EKS-EQC-00380
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-EQC-00380
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
STE/STE11361.53.5E-108537793257
StatusUnreviewed
Ensembl ProteinENSECAP00000022486
UniProt AccessionF6PIL4;
Protein Name
Protein Synonyms/Alias
Gene NameMAP3K5
Gene Synonyms/Alias MAP3K5;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSECAG00000024860ENSECAP00000022486ENSECAT00000026898
OrganismEquus caballus
Functional Description
Protein Length1229
Protein Sequence
(FASTA)
FVSADVAVVE MSDAFRQPSL FYHLGVRESC SMASNIILYC DTNSDSLQSL KEIIFQKNTM 60
CTGNYTFVPY MITPHNKVYC CDSSFMKGLT ELMQPNFELL LGPICLPLVD RFIQLLKVAQ 120
ASSSQYFRES ILNDIRKARN LYTGKELAAE LARIRQRVDN IEVLTADIVI NLLLSYRDIQ 180
DYDSIVKLVE TLEKLPTFDL ASHHHVKFHY AFALNRRNLP GDRAKALDIM IPLVQSEGQV 240
ASDVYCLMGR IYKDMFLDSN FMDTESRDHG ASWFKKAFES EPTLQSGINY AVLLLAAGHQ 300
FESSFELRKV GVKLSSLLGK KGNLEKLQSY WEVGFFLGAS VLANDHVRVI QASEKLFKLK 360
TPAWYLRSIV ETILIYKHFV KLTTEQPVAK QELVDFWMDF LVEATKTDVA VVRFPVLILE 420
PTKIYQPSYL SINNEVEEKT ISIWHVLPDD KKGIHEWNFS ASSVRGVSIS KFEERCCFLY 480
VLHNSDDFQI YFCTELHCKK FFEMVNTITE EKGRNTEEGD CEADSLEYDY EYDENGDRVV 540
LGKGTYGIVY AGRDLSNQVR IAIKEIPERD SRYSQPLHEE IALHKHLKHK NIVQYLGSFS 600
ENGFIKIFME QVPGGSLSAL LRSKWGPLKD NEQTIGFYTK QILEGLKYLH DNQIVHRDIK 660
GDNVLINTYS GVLKISDFGT SKRLAGINPC TETFTGTLQY MAPEIIDQGP RGYGRAADIW 720
SLGCTIIEMA TGKPPFYELG EPQAAMFKVG MFKVHPEVPE SMSAEAKAFI LKCFEPDPDK 780
RDGANDLLLD EFLKVSGKKK KTQPKLSALA AGSNEYLRSI SLPVPVLVED TSSSSEYGSV 840
SPDTELKVDP FSFKTRAKSC GEKDGKGIRT LFLGIPDENF EDHSAPPSPE EKDSGFFMLR 900
KDSERRATLH RILTEDQDKV VRNLMEALAQ GAEEPKLKWE HITTLIASLR EFVRSTDRKI 960
IATTLSKLKL ELDFDSHGIS QVQVVLFGFQ DAVNKVLRNH NIKPHWMFAL DSIIRKAVQA 1020
AITILVPELR PHFSLASESD TADQDDLEAE DDHEEQPSSQ TVQRPHVVLD DAVATSGVST 1080
LSSTVSHDSQ SAHRSLTVQL GRMKIETNRL LEELVQKEKE LQALLHQAIE EKDQEIKHLK 1140
LKSQPIDIPG LPVCHLNSPG TNTEDSELTE WLRENGADED TISRFLAEDY SLVDVLYYVT 1200
RDDLKCLRLR GGVLCTLWKA ITDFRDKQT 1229
Nucleotide Sequence
(FASTA)
TTTGTGTCTG CAGACGTCGC CGTGGTGGAG ATGAGCGACG CCTTCCGGCA GCCGTCCTTG 60
TTCTACCACC TCGGGGTGAG GGAGAGCTGC AGTATGGCCA GCAACATCAT CCTCTACTGC 120
GACACCAACT CAGACTCCCT GCAGTCGCTC AAGGAAATCA TTTTCCAGAA GAATACTATG 180
TGCACCGGGA ACTACACGTT CGTCCCCTAC ATGATCACGC CGCACAACAA GGTCTACTGC 240
TGCGACAGCA GCTTCATGAA GGGGCTCACG GAGCTCATGC AGCCCAACTT CGAGCTGCTC 300
CTTGGGCCCA TCTGCTTACC TCTTGTGGAT CGTTTCATTC AGCTTCTGAA GGTGGCACAA 360
