EKS-FEC-00029
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-FEC-00029
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/Jak338.92.2E-1018471120274
StatusUnreviewed
Ensembl ProteinENSFCAP00000006963
UniProt AccessionQ8HYM5;
Protein Name
Protein Synonyms/Alias Janus kinase 3;
Gene NameJAK3
Gene Synonyms/Alias JAK3;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSFCAG00000007517ENSFCAP00000006963ENSFCAT00000007519
OrganismFelis catus
Functional Description
Protein Length1138
Protein Sequence
(FASTA)
ALGDQPTAGA MGLLEQTKAG GEQATPMAPP KAGALHVLLP PRGPGPPQRL SFSFGDHSAE 60
ELCVWAAKAS GILPVYHSLF ALATEDLSYW YPPSHIFSVE DASTQILLYR LRFYFPNWFG 120
LEKCHRFGLR KDLASAILDL PVLEHLFAQH RNDLVSGRLA VGLSLKEQGE CLSLAVLDLA 180
RMAREQAQQP EELLKTVSYK ACLPPDLRDL IQGLSFVTRK RIRRTVRRAL GRVTACQADR 240
HSLMAKYIMD LERLDPARAA ETFLVSLPGA AGGQDAPGLL RVAGDSGIHW SPGGHEVWEA 300
AGRDRRQGRS LGRRGGRVGG VKAWKDWESF ERGPLRGALQ PFCDFPEIVD ISIKQAPRVG 360
PAGEHRLVTV TRTDNQILSF VALVDGYFRL TSDSRHFFCK EVAPPRLLEE VAEQCHGPIT 420
LDFAINKLKT GGSLPGSYVL RRSPQDFDSF LLTVCVQTPL GPDYKGCLIR CDPTGTFSLA 480
GLGRPHSSLR ELLAACWDAG LHVDGVALNL TSCCAPRPKE KSNLIVVRRG CSTPTSSLVW 540
PQSQCQLSQM TFHKIPADSL EWHENLGHGS FTKIYRGCRH EAVDGEARET EVLLKVMDAK 600
HRNCMESFLE AASLMSQVSY QHLVLLHGVC MAGDSVMVQE FVRLGALDTY LRKSGHLVPA 660
SWKLQVIKQL AYALNYLEDK GLPHGNVSAR KVLLAREGAD GNLPFIKLSD PGVSPTVLSL 720
EMLTDRIPWV APECLQEART LGLEADKWGF GATVWEVFSG IPMPISTLDP AKKLQFYEER 780
QHLPAPKWME LATLIQQCMA YEPGQRPSFR AIIRDLNSLI TSERTERVSR RIEAPQQDPT 840
IFEERHLKYI SQLGKGNFGS VELCRYDPLG DNTGALVAVK QLQHSGPDQQ RDFQREIQIL 900
KALHSDFIVK YRGVSYGPGR QSLRLVMEYL PSGCLRDFLQ RHRARLDASR LLLYASQICK 960
GMEYLGSRRC VHRDLAARNI LVESETHVKI ADFGLAKLLP LDKDYYVVRE PGQSPIFWYA 1020
PESLSDNIFS RQSDVWSFGV VLYELFTYGN KNCSPSAEFL RMMGCERDVP ALCRLLELLA 1080
EGQRLPAPPA CPGEVHELMK LCWAPSPQDR PTFSALGPQL DTLWSGSRGD VATLWASC 1138
Nucleotide Sequence
(FASTA)
GCATTGGGTG ACCAACCCAC TGCGGGGGCT ATGGGACTTT TGGAGCAAAC CAAGGCAGGC 60
GGGGAACAGG CTACACCCAT GGCGCCTCCA AAGGCTGGTG CCCTGCACGT GCTGCTGCCC 120
CCTCGGGGCC CCGGACCCCC ACAACGCCTG TCCTTCTCCT TTGGGGACCA TTCAGCTGAA 180
GAGCTATGTG TTTGGGCTGC TAAGGCCAGT GGCATCCTGC CTGTGTACCA CTCCCTCTTT 240
GCTCTGGCCA CGGAGGACCT GTCCTACTGG TACCCCCCGA GCCACATCTT CTCCGTGGAG 300
GATGCAAGCA CCCAAATCCT GCTCTACAGG CTCCGCTTTT ACTTCCCCAA CTGGTTTGGG 360
