EKS-EQC-00314

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-EQC-00314

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
STE/STE20	324.2	6.5E-97	2	243	242

Status

Unreviewed

Ensembl Protein

ENSECAP00000022778

UniProt Accession

F6S8K3;

Protein Name

Mitogen-activated protein kinase kinase kinase kinase

Protein Synonyms/Alias

Gene Name

MAP4K3

Gene Synonyms/Alias

MAP4K3;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSECAG00000026902	ENSECAP00000022778	ENSECAT00000029028

Organism

Equus caballus

Functional Description

Protein Length

864

Protein Sequence
(FASTA)

LFARNVNTGE LAAIKVIKLE PGEDFAVVQQ EIIMMKDCKH PNIVAYFGSY LRRDKLWICM 60

EFCGGGSLQD IYHVTGPLSE LQIAYVSRET LQGLYYLHSK GKMHRDIKGA NILLTDNGHV 120

KLADFGVSAQ ITATIAKRKS FIGTPYWMAP EVAAVERKGG YNQLCDLWAV GITAIELAEL 180

QPPMFDLHPM RALFLMTKSN FQPPKLKDKM KWSNSFHHFV KMALTKNPKK RPTAEKLLQH 240

PFVTQPLTRS LAIELLDKVN NPDHSTYHDF DDDDPEPLVA VPHRIHSTSR NVREEKTRSE 300

INFGQIKFDP PLRKETEPHH ELPDSDGFLD SSEEIYYTAR SNLDLQLEYG QGHQGSYFLG 360

ANKSLLKSVE EELHQRGHVA HLEDDEGDDD ESKHSTMKAK VPPPLPPKPK SIFIPQETHS 420

AEDDNQGTIK RCPMSESPAK PSQVPPRPPP PRLPPQKPVA LGNGVNSFQL NGERDGSLYQ 480

QQNEHRGTNL SRKEKKDVPK PISNGLPPTP KVHMGACFSK VFNGCPLKIH CATSWINPDT 540

RDQYLIFGAE EGIYTLNLNE LHETSMEQLF PRRCTWLYVM NNCLLSISGK ASQLYSHNLP 600

GLFDYARQMQ KLPVAIPAHK LPDRILPRKF AVSAKIPETK WCQKCCVVRN PYTGHKYLCG 660

ALQTSIVLLE WVEPMQKFML IKHIDFPIPC PLRMFEMLVV PEQEYPLVCV GVSRGRDFNQ 720

VVRFETVNPN STSSWFTESD TPQTSVTHVT QLERDTILVC LDCCIKIVNL QGRLKSSRKL 780

SSELTFDFQI ESIVCLQDSV LAFWKHGMQG RSFRSNEVTQ EISDSTRIFR LLGSDRVVVL 840

ESRPTDNPTA NSNLYILAGH ENSY 864

Nucleotide Sequence
(FASTA)

