EKS-EQC-00395
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-EQC-00395
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/PDGFR600.11.5E-180581939359
StatusUnreviewed
Ensembl ProteinENSECAP00000022400
UniProt AccessionF6Q748;
Protein NameTyrosine-protein kinase receptor
Protein Synonyms/Alias
Gene NamePDGFRB
Gene Synonyms/Alias PDGFRB;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSECAG00000024793ENSECAP00000022400ENSECAT00000026808
OrganismEquus caballus
Functional Description
Protein Length1081
Protein Sequence
(FASTA)
LLLPLLLLLG PRASRGLVIT PPGPELVLNI SSTFVLTCSG PAPVVWERLS QEPLQETAKT 60
QDGTFSSMLT LTNVTGLDTG EYFCAYKGSH GLEPGERKRI YIFVPDPTVG FLPVDPEELF 120
IFLTEITETT IPCRVTDPQL VVTLHEKKVD VPLPIPYDHQ RGFSGTFEDK TYVCKTTIGD 180
REVDSEAYYI YSLQVSSINV SVNAVQTVVR QGENITIMCI VTGNEVVNFE WTYPRMESGR 240
LVEPVTDFLF DMPSHIRSIL HIPSAELGDS GTYICNVSES VNDHRDEKAI NVTVVESGYL 300
RLLGELDPVQ FAELHRSRTL QVVFEAYPPP TVVWFKDNRT LGDSSAGEIA LSTRNVSETR 360
YVSELTLVRV KVAEAGHYTM RAFHEDAEAQ LSFQLQVNVP VRVLELSESH PASGEQTVRC 420
RGRGMPQPHL TWSTCSDLKR CPRELPRRLG NSSEEESQLE HVTYWAEEQS SRCAPLRLRR 480
VDRPLSVRCT LRNLLGHDVQ EVTVVPHSLP FKVVVISAIL ALVVLTIISL IILIMLWQKK 540
PRYEIRWKVI ESVSSDGHEY IYVDPMQLPY DSTWELPRDQ LVLGRTLGSG AFGQVVEATA 600
HGLSHSQATM KVAVKMLKST ARSSEKQALM SELKIMSHLG PHLNVVNLLG ACTKGGPIYI 660
ITEYCRYGDL VDYLHRNKHT FLQHCSEKRR PPSTELYSNA LPVGLPLLSH MSLPGESDGG 720
YMDMSKDESV DYVPMLDMKG DVKYADIESS NYMAPYDNYV PSAPERTCRA TLINDSPVLS 780
YTDLVGFSYQ VANGMEFLAS KNCVHRDLAA RNVLICEGKL VKICDFGLAR DIMRDSNYIS 840
KGSTFLPLKW MAPESIFNSL YTTLSDVWSF GILLWEIFTL GGTPYPELPM NEQFYNAIKR 900
GYRMAQPAHA SDEIYEIMQK CWEEKFEIRP PFSQLVLLLE RLLGEGYKKK YQQVDEEFLR 960
SDHPAILRSQ ARLPGFHGLQ SPLDASSVLY TAVQPNEGDN DYIIPLPDPK PEVADEGPVE 1020
GSPSLASSTL NEVNTSSTIS CDSPLEPQEE PEPEAQPEPQ PEWPLDSSCP GPRAEAEDSF 1080
L 1081
Nucleotide Sequence
(FASTA)
CTGCTGCTGC CCCTGCTGTT GCTGCTGGGA CCACGGGCCT CCCGGGGCCT GGTCATCACG 60
CCCCCGGGGC CAGAGCTTGT CCTCAATATC TCCAGTACCT TCGTGCTCAC CTGCTCGGGT 120
CCAGCTCCAG TGGTATGGGA ACGGTTATCC CAAGAGCCCC TGCAGGAAAC GGCCAAGACC 180
CAGGACGGCA CCTTCTCCAG CATGCTGACG CTGACCAATG TCACTGGGCT AGACACAGGA 240
GAATATTTCT GTGCCTACAA AGGCTCCCAT GGGCTGGAGC CTGGTGAGCG AAAACGGATC 300
TACATCTTTG TGCCAGATCC CACTGTGGGC TTCCTCCCCG TCGACCCCGA GGAACTATTC 360
ATCTTTCTCA CGGAAATAAC TGAGACCACA ATTCCATGCC GAGTGACGGA TCCACAACTG 420
GTGGTGACAC TGCATGAGAA GAAAGTGGAT GTCCCGCTGC CCATCCCCTA TGACCACCAA 480
CGTGGCTTCT CTGGTACCTT TGAGGACAAG ACCTATGTCT GCAAAACCAC CATCGGGGAC 540
AGGGAGGTGG ATTCGGAAGC TTACTACATC TACAGCCTCC AGGTGTCATC CATCAATGTC 600
