTGAA TGAGCCGCTA 540
ACCCCTCAGG GTCCCAGCTC CTGCACCCAG CACCGGGACC CTGAGCACTT CCCCTTCCCT 600
GCCTCGGCCA ACGCCCCCCT CCAGCGCATC CGTTCCACCT CCACCCCCAA CGTCCATATG 660
GTCAGCACCA CAGCTCCCAT GGACTCCAGC CTCATCCAGG TTGGTGTCGG GGGGCATTTC 720
AGCACCGATG CCGCTGGAGG TAGAAGTGGT GGTGATGGAG CCTCCCGGGG GAGCCCCAGC 780
CCGGCCAGCG TGTCCTCGGG GAGGAAGTCC CCACATTCCA AGTCCCCATC GGAGCAGCGG 840
GAGCGAAAGT CCTTGGCTGA CGACAAGAAG AAAGTGAAGA ATCTGGGGTA CCGGGACTCA 900
GGCTATTACT GGGAGGTGCC ACCCAGCGAG GTGCAGCTGC TGAAGAGGAT CGGGACAGGC 960
TCATTTGGCA CCGTGTTTCG CGGGCGGTGG CATGGTGATG TGGCCGTGAA GGTGCTCAAG 1020
GTGGCGCAAC CCACAGCTGA GCAGGCCCAG GCCTTCAAGA ACGAGATGCA GGTGCTCAGG 1080
AAGACGCGTC ATGTCAACAT CTTGCTGTTC ATGGGCTTCA TGACCCGGCC GGGCTTTGCC 1140
ATCATCACAC AGTGGTGCGA GGGCTCCAGC CTCTACCACC ACCTGCACGT GGCGGACACA 1200
CGCTTCGACA TGGTCCAGCT CATCGACGTG GCCCGGCAGA CCGCCCAGGG CATGGACTAC 1260
CTTCATGCCA AGAACATCAT CCATCGAGAT CTCAAGTCTA ACAGTATCTC CCTGTCCCTG 1320
GGGCTCACGG TGAAGATCGG TGACTTCGGC CTGGCCACAG TGAAGACGAG GTGGAGCGGG 1380
GCCCAGCCCT TGGAGCAGCC CTCGGGCTCT GTGCTATGGA TGGCGGCCGA GGTGATCCGT 1440
ATGCAGGACC CAAACCCCTA CAGCTTCCAG TCGGATGTCT ACGCCTATGG GGTTGTGCTC 1500
TATGAGCTCA TGACCGGCTC ACTGCCTTAC AGCCACATTG GCAGCCGTGA CCAGATTATC 1560
TTTATGGTGG GCCGTGGCTA TCTGTCCCCG GACCTCAGCA AAATCTCCAG CAACTGCCCC 1620
AAGGCCATGC GGCGCCTGCT GTCTGACTGC CTCAAGTTCC AGCGGGAGGA GCGGCCCCTC 1680
TTCCCCCAGA TCCTGGCCAC GATTGAGCTA CTGCAGCGGT CACTCCCCAA GATCGAGCGG 1740
AGTGCGTCCG AACCCTCCTT GCACCGCACC CAGGCTGACG AGTTGCCTGC CTGCCTACTC 1800
AGCGCAGCCC GCCTTGTGCC TTAG 1824
Domain Profile
S: 1     velaekiGsGrfGtvyrgkwhGdvavkllnveelseeqleaFkkevaaykktRhenivLF  60
         v+l ++iG+G+fGtv+rg+whGdvavk+l+v ++++eq++aFk+e+++++ktRh+ni+LF
Q: 311   VQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVAQPTAEQAQAFKNEMQVLRKTRHVNILLF  370
         67899*******************************************************
S: 61    mGyvskpelaivtslckgssLykllheqetkldlaklidiarqiaqgmdYLhakkilhkD  120
         mG++++p +ai+t++c+gssLy++lh+++t++d+++lid+arq+aqgmdYLhak+i+h+D
Q: 371   MGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRD  430
         ************************************************************
S: 121   lksknilleeglkvvitDFgllsvkrllsgrrekqleipkgwilylapeviralsidleq  180
         lks+ i l+ gl+v+i+DFgl++vk+++sg  ++ le+p+g++l++a+evir+      q
Q: 431   LKSNSISLSLGLTVKIGDFGLATVKTRWSG--AQPLEQPSGSVLWMAAEVIRM------Q  482
         ******************************..9********************......*
S: 181   delpfskesDvyafGivlyellarelpyke.esadqilfavgrG.lkpdlskvksklpke  238
