EKS-EQC-00215
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-EQC-00215
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
AGC/PKN555.41.9E-167662921260
StatusUnreviewed
Ensembl ProteinENSECAP00000022534
UniProt AccessionF6S2E6;
Protein Name
Protein Synonyms/Alias
Gene NamePKN2
Gene Synonyms/Alias PKN2;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSECAG00000024916ENSECAP00000022534ENSECAT00000026949
OrganismEquus caballus
Functional Description
Protein Length989
Protein Sequence
(FASTA)
MASNPERAEI LLTELQGDSR GLPFSENVSA VQKLDFSDTM VQQRLDDIKD RIKREIRKEL 60
KIKEGAENLR KVTTDKKNLA YVDNILKKSN KKLEELHHKL QELNAHIVVS DPEDVTDCPR 120
TPDTPSSDPR CSTSNNRLMA LQKQLDIELK VKQGAENMIQ MYSNGSSKDR KLHGTAQQLL 180
QDSKTKIEVI RMQILQAVQT NELAFDNAKP VISPLELRME ELRHHFRIEF AVAEGAKNVM 240
KLLGSGKVTD RKALSEAQAR FNESSQKLDL LKYSLEQRLN ELPKNHPKSS IIIEELSLVA 300
SPTLSPRQSM ISTQNQYSTL SKPAALTGTL EVRLMGCQDI LENVPGRSKA TSVALPGWSP 360
SETRSSFMSR TSKSKSGSSR NLLKTDDLSN DVCAVLKLDN TVVGQTSWKP ISNQSWDQKF 420
TLELDRSREL EISVYWRDWR SLCAVKFLRL EDFLDNQRHG MCLYLEPQGT LFAEVTFFNP 480
VIERRPKLQR QKKIFSKQQG KTFLRAPQMN INIATWGRLV RRAIPTVNHS GTFSPQAPVP 540
ATVPVVDVRI PELVPPASDS TVTKLDFDLE PEPPPAPPRD SSLGEINESA ELRDLDTPGQ 600
ARHFKSDSET VFDIENDRNS ILPKSQSEYE PDIPQSGLEY SGIRELEDRR SQQMFQFNLQ 660
DFRCCAVLGR GHFGKVLLAE YKHTNEMFAI KALKKGDIVA RDEVDSLMCE KRIFETVNSV 720
RHPFLVNLFA CFQTKEHVCF VMEYAAGGDL MMHIHTDVFS EPRAVFYAAC VVLGLQYLHE 780
HKIVYRDLKL DNLLLDTEGF VKIADFGLCK EGMGYGDRTS TFCGTPEFLA PEVLTETSYT 840
RAVDWWGLGV LIYEMLVGES PFPGDDEEEV FDSIVNDEVR YPRFLSTEAI SIMRRLLRRN 900
PERRLGAGEK DAEDVKKHPF FRLIDWSALM DKKVKPPFVP TIRGREDVSN FDDEFTSEAP 960
ILTPPREPRI LSEEEQEMFR DFDYIADWC 989
Nucleotide Sequence
(FASTA)
ATGGCGTCCA ACCCCGAACG GGCGGAGATC CTGCTCACGG AGCTGCAGGG AGATTCCCGA 60
GGTCTTCCAT TTTCTGAGAA TGTGAGTGCC GTTCAAAAAT TAGACTTTTC AGATACTATG 120
GTGCAACAGA GATTGGATGA TATCAAGGAT CGAATCAAGA GAGAAATAAG GAAAGAACTG 180
AAAATCAAAG AAGGAGCTGA AAATCTGAGG AAAGTCACAA CAGATAAAAA AAATTTGGCT 240
TATGTGGACA ACATTTTAAA AAAATCAAAT AAAAAATTAG AAGAACTGCA TCATAAGCTA 300
CAGGAACTAA ATGCACATAT TGTTGTATCA GATCCAGAAG ATGTTACAGA TTGCCCAAGG 360
ACTCCAGATA CTCCCAGTAG TGACCCTCGT TGTTCCACTA GCAATAATAG ATTGATGGCC 420
