EKS-EQC-00291
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-EQC-00291
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/EGFR456.92.0E-137682938257
StatusUnreviewed
Ensembl ProteinENSECAP00000022150
UniProt AccessionF6RXS0;
Protein Name
Protein Synonyms/Alias
Gene NameERBB3
Gene Synonyms/Alias ERBB3;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSECAG00000024374ENSECAP00000022150ENSECAT00000026542
OrganismEquus caballus
Functional Description
Protein Length1312
Protein Sequence
(FASTA)
VCPGTLNGLS VTGDAENQYQ TLQKLYERCE VVMGNLEIVL TGHNADLSFL QWIREVTGYV 60
LVAMNEFSTL PLPNLRVVRG TQVYDGKFAI FVMLNYNTNS SHALRELRFT QLTEILSGGV 120
YIEKNDKLCH MDTIDWRDIV RDPDAEIVVK DNGRSCPPCH EVCKGRCWGP GPEDCQTLTK 180
TICAPQCNGH CFGPNPNQCC HDECAGGCSG PQDTDCFACR LFNDSGACVR QCPQPLVYNK 240
LTFQLEPNPH TKYQYGGVCV ASCPHNFVVD QTSCVRACPP DKMEVDKNGL KMCEPCGGLC 300
PKACEGTGSG SRFQTVDSSN IDGFVNCTKI LGNLDFLITG LNGDPWHKIP ALDPEKLNVF 360
RTVREITGYL NIQSWPPHMH NFSVFSNLTT IGGRSLYNRG FSLLIMKNLN ITSLGLRSLK 420
EISAGRIYIS ANRQLCYHHS LNWTRLLRGP SEERLDIKHN RPRRDCMAEG KVCDPLCSSG 480
GCWGPGPGQC LSCRNYSRGG VCVTHCNFLN GEPREFAHEA ECFSCHLECQ PMEGTATCNG 540
SGSDACAQCA HFRDGPHCVS SCPNGVLGAK GPIYKYPDAQ NECRPCHENC TQGCKGPELQ 600
DCLGQTLVLI SKTHLAMALT LVVGLAVIFL ILGGSFLYWR GRRIQNKRAM RRYLERGESI 660
EPLDPSEKAN KVLARIFKET ELRKLKVLGS GVFGTVHKGV WIPEGESIKI PVCIKVIEDK 720
SGRQSFQAVT DHMLAIGSLD HAHIVRLLGL CPGSSLQLVT QYLPLGSLLD HVRQHREALG 780
PQLLLNWGVQ IAKGMYYLEE HGMVHRNLAA RNVLLKSPSQ VQVADFGVAD LLPPDDKQLL 840
HSEAKTPIKW MALESIHFGK YTHQSDVWSY GVTVWELMTF GAEPYAGLRL AEVPDLLEKG 900
ERLAQPQICT IDVYMVMVKC WMIDENIRPT FKELANEFTR MARDPPRYLV IKRESGPGIP 960
PGAEPPALTN KELEEVELEP ELDLDLDLEA EEDNLATTLG SALSLPVGTL NRPRGSQSLL 1020
SPSSGYMPMN QGNLGEACQE SAVCGSSERC PRPASLHPMP RGRLASESSE GHVTGSEAEL 1080
QEKVSMCRSR SRSPRPRGDS AYHSQRHSLL TPVTPLSPPG LEEEDVNGYV MPDAHVKGTP 1140
SSREGTLSSV GLSSVLGTEE EDEDEEYEYM NRKRRRSPPR PPRPSSLEEL GYEYMDVGSD 1200
LSASLGSTQS CPLHPVPIMP TAGTTPDEDY EYMNRRRGGG GPGGDYAAMG ACPAAEQGYE 1260
EMRAFQGPGH HAPHVHYARL KTLRSLEATD SAFDNPDYWH SRLFPKANAQ RT 1312
Nucleotide Sequence
(FASTA)
GTGTGTCCTG GGACTCTGAA TGGGCTGAGT GTGACTGGTG ATGCCGAGAA CCAATACCAG 60
ACGCTGCAAA AGCTCTATGA GAGGTGTGAG GTGGTGATGG GGAACCTGGA GATTGTGCTC 120
ACAGGACACA ATGCTGACCT CTCCTTCCTG CAGTGGATCC GAGAAGTGAC CGGCTATGTC 180
CTTGTGGCCA TGAATGAGTT CTCTACACTG CCACTGCCCA ACCTCCGGGT GGTGCGGGGC 240
ACTCAGGTCT ACGATGGGAA GTTCGCCATC TTTGTCATGT TGAACTATAA CACCAACTCC 300
AGCCATGCGC TGCGCGAGCT CCGCTTTACT CAGCTCACTG AGATTCTGTC AGGGGGCGTT 360
TATATTGAGA AGAACGATAA ACTCTGTCAC ATGGACACAA TTGACTGGAG GGACATCGTG 420
AGGGACCCAG ATGCCGAGAT AGTGGTGAAG GACAATGGCA GGAGCTGTCC CCCCTGTCAT 480
