EKS-EQC-00105

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-EQC-00105

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/Tec	489.5	1.9E-147	370	620	251

Status

Unreviewed

Ensembl Protein

ENSECAP00000022080

UniProt Accession

F6QY61;

Protein Name

Protein Synonyms/Alias

Gene Name

TEC

Gene Synonyms/Alias

TEC;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSECAG00000024389	ENSECAP00000022080	ENSECAT00000026467

Organism

Equus caballus

Functional Description

Protein Length

631

Protein Sequence
(FASTA)

MNFNTILEEI LIKRSQQKKK TSPLNYKERL FVLTKSMLTY YEGRAEKKYR KGFIDVSKIK 60

CVEIVKNDDG VIPCQNKYPF QVVHDANTLY VFAPSAQSRD RWVKKLKEEI KNNNNIMIKY 120

HPKFWTDGSY QCCRQTEKLA PGCEKYNLFE SSIRKALPPA PETKKRRPPP PIPIEEEDNS 180

EEIVVAMYDF QATEAHDLRL ERGQEYIILE KNDVHWWRAR DKYGSEGYIP SNYVTGKKSN 240

NLDQYEWYCR NMNRSKAEQL LRSEDKEGGF MVRDSSQPGM YTVSLYTKFG GEGSSGFRHY 300

HIKETTTSPK KYYLAEKHAF GSIPEIIEYH KHNAAGLVTR LRYPVSAKEK NAPTTAGFSY 360

EKWEINPSEL TFMRELGSGL FGVVRLGKWR AQYKVAIKAI REGAMCEEDF IEEAKVMMKL 420

THPKLVQLYG VCTQQKPIYI VTEFMERGCL LNFLRQRQGH FSRDVLLSMC QDVCEGMEYL 480

ERNSFIHRDL AARNCLVNEA GIVKVSDFGM ARYVLDDQYT SSSGAKFPVK WCPPEVFNYS 540

RFSSKSDVWS FGVLMWEVFT EGRMPFEKNT NYEVVTMVTR GHRLYRPKLA CKYVYELMLR 600

CWQEKPEGRP SFEDLLRTID ELVESEETFG R 631

Nucleotide Sequence
(FASTA)

