EKS-EQC-00060

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-EQC-00060

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CMGC/CDK	386.9	5.7E-116	4	288	285

Status

Unreviewed

Ensembl Protein

ENSECAP00000021772

UniProt Accession

F6YF11;

Protein Name

Protein Synonyms/Alias

Gene Name

CDK5

Gene Synonyms/Alias

CDK5;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSECAG00000024299	ENSECAP00000021772	ENSECAT00000026127

Organism

Equus caballus

Functional Description

Protein Length

294

Protein Sequence
(FASTA)

MQKYEKLEKI GEGTYGTVFK AKNRETHEIV ALKRVRLDDD DEGVPSSALR EICLLKELKH 60

KNIVRLHDVL HSDKKLTLVF EFCDQDLKKY FDSCNGDLDP EIVKSFLFQL LKGLGFCHSR 120

NVLHRDLKPQ NLLINRNGEL KLADFGLARA FGIPVRCYSA EVVTLWYRPP DVLFGAKLYS 180

TSIDMWSAGC IFAELANAGR PLFPGNDVDD QLILDPVDTL LGTPTEEQWP AMTKLPDYKP 240

YPMYPATTSL VNVVPKLNAT GRDLLQNLLK CNPVQRISAE EALQHPYFSD FCPP 294

Nucleotide Sequence
(FASTA)

