EKS-EQC-00399
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-EQC-00399
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TKL/IRAK397.34.3E-119118396279
StatusUnreviewed
Ensembl ProteinENSECAP00000022862
UniProt AccessionF6QZW8;
Protein Name
Protein Synonyms/Alias
Gene NameIRAK3
Gene Synonyms/Alias IRAK3;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSECAG00000026958ENSECAP00000022862ENSECAT00000029063
OrganismEquus caballus
Functional Description
Protein Length549
Protein Sequence
(FASTA)
AERLSSSWLD VRHIEKYVDQ GKSGTRELLW SWAQKNKTIG DLLQILQEMG HHRAIHLITN 60
HGKHFLGGSQ WNYFNMCFFS ETTNVTVDNV LIPKHNEKGI LFKPSISFQN ITEGTKNFHK 120
DFLIGEGEIF EVYRVEIQNR TYAVKLFKQE KKMQCKQQWK SFLSELEVLL LFHHPNILEL 180
AAYFTESDKF CLVYPYMRNG SLFDRLQCVG NTAPLSWHIR ISILIGACKA IQYLHNIEPC 240
SVVCGSISSA NILLDDQFQP KLTDFAVAHF RPHLEHQHCT ISVTGCNRKH LWYMPEEYVR 300
QGRLTVKTDV YSFGIVIMEV LTGCKVVLDE PKHIQLRDLL MELMEKRGLD SCLSYLDKKV 360
CPCPRNFSAK LFSLAGQCAA TRAKLRPSMD EVLTVLESTP ASLYFAEDPP ASLKSFRCPS 420
PLFLDNVPSI PVENDENQNN SSLPPDKAWR KERMTQKIPF ECSQSEVTFL GFERKTGSQR 480
NEDACNIPSS SCEKSWSPKD AAPSQDSSTC GVTMDPSAEA LGQSYRSRPM EISWSSEFSW 540
NECEEYKKE 549
Nucleotide Sequence
(FASTA)
GCGGAGCGAC TTTCAAGCAG CTGGCTGGAT GTTCGTCACA TTGAAAAGTA TGTAGACCAA 60
GGGAAAAGTG GAACGAGAGA ATTGCTTTGG TCCTGGGCAC AGAAAAACAA GACCATCGGT 120
GACCTTTTAC AGATCCTCCA GGAGATGGGG CATCATCGAG CTATCCATTT AATTACAAAC 180
CATGGTAAAC ACTTCTTAGG TGGCTCTCAA TGGAATTACT TTAATATGTG TTTCTTCTCT 240
GAAACAACCA ATGTCACAGT GGATAATGTT CTTATTCCTA AACATAATGA AAAAGGAATA 300
TTGTTTAAAC CTTCTATCAG CTTTCAAAAC ATCACAGAAG GAACCAAAAA TTTCCACAAA 360
GACTTCCTAA TTGGAGAAGG GGAGATTTTT GAGGTGTACA GAGTGGAGAT CCAAAACCGA 420
ACGTATGCCG TTAAATTATT TAAACAGGAG AAAAAAATGC AATGTAAGCA ACAATGGAAG 480
AGCTTTTTAT CTGAGCTTGA AGTTTTACTA CTGTTTCATC ATCCAAACAT TCTGGAGTTG 540
GCTGCATATT TTACAGAGAG TGACAAGTTC TGCCTGGTTT ATCCGTATAT GAGAAATGGG 600
TCCCTTTTTG ACAGACTGCA GTGTGTAGGT AACACAGCCC CGCTCTCTTG GCACATTCGA 660
ATCAGTATCT TAATAGGAGC GTGCAAGGCC ATCCAGTATT TGCACAACAT CGAGCCGTGC 720
TCAGTTGTCT GTGGCAGCAT CTCCAGTGCA AACATACTTT TGGATGATCA GTTTCAACCC 780
AAACTAACTG ATTTTGCCGT GGCGCACTTC CGACCCCACC TTGAACACCA GCACTGCACC 840
ATCAGCGTGA CCGGCTGCAA CAGGAAACAC CTGTGGTACA TGCCCGAGGA GTACGTCAGG 900
CAGGGCAGAC TCACCGTCAA AACCGACGTC TACAGCTTTG GGATTGTAAT CATGGAAGTT 960
CTGACAGGTT GTAAAGTGGT GTTGGATGAG CCAAAGCACA TCCAGCTGAG GGATCTTCTT 1020
ATGGAATTGA TGGAAAAGAG AGGCCTTGAT TCATGTCTCT CATATCTAGA TAAGAAAGTG 1080
TGTCCCTGTC CTCGGAATTT CTCTGCCAAG CTGTTCTCTT TGGCGGGCCA GTGTGCTGCA 1140
ACACGGGCCA AGTTGAGACC ATCGATGGAT GAAGTCCTGA CCGTTCTTGA GAGCACTCCG 1200
GCCAGCTTGT ATTTTGCTGA AGACCCTCCC GCCTCACTGA AGTCCTTCAG GTGTCCTTCT 1260
CCTCTGTTCT TGGACAACGT ACCAAGTATT CCAGTGGAAA ATGATGAAAA CCAGAATAAC 1320
TCTTCCCTGC CTCCTGATAA AGCTTGGAGA AAAGAGAGAA TGACTCAGAA AATTCCCTTT 1380
GAATGTAGCC AGTCTGAGGT GACGTTTCTG GGCTTTGAGA GAAAGACAGG GAGTCAGAGA 1440
AATGAGGATG CTTGCAACAT ACCCAGTTCT TCTTGTGAAA AGAGTTGGTC TCCAAAGGAT 1500
GCAGCTCCAT CCCAGGACTC CAGCACCTGT GGTGTGACTA TGGACCCTTC TGCAGAAGCT 1560
CTGGGCCAGT CTTACAGGAG CAGGCCAATG GAGATTAGCT GGTCTTCTGA ATTTTCCTGG 1620
AATGAATGTG AAGAGTACAA AAAGGAG 1647
Domain Profile
S: 1     fsednrigeGgfgevyrgelkntavavkklkeeadlslkelkqsfltElkvlarfrHdni  60
         f++d+ igeG+++evyr+e++n ++avk +k+e+++++k+ ++sfl+El+vl+ f+H+ni
Q: 118   FHKDFLIGEGEIFEVYRVEIQNRTYAVKLFKQEKKMQCKQQWKSFLSELEVLLLFHHPNI  177
         89**********************************************************