TTGGAGAAAT GCCACCGCTT CGGGCTACGG AAGGACTTGG CCAGTGCCAT CCTTGACCTG 420
CCAGTCCTGG AGCACCTCTT CGCCCAGCAC CGAAATGACC TGGTGAGCGG CCGCCTCGCC 480
GTGGGCCTCA GTCTCAAGGA GCAGGGTGAA TGTCTCAGCC TGGCAGTGCT GGACCTGGCT 540
CGGATGGCCC GTGAGCAGGC TCAGCAGCCT GAGGAGCTGC TGAAGACCGT CAGCTACAAG 600
GCCTGCCTGC CCCCCGATCT GCGCGACCTG ATCCAGGGCC TGAGCTTCGT GACGCGGAAG 660
CGTATCCGGA GGACTGTGCG TCGGGCCCTG GGCCGCGTGA CCGCCTGCCA GGCTGACAGG 720
CACTCGCTCA TGGCCAAGTA CATCATGGAC CTGGAGAGGC TGGACCCGGC CAGGGCCGCC 780
GAGACCTTCC TCGTGAGCCT CCCCGGGGCT GCTGGTGGCC AGGATGCTCC GGGGCTGCTC 840
CGAGTGGCTG GTGACAGCGG CATCCACTGG AGTCCGGGAG GACACGAGGT GTGGGAGGCC 900
GCAGGGCGGG ACCGACGGCA GGGGAGGAGC CTAGGAAGGA GGGGCGGGAG AGTGGGCGGG 960
GTGAAGGCGT GGAAGGACTG GGAGAGCTTC GAGAGGGGCC CGTTGCGAGG GGCCCTCCAG 1020
CCCTTCTGCG ACTTTCCAGA AATTGTGGAC ATCAGCATCA AGCAGGCTCC TCGTGTTGGC 1080
CCCGCCGGGG AGCACCGCCT GGTCACCGTC ACCAGGACGG ACAACCAGAT CCTGTCCTTC 1140
GTGGCGCTCG TGGATGGCTA CTTCCGGCTG ACTTCCGACT CCAGGCACTT CTTCTGCAAG 1200
GAGGTTGCGC CGCCGCGGCT GCTGGAGGAG GTGGCCGAAC AGTGCCACGG TCCCATCACC 1260
CTGGATTTTG CCATCAACAA GCTCAAGACC GGGGGCTCCC TTCCCGGCTC CTATGTTCTC 1320
CGCCGCAGCC CCCAGGATTT CGACAGCTTC CTCCTCACTG TCTGCGTCCA GACCCCCCTG 1380
GGTCCTGATT ACAAGGGCTG CCTCATCCGG TGTGACCCCA CGGGAACCTT CTCCCTGGCT 1440
GGCCTCGGCC GGCCCCACAG CAGTCTTCGA GAGCTCTTGG CAGCCTGCTG GGATGCTGGG 1500
CTGCACGTGG ATGGGGTTGC GCTGAACCTC ACCTCCTGCT GCGCCCCCAG ACCCAAAGAA 1560
AAGTCCAACC TGATCGTGGT GCGGAGAGGT TGCAGCACTC CCACATCATC CCTTGTTTGG 1620
CCCCAATCCC AGTGTCAGCT GAGTCAGATG ACGTTTCACA AGATCCCCGC TGACAGCCTG 1680
GAGTGGCACG AGAACCTGGG TCACGGGTCC TTCACCAAGA TTTACCGAGG TTGTCGCCAT 1740
GAGGCTGTGG ACGGGGAAGC CCGGGAGACA GAGGTGCTAC TCAAAGTGAT GGATGCCAAG 1800
CACAGAAACT GCATGGAGTC CTTCCTGGAA GCAGCGAGCC TGATGAGCCA AGTGTCGTAT 1860
CAGCACCTCG TGTTGCTCCA CGGCGTGTGC ATGGCTGGAG ACAGTGTCAT GGTGCAGGAA 1920
TTTGTGCGCC TGGGAGCCCT GGATACATAT CTGCGCAAGT CTGGCCACCT GGTACCAGCC 1980
AGCTGGAAGC TGCAGGTGAT CAAACAGCTG GCCTATGCCC TCAACTATCT GGAAGACAAA 2040
GGCCTCCCCC ATGGCAATGT CTCAGCCCGG AAGGTGCTCT TGGCTCGGGA GGGGGCTGAC 2100
GGGAACCTGC CCTTCATCAA GTTGAGTGAC CCTGGTGTCA GCCCCACTGT GCTGAGCCTG 2160
GAGATGCTCA CTGACAGGAT CCCCTGGGTG GCCCCTGAGT GTCTCCAGGA GGCCCGGACC 2220
CTTGGCTTGG AAGCTGACAA GTGGGGTTTC GGTGCCACAG TCTGGGAAGT GTTCAGCGGG 2280