TCAGTGAATG CAGTGCAGAC TGTGGTACGC CAGGGTGAGA ACATCACCAT CATGTGCATT 660
GTGACTGGGA ACGAGGTGGT CAACTTTGAG TGGACATACC CACGCATGGA GAGTGGGCGG 720
TTGGTGGAGC CAGTGACTGA CTTCCTCTTC GATATGCCCT CCCACATACG CTCCATCCTG 780
CACATCCCCA GTGCCGAGCT GGGTGACTCA GGGACCTATA TCTGCAATGT ATCAGAGAGT 840
GTGAATGACC ATCGTGATGA AAAAGCCATC AATGTCACTG TGGTTGAGAG CGGCTACCTG 900
CGGCTGCTGG GAGAGCTGGA CCCTGTACAA TTCGCGGAGC TGCACCGCAG CCGGACACTG 960
CAGGTGGTGT TCGAGGCCTA CCCGCCACCC ACTGTCGTGT GGTTCAAGGA CAACCGCACG 1020
CTGGGCGACT CCAGCGCCGG CGAGATCGCC CTGTCCACGC GCAATGTGTC CGAGACCCGG 1080
TACGTGTCAG AACTGACACT GGTGCGGGTG AAGGTGGCTG AGGCTGGCCA CTACACCATG 1140
CGGGCCTTCC ATGAGGACGC TGAGGCCCAG CTCTCCTTCC AGCTGCAGGT CAACGTCCCT 1200
GTCCGCGTGC TGGAGCTGAG CGAGAGCCAT CCCGCCAGCG GGGAGCAGAC AGTCCGCTGT 1260
CGCGGCCGGG GCATGCCACA GCCGCACCTC ACCTGGTCCA CTTGCAGCGA CCTCAAAAGG 1320
TGTCCGCGCG AGCTGCCACG CCGCTTGGGG AACAGTTCTG AGGAGGAGAG CCAGCTGGAG 1380
CACGTGACGT ATTGGGCGGA GGAGCAGAGT TCGAGGTGTG CACCGCTGCG CCTGCGCCGC 1440
GTGGATCGAC CACTGTCGGT GCGCTGCACG CTGCGCAACT TGCTGGGCCA TGATGTGCAA 1500
GAGGTCACTG TGGTGCCACA TTCTCTGCCC TTCAAGGTGG TGGTGATCTC GGCCATCCTG 1560
GCCTTGGTGG TCCTCACGAT CATCTCCCTC ATCATCCTCA TCATGCTCTG GCAGAAGAAG 1620
CCACGTTATG AGATCCGATG GAAGGTGATT GAATCTGTGA GCTCTGATGG CCATGAGTAC 1680
ATCTACGTGG ACCCGATGCA GCTGCCCTAC GACTCCACCT GGGAGCTGCC TCGGGACCAG 1740
CTTGTGCTTG GACGCACGCT TGGCTCCGGG GCCTTTGGGC AGGTGGTGGA GGCCACGGCT 1800
CATGGCCTGA GCCATTCACA AGCCACGATG AAAGTGGCCG TCAAGATGCT GAAATCCACA 1860
GCCCGCAGCA GTGAGAAGCA AGCCCTCATG TCGGAGCTGA AGATCATGAG TCACCTCGGG 1920
CCCCATCTGA ATGTGGTCAA CCTGCTGGGG GCCTGCACCA AAGGAGGACC CATCTACATC 1980
ATCACCGAAT ACTGCCGCTA CGGCGACCTG GTGGACTACC TGCACCGCAA CAAGCACACA 2040
TTCCTGCAGC ACTGCTCCGA GAAGCGCCGG CCGCCCAGCA CCGAGCTCTA CAGCAATGCC 2100
CTGCCCGTCG GCCTCCCCCT GCTCAGCCAC ATGTCCCTGC CTGGGGAGAG TGACGGTGGC 2160
TACATGGACA TGAGCAAGGA CGAGTCGGTG GACTACGTGC CCATGCTGGA CATGAAAGGA 2220
GACGTCAAAT ATGCAGACAT CGAGTCCTCC AACTACATGG CCCCTTACGA TAACTACGTC 2280
CCCTCTGCCC CCGAGAGGAC CTGCCGGGCG ACTTTGATCA ACGACTCCCC AGTGCTCAGC 2340
TACACCGACC TTGTGGGCTT CAGCTATCAG GTGGCCAATG GCATGGAGTT CCTGGCCTCC 2400
AAGAATTGCG TCCACCGAGA CCTGGCAGCC AGGAACGTGC TCATCTGTGA GGGCAAGCTG 2460
GTCAAGATCT GTGACTTTGG CCTGGCTCGT GACATCATGC GGGACTCGAA CTACATCTCC 2520
AAAGGCAGTA CCTTCCTGCC TTTGAAGTGG ATGGCCCCCG AGAGCATCTT CAACAGCCTC 2580
TACACCACCC TGAGCGACGT GTGGTCCTTC GGGATCTTAC TCTGGGAGAT CTTCACCCTG 2640
GGTGGCACCC CTTACCCAGA GCTGCCCATG AACGAGCAGT TCTACAATGC CATCAAGCGG 2700
GGCTACCGCA TGGCCCAGCC TGCCCACGCC TCCGACGAGA TCTACGAGAT CATGCAGAAG 2760