S: 61    lellgysaeseklcLvYqymknGsLedrLqcqkgsepLsWpqRlsillGtaraiefLHea  120
         lel++y++es+k+cLvY+ym+nGsL+drLqc ++++pLsW++R+sil+G+ +ai++LH+ 
Q: 178   LELAAYFTESDKFCLVYPYMRNGSLFDRLQCVGNTAPLSWHIRISILIGACKAIQYLHNI  237
         ************************************************************
S: 121   sp.slihgdiksaNiLLDekltpKlgDfglarfapesekqsstvlrtskvrgtlaYlpee  179
         +p s+++g+i+saNiLLD++++pKl+Df++a+f+p+ e+q++t+  t   r++l+Y+pee
Q: 238   EPcSVVCGSISSANILLDDQFQPKLTDFAVAHFRPHLEHQHCTISVTGCNRKHLWYMPEE  297
         ************************************************************
S: 180   firvgqltvkvDvySfGiVllEvltGlravdedrktkyLkdllkeeieeekveilekfld  239
         ++r+g+ltvk+DvySfGiV++EvltG+++v +++k+ +L+dll+e +e+++++++ ++ld
Q: 298   YVRQGRLTVKTDVYSFGIVIMEVLTGCKVVLDEPKHIQLRDLLMELMEKRGLDSCLSYLD  357
         ************************************************************
S: 240   kkagkleeellealielalaclaekakkrPtmsqvlell  278
         kk+ +++++++++l++la++c+a++ak rP+m++vl  l
Q: 358   KKVCPCPRNFSAKLFSLAGQCAATRAKLRPSMDEVLTVL  396
         ***********************************9765
Domain Sequence
(FASTA)
FHKDFLIGEG EIFEVYRVEI QNRTYAVKLF KQEKKMQCKQ QWKSFLSELE VLLLFHHPNI 60
LELAAYFTES DKFCLVYPYM RNGSLFDRLQ CVGNTAPLSW HIRISILIGA CKAIQYLHNI 120
EPCSVVCGSI SSANILLDDQ FQPKLTDFAV AHFRPHLEHQ HCTISVTGCN RKHLWYMPEE 180
YVRQGRLTVK TDVYSFGIVI MEVLTGCKVV LDEPKHIQLR DLLMELMEKR GLDSCLSYLD 240
KKVCPCPRNF SAKLFSLAGQ CAATRAKLRP SMDEVLTVL 279
KeywordComplete proteome; Reference proteome.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Echinops telfairi"; ?>Felis catus"; ?>Gasterosteus aculeatus"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>
EKS-AIM-00378
EKS-BOT-00407
EKS-CAJ-00410
EKS-CAF-00407
EKS-CAP-00435
EKS-DAR-00794
EKS-ECT-00006
EKS-FEC-00390
EKS-GAA-00494
EKS-HOS-00413
EKS-ICT-00386
EKS-LAC-00422
EKS-LOA-00416
EKS-MAM-00405
EKS-MOD-00398
EKS-MUM-00439
EKS-MUP-00401
EKS-MYL-00402
EKS-NOL-00370
EKS-OCP-00086
EKS-ORA-00355
EKS-ORC-00382
EKS-OTG-00409
EKS-PEM-00222
EKS-POA-00397
EKS-RAN-00421
EKS-SAH-00378
EKS-SUS-00359
EKS-TUT-00121
EKS-VIP-00063
Gene Ontology
GO:0005737; C:cytoplasm
GO:0005634; C:nucleus
GO:0005524; F:ATP binding
GO:0000287; F:magnesium ion binding
GO:0004674; F:protein serine/threonine kinase activity
GO:0070498; P:interleukin-1-mediated signaling pathway
GO:0045824; P:negative regulation of innate immune response
GO:0010936; P:negative regulation of macrophage cytokine production
GO:0043407; P:negative regulation of MAP kinase activity
GO:0032088; P:negative regulation of NF-kappaB transcription factor activity
GO:0042177; P:negative regulation of protein catabolic process
GO:0043242; P:negative regulation of protein complex disassembly
GO:0034122; P:negative regulation of toll-like receptor signaling pathway
GO:0032720; P:negative regulation of tumor necrosis factor production
GO:0010933; P:positive regulation of macrophage tolerance induction
GO:0051092; P:positive regulation of NF-kappaB transcription factor activity
GO:0046777; P:protein autophosphorylation
GO:0043330; P:response to exogenous dsRNA
GO:0032496; P:response to lipopolysaccharide
GO:0032494; P:response to peptidoglycan
KEGG
InterPros
IPR000488; Death.
IPR011029; DEATH-like.
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
Pfam
PF00531; Death; 1.
PF00069; Pkinase; 1.
SMARTs
Prosites
PS50011; PROTEIN_KINASE_DOM; 1.
Prints
Created Date20-Feb-2013