ATGAATTTTA ACACTATTCT AGAAGAGATT CTTATTAAAA GGTCACAGCA GAAAAAGAAG 60

ACATCGCCCT TAAACTACAA AGAGAGACTT TTTGTACTAA CAAAGTCCAT GTTAACCTAC 120

TATGAGGGTC GAGCAGAGAA AAAATACAGA AAGGGATTTA TTGATGTTTC AAAAATCAAG 180

TGTGTGGAAA TAGTGAAGAA TGATGACGGT GTCATTCCCT GTCAAAATAA ATATCCATTT 240

CAGGTTGTTC ATGATGCTAA CACACTTTAC GTTTTTGCAC CTAGTGCACA AAGCAGAGAC 300

CGGTGGGTGA AGAAGTTAAA AGAAGAAATA AAGAACAACA ATAATATTAT GATTAAATAT 360

CATCCTAAAT TTTGGACAGA TGGAAGTTAT CAGTGTTGCA GACAAACTGA AAAACTAGCA 420

CCTGGTTGTG AAAAATATAA TCTTTTTGAG AGTAGTATAA GAAAAGCACT ACCTCCAGCA 480

CCAGAAACAA AGAAGCGAAG GCCTCCCCCA CCAATTCCAA TTGAAGAAGA AGATAATAGT 540

GAAGAAATAG TTGTAGCTAT GTATGATTTC CAAGCGACAG AAGCACATGA CCTCAGATTA 600

GAGAGAGGCC AAGAGTATAT CATATTAGAG AAGAATGATG TTCATTGGTG GAGAGCGAGA 660

GATAAATACG GGAGTGAAGG ATATATCCCA AGTAATTATG TAACGGGAAA GAAATCAAAC 720

AACTTAGATC AGTATGAATG GTATTGCAGA AATATGAACA GAAGCAAAGC AGAGCAACTC 780

CTCAGAAGTG AAGATAAAGA AGGTGGTTTT ATGGTACGGG ATTCCAGTCA ACCGGGCATG 840

TACACAGTCT CCCTGTATAC AAAGTTTGGA GGAGAAGGCT CATCAGGTTT CAGGCATTAT 900

CATATAAAAG AAACAACAAC ATCCCCAAAG AAATATTATC TGGCAGAAAA ACATGCATTT 960

GGTTCAATTC CTGAGATTAT TGAATATCAT AAGCACAATG CGGCAGGACT TGTGACAAGG 1020

CTGCGGTACC CAGTTAGTGC GAAGGAGAAG AATGCACCAA CCACTGCAGG ATTCAGCTAC 1080

GAAAAATGGG AGATTAACCC TTCAGAGCTG ACCTTTATGA GGGAATTGGG GAGCGGACTG 1140

TTCGGAGTGG TGAGGCTTGG CAAGTGGCGA GCTCAGTACA AAGTAGCAAT CAAAGCCATT 1200

AGGGAAGGCG CCATGTGTGA GGAGGACTTT ATAGAAGAAG CTAAAGTGAT GATGAAACTG 1260

ACACACCCGA AATTAGTGCA GCTTTATGGT GTATGCACCC AGCAGAAACC AATTTACATT 1320

GTTACTGAGT TCATGGAAAG GGGCTGTCTT CTGAATTTCC TCCGACAGAG ACAAGGTCAT 1380

TTTAGTAGAG ATGTGCTGCT GAGCATGTGT CAAGATGTGT GTGAAGGGAT GGAATACCTG 1440

GAGAGAAACA GCTTCATCCA CAGAGATCTG GCTGCCAGAA ATTGTCTCGT AAATGAGGCA 1500

GGAATTGTGA AAGTATCTGA TTTTGGAATG GCCAGGTACG TTCTGGATGA TCAATACACA 1560

AGTTCTTCCG GTGCTAAATT TCCTGTGAAG TGGTGTCCGC CTGAGGTGTT TAATTACAGC 1620

CGCTTTAGCA GCAAATCAGA TGTCTGGTCA TTTGGTGTGT TAATGTGGGA AGTATTCACT 1680

GAAGGCAGAA TGCCCTTTGA GAAAAACACC AACTATGAAG TGGTAACCAT GGTTACTCGT 1740

GGCCACCGAC TCTACCGGCC GAAATTGGCA TGCAAATATG TGTATGAGTT GATGCTGAGA 1800

TGTTGGCAGG AGAAACCAGA GGGAAGGCCT TCCTTTGAAG ATTTGCTTCG CACGATAGAT 1860

GAACTAGTCG AGAGTGAAGA AACTTTTGGA AGATAA 1896

Domain Profile

S: 1     ltllkelgsgqfgvvklgkwrakidvaikaikegamseedfieeakvmmklshpklvqly  60

         lt+++elgsg fgvv+lgkwra+++vaikai+egam+eedfieeakvmmkl+hpklvqly

Q: 370   LTFMRELGSGLFGVVRLGKWRAQYKVAIKAIREGAMCEEDFIEEAKVMMKLTHPKLVQLY  429

         79**********************************************************

S: 61    gvclkqkpiyivteylengcllnylrekkkklekelllemckdvcegmeylerksfihrd  120

         gvc++qkpiyivte++e+gclln+lr++++++++++ll+mc+dvcegmeyler+sfihrd

Q: 430   GVCTQQKPIYIVTEFMERGCLLNFLRQRQGHFSRDVLLSMCQDVCEGMEYLERNSFIHRD  489

         ************************************************************

S: 121   laarnclvdeelvvkvsdfglaryvlddqyvssvgakfpvkwsppevlsyskyssksdvw  180

         laarnclv+e+ +vkvsdfg+aryvlddqy+ss+gakfpvkw+ppev++ys++ssksdvw

Q: 490   LAARNCLVNEAGIVKVSDFGMARYVLDDQYTSSSGAKFPVKWCPPEVFNYSRFSSKSDVW  549

         ************************************************************

S: 181   afgvlmwevfsegklpyekksnsevvekvsrglrlyrpklaskkvyevmkscwkekpeer  240

         +fgvlmwevf+eg++p+ek++n+evv++v+rg+rlyrpkla k+vye+m +cw+ekpe+r

Q: 550   SFGVLMWEVFTEGRMPFEKNTNYEVVTMVTRGHRLYRPKLACKYVYELMLRCWQEKPEGR  609

         ************************************************************

S: 241   ptfkellsale  251

         p+f++ll+++

Q: 610   PSFEDLLRTID  620

         ********995

Domain Sequence
(FASTA)

LTFMRELGSG LFGVVRLGKW RAQYKVAIKA IREGAMCEED FIEEAKVMMK LTHPKLVQLY 60

GVCTQQKPIY IVTEFMERGC LLNFLRQRQG HFSRDVLLSM CQDVCEGMEY LERNSFIHRD 120

LAARNCLVNE AGIVKVSDFG MARYVLDDQY TSSSGAKFPV KWCPPEVFNY SRFSSKSDVW 180

SFGVLMWEVF TEGRMPFEKN TNYEVVTMVT RGHRLYRPKL ACKYVYELML RCWQEKPEGR 240

PSFEDLLRTI D 251

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; SH3 domain; Transferase; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Dasypus novemcinctus"; ?>Drosophila melanogaster"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005737	; C:cytoplasm
GO:0005856	; C:cytoskeleton
GO:0005524	; F:ATP binding
GO:0004715	; F:non-membrane spanning protein tyrosine kinase activity
GO:0005543	; F:phospholipid binding
GO:0050853	; P:B cell receptor signaling pathway
GO:0007229	; P:integrin-mediated signaling pathway
GO:0035556	; P:intracellular signal transduction
GO:0010543	; P:regulation of platelet activation

KEGG

ecb:100061381

;

InterPros

IPR011009	; Kinase-like_dom.
IPR011993	; PH_like_dom.
IPR001849	; Pleckstrin_homology.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR000980	; SH2.
IPR001452	; SH3_domain.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.
IPR001562	; Znf_Btk_motif.

Pfam

PF00779	; BTK; 1.
PF00169	; PH; 1.
PF07714	; Pkinase_Tyr; 1.
PF00017	; SH2; 1.
PF00018	; SH3_1; 1.

SMARTs

SM00107	; BTK; 1.
SM00233	; PH; 1.
SM00252	; SH2; 1.
SM00326	; SH3; 1.
SM00219	; TyrKc; 1.

Prosites

PS50003	; PH_DOMAIN; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.
PS50001	; SH2; 1.
PS50002	; SH3; 1.
PS51113	; ZF_BTK; 1.

Prints

PR00401	; SH2DOMAIN.
PR00452	; SH3DOMAIN.
PR00402	; TECBTKDOMAIN.
PR00109	; TYRKINASE.

Created Date

20-Feb-2013