TGCTGGGAAG AGAAGTTTGA GATTCGGCCT CCCTTCTCCC AGCTGGTGCT GCTTCTCGAG 2820
AGACTGCTGG GTGAGGGTTA CAAAAAGAAG TACCAGCAGG TGGATGAGGA GTTTCTGAGG 2880
AGCGACCACC CAGCCATCCT TCGGTCCCAA GCCCGCTTGC CCGGCTTCCA TGGTCTCCAA 2940
TCACCCCTGG ACGCCAGCTC CGTCCTCTAC ACTGCTGTGC AGCCCAATGA GGGTGACAAC 3000
GACTATATCA TCCCCCTGCC CGACCCCAAA CCCGAGGTTG CTGATGAGGG CCCAGTGGAG 3060
GGTTCCCCCA GCCTTGCCAG CTCCACCCTG AATGAAGTCA ACACCTCCTC TACCATCTCC 3120
TGTGACAGCC CCCTGGAACC ACAAGAGGAA CCAGAGCCAG AGGCCCAGCC CGAGCCCCAG 3180
CCAGAGTGGC CGCTGGATTC AAGCTGCCCC GGGCCTCGGG CCGAGGCGGA GGACAGCTTC 3240
CTGTAG 3246
Domain Profile
S: 1     lelGkvlGsGafGkvveatayGlsksdavlkvavkmlkstarssekealmselkilshlG  60
         l+lG++lGsGafG+vveata+Gls+s+a++kvavkmlkstarssek+almselki+shlG
Q: 581   LVLGRTLGSGAFGQVVEATAHGLSHSQATMKVAVKMLKSTARSSEKQALMSELKIMSHLG  640
         78**********************************************************
S: 61    ehenivnllGactkgGpiyviteyccyGdllnylrrkresflkkslekkkekeeeldska  120
         +h+n+vnllGactkgGpiy+iteyc+yGdl++yl+r++++fl++ +ek++++++el+s+a
Q: 641   PHLNVVNLLGACTKGGPIYIITEYCRYGDLVDYLHRNKHTFLQHCSEKRRPPSTELYSNA  700
         ************************************************************
S: 121   lladkslrsksslssesseeyvdlkkd................vsdvssskadklasekk  164
         l+++  l s++sl  es++ y+d++kd                ++d++ss++++++++++
Q: 701   LPVGLPLLSHMSLPGESDGGYMDMSKDesvdyvpmldmkgdvkYADIESSNYMAPYDNYV  760
         ************************************************************
S: 165   ksalerevkaaleeedsevleledllsfsyqvakGmeflaskncvhrdlaarnvllteGk  224
          sa er+++a+l+++ s vl+++dl+ fsyqva+Gmeflaskncvhrdlaarnvl++eGk
Q: 761   PSAPERTCRATLIND-SPVLSYTDLVGFSYQVANGMEFLASKNCVHRDLAARNVLICEGK  819
         *************98.9*******************************************
S: 225   vvkicdfGlardimkdsnyvvkGnarlpvkwmapesifdslytvksdvwsyGillweifs  284
         +vkicdfGlardim+dsny++kG+++lp+kwmapesif+slyt+ sdvws+Gillweif+
Q: 820   LVKICDFGLARDIMRDSNYISKGSTFLPLKWMAPESIFNSLYTTLSDVWSFGILLWEIFT  879
         ************************************************************
S: 285   lGstpypgllvdskfyklikeGyrmaqpayateeiyeimqkcweaepekrpsfkqlvell  344
         lG+tpyp+l+++++fy++ik+Gyrmaqpa+a++eiyeimqkcwe+++e rp+f+qlv ll
Q: 880   LGGTPYPELPMNEQFYNAIKRGYRMAQPAHASDEIYEIMQKCWEEKFEIRPPFSQLVLLL  939
         ********************************************************9986
Domain Sequence
(FASTA)
LVLGRTLGSG AFGQVVEATA HGLSHSQATM KVAVKMLKST ARSSEKQALM SELKIMSHLG 60
PHLNVVNLLG ACTKGGPIYI ITEYCRYGDL VDYLHRNKHT FLQHCSEKRR PPSTELYSNA 120
LPVGLPLLSH MSLPGESDGG YMDMSKDESV DYVPMLDMKG DVKYADIESS NYMAPYDNYV 180
