EKS-FEC-00267
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-FEC-00267
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TKL/STKR432.19.4E-130205491287
StatusUnreviewed
Ensembl ProteinENSFCAP00000000243
UniProt AccessionB0I548;
Protein Name
Protein Synonyms/Alias Activin A receptor type II-like 1;
Gene NameACVRL1
Gene Synonyms/Alias ACVRL1;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSFCAG00000000265ENSFCAP00000000243ENSFCAT00000000265
OrganismFelis catus
Functional Description
Protein Length505
Protein Sequence
(FASTA)
MTLDSLRRGF LMLLMALGLT QGDPVKPSRG PLVTCTCEGP TCRGSTCQGA WCIVVLVREE 60
GGQPQEHRGC GSLHEELCKG RPTEFVNHYC CYSSLCNQNV SLALDDTQTP PEQPKVDGQL 120
PLILGPVLAL LVLVALAALG LWHVRRRRRE KQRCLRSDLG ESSLILKASE QGDSMLGDLL 180
DSDCTTGSGS GLPFLVQRTV ARQVALVECV GKGRYGEVWR GLWHGESVAI KIFSSRDEQS 240
WFRETEIYNT VLLRHDNILG FIASDMTSRN SSTQLWLITH YHEHGSLYDF LQRQTLEPQL 300
ALRLAVSAAC GLAHLHVEIF GTQGKPAIAH RDLKSRNVLV KSNLQCCIAD LGLAVMHSQG 360
SDYLDIGNNP RVGTKRYMAP EVLEEQIRTD CFESYKWTDI WAFGLVLWEI ARRTIVNGIV 420
EDYRPPFYDV VPNDPSFEDM KKVVCVDQQT PTIPNRLTAD PVLSGLAQMM RECWYPNPSA 480
RLTALRIKKT LQKLSNGLEK PKVIR 505
Nucleotide Sequence
(FASTA)
ATGACCTTGG ACTCCCTCAG GAGAGGCTTT CTGATGCTAC TGATGGCCTT GGGCTTGACC 60
CAGGGAGACC CTGTGAAGCC CTCCCGGGGC CCGCTGGTGA CCTGCACGTG TGAGGGTCCA 120
ACCTGCAGGG GGTCCACCTG CCAGGGGGCC TGGTGCATAG TAGTGCTGGT GCGGGAGGAG 180
GGCGGACAAC CCCAGGAGCA TCGGGGCTGT GGGAGCCTGC ATGAGGAGCT ATGCAAGGGG 240
CGTCCCACCG AGTTCGTCAA CCACTACTGC TGCTACAGCT CCCTGTGCAA CCAAAACGTG 300
TCTCTGGCAC TGGATGACAC CCAGACTCCT CCAGAACAGC CGAAAGTAGA CGGCCAGCTG 360
CCTCTGATCC TGGGCCCTGT GCTGGCCTTA TTGGTCCTGG TGGCCCTGGC TGCCCTGGGC 420
CTGTGGCATG TCCGGCGGCG GAGGCGGGAG AAGCAGAGGT GTCTGCGCAG CGATCTGGGC 480
GAGTCCAGCC TCATCCTGAA GGCGTCGGAG CAGGGGGACA GCATGCTGGG GGATCTCCTG 540
GACAGTGACT GCACCACGGG CAGTGGCTCA GGACTGCCCT TCCTGGTGCA GAGGACAGTG 600
GCACGGCAGG TGGCCCTGGT GGAGTGTGTA GGAAAGGGCC GCTACGGCGA GGTGTGGCGC 660
GGCCTGTGGC ATGGTGAGAG CGTGGCCATC AAGATCTTCT CTTCAAGGGA TGAACAGTCC 720
TGGTTCCGGG AGACGGAGAT CTACAATACG GTGCTGCTCA GACACGACAA CATTCTAGGC 780
TTTATCGCCT CGGACATGAC TTCCCGCAAT TCGAGCACAC AGCTGTGGCT CATCACGCAC 840
TACCACGAGC ATGGGTCACT CTATGACTTT CTGCAGAGGC AGACGCTGGA GCCCCAGCTG 900
GCCCTGAGGC TGGCTGTATC GGCCGCCTGC GGCCTGGCAC ACTTGCACGT GGAGATCTTT 960
GGCACGCAGG GCAAACCGGC CATCGCCCAC CGGGACCTCA AAAGCCGCAA TGTGTTGGTC 1020
AAGAGCAACC TCCAGTGCTG CATCGCCGAC CTGGGCCTGG CTGTGATGCA CTCCCAGGGT 1080
AGTGATTACC TGGACATCGG AAACAACCCA CGAGTGGGCA CCAAGCGGTA CATGGCCCCT 1140
GAGGTGCTGG AAGAGCAGAT CCGCACCGAC TGCTTCGAGT CCTACAAGTG GACAGACATC 1200
TGGGCCTTTG GCCTGGTGCT GTGGGAGATC GCCCGTCGGA CCATTGTCAA TGGCATCGTG 1260
GAGGACTACC GGCCACCCTT CTATGACGTG GTGCCCAATG ATCCCAGCTT TGAGGACATG 1320
AAGAAGGTGG TGTGTGTTGA TCAGCAGACC CCCACCATCC CCAACCGGCT GACCGCAGAC 1380
CCGGTCCTCT CAGGCCTGGC TCAGATGATG CGGGAGTGCT GGTACCCCAA CCCTTCTGCC 1440
CGCCTCACGG CTCTGCGGAT CAAGAAGACA CTACAGAAAC TCAGCAACGG TCTCGAGAAG 1500
CCCAAAGTGA TTCGCTAG 1518
Domain Profile
S: 2     klleligkGrygeVwkaklrgeevAvKifstedeaswkrEkeiyqtvllrhenilqfiaa  61
          l+e++gkGrygeVw++ ++ge+vA+Kifs++de+sw+rE+eiy+tvllrh+nil+fia+
Q: 205   ALVECVGKGRYGEVWRGLWHGESVAIKIFSSRDEQSWFRETEIYNTVLLRHDNILGFIAS  264
         689*********************************************************
S: 62    dkkeedsltelllvteyhekgsLsdyLkretldveellrlalslasGlahLHeeivgtkg  121
         d+++++s+t+l+l+t+yhe+gsL+d+L+r+tl+ + +lrla s+a+GlahLH ei+gt+g
Q: 265   DMTSRNSSTQLWLITHYHEHGSLYDFLQRQTLEPQLALRLAVSAACGLAHLHVEIFGTQG  324
         ************************************************************
S: 122   kkKpaiaHRDlkskNilvkkdltcciaDlGLalkleeekeeldlaansqvGtkRYmaPEv  181
