EKS-EQC-00217

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-EQC-00217

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
STE/STE7	392.3	1.2E-117	91	356	266

Status

Unreviewed

Ensembl Protein

ENSECAP00000022737

UniProt Accession

F6SMU6;

Protein Name

Protein Synonyms/Alias

Gene Name

MAP2K4

Gene Synonyms/Alias

MAP2K4;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSECAG00000025163	ENSECAP00000022737	ENSECAT00000027173

Organism

Equus caballus

Functional Description

Protein Length

388

Protein Sequence
(FASTA)

SGGGSGARLP GPVGAPVSAV HVDPPAQGKR KALKLNFANP PFKSTARFTL NPNPTGVQNP 60

HIERLRTHSI ESSGKLKISP EQHWDFTAED LKDLGEIGRG AYGSVNKMVH KPSGQIMAVK 120

RIRSTVDEKE QKQLLMDLDV VMRSSDCPYI VQFYGALFRE GDCWICMELM STSFDKFYKY 180

VYSVLDDVIP EEILGKITLA TVKALNHLKE NLKIIHRDIK PSNILLDRSG NIKLCDFGIS 240

GQLVDSIAKT RDAGCRPYMA PERIDPSASR QGYDVRSDVW SLGITLYELA TGRFPYPKWN 300

SVFDQLTQVV KGDPPQLSNS EEREFSPSFI NFVNLCLTKD ESKRPKYKEL LKHPFILMYE 360

ERTVEVACYV CKILDQMPAT PSSPMYVD 388

Nucleotide Sequence
(FASTA)

TCGGGTGGAG GGAGCGGAGC GCGCCTGCCA GGCCCCGTCG GTGCTCCTGT TTCTGCAGTG 60

CACGTTGATC CCCCTGCTCA GGGTAAACGC AAAGCACTGA AGTTGAATTT TGCAAATCCA 120

CCTTTCAAAT CTACAGCAAG GTTTACTCTG AATCCCAATC CTACAGGAGT TCAAAACCCA 180

CACATAGAGA GACTGAGAAC ACACAGCATT GAATCGTCAG GAAAACTGAA GATCTCCCCT 240

GAACAACACT GGGATTTCAC TGCAGAGGAC TTGAAAGACC TTGGAGAAAT TGGACGAGGA 300

GCTTATGGTT CCGTCAACAA AATGGTCCAC AAACCAAGTG GGCAAATAAT GGCAGTTAAA 360

AGAATTCGGT CAACAGTGGA TGAAAAAGAA CAAAAACAAC TTCTCATGGA TTTGGATGTA 420

GTAATGCGGA GTAGTGATTG CCCATACATT GTTCAATTTT ATGGTGCACT CTTCAGAGAG 480

GGTGACTGTT GGATCTGTAT GGAACTCATG TCTACCTCGT TTGATAAGTT TTACAAATAT 540

GTATATAGTG TATTAGATGA TGTTATTCCA GAAGAAATTT TAGGCAAAAT CACTTTAGCA 600

ACTGTGAAGG CTCTAAACCA CTTAAAGGAA AACTTGAAAA TCATTCACAG AGATATCAAA 660

CCTTCCAATA TTCTTCTGGA CAGAAGTGGA AATATTAAAC TCTGTGACTT TGGCATCAGT 720

GGACAGCTTG TGGACTCCAT TGCCAAGACA AGAGATGCTG GGTGTAGACC ATACATGGCA 780

CCTGAAAGAA TAGACCCAAG TGCGTCGCGA CAAGGATATG ATGTCCGCTC TGACGTCTGG 840

AGTTTGGGGA TCACATTGTA CGAGTTGGCC ACGGGCCGAT TTCCTTATCC AAAGTGGAAT 900

AGTGTATTTG ATCAACTAAC ACAAGTCGTA AAAGGAGATC CTCCACAGCT GAGCAATTCT 960

GAGGAAAGAG AATTCTCCCC AAGTTTCATC AACTTTGTCA ACTTGTGCCT TACAAAGGAT 1020

GAATCCAAAA GGCCAAAGTA TAAAGAACTT CTGAAACATC CCTTTATTTT GATGTATGAA 1080

GAACGTACCG TAGAGGTCGC ATGCTATGTT TGTAAAATCC TGGATCAAAT GCCAGCTACT 1140

CCCAGCTCTC CCATGTATGT CGATTGA 1167

Domain Profile

S: 1     lekleelGaGnggvVekvlhkksgkilavKtirleikkeeqkqilrelevlkkssnspyi  60

         l++l+e+G+G++g+V+k++hk+sg+i+avK+ir++++++eqkq+l++l+v+++ss++pyi

Q: 91    LKDLGEIGRGAYGSVNKMVHKPSGQIMAVKRIRSTVDEKEQKQLLMDLDVVMRSSDCPYI  150

         68899*******************************************************

S: 61    vkfyGafvsegdvsicmelmdgtsldkvlkkvlek.kkripekvlgkiavavvkaleylk  119

         v+fyGa+++egd++icmelm+ ts+dk++k v+++ ++ ipe++lgki++a+vkal++lk

Q: 151   VQFYGALFREGDCWICMELMS-TSFDKFYKYVYSVlDDVIPEEILGKITLATVKALNHLK  209

         *********************.*************9************************

S: 120   eklkiiHRDvKPsNiLvnskGevKlCDFGvsgqlvdsiAksa.vGtksYmaPErieg...  175

         e+lkiiHRD+KPsNiL++++G++KlCDFG+sgqlvdsiAk++ +G+++YmaPEri++

Q: 210   ENLKIIHRDIKPSNILLDRSGNIKLCDFGISGQLVDSIAKTRdAGCRPYMAPERIDPsas  269

         *********************************************************999

S: 176   kkkYsvksdvWslGltlvelatgrypyeklkeilellkaivneeppklpee...efseef  232

         ++ Y+v+sdvWslG+tl+elatgr+py+k+++ +++l+++v+++pp+l+++   efs++f

Q: 270   RQGYDVRSDVWSLGITLYELATGRFPYPKWNSVFDQLTQVVKGDPPQLSNSeerEFSPSF  329

         9***********************************************988788******

S: 233   qefvskClkkdekeRpklkellkhafi  259

         ++fv+ Cl+kde++Rpk+kellkh+fi

Q: 330   INFVNLCLTKDESKRPKYKELLKHPFI  356

         **************************7

Domain Sequence
(FASTA)

LKDLGEIGRG AYGSVNKMVH KPSGQIMAVK RIRSTVDEKE QKQLLMDLDV VMRSSDCPYI 60

VQFYGALFRE GDCWICMELM STSFDKFYKY VYSVLDDVIP EEILGKITLA TVKALNHLKE 120

NLKIIHRDIK PSNILLDRSG NIKLCDFGIS GQLVDSIAKT RDAGCRPYMA PERIDPSASR 180

QGYDVRSDVW SLGITLYELA TGRFPYPKWN SVFDQLTQVV KGDPPQLSNS EEREFSPSFI 240

NFVNLCLTKD ESKRPKYKEL LKHPFI 266

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Choloepus hoffmanni"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Drosophila melanogaster"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sorex araneus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0071260	; P:cellular response to mechanical stimulus
GO:0000165	; P:MAPK cascade

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013