GCAAGTTCCA GCCAGTATTT CCGGGAATCT ATACTCAATG ATATCAGGAA AGCTCGTAAT 420
TTATACACTG GTAAAGAACT GGCAGCTGAA TTGGCAAGAA TTCGTCAGCG AGTAGATAAT 480
ATTGAAGTCT TGACAGCAGA CATTGTCATC AATCTGTTGC TTTCCTACAG AGATATCCAG 540
GACTACGACT CGATTGTGAA GCTGGTGGAG ACACTGGAAA AGCTGCCCAC CTTTGACCTG 600
GCCTCCCATC ACCACGTGAA GTTCCATTAT GCGTTCGCTC TGAACAGGAG AAATCTCCCT 660
GGAGACAGAG CGAAGGCTCT TGACATCATG ATCCCGCTGG TGCAGAGCGA AGGGCAGGTG 720
GCTTCCGACG TGTACTGCCT CATGGGTCGA ATCTACAAAG ACATGTTTTT GGACTCTAAT 780
TTCATGGACA CTGAAAGTAG AGACCATGGA GCTTCTTGGT TCAAAAAGGC ATTTGAATCT 840
GAGCCAACAC TACAGTCAGG AATTAATTAT GCGGTCCTCC TCCTGGCAGC TGGGCACCAG 900
TTTGAATCTT CCTTTGAGCT CCGGAAAGTT GGCGTGAAGC TCAGCAGCCT TCTGGGGAAA 960
AAGGGAAACT TGGAAAAGCT CCAGAGCTAC TGGGAAGTCG GGTTTTTCCT GGGCGCCAGT 1020
GTCCTGGCCA ATGACCACGT GAGAGTCATT CAGGCCTCTG AAAAGCTTTT CAAACTGAAG 1080
ACGCCGGCAT GGTACCTCAG GTCTATTGTG GAGACAATTT TGATCTATAA GCATTTTGTG 1140
AAGCTGACTA CAGAACAGCC GGTGGCCAAG CAGGAGCTCG TGGACTTCTG GATGGACTTC 1200
CTCGTCGAGG CCACCAAGAC GGACGTGGCG GTGGTGAGGT TCCCAGTATT GATCTTAGAA 1260
CCAACCAAAA TCTATCAACC TTCGTATTTA TCTATCAACA ATGAAGTTGA GGAAAAGACG 1320
ATATCCATTT GGCACGTGCT CCCAGATGAC AAGAAGGGCA TCCATGAGTG GAATTTCAGT 1380
GCTTCGTCTG TCAGGGGAGT GAGTATTTCT AAATTTGAAG AACGATGCTG TTTTCTTTAT 1440
GTGCTTCATA ATTCTGACGA TTTCCAAATC TATTTCTGTA CAGAACTTCA CTGTAAAAAG 1500
TTTTTTGAGA TGGTGAACAC CATTACCGAA GAGAAGGGCA GGAACACGGA GGAAGGAGAC 1560
TGTGAGGCTG ACTCCCTGGA GTATGACTAC GAATATGATG AAAACGGGGA CAGAGTGGTT 1620
CTAGGAAAAG GCACTTACGG GATCGTCTAT GCAGGCCGAG ACCTGAGCAA CCAAGTCCGA 1680
ATCGCTATTA AGGAAATCCC AGAGAGAGAT AGCAGGTACT CCCAGCCCCT ACATGAAGAA 1740
ATAGCGTTGC ATAAGCATCT GAAGCACAAA AATATCGTCC AGTATCTGGG CTCTTTCAGT 1800
GAGAACGGTT TCATTAAAAT CTTCATGGAG CAGGTCCCAG GAGGAAGTCT TTCTGCTCTC 1860
CTTCGTTCCA AGTGGGGCCC ATTGAAAGAC AATGAGCAAA CAATTGGCTT TTATACAAAG 1920
CAAATACTCG AAGGATTAAA ATACCTCCAT GACAATCAGA TAGTTCACCG GGATATAAAG 1980
GGTGACAATG TGTTGATTAA TACATACAGC GGTGTTCTCA AGATCTCCGA CTTCGGGACA 2040
TCAAAGAGGC TCGCTGGCAT CAACCCATGC ACTGAAACCT TTACTGGTAC CCTTCAGTAC 2100
ATGGCACCAG AGATCATAGA CCAAGGACCC AGGGGTTACG GGAGGGCTGC AGACATTTGG 2160
TCTCTGGGCT GCACCATCAT CGAAATGGCC ACGGGAAAAC CACCATTTTA TGAGCTGGGA 2220
GAGCCACAAG CTGCTATGTT CAAGGTGGGG ATGTTCAAAG TCCACCCGGA GGTCCCGGAG 2280
TCCATGTCGG CAGAGGCCAA GGCGTTCATC CTGAAGTGTT TTGAACCTGA CCCTGACAAG 2340
AGAGACGGCG CGAACGACCT GCTTCTGGAT GAGTTCTTAA AAGTTTCGGG CAAGAAGAAG 2400