PSAPERTCRA TLINDSPVLS YTDLVGFSYQ VANGMEFLAS KNCVHRDLAA RNVLICEGKL 240
VKICDFGLAR DIMRDSNYIS KGSTFLPLKW MAPESIFNSL YTTLSDVWSF GILLWEIFTL 300
GGTPYPELPM NEQFYNAIKR GYRMAQPAHA SDEIYEIMQK CWEEKFEIRP PFSQLVLLL 359
KeywordATP-binding; Complete proteome; Disulfide bond; Immunoglobulin domain; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Receptor; Reference proteome; Repeat; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00377
EKS-ANC-00390
EKS-BOT-00403
EKS-CAJ-00406
EKS-CAF-00403
EKS-CAP-00431
EKS-FEC-00387
EKS-GAG-00340
EKS-GAA-00491
EKS-GOG-00395
EKS-HOS-00408
EKS-ICT-00382
EKS-LAC-00418
EKS-LOA-00411
EKS-MAM-00401
EKS-MEG-00334
EKS-MOD-00394
EKS-MUM-00434
EKS-MUP-00396
EKS-MYL-00398
EKS-NOL-00367
EKS-OCP-00083
EKS-ORN-00513
EKS-ORA-00353
EKS-ORC-00377
EKS-ORL-00471
EKS-OTG-00404
EKS-PES-00358
EKS-POA-00393
EKS-RAN-00417
EKS-SAH-00371
EKS-SUS-00358
EKS-TAG-00472
EKS-TAR-00509
EKS-TEN-00510
EKS-XET-00513
EKS-XIM-00505
Gene Ontology
GO:0016021; C:integral to membrane
GO:0031226; C:intrinsic to plasma membrane
GO:0005524; F:ATP binding
GO:0005019; F:platelet-derived growth factor beta-receptor activity
GO:0030325; P:adrenal gland development
GO:0060326; P:cell chemotaxis
GO:0001701; P:in utero embryonic development
GO:0001822; P:kidney development
GO:0006807; P:nitrogen compound metabolic process
GO:0018108; P:peptidyl-tyrosine phosphorylation
GO:0046488; P:phosphatidylinositol metabolic process
GO:0048015; P:phosphatidylinositol-mediated signaling
GO:0030335; P:positive regulation of cell migration
GO:0038091; P:positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathway
GO:0043552; P:positive regulation of phosphatidylinositol 3-kinase activity
GO:0010863; P:positive regulation of phospholipase C activity
GO:0032516; P:positive regulation of phosphoprotein phosphatase activity
GO:0046777; P:protein autophosphorylation
GO:0050730; P:regulation of peptidyl-tyrosine phosphorylation
GO:0048705; P:skeletal system morphogenesis
GO:0048745; P:smooth muscle tissue development
GO:0001894; P:tissue homeostasis
KEGG
InterPros
IPR007110; Ig-like.
IPR013783; Ig-like_fold.
IPR013098; Ig_I-set.
IPR003599; Ig_sub.
IPR003598; Ig_sub2.
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
IPR016243; Tyr_kinase_CSF1/PDGF_rcpt.
IPR001824; Tyr_kinase_rcpt_3_CS.
Pfam
PF07679; I-set; 1.
PF07714; Pkinase_Tyr; 1.
SMARTs
SM00409; IG; 2.
SM00408; IGc2; 1.
SM00219; TyrKc; 1.
Prosites
PS50835; IG_LIKE; 2.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
PS00240; RECEPTOR_TYR_KIN_III; 1.
Prints
Created Date20-Feb-2013