EKS-EQC-00069

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-EQC-00069

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CMGC/CDK	339.7	1.4E-101	6	295	290

Status

Unreviewed

Ensembl Protein

ENSECAP00000022611

UniProt Accession

F6QM47;

Protein Name

Protein Synonyms/Alias

Gene Name

CDK4

Gene Synonyms/Alias

CDK4;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSECAG00000025015	ENSECAP00000022611	ENSECAT00000027031

Organism

Equus caballus

Functional Description

Protein Length

303

Protein Sequence
(FASTA)

MATPRYEPVA EIGVGAYGTV YKARDPHSGH FVALKSVRVP NGGGAGGGLP ISTVREVALL 60

RRLEAFEHPN VVRLMDVCAT ARTDRETKVT LVFEHVDQDL RTYLDKAPPP GLPVETIKDL 120

MRQFLRGLDF LHANCIVHRD LKPENILVTS GGTVKLADFG LARIYSYQMA LTPVVVTLWY 180

RAPEVLLQST YATPVDMWSV GCIFAEMFRR KPLFCGNSEA DQLGKIFDLI GLPPEEDWPR 240

DVSLPRGAFP PRGPRPVQSV VPEMEESGAQ LLLEMLTFNP HKRISAFRAL QHSYLQKPEG 300

NPE 303

Nucleotide Sequence
(FASTA)

ATGGCTACCC CTCGGTATGA GCCAGTGGCT GAGATTGGTG TCGGCGCCTA TGGGACGGTG 60

TACAAGGCCC GTGATCCCCA CAGTGGCCAC TTTGTGGCCC TTAAGAGCGT GAGAGTCCCC 120

AATGGAGGAG GCGCTGGAGG GGGCCTTCCC ATCAGCACAG TTCGTGAGGT GGCCTTGCTG 180

AGGCGGCTGG AGGCTTTTGA GCATCCCAAT GTTGTCCGGC TGATGGACGT CTGTGCCACT 240

GCCCGAACTG ACCGGGAGAC CAAAGTGACC CTGGTATTTG AGCATGTGGA CCAAGACCTA 300

AGGACGTATC TGGACAAGGC ACCCCCGCCC GGCTTGCCAG TGGAGACCAT CAAGGATCTG 360

ATGCGCCAGT TCCTAAGAGG CCTAGATTTC CTTCATGCCA ACTGCATCGT TCACCGAGAC 420

CTGAAGCCAG AGAACATTCT GGTGACAAGT GGTGGGACAG TCAAGCTGGC TGACTTTGGC 480

CTGGCCAGAA TCTACAGCTA CCAGATGGCA CTTACACCTG TGGTTGTTAC ACTCTGGTAC 540

CGTGCTCCGG AAGTTCTTCT GCAATCTACG TATGCAACAC CTGTGGACAT GTGGAGTGTG 600

GGCTGTATTT TCGCAGAGAT GTTTCGTCGA AAGCCTCTCT TCTGTGGAAA CTCTGAAGCT 660

GACCAGTTAG GCAAAATCTT TGACCTGATC GGGCTACCCC CAGAGGAAGA CTGGCCGCGA 720

GATGTGTCTC TACCCCGAGG AGCCTTTCCC CCCAGAGGGC CCCGCCCCGT GCAGTCGGTG 780

GTGCCCGAGA TGGAGGAGTC TGGAGCACAG CTGCTTCTGG AGATGCTGAC TTTTAACCCA 840

CACAAGCGAA TCTCTGCCTT CCGAGCCCTG CAGCACTCTT ATCTACAAAA GCCGGAAGGT 900

AACCCAGAGT GA 912

Domain Profile

S: 1     yeklekigeGtygkvykakdketgevvAlKkirlekeke...gvpitalrEisllkel..  55

         ye +++ig G+yg+vyka+d ++g++vAlK++r+ +      g+pi+++rE++ll++l

Q: 6     YEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGaggGLPISTVREVALLRRLea  65

         88899*****************************99874444***************988

S: 56    .khknivkLlevva....kdkkklyLvfefleqdLkkllkkkkkkklsleevkslllqll  110

          +h+n+v+L++v+a     +++k++Lvfe+++qdL ++l+k +  +l+ e++k l++q+l

Q: 66    fEHPNVVRLMDVCAtartDRETKVTLVFEHVDQDLRTYLDKAPPPGLPVETIKDLMRQFL  125

         89************99855569**************************************

S: 111   eglaylHsnkilHRDlKpqNlLiskegklklaDfGlarafssplktytkevvTlwYraPe  170

         +gl++lH+n i+HRDlKp+N+L+++ g++klaDfGlar +s ++  +t++vvTlwYraPe

Q: 126   RGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIYSYQMA-LTPVVVTLWYRAPE  184

         ******************************************999.**************

S: 171   lLlgakeYstavDiWsvgcilaelltrkplfqgkseidqlerifkllgtpsekvwpevsk  230

         +Ll+++ Y t vD+Wsvgci+ae+++rkplf g+se dql +if+l+g p e++wp+  +

Q: 185   VLLQST-YATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEEDWPRDVS  243

         ***985.*****************************************************

S: 231   lpeykksfpkkkkkklkekvkklkekaldllekllaldpkkRisakealqhkyf  284

         lp+    fp++ ++ ++++v++++e++ +ll ++l+++p+kRisa +alqh+y+

Q: 244   LPRGA--FPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRALQHSYL  295

         ***65..*********************************************96

Domain Sequence
(FASTA)

YEPVAEIGVG AYGTVYKARD PHSGHFVALK SVRVPNGGGA GGGLPISTVR EVALLRRLEA 60

FEHPNVVRLM DVCATARTDR ETKVTLVFEH VDQDLRTYLD KAPPPGLPVE TIKDLMRQFL 120

RGLDFLHANC IVHRDLKPEN ILVTSGGTVK LADFGLARIY SYQMALTPVV VTLWYRAPEV 180

LLQSTYATPV DMWSVGCIFA EMFRRKPLFC GNSEADQLGK IFDLIGLPPE EDWPRDVSLP 240

RGAFPPRGPR PVQSVVPEME ESGAQLLLEM LTFNPHKRIS AFRALQHSYL 290

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Echinops telfairi"; ?>Erinaceus europaeus"; ?>Felis catus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Macropus eugenii"; ?>Microcebus murinus"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sorex araneus"; ?>Sus scrofa"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0000785	; C:chromatin
GO:0000307	; C:cyclin-dependent protein kinase holoenzyme complex
GO:0005829	; C:cytosol
GO:0031965	; C:nuclear membrane
GO:0005730	; C:nucleolus
GO:0005667	; C:transcription factor complex
GO:0005524	; F:ATP binding
GO:0004693	; F:cyclin-dependent protein kinase activity
GO:0000082	; P:G1/S transition of mitotic cell cycle
GO:0048146	; P:positive regulation of fibroblast proliferation
GO:0051726	; P:regulation of cell cycle
GO:0010468	; P:regulation of gene expression
GO:0042493	; P:response to drug
GO:0007165	; P:signal transduction

KEGG

ecb:100051005

;

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013