GAGGTCTGCA AGGGGCGATG CTGGGGTCCT GGACCAGAAG ACTGCCAGAC ACTGACCAAG 540
ACCATCTGTG CCCCTCAGTG TAATGGCCAC TGCTTTGGGC CCAACCCCAA CCAGTGTTGC 600
CATGATGAGT GTGCAGGGGG CTGTTCAGGC CCTCAGGACA CAGACTGCTT TGCCTGCCGA 660
CTCTTCAATG ACAGTGGAGC CTGTGTACGC CAGTGTCCAC AGCCTCTTGT CTACAACAAG 720
CTAACTTTCC AGCTAGAACC CAATCCTCAC ACCAAGTATC AGTATGGAGG AGTTTGTGTG 780
GCCAGCTGTC CCCACAACTT TGTGGTGGAT CAGACATCTT GTGTCAGGGC CTGTCCTCCT 840
GACAAGATGG AGGTAGATAA AAATGGACTC AAGATGTGTG AACCTTGTGG GGGGCTGTGC 900
CCCAAAGCCT GTGAGGGGAC AGGCTCTGGG AGCCGCTTCC AGACTGTGGA CTCTAGCAAC 960
ATTGATGGAT TTGTGAACTG CACCAAGATC CTGGGCAACC TAGACTTTCT TATCACCGGC 1020
CTCAATGGAG ACCCCTGGCA CAAGATCCCT GCCCTGGACC CTGAGAAGCT CAACGTCTTC 1080
CGGACAGTAC GGGAGATCAC AGGTTACTTG AACATCCAGT CCTGGCCTCC CCACATGCAC 1140
AACTTCAGCG TCTTTTCCAA CCTGACAACC ATTGGGGGCA GAAGCCTCTA CAACCGGGGC 1200
TTCTCATTGT TGATCATGAA GAACTTGAAT ATAACATCCC TGGGCCTCCG ATCCTTGAAA 1260
GAAATTAGTG CTGGGCGTAT CTACATAAGT GCCAATCGGC AGCTCTGCTA CCACCATTCT 1320
CTGAACTGGA CCAGGCTGCT TCGTGGGCCT TCGGAAGAGA GACTAGACAT CAAGCATAAT 1380
CGGCCTCGCA GAGACTGCAT GGCAGAAGGC AAAGTGTGTG ACCCACTGTG CTCCTCCGGG 1440
GGATGCTGGG GCCCAGGCCC TGGTCAGTGC CTATCCTGTC GAAACTACAG CCGAGGAGGT 1500
GTCTGTGTGA CCCACTGCAA CTTTCTGAAT GGGGAGCCTC GTGAGTTTGC CCATGAGGCT 1560
GAATGCTTCT CCTGCCACCT GGAATGCCAA CCCATGGAGG GCACCGCCAC ATGCAATGGC 1620
TCGGGCTCTG ATGCTTGTGC CCAGTGTGCC CATTTTCGTG ATGGGCCTCA CTGTGTGAGC 1680
AGCTGTCCCA ATGGAGTCCT CGGTGCCAAG GGCCCCATCT ACAAGTACCC AGATGCCCAG 1740
AATGAATGTC GGCCCTGCCA TGAGAACTGC ACCCAGGGGT GTAAGGGACC AGAGCTACAA 1800
GACTGTTTGG GCCAAACACT GGTACTGATC AGCAAAACCC ACCTGGCAAT GGCTTTAACA 1860
CTGGTAGTGG GATTGGCGGT GATTTTCCTG ATCCTGGGTG GCTCTTTTCT CTACTGGCGT 1920
GGGCGCCGGA TTCAGAATAA GAGGGCTATG AGGCGCTACT TGGAACGGGG TGAGAGCATA 1980
GAGCCGCTGG ATCCCAGTGA GAAGGCTAAC AAAGTCTTGG CCAGAATCTT CAAAGAGACA 2040
GAGCTGAGGA AGCTTAAAGT GCTTGGCTCA GGCGTCTTTG GAACTGTGCA CAAAGGAGTG 2100
TGGATTCCTG AGGGTGAATC AATCAAGATT CCAGTCTGCA TTAAAGTCAT TGAGGACAAG 2160
AGTGGACGGC AAAGTTTTCA GGCTGTGACA GATCATATGC TGGCCATTGG CAGCCTAGAC 2220
CATGCCCACA TTGTACGGCT GCTGGGACTC TGCCCAGGGT CATCTCTGCA GCTCGTCACT 2280
CAATACTTGC CTCTGGGTTC CCTGCTGGAT CATGTGAGGC AACACCGGGA GGCACTGGGG 2340
CCACAGCTGC TGCTCAACTG GGGAGTACAA ATTGCCAAGG GTATGTACTA CCTTGAGGAG 2400
CATGGTATGG TGCATAGGAA CCTGGCTGCC CGAAATGTGC TACTCAAGTC ACCCAGTCAG 2460
GTTCAGGTGG CGGATTTTGG GGTAGCTGAC CTGCTGCCCC CTGATGATAA GCAGCTACTA 2520
CACAGTGAGG CCAAGACTCC AATTAAGTGG ATGGCCCTCG AGAGTATCCA CTTTGGGAAA 2580
TACACACACC AGAGTGACGT CTGGAGCTAT GGTGTGACAG TTTGGGAGCT GATGACATTT 2640
GGGGCAGAGC CCTATGCAGG ACTGCGACTG GCTGAAGTAC CAGACCTTCT GGAGAAGGGG 2700