           KpaiaHRDlks+N+lvk++l+cciaDlGLa+++++ ++ ld+ +n +vGtkRYmaPEv
Q: 325   --KPAIAHRDLKSRNVLVKSNLQCCIADLGLAVMHSQGSDYLDIGNNPRVGTKRYMAPEV  382
         ..**********************************************************
S: 182   leealnlkdfeafkraDvYslgLvlWEvasRceevdeeveeyklpfeevvgsdPsleemk  241
         lee++ +++fe++k++D++++gLvlWE+a+R+   +++ve+y++pf++vv++dPs+e+mk
Q: 383   LEEQIRTDCFESYKWTDIWAFGLVLWEIARRTIV-NGIVEDYRPPFYDVVPNDPSFEDMK  441
         ********************************99.*************************
S: 242   evvvekklrPkipeawkkkealkelsklleecWdadpeaRltalrvkkrl  291
         +vv+++++ P+ip++++++++l+ l+++++ecW+ +p+aRltalr+kk+l
Q: 442   KVVCVDQQTPTIPNRLTADPVLSGLAQMMRECWYPNPSARLTALRIKKTL  491
         ************************************************97
Domain Sequence
(FASTA)
ALVECVGKGR YGEVWRGLWH GESVAIKIFS SRDEQSWFRE TEIYNTVLLR HDNILGFIAS 60
DMTSRNSSTQ LWLITHYHEH GSLYDFLQRQ TLEPQLALRL AVSAACGLAH LHVEIFGTQG 120
KPAIAHRDLK SRNVLVKSNL QCCIADLGLA VMHSQGSDYL DIGNNPRVGT KRYMAPEVLE 180
EQIRTDCFES YKWTDIWAFG LVLWEIARRT IVNGIVEDYR PPFYDVVPND PSFEDMKKVV 240
CVDQQTPTIP NRLTADPVLS GLAQMMRECW YPNPSARLTA LRIKKTL 287
KeywordReceptor.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Echinops telfairi"; ?>Equus caballus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Macropus eugenii"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sorex araneus"; ?>Sus scrofa"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>
EKS-AIM-00263
EKS-BOT-00281
EKS-CAJ-00287
EKS-CAF-00287
EKS-CAP-00316
EKS-ECT-00031
EKS-EQC-00273
EKS-GOG-00280
EKS-HOS-00287
EKS-ICT-00265
EKS-LOA-00291
EKS-MAM-00283
EKS-MAE-00018
EKS-MUM-00312
EKS-MUP-00276
EKS-MYL-00284
EKS-NOL-00259
EKS-OCP-00028
EKS-OTG-00286
EKS-PAT-00265
EKS-PES-00250
EKS-POA-00271
EKS-PRC-00026
EKS-RAN-00296
EKS-SAH-00263
EKS-SOA-00026
EKS-SUS-00247
EKS-TUT-00043
EKS-VIP-00020
Gene Ontology
GO:0009986; C:cell surface
GO:0005887; C:integral to plasma membrane
GO:0005524; F:ATP binding
GO:0005024; F:transforming growth factor beta-activated receptor activity
GO:0001525; P:angiogenesis
GO:0060840; P:artery development
GO:0001974; P:blood vessel remodeling
GO:0030509; P:BMP signaling pathway
GO:0071773; P:cellular response to BMP stimulus
GO:0071560; P:cellular response to transforming growth factor beta stimulus
GO:0061154; P:endothelial tube morphogenesis
GO:0001701; P:in utero embryonic development
GO:0001946; P:lymphangiogenesis
GO:0060836; P:lymphatic endothelial cell differentiation
GO:0043537; P:negative regulation of blood vessel endothelial cell migration
GO:0030308; P:negative regulation of cell growth
GO:2000279; P:negative regulation of DNA biosynthetic process
GO:0045602; P:negative regulation of endothelial cell differentiation
GO:0001937; P:negative regulation of endothelial cell proliferation
GO:0051895; P:negative regulation of focal adhesion assembly
GO:0045603; P:positive regulation of endothelial cell differentiation
GO:0001938; P:positive regulation of endothelial cell proliferation
GO:0010862; P:positive regulation of pathway-restricted SMAD protein phosphorylation
GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter
GO:0008217; P:regulation of blood pressure
GO:0061298; P:retina vasculature development in camera-type eye
GO:0007179; P:transforming growth factor beta receptor signaling pathway
GO:0060841; P:venous blood vessel development
GO:0035313; P:wound healing, spreading of epidermal cells
KEGG
InterPros
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
Pfam
PF00069; Pkinase; 1.
SMARTs
Prosites
PS50011; PROTEIN_KINASE_DOM; 1.
Prints
Created Date20-Feb-2013