EKS-EQC-00233

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-EQC-00233

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CAMK/CAMKL	387.6	2.5E-116	43	294	252

Status

Unreviewed

Ensembl Protein

ENSECAP00000022122

UniProt Accession

F6QQA2;

Protein Name

Protein Synonyms/Alias

Gene Name

MARK1

Gene Synonyms/Alias

MARK1;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSECAG00000024459	ENSECAP00000022122	ENSECAT00000026510

Organism

Equus caballus

Functional Description

Protein Length

778

Protein Sequence
(FASTA)

HTSVDGYTEP HIQPPKSSSR QNIPRCRNSI TSATDEQPHI GNYRLQKTIG KGNFAKVKLA 60

RHVLTGREVA VKIIDKTQLN PTSLQKLFRE VRIMKILNHP NIVKLFEVIE TEKTLYLVME 120

YASGGEVFDY LVAHGRMKEK EARAKFRQIV SAVQYCHQKC IVHRDLKAEN LLLDADMNIK 180

IADFGFSNEF TVGNKLDTFC GSPPYAAPEL FQGKKYDGPE VDVWSLGVIL YTLVSGSLPF 240

DGQNLKELRE RVLRGKYRIP FYMSTDCENL LKKLLVLNPI KRGSLEQIMK DRWMNVGHEE 300

EELKPYAEPE PDFNDAKRID IMITMGFARD EINDALISQK YDEVMATYIL LGRKPPEFEG 360

GESLSSGNLS QRSRPSSDLN NSSLQSPAHL KVQRSVSANQ KQRRFSDHAG PSIPPAVSYT 420

KRPQANSVES EQKEEWDKDV ARKLGSTTVG SKSEVTASPL VGPERKKSST IPSTNVYPGG 480

SMARRNTYVC ERTTDRYAAL QNGKDSSLTE MSASSISSAG SAVASAVPSA RPRHQKSMSA 540

SGHPIKVTLP TIKDSSEAYR PGTTQRVPAA SPSAHSISAT TPDRTRFPRG SSSRSTFHGE 600

QLRERRSAAY NGPPASPSHE TGAFAHARRG TSTGIISKIT SKFVRRDPSE GEASGRTDTS 660

RSTSGEPKER DKEEGKDSKP RSLRFTWSMK TTSSMDPNDM MREIRKVLDA NNCDYEQKER 720

FLLFCVHGDA RQDSLVQWEM EVCKLPRLSL NGVRFKRISG TSIAFKNIAS KIANELKL 778

Nucleotide Sequence
(FASTA)