AAGACACAGC CGAAGCTTTC GGCTCTGGCC GCCGGATCGA ATGAGTACCT CAGGAGCATC 2460
TCCCTGCCGG TGCCCGTGCT GGTGGAGGAC ACAAGCAGCA GCAGCGAGTA CGGCTCCGTC 2520
TCTCCTGACA CGGAGCTCAA GGTGGACCCC TTCTCTTTCA AGACGAGAGC CAAGTCCTGC 2580
GGGGAGAAAG ACGGAAAAGG AATACGGACT CTCTTTCTGG GCATCCCGGA TGAAAACTTC 2640
GAAGACCACA GCGCGCCCCC GTCCCCTGAG GAGAAGGACT CCGGGTTCTT CATGCTGAGG 2700
AAGGACAGCG AACGGCGGGC CACGCTGCAC AGGATCCTGA CGGAAGACCA GGACAAGGTC 2760
GTGAGGAACC TGATGGAGGC TTTGGCTCAG GGGGCCGAGG AACCAAAGCT AAAGTGGGAG 2820
CACATCACAA CCCTCATCGC AAGCCTCAGA GAATTTGTGA GATCCACCGA CCGAAAAATC 2880
ATCGCCACCA CGCTGTCGAA GCTGAAGCTG GAGCTGGACT TCGACAGCCA CGGCATCAGC 2940
CAGGTCCAGG TGGTTCTCTT TGGTTTCCAA GACGCTGTCA ATAAAGTTCT TCGGAATCAT 3000
AACATCAAGC CACACTGGAT GTTTGCCTTA GACAGTATCA TCCGGAAGGC GGTGCAGGCA 3060
GCCATCACCA TTCTGGTTCC AGAGCTGAGG CCGCATTTTA GCCTCGCATC TGAGAGTGAT 3120
ACCGCCGATC AAGACGACTT GGAGGCGGAG GATGACCATG AGGAGCAGCC CTCGAGTCAG 3180
ACTGTCCAAA GACCTCACGT GGTCCTCGAT GACGCCGTGG CCACCTCGGG GGTGAGCACG 3240
CTCAGCTCCA CCGTCTCGCA CGACTCGCAG AGCGCCCACC GATCGCTGAC CGTCCAGCTT 3300
GGGAGGATGA AGATAGAAAC GAACAGGTTA CTGGAAGAAT TGGTTCAGAA AGAGAAAGAA 3360
TTACAAGCAC TCCTTCATCA AGCTATTGAA GAAAAAGACC AAGAAATTAA ACACCTGAAG 3420
CTTAAGTCCC AACCAATAGA CATTCCTGGG TTGCCCGTGT GTCACCTGAA TTCTCCTGGG 3480
ACAAATACTG AAGATTCTGA ACTTACTGAG TGGCTGAGAG AAAATGGAGC CGATGAAGAC 3540
ACCATAAGTC GGTTTTTGGC TGAGGATTAT TCACTAGTGG ATGTTCTCTA CTATGTTACA 3600
CGTGATGATT TAAAATGCCT GAGACTAAGG GGAGGGGTGC TCTGCACGCT GTGGAAGGCC 3660
ATCACGGACT TTCGAGACAA ACAGACTTGA 3690
Domain Profile
S: 3     krevigkGsfgsvyaaldvdtgellavKeveikpekksekkevkalkeEikllkelkHen  62
         +r v+gkG++g vya++d++++ ++a+Ke+   pe++s+  ++++l+eEi+l+k+lkH+n
Q: 537   DRVVLGKGTYGIVYAGRDLSNQVRIAIKEI---PERDSR--YSQPLHEEIALHKHLKHKN  591
         5789**************************...888775..9******************
S: 63    ivkyyGveveeeelkiflEyvegGslsslle.kygkle..esvikkytkqileglayLHe  119
         iv+y+G+ +e++ +kif+E+v+gGsls+ll+ k+g+l+  e++i +ytkqilegl+yLH+
Q: 592   IVQYLGSFSENGFIKIFMEQVPGGSLSALLRsKWGPLKdnEQTIGFYTKQILEGLKYLHD  651
         *******************************9*****9999*******************
S: 120   kkivHRDiKgaNillds.sgvvklsDFGaskrlaelntkaaelesltGtlaymaPEvikk  178
         ++ivHRDiKg+N+l+++ sgv+k+sDFG+skrla +n++   +e++tGtl+ymaPE+i++
Q: 652   NQIVHRDIKGDNVLINTySGVLKISDFGTSKRLAGINPC---TETFTGTLQYMAPEIIDQ  708