TTACAGAAAC AATTGGATAT AGAACTTAAA GTAAAACAAG GTGCAGAAAA CATGATACAG 480
ATGTATTCAA ATGGATCTTC AAAGGATCGG AAACTCCATG GCACAGCTCA GCAACTGCTC 540
CAGGACAGCA AGACAAAAAT AGAAGTGATA CGAATGCAGA TTCTTCAGGC AGTCCAGACC 600
AATGAATTGG CTTTTGATAA TGCAAAACCT GTCATAAGTC CTCTTGAACT TCGGATGGAA 660
GAATTAAGGC ATCATTTTAG GATAGAGTTT GCAGTAGCAG AAGGTGCAAA GAATGTAATG 720
AAATTACTTG GCTCAGGAAA AGTAACAGAC AGAAAAGCAC TTTCAGAAGC TCAAGCAAGA 780
TTTAATGAAT CGAGTCAGAA GTTGGACCTT TTAAAGTATT CGTTAGAGCA AAGATTAAAT 840
GAACTTCCCA AGAATCATCC CAAAAGCAGT ATTATTATTG AGGAACTTTC GCTTGTTGCA 900
TCACCAACAC TAAGTCCACG TCAAAGTATG ATATCAACAC AAAACCAATA TAGTACGCTA 960
TCCAAACCAG CAGCACTAAC AGGTACTTTG GAAGTTCGTC TCATGGGCTG TCAAGATATC 1020
CTAGAGAATG TCCCTGGACG GTCAAAAGCA ACATCGGTTG CACTACCTGG TTGGAGTCCA 1080
AGTGAAACCA GATCGTCTTT CATGAGCAGG ACGAGTAAAA GTAAAAGTGG AAGCAGTCGA 1140
AATCTCCTAA AAACCGATGA CTTGTCCAAT GATGTCTGTG CAGTTTTGAA GCTAGATAAT 1200
ACTGTGGTTG GTCAAACTAG CTGGAAACCC ATTTCCAATC AGTCTTGGGA CCAGAAGTTT 1260
ACACTGGAAC TAGACAGGTC ACGTGAACTG GAAATTTCAG TTTATTGGCG TGATTGGCGA 1320
TCTCTGTGTG CTGTAAAATT TCTGAGGTTA GAAGATTTTT TAGACAACCA ACGGCATGGC 1380
ATGTGTCTCT ATTTGGAACC ACAGGGTACT TTATTTGCAG AGGTTACCTT TTTTAATCCA 1440
GTTATTGAAA GAAGACCAAA ACTCCAAAGA CAAAAGAAAA TTTTTTCAAA ACAACAAGGC 1500
AAAACATTTC TCAGAGCTCC TCAAATGAAT ATTAATATTG CCACTTGGGG AAGGCTAGTG 1560
AGAAGAGCTA TTCCTACAGT AAATCATTCT GGCACCTTCA GCCCTCAAGC TCCTGTGCCT 1620
GCTACAGTGC CAGTGGTTGA TGTACGCATC CCTGAACTAG TGCCTCCAGC TAGTGATTCT 1680
ACAGTAACCA AATTGGACTT TGATCTTGAA CCTGAGCCTC CTCCGGCCCC ACCACGAGAT 1740
TCTTCCCTTG GAGAAATAAA TGAATCTGCT GAATTAAGAG ATTTGGATAC ACCAGGACAG 1800
GCAAGGCATT TTAAATCTGA TTCAGAAACT GTTTTTGATA TTGAGAATGA CAGAAATAGT 1860
ATACTACCAA AATCTCAATC TGAATATGAA CCTGATATTC CTCAGTCAGG CCTAGAATAT 1920
AGTGGTATTC GAGAACTTGA GGATAGAAGA TCTCAACAAA TGTTTCAGTT TAATCTACAA 1980
GACTTCAGAT GTTGTGCTGT CTTGGGTAGA GGACATTTTG GAAAGGTGCT TTTGGCTGAA 2040
TATAAACACA CAAACGAGAT GTTTGCCATA AAAGCCTTAA AGAAAGGAGA CATTGTAGCT 2100
CGAGATGAAG TAGACAGCCT GATGTGTGAA AAAAGAATTT TTGAAACTGT GAACAGTGTA 2160
AGGCATCCCT TTTTGGTGAA CCTTTTTGCA TGTTTCCAAA CCAAAGAGCA TGTTTGCTTT 2220
GTAATGGAAT ATGCTGCCGG TGGGGACCTA ATGATGCACA TTCATACTGA TGTCTTTTCT 2280