         d +p+s++sDvya+G+vlyel++++lpy++  s+dqi+f+vgrG l+pdlsk++s++pk+
Q: 483   DPNPYSFQSDVYAYGVVLYELMTGSLPYSHiGSRDQIIFMVGRGyLSPDLSKISSNCPKA  542
         ************************************************************
S: 239   lkellleClkfekeeRPlftqilkkl  264
         +++ll++Clkf++eeRPlf+qil+++
Q: 543   MRRLLSDCLKFQREERPLFPQILATI  568
         **********************9875
Domain Sequence
(FASTA)
VQLLKRIGTG SFGTVFRGRW HGDVAVKVLK VAQPTAEQAQ AFKNEMQVLR KTRHVNILLF 60
MGFMTRPGFA IITQWCEGSS LYHHLHVADT RFDMVQLIDV ARQTAQGMDY LHAKNIIHRD 120
LKSNSISLSL GLTVKIGDFG LATVKTRWSG AQPLEQPSGS VLWMAAEVIR MQDPNPYSFQ 180
SDVYAYGVVL YELMTGSLPY SHIGSRDQII FMVGRGYLSP DLSKISSNCP KAMRRLLSDC 240
LKFQREERPL FPQILATI 258
KeywordATP-binding; Complete proteome; Kinase; Metal-binding; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase; Zinc.
Sequence SourceEnsembl
Orthology
Ortholog group
Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Felis catus"; ?>Gadus morhua"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Macropus eugenii"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pongo abelii"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xiphophorus maculatus"; ?>
EKS-ANC-00045
EKS-BOT-00052
EKS-CAJ-00052
EKS-CAF-00053
EKS-CAP-00052
EKS-CIS-00058
EKS-DAR-00067
EKS-FEC-00050
EKS-GAM-00023
EKS-GAA-00070
EKS-GOG-00051
EKS-HOS-00053
EKS-ICT-00049
EKS-LAC-00056
EKS-LOA-00052
EKS-MAM-00052
EKS-MAE-00026
EKS-MUM-00053
EKS-MUP-00054
EKS-MYL-00054
EKS-NOL-00052
EKS-ORN-00071
EKS-ORC-00048
EKS-ORL-00065
EKS-OTG-00055
EKS-POA-00049
EKS-SAH-00049
EKS-SUS-00043
EKS-TAR-00072
EKS-TEN-00076
EKS-TUT-00052
EKS-XIM-00069
Gene Ontology
GO:0005739; C:mitochondrion
GO:0005524; F:ATP binding
GO:0046872; F:metal ion binding
GO:0004674; F:protein serine/threonine kinase activity
GO:0005057; F:receptor signaling protein activity
GO:0035556; P:intracellular signal transduction
GO:0043066; P:negative regulation of apoptotic process
GO:0033138; P:positive regulation of peptidyl-serine phosphorylation
KEGG
InterPros
IPR020454; DAG/PE-bd.
IPR011009; Kinase-like_dom.
IPR002219; Prot_Kinase_C-like_PE/DAG-bd.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR003116; Raf-like_ras-bd.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
Pfam
PF00130; C1_1; 1.
PF07714; Pkinase_Tyr; 1.
PF02196; RBD; 1.
SMARTs
SM00109; C1; 1.
SM00455; RBD; 1.
Prosites
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS50898; RBD; 1.
PS00479; ZF_DAG_PE_1; 1.
PS50081; ZF_DAG_PE_2; 1.
Prints
PR00008; DAGPEDOMAIN.
Created Date20-Feb-2013