EKS-EQC-00165

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-EQC-00165

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
AGC/PKG	495.4	3.4E-149	453	711	259

Status

Unreviewed

Ensembl Protein

ENSECAP00000022043

UniProt Accession

F6RQA9;

Protein Name

cGMP-dependent protein kinase

Protein Synonyms/Alias

Gene Name

PRKG2

Gene Synonyms/Alias

PRKG2;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSECAG00000024387	ENSECAP00000022043	ENSECAT00000026428

Organism

Equus caballus

Functional Description

Protein Length

762

Protein Sequence
(FASTA)

MGNGSVKPKH SKHPDGHSGN LTTDALQSKV TELERELRRK DAEIQEREYH LKELREQLSK 60

QTVAIAELTE ELQNKCIQLN KLQDVLHMQG GSPLQASPDK VPLEVHRKTS GLVSLHSRRG 120

AKAGVSAEPT TRTYDLNKPP EFSFEKARVR KDSSEKKLIT DALNKNQFLK RLDPQQIKDM 180

VECMYGRNYQ QGSYIIKQGE PGNHIFVLAE GQLEVFQGEK LLSSIPMWTT FGELAILYNC 240

TRTASVKAIT NVKTWALDRE VFQNIMRRTA QARDEQYRNF LRSVSLLKNL PEDKLTKIID 300

CLEVEYYDKG DYIIREGEEG STFFILAKGK VKVTQSTEGH DQPQLIKTLQ KGEYFGEKAL 360

ISEDVRSANI IAEENDVACL VIDRETFNQT VGTFEELQKY LEGYVANLNR DDEKRHAKRS 420

MSNWKLSKAL SLEMIQLKEK VARFSSSSPF QNLEIIATLG VGGFGRVELV KVKNENVAFA 480

MKCIRKKHIV DTKQQEHVYS EKRILEELCS PFIVKLYRTF KDNKYVYMLL EACLGGELWS 540

ILRDRGSFDE PTSKFCVACV TEAFDYLHRL GIIYRDLKPE NLILDAEGYL KLVDFGFAKK 600

IGSGQKTWTF CGTPEYVAPE VILNKGHDFS VDFWSLGILV YELLTGNPPF SGIDQMMTYN 660

LILKGIEKMD FPRKITRRPE DLIRRLCRQN PTERLGNLKN GINDIKRHRW LNGFNWEGLK 720

ARNLPSPLQR ELSGPTDHSY FDKYPPEKGV PPDELSGWDK DF 762

Nucleotide Sequence
(FASTA)