GAACCAAGAG CTGTATTTTA TGCTGCATGT GTAGTTCTTG GGTTGCAGTA TTTACATGAA 2340
CACAAAATTG TTTATAGAGA TTTGAAATTG GATAACTTAT TGCTAGATAC AGAGGGCTTT 2400
GTGAAAATTG CTGATTTTGG TCTTTGCAAA GAAGGAATGG GATATGGAGA TAGAACAAGT 2460
ACATTTTGTG GCACTCCTGA ATTTCTTGCC CCAGAAGTAT TAACAGAAAC TTCCTATACG 2520
AGAGCTGTAG ATTGGTGGGG CCTTGGTGTA CTTATATATG AAATGCTCGT TGGTGAGTCT 2580
CCCTTTCCTG GTGATGATGA AGAGGAGGTT TTTGACAGTA TTGTAAATGA TGAAGTAAGA 2640
TATCCAAGGT TCTTATCTAC AGAAGCCATT TCAATAATGA GAAGGCTATT AAGAAGAAAT 2700
CCTGAGCGGC GCCTTGGAGC GGGTGAGAAA GATGCAGAGG ATGTAAAAAA GCACCCATTT 2760
TTCCGGCTAA TTGATTGGAG TGCTCTGATG GACAAAAAAG TAAAGCCGCC ATTTGTACCT 2820
ACCATTAGAG GACGGGAAGA CGTTAGTAAT TTTGATGATG AATTTACCTC AGAAGCACCT 2880
ATTCTAACTC CACCTCGAGA ACCAAGGATA CTTTCAGAAG AGGAGCAGGA AATGTTCAGA 2940
GATTTTGACT ACATTGCTGA TTGGTGTTAA 2970
Domain Profile
S: 1     frllavlgrghfgkvllseykstgelyaikalkkgdilardevesllcekrileavssvr  60
         fr++avlgrghfgkvll+eyk+t+e++aikalkkgdi+ardev+sl+cekri+e+v+svr
Q: 662   FRCCAVLGRGHFGKVLLAEYKHTNEMFAIKALKKGDIVARDEVDSLMCEKRIFETVNSVR  721
         9***********************************************************
S: 61    hpflvnllacfqtkehvcfvmeyaaggdlmlhihedvfsepravfyaacvvlglqflhek  120
         hpflvnl+acfqtkehvcfvmeyaaggdlm+hih+dvfsepravfyaacvvlglq+lhe+
Q: 722   HPFLVNLFACFQTKEHVCFVMEYAAGGDLMMHIHTDVFSEPRAVFYAACVVLGLQYLHEH  781
         ************************************************************
S: 121   kivyrdlkldnllldtegyvkiadfglckeglgygdrtstfcgtpeflapevltetsytr  180
         kivyrdlkldnllldteg+vkiadfglckeg+gygdrtstfcgtpeflapevltetsytr
Q: 782   KIVYRDLKLDNLLLDTEGFVKIADFGLCKEGMGYGDRTSTFCGTPEFLAPEVLTETSYTR  841
         ************************************************************
S: 181   avdwwglgvllyemlvgespfpgddeeevfdsivndevryprflsveaieilrrllrknp  240
         avdwwglgvl+yemlvgespfpgddeeevfdsivndevryprfls+eai+i+rrllr+np
Q: 842   AVDWWGLGVLIYEMLVGESPFPGDDEEEVFDSIVNDEVRYPRFLSTEAISIMRRLLRRNP  901
         ************************************************************
S: 241   ekrlgaserdaedvkkqpff  260
         e+rlga+e+daedvkk+pff
Q: 902   ERRLGAGEKDAEDVKKHPFF  921
         *******************9
Domain Sequence
(FASTA)