CATACATCTG TGGATGGATA TACTGAACCA CATATCCAGC CTCCCAAGTC AAGTAGCAGA 60

CAGAACATCC CTCGGTGTAG AAACTCCATT ACGTCAGCAA CAGACGAACA GCCTCACATT 120

GGAAATTACC GTTTACAAAA AACAATAGGG AAGGGAAATT TTGCCAAAGT GAAATTGGCG 180

AGACATGTTC TAACTGGTAG AGAGGTTGCT GTGAAAATAA TAGACAAAAC TCAGCTGAAT 240

CCGACTAGTC TACAAAAGTT GTTTCGAGAA GTACGAATAA TGAAGATATT GAATCATCCT 300

AATATAGTAA AATTGTTTGA AGTTATTGAA ACAGAGAAGA CCCTCTATTT AGTCATGGAA 360

TACGCGAGTG GGGGTGAAGT ATTTGATTAC TTAGTTGCCC ATGGAAGAAT GAAAGAAAAA 420

GAGGCCCGTG CAAAATTTAG GCAGATTGTA TCTGCTGTAC AGTATTGTCA TCAAAAATGC 480

ATTGTTCACC GAGATCTTAA GGCTGAAAAC CTTCTCCTTG ATGCTGATAT GAATATTAAA 540

ATTGCTGACT TTGGTTTTAG TAATGAATTT ACAGTGGGGA ACAAATTGGA CACATTTTGT 600

GGAAGCCCAC CCTATGCTGC ACCCGAGCTT TTCCAGGGAA AGAAGTACGA CGGGCCCGAG 660

GTGGATGTGT GGAGTCTTGG CGTCATTCTC TATACGTTAG TCAGTGGCTC GTTGCCTTTT 720

GATGGCCAGA ATTTAAAGGA GCTGCGGGAG CGAGTCTTAC GGGGAAAGTA CCGTATTCCC 780

TTCTACATGT CCACGGACTG TGAAAATCTT CTGAAGAAGT TGCTAGTACT GAATCCCATA 840

AAGAGAGGCA GCCTGGAACA AATAATGAAA GATCGATGGA TGAATGTTGG TCATGAAGAA 900

GAAGAACTAA AGCCGTATGC TGAGCCTGAG CCAGATTTCA ATGACGCGAA AAGAATAGAC 960

ATCATGATCA CCATGGGTTT TGCACGAGAT GAGATAAATG ACGCCTTAAT AAGTCAGAAA 1020

TATGATGAAG TTATGGCTAC TTATATTCTT CTAGGTAGAA AACCACCTGA ATTTGAAGGC 1080

GGTGAGTCAT TATCCAGTGG AAACTTGAGT CAGAGGTCAC GGCCCAGTAG TGACTTAAAC 1140

AACAGCTCTC TGCAGTCCCC CGCTCACCTG AAGGTCCAGC GGAGCGTCTC AGCAAATCAG 1200

AAGCAGCGGC GCTTTAGTGA TCATGCTGGT CCATCCATTC CGCCTGCCGT ATCATACACC 1260

AAAAGGCCTC AGGCTAACAG CGTGGAAAGT GAACAGAAGG AGGAGTGGGA CAAAGATGTG 1320

GCTCGTAAAC TCGGCAGCAC AACCGTTGGA TCAAAAAGCG AGGTGACTGC GAGCCCTCTT 1380

GTAGGGCCGG AGAGGAAAAA GTCCTCAACT ATCCCAAGTA CCAATGTATA TCCTGGAGGT 1440

AGCATGGCAA GAAGGAATAC ATACGTGTGT GAAAGGACCA CAGATCGATA CGCGGCATTG 1500

CAGAATGGAA AAGACAGCAG CCTTACGGAG ATGTCCGCGA GTAGCATATC TTCTGCAGGC 1560

TCTGCTGTGG CTTCTGCTGT CCCCTCGGCA CGACCCCGCC ACCAGAAGTC CATGTCTGCT 1620

TCTGGTCATC CTATTAAAGT TACACTGCCA ACCATTAAGG ACAGCTCTGA AGCTTACCGG 1680

CCTGGTACGA CCCAGAGAGT GCCTGCTGCT TCCCCATCTG CCCACAGTAT TAGTGCCACC 1740

ACTCCAGACA GAACCCGTTT TCCCCGGGGA AGTTCAAGCC GAAGCACTTT CCATGGGGAA 1800

CAGCTCCGGG AGCGACGCAG CGCTGCTTAT AACGGGCCAC CTGCTTCCCC CTCCCATGAA 1860

ACGGGTGCAT TTGCACATGC CAGAAGGGGC ACGTCAACTG GCATCATAAG CAAAATAACA 1920

TCCAAATTTG TTCGCAGGGA TCCAAGTGAA GGCGAAGCCA GTGGCAGAAC CGACACCTCA 1980

AGAAGTACAT CAGGGGAACC AAAAGAAAGA GACAAGGAAG AGGGTAAAGA CTCCAAGCCA 2040

CGGTCTCTGC GATTCACATG GAGCATGAAG ACCACTAGCT CAATGGACCC CAATGACATG 2100

ATGAGAGAAA TCCGCAAAGT GTTAGATGCC AATAACTGTG ATTATGAACA AAAGGAAAGG 2160

TTTTTGCTTT TCTGTGTCCA TGGAGATGCT AGACAGGATA GCCTCGTGCA GTGGGAGATG 2220

GAAGTCTGCA AGCTGCCCCG GCTGTCACTT AATGGGGTCC GCTTCAAGCG AATATCTGGG 2280

ACATCTATTG CCTTTAAGAA CATTGCATCT AAAATAGCAA ATGAGCTTAA GCTGTAA 2337

Domain Profile

S: 1     ykllktlGegsfgkVklakhketkekvavKiikkkklseeslekikrEieilkklkhpni  60

         y+l+kt+G+g+f+kVkla+h +t+++vavKii+k++l+ +sl+k++rE++i+k+l+hpni

Q: 43    YRLQKTIGKGNFAKVKLARHVLTGREVAVKIIDKTQLNPTSLQKLFREVRIMKILNHPNI  102

         99**********************************************************

S: 61    ikllevietkkklylvleyasggeLfdyieekgrlkekearklfkqlvsavkYlhskgiv  120

         +kl+eviet+k+lylv+eyasgge+fdy++++gr+kekear+ f+q+vsav+Y+h+k iv

Q: 103   VKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQKCIV  162

         ************************************************************

S: 121   HrDlKpeNllldkkenikiaDFGlanlfkegklletfcGsppYaaPellkgkkYegpkvD  180

         HrDlK+eNllld+++nikiaDFG++n+f+ g++l+tfcGsppYaaPel++gkkY+gp+vD

Q: 163   HRDLKAENLLLDADMNIKIADFGFSNEFTVGNKLDTFCGSPPYAAPELFQGKKYDGPEVD  222

         ************************************************************

S: 181   vWslGvvLyalvtgklPfdeenlkellekilkgkleipkklskelesLlrklLvvdpekR  240

         vWslGv+Ly+lv+g+lPfd++nlkel+e++l+gk++ip+++s+++e+Ll+klLv +p kR

Q: 223   VWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKKLLVLNPIKR  282

         ************************************************************

S: 241   atieeilkhewl  252

          ++e+i+k++w+

Q: 283   GSLEQIMKDRWM  294

         ***********8

Domain Sequence
(FASTA)

YRLQKTIGKG NFAKVKLARH VLTGREVAVK IIDKTQLNPT SLQKLFREVR IMKILNHPNI 60

VKLFEVIETE KTLYLVMEYA SGGEVFDYLV AHGRMKEKEA RAKFRQIVSA VQYCHQKCIV 120

HRDLKAENLL LDADMNIKIA DFGFSNEFTV GNKLDTFCGS PPYAAPELFQ GKKYDGPEVD 180

VWSLGVILYT LVSGSLPFDG QNLKELRERV LRGKYRIPFY MSTDCENLLK KLLVLNPIKR 240

GSLEQIMKDR WM 252

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Tetraodon nigroviridis"; ?>Tupaia belangeri"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005886	; C:plasma membrane
GO:0005524	; F:ATP binding
GO:0000287	; F:magnesium ion binding
GO:0070300	; F:phosphatidic acid binding
GO:0005546	; F:phosphatidylinositol-4,5-bisphosphate binding
GO:0001786	; F:phosphatidylserine binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0007243	; P:intracellular protein kinase cascade

KEGG

InterPros

IPR001772	; Kinase-assoc_KA1.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.
IPR015940	; UBA/transl_elong_EF1B_N_euk.

Pfam

PF02149	; KA1; 1.
PF00069	; Pkinase; 1.

SMARTs

SM00220	; S_TKc; 1.
SM00165	; UBA; 1.

Prosites

PS50032	; KA1; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.
PS50030	; UBA; 1.

Prints

Created Date

20-Feb-2013