CTTTTTGCAC GGAATGTTAA CACTGGTGAA TTGGCAGCAA TTAAAGTAAT AAAATTGGAA 60

CCAGGAGAAG ACTTTGCAGT TGTGCAGCAA GAAATTATTA TGATGAAAGA CTGTAAACAT 120

CCAAATATTG TTGCTTATTT TGGAAGCTAT CTCAGGCGAG ATAAACTTTG GATTTGCATG 180

GAGTTTTGTG GAGGTGGTTC TTTACAGGAT ATCTATCATG TAACAGGACC TCTATCAGAA 240

CTGCAAATTG CATATGTTAG CAGAGAAACA CTACAGGGAT TATACTACCT TCACAGTAAA 300

GGAAAAATGC ACAGAGATAT AAAGGGAGCC AACATTCTAT TAACGGATAA TGGTCATGTG 360

AAATTGGCTG ATTTTGGAGT ATCTGCACAG ATAACAGCTA CAATTGCCAA ACGGAAGTCT 420

TTCATTGGTA CACCATATTG GATGGCTCCA GAAGTCGCAG CCGTTGAGAG GAAAGGGGGG 480

TACAATCAGC TCTGTGACCT CTGGGCGGTG GGAATCACTG CCATAGAACT TGCTGAGCTT 540

CAGCCGCCTA TGTTTGACTT ACACCCGATG AGAGCATTGT TTCTAATGAC AAAAAGCAAT 600

TTTCAGCCTC CTAAACTAAA GGATAAAATG AAATGGTCAA ATAGTTTTCA TCATTTTGTG 660

AAAATGGCAC TTACCAAAAA TCCAAAAAAA AGACCTACTG CCGAAAAGTT ACTACAGCAT 720

CCGTTTGTCA CACAACCTTT GACCCGGTCT TTGGCAATCG AACTGTTGGA TAAAGTGAAT 780

AATCCAGATC ATTCCACTTA CCATGATTTT GATGATGATG ATCCTGAGCC TCTTGTTGCC 840

GTACCACATA GAATTCACTC AACAAGTAGA AATGTGAGAG AAGAAAAAAC ACGCTCAGAG 900

ATAAACTTTG GACAAATAAA ATTTGATCCA CCCTTAAGGA AGGAGACAGA ACCACATCAT 960

GAACTTCCCG ACAGTGATGG TTTTTTGGAC AGTTCAGAAG AAATATACTA CACTGCAAGA 1020

TCTAATCTGG ATCTACAACT AGAATATGGA CAAGGACACC AAGGTAGTTA CTTTTTAGGT 1080

GCAAACAAGA GTCTTCTGAA GTCTGTAGAA GAAGAGTTAC ATCAGCGAGG GCATGTGGCA 1140

CATTTAGAAG ATGATGAAGG GGATGATGAT GAATCTAAAC ATTCAACCAT GAAAGCAAAA 1200

GTTCCACCTC CTTTGCCACC AAAGCCTAAG TCCATATTCA TACCACAAGA AACTCATTCT 1260

GCTGAGGATG ATAATCAGGG AACAATCAAG AGATGTCCCA TGTCAGAGAG CCCAGCAAAA 1320

CCATCCCAGG TGCCACCTAG ACCACCACCT CCCAGATTAC CTCCACAAAA GCCTGTTGCT 1380

TTAGGAAATG GAGTGAATTC CTTTCAGTTA AATGGTGAAC GAGATGGTTC ATTATATCAA 1440

CAACAGAATG AACACAGAGG CACAAACCTT TCAAGGAAAG AAAAGAAAGA TGTACCAAAG 1500

CCTATTAGTA ACGGTCTACC CCCAACACCT AAAGTGCATA TGGGTGCATG TTTTTCAAAG 1560

GTTTTTAATG GATGTCCCTT GAAAATTCAC TGTGCAACAT CATGGATAAA CCCAGATACG 1620

AGAGATCAAT ACTTGATATT TGGTGCTGAA GAAGGGATTT ATACCTTGAA TCTTAATGAA 1680

CTTCATGAAA CATCAATGGA ACAGCTATTC CCCCGAAGGT GTACGTGGTT GTATGTAATG 1740

AACAATTGCT TACTATCAAT ATCTGGTAAA GCTTCTCAGC TTTATTCCCA TAATTTACCA 1800

GGGCTTTTTG ATTATGCAAG ACAAATGCAG AAGTTACCTG TTGCTATTCC AGCACACAAA 1860

CTCCCTGACA GAATACTGCC ACGGAAATTT GCTGTATCAG CAAAAATCCC TGAAACCAAG 1920

TGGTGTCAGA AGTGTTGTGT TGTGAGAAAT CCTTACACAG GCCATAAATA CCTATGTGGG 1980

GCGCTTCAGA CTAGCATTGT TCTTTTAGAA TGGGTTGAAC CAATGCAGAA ATTTATGTTA 2040

ATTAAGCACA TAGATTTCCC TATACCGTGT CCACTTAGAA TGTTTGAAAT GCTGGTAGTT 2100

CCTGAGCAGG AGTACCCTTT AGTTTGTGTT GGTGTCAGTA GAGGGAGAGA CTTCAACCAA 2160

GTGGTTCGAT TTGAAACAGT CAATCCAAAT TCTACCTCTT CATGGTTTAC AGAATCAGAT 2220