FRCCAVLGRG HFGKVLLAEY KHTNEMFAIK ALKKGDIVAR DEVDSLMCEK RIFETVNSVR 60
HPFLVNLFAC FQTKEHVCFV MEYAAGGDLM MHIHTDVFSE PRAVFYAACV VLGLQYLHEH 120
KIVYRDLKLD NLLLDTEGFV KIADFGLCKE GMGYGDRTST FCGTPEFLAP EVLTETSYTR 180
AVDWWGLGVL IYEMLVGESP FPGDDEEEVF DSIVNDEVRY PRFLSTEAIS IMRRLLRRNP 240
ERRLGAGEKD AEDVKKHPFF 260
KeywordATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>Saccharomyces cerevisiae"; ?>Schizosaccharomyces pombe"; ?>
EKS-AIM-00205
EKS-ANC-00212
EKS-BOT-00221
EKS-CAE-00188
EKS-CAJ-00222
EKS-CAF-00224
EKS-CAP-00245
EKS-CII-00131
EKS-CIS-00248
EKS-DAR-00523
EKS-DRM-00113
EKS-FEC-00203
EKS-GAM-00123
EKS-GAG-00185
EKS-GAA-00270
EKS-GOG-00215
EKS-HOS-00222
EKS-LAC-00233
EKS-LOA-00213
EKS-MAM-00223
EKS-MEG-00170
EKS-MOD-00219
EKS-MUM-00224
EKS-MUP-00219
EKS-MYL-00222
EKS-NOL-00205
EKS-ORN-00278
EKS-ORA-00193
EKS-ORC-00197
EKS-ORL-00262
EKS-OTG-00227
EKS-PAT-00211
EKS-PES-00193
EKS-POA-00215
EKS-PTV-00190
EKS-RAN-00219
EKS-SAH-00211
EKS-SUS-00193
EKS-TAG-00238
EKS-TAR-00284
EKS-TAS-00077
EKS-TEN-00273
EKS-VIP-00101
EKS-XET-00248
EKS-XIM-00275
EKS-SAC-00081
EKS-SCP-00080
Gene Ontology
GO:0043296; C:apical junction complex
GO:0032154; C:cleavage furrow
GO:0005737; C:cytoplasm
GO:0030027; C:lamellipodium
GO:0030496; C:midbody
GO:0005634; C:nucleus
GO:0005524; F:ATP binding
GO:0004674; F:protein serine/threonine kinase activity
GO:0043297; P:apical junction assembly
GO:0010631; P:epithelial cell migration
GO:0071777; P:positive regulation of cell cycle cytokinesis
GO:0045931; P:positive regulation of mitotic cell cycle
GO:2000145; P:regulation of cell motility
GO:0007165; P:signal transduction
KEGG
InterPros
IPR000961; AGC-kinase_C.
IPR000008; C2_Ca-dep.
IPR008973; C2_Ca/lipid-bd_dom_CaLB.
IPR011072; HR1_rho-bd.
IPR011009; Kinase-like_dom.
IPR017892; Pkinase_C.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR002290; Ser/Thr_dual-sp_kinase_dom.
IPR008271; Ser/Thr_kinase_AS.
Pfam
PF02185; HR1; 3.
PF00069; Pkinase; 1.
PF00433; Pkinase_C; 1.
SMARTs
SM00239; C2; 1.
SM00742; Hr1; 3.
SM00133; S_TK_X; 1.
SM00220; S_TKc; 1.
Prosites
PS51285; AGC_KINASE_CTER; 1.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00108; PROTEIN_KINASE_ST; 1.
Prints
Created Date20-Feb-2013