EKS-EQC-00065

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-EQC-00065

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CMGC/CDK	369.6	1.0E-110	39	323	285

Status

Unreviewed

Ensembl Protein

ENSECAP00000022570

UniProt Accession

F6RSU5;

Protein Name

Protein Synonyms/Alias

Gene Name

CDK10

Gene Synonyms/Alias

CDK10;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSECAG00000024995	ENSECAP00000022570	ENSECAT00000026987

Organism

Equus caballus

Functional Description

Protein Length

359

Protein Sequence
(FASTA)

MGDPEPESEQ IRLKCIRKEG FFTVPPEHRL GRCRSVKEFE KLNRIGEGTY GIVYRARDTQ 60

TDEIVALKKV RMDKEKDGVP ISSLREITLL LRLRHPNIVE LKEVVVGNHL ESIFLVMGYC 120

EQDLASLLEN MPTPFSEAQV KCIVLQVLRG LQYLHQNFII HRDLKVSNLL MTDKGCVKTA 180

DFGLARAYGV PVKPMTPKVV TLWYRAPELL LGTTTQTTSI DMWAVGCILA ELLAHKPLLP 240

GTSEIHQVDL IVQLLGTPSE NIWPGFSKLP LVSQYSLRKQ PYNNLKHRFP WLSEAGLRLL 300

NLLFMYDPRK RATAGDCLES SYFKEKPLPC EPELMPTFPH HRNKRAPAAA SGQSKRSKP 359

Nucleotide Sequence
(FASTA)

ATGGGGGATC CGGAGCCGGA GTCGGAGCAG ATCCGTCTGA AATGTATCCG TAAGGAAGGC 60

TTCTTCACGG TGCCTCCAGA ACACAGGCTG GGACGGTGCC GGAGCGTGAA GGAGTTTGAG 120

AAGCTGAACC GCATCGGGGA AGGCACCTAC GGCATTGTGT ATCGGGCCCG GGATACCCAG 180

ACGGATGAGA TTGTCGCCCT GAAAAAGGTG CGGATGGACA AGGAGAAGGA TGGGGTCCCC 240

ATCAGCAGCC TTCGAGAGAT TACACTGCTC CTTCGCCTTC GCCATCCAAA TATCGTGGAG 300

CTGAAGGAGG TGGTTGTGGG GAACCACCTG GAGAGCATCT TCCTGGTGAT GGGTTACTGT 360

GAGCAAGACT TGGCCAGCCT TCTGGAAAAC ATGCCAACAC CCTTCTCTGA GGCCCAGGTC 420

AAGTGCATTG TGCTTCAGGT GCTCAGGGGC CTCCAGTACC TGCACCAGAA CTTCATCATC 480

CACAGGGACC TGAAGGTCTC CAACCTGCTC ATGACCGACA AGGGCTGTGT GAAGACAGCG 540

GATTTTGGCC TGGCCCGGGC CTATGGCGTT CCAGTGAAGC CAATGACCCC CAAGGTGGTC 600

ACTCTTTGGT ACCGAGCCCC TGAACTGCTG CTGGGAACCA CCACGCAGAC CACCAGCATC 660

GACATGTGGG CCGTGGGCTG CATCCTGGCT GAGCTGCTGG CCCACAAGCC CCTGCTCCCT 720

GGCACTTCCG AGATCCACCA GGTGGACCTG ATCGTCCAGC TGCTGGGGAC ACCTAGTGAG 780

AACATCTGGC CGGGCTTCTC CAAGCTGCCC CTCGTGAGCC AGTACAGCCT GCGGAAGCAG 840

CCCTACAACA ACCTCAAGCA CAGGTTCCCG TGGCTCTCAG AGGCTGGCCT GCGCCTGCTC 900

AATCTCCTCT TCATGTACGA CCCTAGGAAA AGGGCGACGG CGGGGGACTG CCTGGAGAGC 960

TCCTACTTCA AGGAGAAGCC CCTGCCCTGT GAGCCGGAGC TCATGCCCAC CTTCCCCCAC 1020

CACCGCAACA AGCGGGCCCC AGCCGCAGCC TCGGGCCAGA GCAAGCGCAG CAAGCCCTGA 1080

Domain Profile

S: 1     yeklekigeGtygkvykakdketgevvAlKkirlekekegvpitalrEisllkelkhkni  60

         +ekl++igeGtyg vy+a+d++t+e+vAlKk+r++kek+gvpi++lrEi+ll +l+h+ni

Q: 39    FEKLNRIGEGTYGIVYRARDTQTDEIVALKKVRMDKEKDGVPISSLREITLLLRLRHPNI  98

         89**********************************************************

S: 61    vkLlevvakdk.kklyLvfefleqdLkkllkkkkkkklsleevkslllqlleglaylHsn  119

         v+L+evv+ ++ ++++Lv+ ++eqdL++ll+++++  +s+++vk ++lq+l+gl+ylH+n

Q: 99    VELKEVVVGNHlESIFLVMGYCEQDLASLLENMPT-PFSEAQVKCIVLQVLRGLQYLHQN  157

         ********5555***********************.************************

S: 120   kilHRDlKpqNlLiskegklklaDfGlarafssplktytkevvTlwYraPelLlgakeYs  179

          i+HRDlK +NlL++++g++k aDfGlara+++p+k +t++vvTlwYraPelLlg+++ +

Q: 158   FIIHRDLKVSNLLMTDKGCVKTADFGLARAYGVPVKPMTPKVVTLWYRAPELLLGTTTQT  217

         ************************************************************

S: 180   tavDiWsvgcilaelltrkplfqgkseidqlerifkllgtpsekvwpevsklpeyk.ksf  238

         t++D+W+vgcilaell++kpl++g+sei+q++ i++llgtpse++wp++sklp ++ +s+

Q: 218   TSIDMWAVGCILAELLAHKPLLPGTSEIHQVDLIVQLLGTPSENIWPGFSKLPLVSqYSL  277

         ********************************************************88**

S: 239   pkkkkkklkekvkklkekaldllekllaldpkkRisakealqhkyf  284

         +k+++++lk++++ l+e++l+ll+ l+++dp+kR +a ++l+++yf

Q: 278   RKQPYNNLKHRFPWLSEAGLRLLNLLFMYDPRKRATAGDCLESSYF  323

         *********************************************8

Domain Sequence
(FASTA)

FEKLNRIGEG TYGIVYRARD TQTDEIVALK KVRMDKEKDG VPISSLREIT LLLRLRHPNI 60

VELKEVVVGN HLESIFLVMG YCEQDLASLL ENMPTPFSEA QVKCIVLQVL RGLQYLHQNF 120

IIHRDLKVSN LLMTDKGCVK TADFGLARAY GVPVKPMTPK VVTLWYRAPE LLLGTTTQTT 180

SIDMWAVGCI LAELLAHKPL LPGTSEIHQV DLIVQLLGTP SENIWPGFSK LPLVSQYSLR 240

KQPYNNLKHR FPWLSEAGLR LLNLLFMYDP RKRATAGDCL ESSYF 285

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Erinaceus europaeus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity

KEGG

ecb:100052321

;

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013