GAGCGGTTGG CACAGCCCCA GATCTGTACC ATTGATGTCT ACATGGTCAT GGTCAAATGT 2760
TGGATGATTG ATGAGAACAT TCGCCCAACC TTTAAAGAAC TAGCCAATGA ATTCACCAGG 2820
ATGGCTCGAG ACCCACCACG GTATCTGGTC ATAAAGAGAG AGAGTGGGCC TGGAATTCCC 2880
CCTGGGGCAG AACCTCCCGC TCTGACAAAC AAGGAACTGG AGGAAGTAGA GCTGGAGCCA 2940
GAACTAGACC TAGACCTGGA CCTGGAGGCA GAGGAGGACA ACCTGGCGAC AACACTAGGC 3000
TCTGCCCTCA GCCTGCCAGT GGGAACACTT AATCGGCCAC GTGGGAGCCA GAGCCTTTTA 3060
AGCCCATCAT CTGGATATAT GCCTATGAAC CAGGGTAATC TCGGGGAGGC TTGCCAGGAG 3120
TCTGCAGTTT GTGGCAGTAG TGAACGGTGC CCCCGTCCAG CCTCTCTGCA CCCAATGCCA 3180
CGGGGACGCC TGGCATCAGA GTCATCAGAG GGCCATGTGA CCGGTTCTGA GGCTGAGCTC 3240
CAGGAGAAGG TGTCAATGTG TAGAAGCCGG AGCCGGAGCC CACGGCCACG TGGAGACAGT 3300
GCCTACCATT CCCAGCGCCA CAGCCTGCTC ACTCCTGTCA CCCCACTCTC TCCACCAGGG 3360
TTAGAGGAAG AGGATGTCAA TGGTTATGTC ATGCCAGATG CACATGTCAA AGGTACTCCC 3420
TCCTCCCGGG AAGGCACCCT TTCTTCAGTG GGTCTCAGTT CTGTCCTGGG TACTGAAGAA 3480
GAAGATGAAG ATGAGGAGTA TGAATACATG AACCGGAAGA GAAGGCGCAG TCCTCCTCGT 3540
CCTCCTAGGC CAAGTTCCCT TGAGGAGCTG GGTTATGAGT ACATGGATGT TGGATCAGAC 3600
CTCAGTGCTT CCCTGGGCAG CACACAGAGT TGCCCACTCC ACCCTGTGCC CATCATGCCC 3660
ACTGCTGGCA CAACTCCAGA TGAGGACTAT GAATATATGA ATCGGCGACG TGGTGGAGGA 3720
GGTCCTGGGG GGGATTATGC AGCCATGGGC GCCTGCCCAG CAGCTGAGCA AGGGTATGAA 3780
GAGATGAGAG CTTTCCAGGG GCCTGGACAC CATGCCCCCC ATGTCCATTA TGCCCGTCTC 3840
AAAACTCTAC GTAGTTTAGA AGCCACTGAC TCTGCCTTTG ATAACCCTGA TTACTGGCAT 3900
AGCAGGCTTT TCCCCAAGGC TAATGCCCAG AGAACATAA 3939
Domain Profile
S: 1     lkklkvlGsGafGtvykGiwipegenvkipvaikvleektgkkankelldealvlasldh  60
         l+klkvlGsG+fGtv+kG+wipege++kipv+ikv+e+k+g++++++++d++l+++sldh
Q: 682   LRKLKVLGSGVFGTVHKGVWIPEGESIKIPVCIKVIEDKSGRQSFQAVTDHMLAIGSLDH  741
         69**********************************************************
S: 61    anlvrllglclsstlqlvtqllplGclldyvrehkdklGsqellnwcvqiakGmsyleek  120
         a++vrllglc  s+lqlvtq+lplG+lld+vr+h+++lG+q llnw+vqiakGm+ylee+
Q: 742   AHIVRLLGLCPGSSLQLVTQYLPLGSLLDHVRQHREALGPQLLLNWGVQIAKGMYYLEEH  801
         ************************************************************
S: 121   rlvhrdlaarnvlvkspnhvkitdfGlaklleadekelkaeggkvpikwlalesilkrky  180
          +vhr+laarnvl+ksp++v+++dfG+a+ll  d+k+l ++++k+pikw+alesi++ ky
Q: 802   GMVHRNLAARNVLLKSPSQVQVADFGVADLLPPDDKQLLHSEAKTPIKWMALESIHFGKY  861
         ************************************************************
S: 181   thqsdvwsyGvtvwelltfGakpydgipakeipdllekGerlaqppictidvymvlvkcw  240
         thqsdvwsyGvtvwel+tfGa+py+g++++e+pdllekGerlaqp+ictidvymv+vkcw
Q: 862   THQSDVWSYGVTVWELMTFGAEPYAGLRLAEVPDLLEKGERLAQPQICTIDVYMVMVKCW  921
         ************************************************************
S: 241   midaesrpkfkelaeef  257