ATCCCGATGC CCATCAGTAC CCTGGATCCT GCCAAGAAGC TCCAGTTTTA CGAGGAACGG 2340
CAGCACCTTC CCGCCCCCAA GTGGATGGAG CTGGCCACCC TGATCCAACA GTGCATGGCC 2400
TATGAGCCAG GCCAGAGGCC CTCCTTCCGT GCCATCATCC GTGACCTGAA CAGCCTCATC 2460
ACTTCAGAAC GCACAGAGAG GGTAAGCAGG CGGATCGAAG CCCCACAGCA AGACCCTACC 2520
ATTTTTGAGG AGAGACATCT CAAGTACATC TCACAGCTGG GCAAGGGCAA CTTTGGCAGC 2580
GTGGAGCTGT GCCGCTATGA CCCGCTGGGC GACAACACGG GCGCCCTAGT GGCTGTGAAG 2640
CAGCTTCAGC ACAGCGGGCC AGACCAGCAG AGGGACTTCC AGCGGGAGAT CCAGATCCTC 2700
AAAGCCCTCC ACAGCGACTT CATTGTCAAG TACCGCGGTG TCAGCTATGG CCCGGGCCGC 2760
CAGAGCCTGC GGCTGGTGAT GGAGTACCTG CCCAGCGGCT GCCTGCGCGA CTTCCTGCAG 2820
CGACACCGCG CGCGCCTGGA CGCCAGCCGC CTGCTCCTCT ACGCCTCGCA GATCTGCAAG 2880
GGCATGGAGT ACCTGGGCTC CCGCCGCTGC GTGCACCGCG ACCTGGCGGC CCGTAACATC 2940
CTGGTGGAGA GCGAGACGCA CGTCAAGATC GCCGACTTTG GCCTCGCCAA GCTGCTGCCG 3000
CTCGACAAAG ACTACTACGT GGTCCGCGAG CCCGGCCAGA GCCCCATCTT CTGGTACGCC 3060
CCAGAGTCCC TCTCTGACAA CATCTTCTCG CGCCAATCGG ACGTCTGGAG CTTCGGGGTC 3120
GTCCTGTACG AACTTTTCAC CTACGGCAAC AAGAATTGCA GCCCCTCAGC CGAGTTCCTC 3180
CGGATGATGG GATGTGAGCG AGACGTCCCC GCCCTCTGCC GCCTCCTGGA GCTGCTGGCT 3240
GAGGGCCAGA GGCTGCCCGC GCCTCCTGCC TGCCCCGGTG AGGTTCATGA GCTCATGAAG 3300
CTGTGCTGGG CCCCGAGCCC GCAAGATCGG CCAACATTCA GTGCCCTGGG CCCCCAGCTG 3360
GATACACTGT GGAGTGGAAG CCGGGGGGAC GTTGCCACTC TCTGGGCTTC CTGC 3414
Domain Profile
S: 1     lkqiesLgkgtftkvfevredaegdsteeevalkvLkesgedisrdfkreaeilsqlshe  60
         lk+i++Lgkg+f++v+++r+d+ gd+t++ va+k+L++sg+d++rdf+re++il++l+++
Q: 847   LKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSD  906
         799*********************************************************
S: 61    hivklkgvcvaegen..rlVmeyvesGsLdiyLrkkkealslsslldvakqlakameYLe  118
         +ivk++gv++ +g++  rlVmey++sG+L+++L++++++l++s+ll +a+q++k+meYL+
Q: 907   FIVKYRGVSYGPGRQslRLVMEYLPSGCLRDFLQRHRARLDASRLLLYASQICKGMEYLG  966
         ************************************************************
S: 119   dkklvhrdvaarnvLveresnegtppfvklsdpglakavnqd.eYylvreerdsripwla  177
         ++++vhrd+aarn+Lve+e +      vk++d+glak+++ d +Yy+vre+++s+i+w+a
Q: 967   SRRCVHRDLAARNILVESETH------VKIADFGLAKLLPLDkDYYVVREPGQSPIFWYA  1020
         *********************......*********************************
S: 178   peclseaknlstasdvWsFgvtlyellt.cskgesp....lrsesle.......rklell  225