ATGCAGAAAT ACGAGAAACT GGAGAAGATT GGGGAAGGCA CCTATGGAAC AGTGTTCAAG 60

GCCAAAAACC GAGAGACCCA TGAGATCGTG GCTCTGAAAC GGGTGAGGCT GGATGACGAT 120

GATGAGGGAG TGCCGAGTTC TGCCCTTCGG GAAATCTGCC TACTCAAAGA GCTGAAGCAC 180

AAGAACATCG TCAGGCTTCA TGACGTCCTG CATAGCGACA AGAAGCTGAC TTTGGTTTTT 240

GAGTTCTGTG ACCAGGACCT CAAGAAGTAC TTTGACAGCT GCAATGGTGA CCTAGATCCT 300

GAAATTGTGA AGTCATTCCT CTTCCAGCTG CTAAAGGGCC TGGGATTCTG TCACAGTCGC 360

AACGTGCTGC ACAGGGACCT AAAGCCCCAG AACCTACTCA TAAACAGAAA CGGGGAGCTG 420

AAATTGGCTG ATTTTGGGTT GGCTCGAGCC TTTGGGATCC CTGTTCGCTG TTACTCAGCT 480

GAGGTGGTCA CGCTGTGGTA CCGCCCACCG GATGTCCTCT TTGGGGCCAA GCTGTACTCC 540

ACGTCCATCG ACATGTGGTC AGCCGGCTGC ATCTTTGCAG AGCTGGCCAA TGCGGGGCGG 600

CCGCTTTTCC CTGGCAACGA TGTAGATGAC CAGTTGATCC TTGACCCCGT GGACACGCTG 660

CTGGGGACAC CGACTGAGGA GCAGTGGCCC GCCATGACCA AGCTGCCAGA CTATAAGCCC 720

TACCCGATGT ACCCGGCCAC AACGTCCCTG GTGAACGTCG TACCCAAGCT CAATGCCACA 780

GGGAGGGACC TGCTGCAGAA CCTCCTGAAG TGTAACCCCG TCCAGCGCAT CTCCGCAGAA 840

GAGGCCCTGC AGCACCCCTA CTTCTCCGAC TTCTGCCCCC CCTAG 885

Domain Profile

S: 1     yeklekigeGtygkvykakdketgevvAlKkirlekekegvpitalrEisllkelkhkni  60

         yeklekigeGtyg+v+kak++et+e+vAlK++rl++++egvp++alrEi llkelkhkni

Q: 4     YEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKHKNI  63

         99**********************************************************

S: 61    vkLlevvakdkkklyLvfefleqdLkkllkkkkkkklsleevkslllqlleglaylHsnk  120

         v+L++v++ ++kkl+Lvfef++qdLkk++++++  +l++e vks+l+qll+gl ++Hs++

Q: 64    VRLHDVLH-SDKKLTLVFEFCDQDLKKYFDSCNG-DLDPEIVKSFLFQLLKGLGFCHSRN  121

         ********.99***********************.*************************

S: 121   ilHRDlKpqNlLiskegklklaDfGlarafssplktytkevvTlwYraPelLlgakeYst  180

         +lHRDlKpqNlLi+++g+lklaDfGlaraf+ p++ y+ evvTlwYr+P++L+gak Yst

Q: 122   VLHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFGAKLYST  181

         ************************************************************

S: 181   avDiWsvgcilaellt.rkplfqgkseidql..erifkllgtpsekvwpevsklpeykks  237

         ++D+Ws+gci+ael++  +plf+g++  dql  + + +llgtp+e++wp ++klp+yk

Q: 182   SIDMWSAGCIFAELANaGRPLFPGNDVDDQLilDPVDTLLGTPTEEQWPAMTKLPDYK-P  240

         **************97369********99963378***********************.5

S: 238   fpkkkkk.klkekvkklkekaldllekllaldpkkRisakealqhkyf  284

         +p ++++ +l ++v+kl+ +++dll++ll+++p +Risa+ealqh+yf

Q: 241   YPMYPATtSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPYF  288

         555555559**************************************9

Domain Sequence
(FASTA)

YEKLEKIGEG TYGTVFKAKN RETHEIVALK RVRLDDDDEG VPSSALREIC LLKELKHKNI 60

VRLHDVLHSD KKLTLVFEFC DQDLKKYFDS CNGDLDPEIV KSFLFQLLKG LGFCHSRNVL 120

HRDLKPQNLL INRNGELKLA DFGLARAFGI PVRCYSAEVV TLWYRPPDVL FGAKLYSTSI 180

DMWSAGCIFA ELANAGRPLF PGNDVDDQLI LDPVDTLLGT PTEEQWPAMT KLPDYKPYPM 240

YPATTSLVNV VPKLNATGRD LLQNLLKCNP VQRISAEEAL QHPYF 285

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Drosophila melanogaster"; ?>Erinaceus europaeus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tupaia belangeri"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0030424	; C:axon
GO:0005829	; C:cytosol
GO:0030175	; C:filopodium
GO:0030027	; C:lamellipodium
GO:0005634	; C:nucleus
GO:0030549	; F:acetylcholine receptor activator activity
GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0048148	; P:behavioral response to cocaine
GO:0070509	; P:calcium ion import
GO:0007160	; P:cell-matrix adhesion
GO:0021954	; P:central nervous system neuron development
GO:0021697	; P:cerebellar cortex formation
GO:0022038	; P:corpus callosum development
GO:0048813	; P:dendrite morphogenesis
GO:0021766	; P:hippocampus development
GO:0006886	; P:intracellular protein transport
GO:0021819	; P:layer formation in cerebral cortex
GO:0008045	; P:motor neuron axon guidance
GO:0045786	; P:negative regulation of cell cycle
GO:0046826	; P:negative regulation of protein export from nucleus
GO:0031397	; P:negative regulation of protein ubiquitination
GO:0031914	; P:negative regulation of synaptic plasticity
GO:0045892	; P:negative regulation of transcription, DNA-dependent
GO:0051402	; P:neuron apoptotic process
GO:0001764	; P:neuron migration
GO:0048709	; P:oligodendrocyte differentiation
GO:0018107	; P:peptidyl-threonine phosphorylation
GO:0045956	; P:positive regulation of calcium ion-dependent exocytosis
GO:0032092	; P:positive regulation of protein binding
GO:0045860	; P:positive regulation of protein kinase activity
GO:0090314	; P:positive regulation of protein targeting to membrane
GO:0035418	; P:protein localization to synapse
GO:0032801	; P:receptor catabolic process
GO:0043113	; P:receptor clustering
GO:0030334	; P:regulation of cell migration
GO:0061001	; P:regulation of dendritic spine morphogenesis
GO:0060079	; P:regulation of excitatory postsynaptic membrane potential
GO:0014044	; P:Schwann cell development
GO:0019233	; P:sensory perception of pain
GO:0033136	; P:serine phosphorylation of STAT3 protein
GO:0007519	; P:skeletal muscle tissue development
GO:0007416	; P:synapse assembly
GO:0001963	; P:synaptic transmission, dopaminergic
GO:0035249	; P:synaptic transmission, glutamatergic
GO:0008542	; P:visual learning

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013