ACCCCACAGA CAAGTGTTAC TCATGTAACC CAACTGGAGA GAGATACCAT TCTTGTATGC 2280

TTGGACTGTT GTATAAAAAT AGTAAATCTC CAGGGAAGAT TAAAATCAAG CAGAAAATTG 2340

TCATCAGAAC TCACCTTTGA TTTCCAGATT GAATCAATAG TTTGCCTCCA AGACAGTGTG 2400

CTAGCTTTCT GGAAACATGG AATGCAAGGT AGAAGTTTCA GATCTAATGA GGTAACACAA 2460

GAAATTTCAG ATAGCACAAG AATTTTCAGA CTGCTTGGAT CTGACAGGGT CGTGGTTTTG 2520

GAAAGCAGGC CAACTGATAA CCCCACAGCA AATAGCAATT TATACATCCT GGCAGGTCAT 2580

GAAAACAGTT AC 2592

Domain Profile

S: 17    larekktgelvaikkinlekqekleelqkeisvlkklkhpniveylesflkeeelwlvme  76

          ar+++tgel+aik+i+le  e+ + +q+ei ++k++khpniv+y++s+l++++lw++me

Q: 2     FARNVNTGELAAIKVIKLEPGEDFAVVQQEIIMMKDCKHPNIVAYFGSYLRRDKLWICME  61

         58999*******************************************************

S: 77    ylagGslsdlvkeelkselkEeqiayilrevlkaLeylHskkviHrdikakniLlteege  136

         ++ gGsl+d+++  ++ +l+E qiay+ re+l++L ylHsk+++Hrdik++niLlt++g+

Q: 62    FCGGGSLQDIYH--VTGPLSELQIAYVSRETLQGLYYLHSKGKMHRDIKGANILLTDNGH  119

         ************..**********************************************

S: 137   VkLsdfgvaaqlektrkkrktvvgtpywmAPEviaqe.ekgYdekaDiwslGItaielae  195

         VkL+dfgv+aq+++t +krk+++gtpywmAPEv a+e + gY++ +D+w++GItaielae

Q: 120   VKLADFGVSAQITATIAKRKSFIGTPYWMAPEVAAVErKGGYNQLCDLWAVGITAIELAE  179

         ************************************98889*******************

S: 196   gepPfkdleplkallkilkne..ppklkskkkfskefkefvekclqknpekRpsasellk  253

          +pP++dl+p++al++++k++  ppklk+k k+s++f++fv+ +l+knp+kRp+a++ll+

Q: 180   LQPPMFDLHPMRALFLMTKSNfqPPKLKDKMKWSNSFHHFVKMALTKNPKKRPTAEKLLQ  239

         **************999999888*************************************

S: 254   hkFl  257

         h+F+

Q: 240   HPFV  243

         ***7

Domain Sequence
(FASTA)

FARNVNTGEL AAIKVIKLEP GEDFAVVQQE IIMMKDCKHP NIVAYFGSYL RRDKLWICME 60

FCGGGSLQDI YHVTGPLSEL QIAYVSRETL QGLYYLHSKG KMHRDIKGAN ILLTDNGHVK 120

LADFGVSAQI TATIAKRKSF IGTPYWMAPE VAAVERKGGY NQLCDLWAVG ITAIELAELQ 180

PPMFDLHPMR ALFLMTKSNF QPPKLKDKMK WSNSFHHFVK MALTKNPKKR PTAEKLLQHP 240

FV 242

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Taeniopygia guttata"; ?>Tetraodon nigroviridis"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0005083	; F:small GTPase regulator activity
GO:0007243	; P:intracellular protein kinase cascade
GO:0006950	; P:response to stress

KEGG

InterPros

IPR001180	; Citron.
IPR011009	; Kinase-like_dom.
IPR021160	; MAPKKKK.
IPR000719	; Prot_kinase_cat_dom.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.

Pfam

PF00780	; CNH; 1.
PF00069	; Pkinase; 1.

SMARTs

SM00036	; CNH; 1.
SM00220	; S_TKc; 1.

Prosites

PS50219	; CNH; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.

Prints

Created Date

20-Feb-2013