ATGGGAAATG GTTCAGTGAA ACCCAAACAT TCCAAGCATC CAGATGGCCA CTCTGGGAAC 60

CTCACCACCG ATGCCCTGCA GAGCAAGGTG ACTGAACTGG AGAGAGAATT GAGGAGGAAG 120

GATGCCGAGA TCCAGGAGCG GGAGTACCAT TTGAAGGAGC TGCGGGAGCA GCTGTCGAAG 180

CAGACTGTAG CCATTGCAGA GCTCACGGAG GAGCTCCAGA ACAAGTGCAT CCAGCTGAAC 240

AAGCTTCAGG ATGTGTTGCA CATGCAGGGA GGAAGCCCGC TTCAGGCCTC TCCAGATAAA 300

GTGCCTCTTG AGGTCCACCG GAAGACCTCA GGATTGGTCT CTCTCCATAG CAGAAGGGGA 360

GCAAAGGCTG GGGTGTCTGC TGAGCCAACA ACCCGAACCT ATGACCTCAA TAAACCCCCT 420

GAATTTTCCT TTGAGAAAGC AAGAGTCAGA AAGGACTCCA GTGAGAAGAA GCTCATTACG 480

GATGCCCTTA ATAAAAATCA GTTTCTGAAG AGACTGGATC CTCAGCAGAT CAAAGACATG 540

GTGGAATGCA TGTATGGGAG AAACTACCAG CAAGGGAGTT ACATTATTAA GCAAGGAGAA 600

CCAGGAAACC ATATCTTTGT GCTGGCAGAG GGCCAACTAG AGGTGTTCCA AGGGGAGAAA 660

TTGCTATCGT CCATCCCTAT GTGGACCACG TTTGGGGAAC TAGCCATTTT ATACAACTGT 720

ACAAGGACTG CCTCTGTGAA AGCTATTACC AATGTTAAAA CTTGGGCACT AGATCGAGAG 780

GTATTCCAGA ATATAATGAG AAGGACAGCT CAAGCGAGAG ATGAACAGTA CAGAAACTTC 840

CTTAGAAGTG TATCCTTGCT GAAGAATCTA CCTGAAGATA AATTAACCAA GATTATTGAC 900

TGCCTGGAAG TGGAATACTA TGACAAAGGA GATTACATTA TTAGAGAGGG CGAGGAAGGA 960

AGTACCTTTT TCATTTTAGC AAAAGGAAAG GTAAAAGTCA CCCAGAGTAC AGAGGGCCAC 1020

GATCAACCAC AACTGATAAA AACACTGCAG AAAGGAGAAT ACTTTGGAGA AAAAGCTCTT 1080

ATCAGTGAAG ATGTCAGATC AGCTAACATC ATAGCTGAAG AAAATGATGT CGCCTGCCTG 1140

GTTATAGATC GAGAAACATT CAACCAAACA GTCGGGACTT TTGAAGAACT CCAAAAATAC 1200

CTTGAAGGGT ATGTGGCAAA CCTGAACCGC GATGATGAAA AAAGACATGC GAAGAGATCC 1260

ATGTCTAACT GGAAGCTGTC CAAAGCACTC TCTCTGGAGA TGATTCAGCT CAAGGAGAAG 1320

GTGGCCAGAT TTTCCTCATC GTCCCCATTC CAGAACCTTG AGATTATTGC AACACTGGGC 1380

GTTGGTGGGT TCGGAAGAGT TGAGCTTGTT AAGGTAAAAA ATGAGAATGT CGCTTTTGCT 1440

ATGAAGTGTA TAAGGAAGAA GCACATAGTT GACACTAAGC AGCAGGAGCA CGTCTACTCA 1500

GAAAAGAGGA TCCTGGAAGA GCTGTGTTCT CCCTTCATTG TGAAATTGTA TCGTACTTTC 1560

AAGGACAATA AGTATGTATA TATGCTTCTG GAGGCCTGCT TAGGAGGGGA GTTATGGAGT 1620

ATACTAAGAG ACAGAGGCAG CTTTGATGAA CCCACCTCCA AGTTCTGCGT TGCTTGTGTG 1680

ACCGAAGCAT TTGATTACCT GCATCGACTG GGTATTATCT ACAGAGACCT GAAACCAGAA 1740

AACTTAATTC TGGATGCTGA GGGTTATCTT AAATTGGTTG ACTTTGGATT TGCTAAGAAA 1800

ATAGGATCTG GACAGAAAAC ATGGACGTTC TGTGGAACTC CAGAGTATGT AGCTCCTGAA 1860

GTCATTCTTA ACAAAGGACA TGACTTCAGT GTGGACTTTT GGTCCCTGGG AATTCTAGTG 1920

TATGAGCTCC TAACGGGCAA CCCGCCCTTT TCTGGGATTG ACCAAATGAT GACCTACAAT 1980

TTGATTCTCA AAGGAATTGA GAAAATGGAT TTTCCCAGAA AAATAACAAG ACGACCTGAA 2040

GATTTGATTC GGAGGCTTTG CAGGCAAAAT CCAACAGAAA GACTGGGAAA TCTGAAGAAT 2100

GGAATCAATG ACATTAAGAG ACACAGGTGG TTGAATGGTT TCAATTGGGA GGGACTGAAA 2160

GCACGGAACC TTCCATCACC CTTACAAAGA GAGCTCAGTG GACCCACAGA TCACAGCTAC 2220