         pe+ls++  +s++sdvWsFgv+lyel+t  +k++sp    lr++++e       r+lell
Q: 1021  PESLSDNI-FSRQSDVWSFGVVLYELFTyGNKNCSPsaefLRMMGCErdvpalcRLLELL  1079
         ********.*******************99999***************************
S: 226   eekerlpkpk.cpaelaelmtnclsyepsqrpsFrailedl  265
          e++rlp+p+ cp e++elm+ c++ +p++rp+F+a+  +l
Q: 1080  AEGQRLPAPPaCPGEVHELMKLCWAPSPQDRPTFSALGPQL  1120
         ***********************************998776
Domain Sequence
(FASTA)
LKYISQLGKG NFGSVELCRY DPLGDNTGAL VAVKQLQHSG PDQQRDFQRE IQILKALHSD 60
FIVKYRGVSY GPGRQSLRLV MEYLPSGCLR DFLQRHRARL DASRLLLYAS QICKGMEYLG 120
SRRCVHRDLA ARNILVESET HVKIADFGLA KLLPLDKDYY VVREPGQSPI FWYAPESLSD 180
NIFSRQSDVW SFGVVLYELF TYGNKNCSPS AEFLRMMGCE RDVPALCRLL ELLAEGQRLP 240
APPACPGEVH ELMKLCWAPS PQDRPTFSAL GPQL 274
KeywordKinase; Transferase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Bos taurus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Equus caballus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ornithorhynchus anatinus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Xenopus tropicalis"; ?>
EKS-AIM-00027
EKS-BOT-00033
EKS-CAF-00032
EKS-CAP-00034
EKS-EQC-00030
EKS-GOG-00029
EKS-HOS-00030
EKS-ICT-00030
EKS-LOA-00032
EKS-MAM-00030
EKS-MOD-00032
EKS-MUM-00033
EKS-MUP-00033
EKS-MYL-00033
EKS-NOL-00031
EKS-ORA-00026
EKS-OTG-00032
EKS-PAT-00027
EKS-POA-00030
EKS-PTV-00031
EKS-RAN-00034
EKS-SAH-00030
EKS-SUS-00027
EKS-XET-00033
Gene Ontology
GO:0004713; F:protein tyrosine kinase activity
GO:0030183; P:B cell differentiation
GO:0007167; P:enzyme linked receptor protein signaling pathway
GO:0035771; P:interleukin-4-mediated signaling pathway
GO:0007243; P:intracellular protein kinase cascade
GO:0002731; P:negative regulation of dendritic cell cytokine production
GO:0045221; P:negative regulation of FasL biosynthetic process
GO:0032693; P:negative regulation of interleukin-10 production
GO:0032695; P:negative regulation of interleukin-12 production
GO:0045626; P:negative regulation of T-helper 1 cell differentiation
GO:0070244; P:negative regulation of thymocyte apoptotic process
GO:0018108; P:peptidyl-tyrosine phosphorylation
GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter
GO:0043029; P:T cell homeostasis
KEGG
InterPros
Pfam
SMARTs
Prosites
Prints
Created Date20-Feb-2013