         mid+++rp+fkela+ef
Q: 922   MIDENIRPTFKELANEF  938
         ****************9
Domain Sequence
(FASTA)
LRKLKVLGSG VFGTVHKGVW IPEGESIKIP VCIKVIEDKS GRQSFQAVTD HMLAIGSLDH 60
AHIVRLLGLC PGSSLQLVTQ YLPLGSLLDH VRQHREALGP QLLLNWGVQI AKGMYYLEEH 120
GMVHRNLAAR NVLLKSPSQV QVADFGVADL LPPDDKQLLH SEAKTPIKWM ALESIHFGKY 180
THQSDVWSYG VTVWELMTFG AEPYAGLRLA EVPDLLEKGE RLAQPQICTI DVYMVMVKCW 240
MIDENIRPTF KELANEF 257
KeywordATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Transferase; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Felis catus"; ?>Gadus morhua"; ?>Gasterosteus aculeatus"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00281
EKS-ANC-00291
EKS-BOT-00299
EKS-CAJ-00306
EKS-CAF-00306
EKS-CAP-00335
EKS-DAR-00648
EKS-DRM-00152
EKS-FEC-00285
EKS-GAM-00190
EKS-GAA-00372
EKS-ICT-00282
EKS-LAC-00311
EKS-LOA-00310
EKS-MAM-00303
EKS-MOD-00294
EKS-MUM-00331
EKS-MUP-00297
EKS-MYL-00301
EKS-NOL-00276
EKS-OCP-00048
EKS-ORN-00390
EKS-ORC-00282
EKS-ORL-00361
EKS-OTG-00305
EKS-POA-00291
EKS-PTV-00063
EKS-RAN-00316
EKS-SAH-00281
EKS-SUS-00263
EKS-TAR-00393
EKS-TEN-00390
EKS-TUT-00065
EKS-XET-00373
EKS-XIM-00382
Gene Ontology
GO:0016324; C:apical plasma membrane
GO:0016323; C:basolateral plasma membrane
GO:0005615; C:extracellular space
GO:0016021; C:integral to membrane
GO:0016328; C:lateral plasma membrane
GO:0005524; F:ATP binding
GO:0030296; F:protein tyrosine kinase activator activity
GO:0004716; F:receptor signaling protein tyrosine kinase activity
GO:0004714; F:transmembrane receptor protein tyrosine kinase activity
GO:0021545; P:cranial nerve development
GO:0003197; P:endocardial cushion development
GO:0007162; P:negative regulation of cell adhesion
GO:0043524; P:negative regulation of neuron apoptotic process
GO:0051048; P:negative regulation of secretion
GO:0009968; P:negative regulation of signal transduction
GO:0051402; P:neuron apoptotic process
GO:0014065; P:phosphatidylinositol 3-kinase cascade
GO:0042127; P:regulation of cell proliferation
GO:0014037; P:Schwann cell differentiation
GO:0023014; P:signal transduction by phosphorylation
GO:0007169; P:transmembrane receptor protein tyrosine kinase signaling pathway
KEGG
InterPros
IPR000494; EGF_rcpt_L.
IPR006211; Furin-like_Cys-rich_dom.
IPR006212; Furin_repeat.
IPR009030; Growth_fac_rcpt.
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR020635; Tyr_kinase_cat_dom.
IPR016245; Tyr_kinase_EGF/ERB/XmrK_rcpt.
Pfam
PF00757; Furin-like; 1.
PF07714; Pkinase_Tyr; 1.
PF01030; Recep_L_domain; 2.
SMARTs
SM00261; FU; 5.
SM00219; TyrKc; 1.
Prosites
PS50011; PROTEIN_KINASE_DOM; 1.
Prints
PR00109; TYRKINASE.
Created Date20-Feb-2013