TTTGACAAGT ATCCTCCTGA GAAGGGAGTG CCTCCAGATG AGCTGTCAGG CTGGGATAAA 2280

GACTTCTGA 2289

Domain Profile

S: 1     lkviatlgvggfgrvelvkvksdeskafalkilkkkhivdtkqqehvlsekrileeaksd  60

         l++iatlgvggfgrvelvkvk+ e+ afa+k+++kkhivdtkqqehv+sekrilee++s+

Q: 453   LEIIATLGVGGFGRVELVKVKN-ENVAFAMKCIRKKHIVDTKQQEHVYSEKRILEELCSP  511

         689******************9.999**********************************

S: 61    fivklyrtfkdekyvyllleaclggelwtilrdrgsfddktakfivacvvealeylhskn  120

         fivklyrtfkd+kyvy+lleaclggelw+ilrdrgsfd+ t+kf+vacv+ea++ylh+ +

Q: 512   FIVKLYRTFKDNKYVYMLLEACLGGELWSILRDRGSFDEPTSKFCVACVTEAFDYLHRLG  571

         ************************************************************

S: 121   iiyrdlkpenllldeegylklvdfgfakklksgkktwtfcgtpeyvapeiilnkghdlsv  180

         iiyrdlkpenl+ld+egylklvdfgfakk++sg+ktwtfcgtpeyvape+ilnkghd+sv

Q: 572   IIYRDLKPENLILDAEGYLKLVDFGFAKKIGSGQKTWTFCGTPEYVAPEVILNKGHDFSV  631

         ************************************************************

S: 181   dywalgilvyelltgkppfsgvdplktynlilkgidklelprkitkeaedlikklcrdnp  240

         d+w+lgilvyelltg+ppfsg+d+++tynlilkgi+k+++prkit+++edli++lcr+np

Q: 632   DFWSLGILVYELLTGNPPFSGIDQMMTYNLILKGIEKMDFPRKITRRPEDLIRRLCRQNP  691

         ************************************************************

S: 241   aerlgylkggikdikkhkwf  260

         +erlg+lk+gi+dik+h+w+

Q: 692   TERLGNLKNGINDIKRHRWL  711

         *******************7

Domain Sequence
(FASTA)

LEIIATLGVG GFGRVELVKV KNENVAFAMK CIRKKHIVDT KQQEHVYSEK RILEELCSPF 60

IVKLYRTFKD NKYVYMLLEA CLGGELWSIL RDRGSFDEPT SKFCVACVTE AFDYLHRLGI 120

IYRDLKPENL ILDAEGYLKL VDFGFAKKIG SGQKTWTFCG TPEYVAPEVI LNKGHDFSVD 180

FWSLGILVYE LLTGNPPFSG IDQMMTYNLI LKGIEKMDFP RKITRRPEDL IRRLCRQNPT 240

ERLGNLKNGI NDIKRHRWL 259

Keyword

ATP-binding; cGMP; cGMP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0030553	; F:cGMP binding
GO:0004692	; F:cGMP-dependent protein kinase activity

KEGG

ecb:100060358

;

InterPros

IPR000961	; AGC-kinase_C.
IPR016232	; cGMP-dependent_protein_kinase.
IPR002374	; cGMP_dep_kinase.
IPR018490	; cNMP-bd-like.
IPR018488	; cNMP-bd_CS.
IPR000595	; cNMP-bd_dom.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR014710	; RmlC-like_jellyroll.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00027	; cNMP_binding; 2.
PF00069	; Pkinase; 1.

SMARTs

SM00100	; cNMP; 2.
SM00133	; S_TK_X; 1.
SM00220	; S_TKc; 1.

Prosites

PS51285	; AGC_KINASE_CTER; 1.
PS00888	; CNMP_BINDING_1; 2.
PS00889	; CNMP_BINDING_2; 2.
PS50042	; CNMP_BINDING_3; 2.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

PR00104

; CGMPKINASE.

Created Date

20-Feb-2013