         ***************************************...8*****************
S: 179   kekgygrkaDiWslgcvviemltgkrPfaeldeelaimfkvgakktkPeipeklseegkd  238
         + +gygr+aDiWslgc++iem+tgk+Pf el+e++a+mfkvg+ k++Pe+pe++s+e+k+
Q: 709   GPRGYGRAADIWSLGCTIIEMATGKPPFYELGEPQAAMFKVGMFKVHPEVPESMSAEAKA  768
         ************************************************************
S: 239   flekcleldpkkrpsaeeLLkhefl  263
         f+ kc+e dp+kr  a++LL +efl
Q: 769   FILKCFEPDPDKRDGANDLLLDEFL  793
         ********************99996
Domain Sequence
(FASTA)
DRVVLGKGTY GIVYAGRDLS NQVRIAIKEI PERDSRYSQP LHEEIALHKH LKHKNIVQYL 60
GSFSENGFIK IFMEQVPGGS LSALLRSKWG PLKDNEQTIG FYTKQILEGL KYLHDNQIVH 120
RDIKGDNVLI NTYSGVLKIS DFGTSKRLAG INPCTETFTG TLQYMAPEII DQGPRGYGRA 180
ADIWSLGCTI IEMATGKPPF YELGEPQAAM FKVGMFKVHP EVPESMSAEA KAFILKCFEP 240
DPDKRDGAND LLLDEFL 257
KeywordATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Transferase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00361
EKS-ANC-00378
EKS-BOT-00387
EKS-CAF-00390
EKS-CAP-00418
EKS-DAR-00769
EKS-FEC-00376
EKS-GAG-00327
EKS-GAA-00475
EKS-GOG-00384
EKS-HOS-00395
EKS-LAC-00401
EKS-LOA-00395
EKS-MAM-00386
EKS-MEG-00320
EKS-MOD-00376
EKS-MUM-00421
EKS-MUP-00382
EKS-MYL-00386
EKS-NOL-00355
EKS-ORN-00500
EKS-ORA-00336
EKS-ORC-00364
EKS-ORL-00460
EKS-OTG-00390
EKS-PES-00346
EKS-POA-00379
EKS-RAN-00402
EKS-SAH-00359
EKS-SUS-00345
EKS-TAG-00460
EKS-TAR-00496
EKS-TEN-00496
EKS-XET-00502
EKS-XIM-00493
Gene Ontology
GO:0005524; F:ATP binding
GO:0008656; F:cysteine-type endopeptidase activator activity involved in apoptotic process
GO:0000287; F:magnesium ion binding
GO:0004674; F:protein serine/threonine kinase activity
GO:0000187; P:activation of MAPK activity
GO:0000186; P:activation of MAPKK activity
GO:0070301; P:cellular response to hydrogen peroxide
GO:0010421; P:hydrogen peroxide-mediated programmed cell death
GO:0008631; P:intrinsic apoptotic signaling pathway in response to oxidative stress
GO:0007254; P:JNK cascade
GO:0043065; P:positive regulation of apoptotic process
KEGG
InterPros
IPR025136; DUF4071.
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR013761; SAM/pointed.
IPR002290; Ser/Thr_dual-sp_kinase_dom.
IPR008271; Ser/Thr_kinase_AS.
Pfam
PF13281; DUF4071; 1.
PF00069; Pkinase; 1.
SMARTs
SM00220; S_TKc; 1.
Prosites
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00108; PROTEIN_KINASE_ST; 1.
Prints
Created Date20-Feb-2013